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The map label for this gene is dfp [H]

Identifier: 124025023

GI number: 124025023

Start: 287889

End: 289145

Strand: Reverse

Name: dfp [H]

Synonym: NATL1_03101

Alternate gene names: 124025023

Gene position: 289145-287889 (Counterclockwise)

Preceding gene: 124025025

Following gene: 124025021

Centisome position: 15.51

GC content: 36.91

Gene sequence:

>1257_bases
ATGATTAATTCGACTGCTTTATCTGGGAAAAAAATATTAGTTGCTGTTACGGGGAGTATTGCAGCTGTTAAAGCTCCTAT
TTTAGTTAGCCGCCTAATTAAAGCTGGGGCAGAGGTCAAGTGCGTCATAACGCAAAGCGCCACTAATTTAGTTAGTCCCT
TATCTTTGTCTACTTTAAGCAGAAATAAATGTTACCAAGATAAAGATCAATGGGCTGACTCTCAAACAAAGCCATTGCAC
ATTGCTTTGGCTGAGTGGGCAGAACTAATTATTGTTGCACCATTGAGCGCCACATCCTTATCCAAATTTACTAGTGGAAG
TGCTGATGGACTTTTAGCCAGCATTCTTTTAGCTAGTCAATCTCAAATAGTTATGGCTGCTGCCATGAATACTTCAATGT
GGGAAAATCAATCAGTAAAAAAGAATTGGAATTACGTAAAAACTATTGACCAAGTTATTACTCTCGAACCTAGCGCAGGA
CTTTTAGCTTGCGACAGAGTTGGTGATGGGAAAATGGTCAATTTAGATATTATTGAAATGGCCTCTGAAAGTGCATTTAT
TTTCCATGCAGAAAATAAATTTCTCACTAAAGATTTAAAAGACATAAGGTTTCTCATATCGGCTGGTCCCACCGTCGAAG
CTCTTGATGCCGCAAGACAATTAACTAATCGAAGCAGTGGAAAGATGGGGGTTTTGATAGCTCAAGCAGCAAAGTTAAGA
GGTGCAGAGGTCGATTTAGTTCATGGCCCAGTAAGCGTTCAACAAGATCTGCTTGAGGGACTGAATACTTATCCAGTTAG
AAGCTCAAATGAAATGGGAGAAAAAATTGATGATTTACAACCATCTGCTCAGGTCATCGTTATGGCTGCAGCAGTATCAG
ATTTCAAAAATAATAGTCCCAGTGAACAAAAAATCTCTAAAGAATTTTTTTTAAAGTCCATTTTCGATGACCTAGAAATG
ACATCAGACCTAATCAAAAATCAAACGAAAAAAAAATTAGAACATCAAATTTTTCTTGGTTTTGCTGCTGAGACAGGAAG
TGATAATGAAATCATTGAAAAGGGAAAGAAGAAAATGGTTTCAAAAGGTTGTGACCTTCTCATGGCCAATCCCATTGATA
GAGCCGGGCAAGGATTTGATGAAAACTTCAACAGTGGTTTTTTGTTAGGTCCAAAAAATATGGTCAAAAAATTATCTTTT
TCAACAAAACTTGCAATATCCCATGAACTTTTAGATGAAATTAGAAATTTAAAATAG

Upstream 100 bases:

>100_bases
AAGATATAAAACATCAAATTGCCTTTAATACGAAAAATGCGGCTTATTTTAAATTTGAAAAATATCTTTCAAGGTCTATT
TGATATAAAATCAAAATATC

Downstream 100 bases:

>100_bases
AAAATTTATTGATATTTTTCGAATTTGTTTTTTTCTAAAATCAGTGGCTAAACGCCAAAAAAGACTGCTGTAAAAGGGTT
TTGAATGAAATCGATGTTTT

Product: putative p-pantothenate cysteine ligase and p-pantothenenoylcysteine decarboxylase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MINSTALSGKKILVAVTGSIAAVKAPILVSRLIKAGAEVKCVITQSATNLVSPLSLSTLSRNKCYQDKDQWADSQTKPLH
IALAEWAELIIVAPLSATSLSKFTSGSADGLLASILLASQSQIVMAAAMNTSMWENQSVKKNWNYVKTIDQVITLEPSAG
LLACDRVGDGKMVNLDIIEMASESAFIFHAENKFLTKDLKDIRFLISAGPTVEALDAARQLTNRSSGKMGVLIAQAAKLR
GAEVDLVHGPVSVQQDLLEGLNTYPVRSSNEMGEKIDDLQPSAQVIVMAAAVSDFKNNSPSEQKISKEFFLKSIFDDLEM
TSDLIKNQTKKKLEHQIFLGFAAETGSDNEIIEKGKKKMVSKGCDLLMANPIDRAGQGFDENFNSGFLLGPKNMVKKLSF
STKLAISHELLDEIRNLK

Sequences:

>Translated_418_residues
MINSTALSGKKILVAVTGSIAAVKAPILVSRLIKAGAEVKCVITQSATNLVSPLSLSTLSRNKCYQDKDQWADSQTKPLH
IALAEWAELIIVAPLSATSLSKFTSGSADGLLASILLASQSQIVMAAAMNTSMWENQSVKKNWNYVKTIDQVITLEPSAG
LLACDRVGDGKMVNLDIIEMASESAFIFHAENKFLTKDLKDIRFLISAGPTVEALDAARQLTNRSSGKMGVLIAQAAKLR
GAEVDLVHGPVSVQQDLLEGLNTYPVRSSNEMGEKIDDLQPSAQVIVMAAAVSDFKNNSPSEQKISKEFFLKSIFDDLEM
TSDLIKNQTKKKLEHQIFLGFAAETGSDNEIIEKGKKKMVSKGCDLLMANPIDRAGQGFDENFNSGFLLGPKNMVKKLSF
STKLAISHELLDEIRNLK
>Mature_418_residues
MINSTALSGKKILVAVTGSIAAVKAPILVSRLIKAGAEVKCVITQSATNLVSPLSLSTLSRNKCYQDKDQWADSQTKPLH
IALAEWAELIIVAPLSATSLSKFTSGSADGLLASILLASQSQIVMAAAMNTSMWENQSVKKNWNYVKTIDQVITLEPSAG
LLACDRVGDGKMVNLDIIEMASESAFIFHAENKFLTKDLKDIRFLISAGPTVEALDAARQLTNRSSGKMGVLIAQAAKLR
GAEVDLVHGPVSVQQDLLEGLNTYPVRSSNEMGEKIDDLQPSAQVIVMAAAVSDFKNNSPSEQKISKEFFLKSIFDDLEM
TSDLIKNQTKKKLEHQIFLGFAAETGSDNEIIEKGKKKMVSKGCDLLMANPIDRAGQGFDENFNSGFLLGPKNMVKKLSF
STKLAISHELLDEIRNLK

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=173, Percent_Identity=36.9942196531792, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI87082301, Length=416, Percent_Identity=33.1730769230769, Blast_Score=179, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17560194, Length=183, Percent_Identity=34.4262295081967, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6322762, Length=187, Percent_Identity=31.0160427807487, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24657262, Length=193, Percent_Identity=29.5336787564767, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 45335; Mature: 45335

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINSTALSGKKILVAVTGSIAAVKAPILVSRLIKAGAEVKCVITQSATNLVSPLSLSTLS
CCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHCCCCHHHHHH
RNKCYQDKDQWADSQTKPLHIALAEWAELIIVAPLSATSLSKFTSGSADGLLASILLASQ
HCCCCCCHHHCCCCCCCCEEEEHHHHCCEEEECCCCHHHHHHHCCCCCHHHHHHHHHHCC
SQIVMAAAMNTSMWENQSVKKNWNYVKTIDQVITLEPSAGLLACDRVGDGKMVNLDIIEM
CCEEEEEECCCHHCCCCCHHHCCCHHHHHHHHEEECCCCCEEEEEECCCCCEEEEHHEEC
ASESAFIFHAENKFLTKDLKDIRFLISAGPTVEALDAARQLTNRSSGKMGVLIAQAAKLR
CCCCEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEEHHHHCC
GAEVDLVHGPVSVQQDLLEGLNTYPVRSSNEMGEKIDDLQPSAQVIVMAAAVSDFKNNSP
CCEEEEEECCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHEEEEHHHHHHHCCCCC
SEQKISKEFFLKSIFDDLEMTSDLIKNQTKKKLEHQIFLGFAAETGSDNEIIEKGKKKMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHHH
SKGCDLLMANPIDRAGQGFDENFNSGFLLGPKNMVKKLSFSTKLAISHELLDEIRNLK
HHCCCEEEECCCCCCCCCCCCCCCCCEEECCHHHHHHHCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MINSTALSGKKILVAVTGSIAAVKAPILVSRLIKAGAEVKCVITQSATNLVSPLSLSTLS
CCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHCCCCHHHHHH
RNKCYQDKDQWADSQTKPLHIALAEWAELIIVAPLSATSLSKFTSGSADGLLASILLASQ
HCCCCCCHHHCCCCCCCCEEEEHHHHCCEEEECCCCHHHHHHHCCCCCHHHHHHHHHHCC
SQIVMAAAMNTSMWENQSVKKNWNYVKTIDQVITLEPSAGLLACDRVGDGKMVNLDIIEM
CCEEEEEECCCHHCCCCCHHHCCCHHHHHHHHEEECCCCCEEEEEECCCCCEEEEHHEEC
ASESAFIFHAENKFLTKDLKDIRFLISAGPTVEALDAARQLTNRSSGKMGVLIAQAAKLR
CCCCEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEEEHHHHCC
GAEVDLVHGPVSVQQDLLEGLNTYPVRSSNEMGEKIDDLQPSAQVIVMAAAVSDFKNNSP
CCEEEEEECCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHEEEEHHHHHHHCCCCC
SEQKISKEFFLKSIFDDLEMTSDLIKNQTKKKLEHQIFLGFAAETGSDNEIIEKGKKKMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHHH
SKGCDLLMANPIDRAGQGFDENFNSGFLLGPKNMVKKLSFSTKLAISHELLDEIRNLK
HHCCCEEEECCCCCCCCCCCCCCCCCEEECCHHHHHHHCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]