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The map label for this gene is tmk

Identifier: 124024915

GI number: 124024915

Start: 187161

End: 187796

Strand: Reverse

Name: tmk

Synonym: NATL1_02021

Alternate gene names: 124024915

Gene position: 187796-187161 (Counterclockwise)

Preceding gene: 124024916

Following gene: 124024914

Centisome position: 10.07

GC content: 34.12

Gene sequence:

>636_bases
ATGAAAGGAAAGTTTATTGTTTTTGAGGGTATTGATGGCTCGGGTAAAACCACTCAAATCAATCAATTATCCAAATGGCT
TATTAGTACCGACCTCATACCTGAAAACAATAAATTAGTCATCACTAGAGAGCCAGGAGGGACACAATTAGGAAAATCAA
TAAGATCGCTTCTACTAGATACTTCCATAGAAAAAAGCCCAGATTCTATTACTGAGCTTTTGCTTTATGCCGCAGATAGA
TCACAACATGTAAATGAAATTATTCGCCCAACTTTAGATCAAGGGGATTGGGTAATAAGCGATAGATTTTGTGGCTCAAC
ACTTGCTTATCAAGGTTATGGAAGGAAGTTAGATATCACTTTAATTAAAGATCTCGAAGCAATAGCAACACAGGGCATTG
CTCCGGATATTACATTTCTATTAGACATACCTATTGAAGAAAGTATAAGAAGAAGAAGAAATAGAAAAGATGATCGAATA
GAAAAAGAAGGTAGAGAGTTTTTATCCAATGTTTCTCTCGGCTTTCAAGCATTGTCCGAGGACAGTCACTGGAAAAAAAT
ATCTGCTATTGACTCTAAAGAAAAAATCATATCCGAGATTAAATCTGAAATAAAGAAATTAATAAAAAACAAATAA

Upstream 100 bases:

>100_bases
TACCATCTTCTGGCTTATTACTATCTCCTCCCTTGGCGGCTTTACTTATGGCTTTGAGCTCTATAAGTGTTGTACTTAAT
GCCTTGTCTTTGAAGTCAAA

Downstream 100 bases:

>100_bases
AATGGACAATTTTCAAAATATATGTGGGCAAGATTTAGCAATTAAAATTTTAAAATCTGCTATTTCAAAAGAACATATTT
CTCATGCTTATTTATTTTCT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MKGKFIVFEGIDGSGKTTQINQLSKWLISTDLIPENNKLVITREPGGTQLGKSIRSLLLDTSIEKSPDSITELLLYAADR
SQHVNEIIRPTLDQGDWVISDRFCGSTLAYQGYGRKLDITLIKDLEAIATQGIAPDITFLLDIPIEESIRRRRNRKDDRI
EKEGREFLSNVSLGFQALSEDSHWKKISAIDSKEKIISEIKSEIKKLIKNK

Sequences:

>Translated_211_residues
MKGKFIVFEGIDGSGKTTQINQLSKWLISTDLIPENNKLVITREPGGTQLGKSIRSLLLDTSIEKSPDSITELLLYAADR
SQHVNEIIRPTLDQGDWVISDRFCGSTLAYQGYGRKLDITLIKDLEAIATQGIAPDITFLLDIPIEESIRRRRNRKDDRI
EKEGREFLSNVSLGFQALSEDSHWKKISAIDSKEKIISEIKSEIKKLIKNK
>Mature_211_residues
MKGKFIVFEGIDGSGKTTQINQLSKWLISTDLIPENNKLVITREPGGTQLGKSIRSLLLDTSIEKSPDSITELLLYAADR
SQHVNEIIRPTLDQGDWVISDRFCGSTLAYQGYGRKLDITLIKDLEAIATQGIAPDITFLLDIPIEESIRRRRNRKDDRI
EKEGREFLSNVSLGFQALSEDSHWKKISAIDSKEKIISEIKSEIKKLIKNK

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=215, Percent_Identity=35.8139534883721, Blast_Score=122, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_PROM1 (A2BZV6)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014031.1
- ProteinModelPortal:   A2BZV6
- SMR:   A2BZV6
- STRING:   A2BZV6
- GeneID:   4779173
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_02021
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   PRK13974
- BioCyc:   PMAR167555:NATL1_02021-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23842; Mature: 23842

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGKFIVFEGIDGSGKTTQINQLSKWLISTDLIPENNKLVITREPGGTQLGKSIRSLLLD
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHH
TSIEKSPDSITELLLYAADRSQHVNEIIRPTLDQGDWVISDRFCGSTLAYQGYGRKLDIT
CCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEECCCCCCHHEECCCCCEEEEH
LIKDLEAIATQGIAPDITFLLDIPIEESIRRRRNRKDDRIEKEGREFLSNVSLGFQALSE
HHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
DSHWKKISAIDSKEKIISEIKSEIKKLIKNK
CCCHHHHHHCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKGKFIVFEGIDGSGKTTQINQLSKWLISTDLIPENNKLVITREPGGTQLGKSIRSLLLD
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHH
TSIEKSPDSITELLLYAADRSQHVNEIIRPTLDQGDWVISDRFCGSTLAYQGYGRKLDIT
CCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEECCCCCCHHEECCCCCEEEEH
LIKDLEAIATQGIAPDITFLLDIPIEESIRRRRNRKDDRIEKEGREFLSNVSLGFQALSE
HHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
DSHWKKISAIDSKEKIISEIKSEIKKLIKNK
CCCHHHHHHCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA