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The map label for this gene is purE [H]

Identifier: 124024954

GI number: 124024954

Start: 222503

End: 223039

Strand: Reverse

Name: purE [H]

Synonym: NATL1_02411

Alternate gene names: 124024954

Gene position: 223039-222503 (Counterclockwise)

Preceding gene: 124024957

Following gene: 124024951

Centisome position: 11.96

GC content: 40.6

Gene sequence:

>537_bases
TTGTCTTTAACTGAAGCTAATACATTTAAGCAAGTAGCTGTAGTAATGGGTAGTGATTCAGATCTTAAAACTCTTAAGCC
TGCGGTGGCAATTCTAGATCAATTTGGCATATCTAATGAAGTAAGGATTCTGTCTGCTCATAGGACTCCAAAAGAAATGA
TGGATTTTGCTCAAATGGCAGAATCAAATGGTTTTGGAGTGATAATTGCTGGGGCTGGCGGGGCTGCTCATCTACCAGGA
ATGATCGCATCTCTTACAACCCTTCCTGTCATAGGCGTTCCCGTCAAGAGCAAGGCACTTTCAGGGATAGATTCAATGTA
TTCAATCTTGCAAATGCCCTCAGGCATCCCCGTAGCAACAGTTGCCATAGAAGGGGGCCTAAATGCTGGCCTTTTGGCTA
CTCAAATTTTAGCCATCAACAATACTGAATTAAAAAATAAATTAAACGCCTACAGATGTGAGCTGCACGACCTTGTCGTT
AAAAAAGATCACACACTTAAAGAGATTGGAGCTATAACTTATCTAGAAAAAATGTAA

Upstream 100 bases:

>100_bases
TAATGTTTGTAATTTTTCTCATTTCTTAAAAACTAAAAATAATTAATGCAGAATTCTTAAATAATTGGCATTATAAAAAT
GAGATTTATAAAATTGACAA

Downstream 100 bases:

>100_bases
TTAATTTTCCATTAACTTACTAATTTACTTAGAAATTTTTGAAATAATCTTTCTTTCAACAAGCAAATTAGTAACTATAT
CTACACATTGATCAATCTCT

Product: phosphoribosylaminoimidazole carboxylase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 178; Mature: 177

Protein sequence:

>178_residues
MSLTEANTFKQVAVVMGSDSDLKTLKPAVAILDQFGISNEVRILSAHRTPKEMMDFAQMAESNGFGVIIAGAGGAAHLPG
MIASLTTLPVIGVPVKSKALSGIDSMYSILQMPSGIPVATVAIEGGLNAGLLATQILAINNTELKNKLNAYRCELHDLVV
KKDHTLKEIGAITYLEKM

Sequences:

>Translated_178_residues
MSLTEANTFKQVAVVMGSDSDLKTLKPAVAILDQFGISNEVRILSAHRTPKEMMDFAQMAESNGFGVIIAGAGGAAHLPG
MIASLTTLPVIGVPVKSKALSGIDSMYSILQMPSGIPVATVAIEGGLNAGLLATQILAINNTELKNKLNAYRCELHDLVV
KKDHTLKEIGAITYLEKM
>Mature_177_residues
SLTEANTFKQVAVVMGSDSDLKTLKPAVAILDQFGISNEVRILSAHRTPKEMMDFAQMAESNGFGVIIAGAGGAAHLPGM
IASLTTLPVIGVPVKSKALSGIDSMYSILQMPSGIPVATVAIEGGLNAGLLATQILAINNTELKNKLNAYRCELHDLVVK
KDHTLKEIGAITYLEKM

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=161, Percent_Identity=52.1739130434783, Blast_Score=145, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6324702, Length=165, Percent_Identity=49.6969696969697, Blast_Score=163, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 18820; Mature: 18689

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTEANTFKQVAVVMGSDSDLKTLKPAVAILDQFGISNEVRILSAHRTPKEMMDFAQMA
CCCCCHHHHHEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHH
ESNGFGVIIAGAGGAAHLPGMIASLTTLPVIGVPVKSKALSGIDSMYSILQMPSGIPVAT
CCCCCEEEEECCCCCHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHHHCCCCCCEEE
VAIEGGLNAGLLATQILAINNTELKNKLNAYRCELHDLVVKKDHTLKEIGAITYLEKM
EEEECCCCCCHHHHHEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SLTEANTFKQVAVVMGSDSDLKTLKPAVAILDQFGISNEVRILSAHRTPKEMMDFAQMA
CCCCHHHHHEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHH
ESNGFGVIIAGAGGAAHLPGMIASLTTLPVIGVPVKSKALSGIDSMYSILQMPSGIPVAT
CCCCCEEEEECCCCCHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHHHCCCCCCEEE
VAIEGGLNAGLLATQILAINNTELKNKLNAYRCELHDLVVKKDHTLKEIGAITYLEKM
EEEECCCCCCHHHHHEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]