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The map label for this gene is srrA [H]

Identifier: 124024957

GI number: 124024957

Start: 225041

End: 225769

Strand: Reverse

Name: srrA [H]

Synonym: NATL1_02441

Alternate gene names: 124024957

Gene position: 225769-225041 (Counterclockwise)

Preceding gene: 124024959

Following gene: 124024954

Centisome position: 12.11

GC content: 40.05

Gene sequence:

>729_bases
ATGAGTGACCCCAATCCATCAACACAAGAAGTTTCTCAAACTCCAAGGATATTACTTGTCGATGACGAGCCCGGTTTAAG
AACTGCTGTTCAGGCCTATCTTGAAGATGAAGGATTTCAAGTTACAACCGCTGTCGATGGAGAAGAGGGATGGGAAAAAG
CTCAAAAAATGATCCCTGATGTAATTATCAGTGACGTCATGATGCCTAGATGTGATGGTTATGGGCTTTTAAAAAAAATT
AGAGAAGATGAAAGACTTGGAGGTACACCTGTCATTTTCCTTACTGCTAAAGGTATGACTGCTGATAGGACTCAGGGTTA
TCAAGCGGGTGTAGACGATTACATGCCAAAACCATTTGATCCAGATGAGCTAGTTGCAAGAGTTAAGAATGTAGTTCAGC
GGCAAGAGCGACTATTAACTGAAGCAGCCAGATTTGCTAATGCTGATGTTGGCCAAATGGCAAAACAGATTACAGAAATA
AAATCAATGCTTAGCCATGGGGATAAACACCACTCACGCAAAGATGATTCGATTCCAAATTTCACCCCAAGAGAGGCAAG
CGTTTTGCAACTAGTAGCGGAAGGTTTAATGAACAAAGAAATTGCAAGACAACTTGAGACTTCTATCCGCAATGTAGAGA
AATATGTGAGTCGATTATTTATTAAAACCGGTACTTCCAGTAGAACAGAACTAGTTAGATATGCACTTGAAAATCATTTA
GTTACCTAA

Upstream 100 bases:

>100_bases
AAAAATTAGGTGATTATTATCCATTGATTCATTCGTTAATCTAAATAATAAGAGAGGAATAAAGGTTAATATCCTCCAAA
AGCTCTAGAAGTCCAATTTT

Downstream 100 bases:

>100_bases
ATATGTTTTGAAAAATTAAAAATTTTAGTTCTCTAGGATTTCACAAATTCTATTAATTTCGAAAAATAAAAAGGAGCTTG
ATTCAACTTGCTTTTGACAA

Product: two-component response regulator

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MSDPNPSTQEVSQTPRILLVDDEPGLRTAVQAYLEDEGFQVTTAVDGEEGWEKAQKMIPDVIISDVMMPRCDGYGLLKKI
REDERLGGTPVIFLTAKGMTADRTQGYQAGVDDYMPKPFDPDELVARVKNVVQRQERLLTEAARFANADVGQMAKQITEI
KSMLSHGDKHHSRKDDSIPNFTPREASVLQLVAEGLMNKEIARQLETSIRNVEKYVSRLFIKTGTSSRTELVRYALENHL
VT

Sequences:

>Translated_242_residues
MSDPNPSTQEVSQTPRILLVDDEPGLRTAVQAYLEDEGFQVTTAVDGEEGWEKAQKMIPDVIISDVMMPRCDGYGLLKKI
REDERLGGTPVIFLTAKGMTADRTQGYQAGVDDYMPKPFDPDELVARVKNVVQRQERLLTEAARFANADVGQMAKQITEI
KSMLSHGDKHHSRKDDSIPNFTPREASVLQLVAEGLMNKEIARQLETSIRNVEKYVSRLFIKTGTSSRTELVRYALENHL
VT
>Mature_241_residues
SDPNPSTQEVSQTPRILLVDDEPGLRTAVQAYLEDEGFQVTTAVDGEEGWEKAQKMIPDVIISDVMMPRCDGYGLLKKIR
EDERLGGTPVIFLTAKGMTADRTQGYQAGVDDYMPKPFDPDELVARVKNVVQRQERLLTEAARFANADVGQMAKQITEIK
SMLSHGDKHHSRKDDSIPNFTPREASVLQLVAEGLMNKEIARQLETSIRNVEKYVSRLFIKTGTSSRTELVRYALENHLV
T

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=213, Percent_Identity=31.924882629108, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786599, Length=119, Percent_Identity=40.3361344537815, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI2367329, Length=181, Percent_Identity=34.8066298342541, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1788394, Length=121, Percent_Identity=38.8429752066116, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1790860, Length=151, Percent_Identity=33.7748344370861, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790863, Length=128, Percent_Identity=34.375, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1790299, Length=116, Percent_Identity=37.9310344827586, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1786784, Length=135, Percent_Identity=33.3333333333333, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1787375, Length=127, Percent_Identity=32.2834645669291, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI87082012, Length=179, Percent_Identity=29.0502793296089, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787229, Length=118, Percent_Identity=34.7457627118644, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788550, Length=120, Percent_Identity=35.8333333333333, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1786911, Length=119, Percent_Identity=33.6134453781513, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787473, Length=232, Percent_Identity=30.1724137931034, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1789402, Length=177, Percent_Identity=27.683615819209, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788905, Length=118, Percent_Identity=36.4406779661017, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1786747, Length=221, Percent_Identity=23.9819004524887, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790437, Length=198, Percent_Identity=26.7676767676768, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788521, Length=220, Percent_Identity=29.5454545454545, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI145693157, Length=107, Percent_Identity=37.3831775700935, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788191, Length=120, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1789149, Length=129, Percent_Identity=31.0077519379845, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1788713, Length=158, Percent_Identity=28.4810126582279, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788222, Length=229, Percent_Identity=26.2008733624454, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27151; Mature: 27020

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPNPSTQEVSQTPRILLVDDEPGLRTAVQAYLEDEGFQVTTAVDGEEGWEKAQKMIPD
CCCCCCCHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHH
VIISDVMMPRCDGYGLLKKIREDERLGGTPVIFLTAKGMTADRTQGYQAGVDDYMPKPFD
HHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHCCCCCCCHHHCCCCCCC
PDELVARVKNVVQRQERLLTEAARFANADVGQMAKQITEIKSMLSHGDKHHSRKDDSIPN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCC
FTPREASVLQLVAEGLMNKEIARQLETSIRNVEKYVSRLFIKTGTSSRTELVRYALENHL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
VT
CC
>Mature Secondary Structure 
SDPNPSTQEVSQTPRILLVDDEPGLRTAVQAYLEDEGFQVTTAVDGEEGWEKAQKMIPD
CCCCCCHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHH
VIISDVMMPRCDGYGLLKKIREDERLGGTPVIFLTAKGMTADRTQGYQAGVDDYMPKPFD
HHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHCCCCCCCHHHCCCCCCC
PDELVARVKNVVQRQERLLTEAARFANADVGQMAKQITEIKSMLSHGDKHHSRKDDSIPN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCC
FTPREASVLQLVAEGLMNKEIARQLETSIRNVEKYVSRLFIKTGTSSRTELVRYALENHL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
VT
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA