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The map label for this gene is hemD [H]

Identifier: 124024900

GI number: 124024900

Start: 175478

End: 176263

Strand: Direct

Name: hemD [H]

Synonym: NATL1_01871

Alternate gene names: 124024900

Gene position: 175478-176263 (Clockwise)

Preceding gene: 124024899

Following gene: 124024903

Centisome position: 9.41

GC content: 35.5

Gene sequence:

>786_bases
ATGGCTTTAACCGACAAGAAGATAATTATTACTCGTGCCCTAGAACAGACTTCAGAGGCTCGTGAGATCTTTCGAAAAAA
TGGAGCTGAGGTATTCGATCTTCCTTCATTAGTGATTGGTCCCCCAGATGACTGGGAGCCTCTAGATGGTGCCTTAAAGG
AAATTACTACCTTTGACTGGATCATCTTTTCTAGTGCAAATGGTGTTAGAAATGTTGATGAAAGAATGAAAGAAATTGGC
TTATCTTTGTCGGAAATTTCTGAGAATATTCAAATTGCAGCTGTAGGAAGAAAAACAGCCTCTTTGTTAGAAGATATGGA
TGTAAAGGTTAGTTTTGTTCCTCCTAGTTTTGTTGCAGATAGCTTGGTTGAATATTTTCCTCAGAATCAAAAAGGTTTAA
AATTATTTATTCCCAGAGTACAAACCGGCGGTAGATCAATATTATCTGACTCTTTCAAATTAAAAGGAGCAGAGGTGACG
GAAGTAGCTGCTTATGAATCTTCTTGTCCTAAAGATATTCCTCAAAAGACTATAGATGCTTTGAATAGTGGACAAATAGA
TATTATTGCTTTTACTAGTAGTAAAACAGTAAAAAATACTGTCAGCTTATTTACAAAACACTTTGGTGAAAATTGGTTGA
AGTTGATTCAAAAGATTCAACTTGTTTCGATTGGGCCTCAAACAACTATTAGCTGTAAAAACCTTATTAGAAAGCCAGAC
AAAGAGGCTTCTCCGCATGATTTGGAAGGATTATTGCAAGCTTGTTTAGAACTGAATTTTAATTAA

Upstream 100 bases:

>100_bases
AATTGTTTAATTGAGAATTTGGTATTCAAGAAAAAACCTTATTGTTATTTAAATAACTGCATAGTTATTCTTTAGACTTC
TTAGAAAGAAGCATACAGAA

Downstream 100 bases:

>100_bases
ATTTATCCTGATTTTTCGACGAGATCTTTAAATCCATCAAGATTTTTTTGTAATTCTTTTGTGACCATTCCTCCAAGAAT
ATTTGCTTTCATTAGATTTG

Product: putative uroporphyrinogen III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MALTDKKIIITRALEQTSEAREIFRKNGAEVFDLPSLVIGPPDDWEPLDGALKEITTFDWIIFSSANGVRNVDERMKEIG
LSLSEISENIQIAAVGRKTASLLEDMDVKVSFVPPSFVADSLVEYFPQNQKGLKLFIPRVQTGGRSILSDSFKLKGAEVT
EVAAYESSCPKDIPQKTIDALNSGQIDIIAFTSSKTVKNTVSLFTKHFGENWLKLIQKIQLVSIGPQTTISCKNLIRKPD
KEASPHDLEGLLQACLELNFN

Sequences:

>Translated_261_residues
MALTDKKIIITRALEQTSEAREIFRKNGAEVFDLPSLVIGPPDDWEPLDGALKEITTFDWIIFSSANGVRNVDERMKEIG
LSLSEISENIQIAAVGRKTASLLEDMDVKVSFVPPSFVADSLVEYFPQNQKGLKLFIPRVQTGGRSILSDSFKLKGAEVT
EVAAYESSCPKDIPQKTIDALNSGQIDIIAFTSSKTVKNTVSLFTKHFGENWLKLIQKIQLVSIGPQTTISCKNLIRKPD
KEASPHDLEGLLQACLELNFN
>Mature_260_residues
ALTDKKIIITRALEQTSEAREIFRKNGAEVFDLPSLVIGPPDDWEPLDGALKEITTFDWIIFSSANGVRNVDERMKEIGL
SLSEISENIQIAAVGRKTASLLEDMDVKVSFVPPSFVADSLVEYFPQNQKGLKLFIPRVQTGGRSILSDSFKLKGAEVTE
VAAYESSCPKDIPQKTIDALNSGQIDIIAFTSSKTVKNTVSLFTKHFGENWLKLIQKIQLVSIGPQTTISCKNLIRKPDK
EASPHDLEGLLQACLELNFN

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 28883; Mature: 28752

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTDKKIIITRALEQTSEAREIFRKNGAEVFDLPSLVIGPPDDWEPLDGALKEITTFDW
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEECCCCCCCHHHHHHHHHHHHHE
IIFSSANGVRNVDERMKEIGLSLSEISENIQIAAVGRKTASLLEDMDVKVSFVPPSFVAD
EEEECCCCCHHHHHHHHHHCCCHHHHHCCEEEEEECHHHHHHHHCCCCEEEECCHHHHHH
SLVEYFPQNQKGLKLFIPRVQTGGRSILSDSFKLKGAEVTEVAAYESSCPKDIPQKTIDA
HHHHHCCCCCCCEEEEECCCCCCCHHHHCCCHHCCCCCHHHHHHHHHCCCCCCHHHHHHH
LNSGQIDIIAFTSSKTVKNTVSLFTKHFGENWLKLIQKIQLVSIGPQTTISCKNLIRKPD
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC
KEASPHDLEGLLQACLELNFN
CCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ALTDKKIIITRALEQTSEAREIFRKNGAEVFDLPSLVIGPPDDWEPLDGALKEITTFDW
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEECCCCCCCHHHHHHHHHHHHHE
IIFSSANGVRNVDERMKEIGLSLSEISENIQIAAVGRKTASLLEDMDVKVSFVPPSFVAD
EEEECCCCCHHHHHHHHHHCCCHHHHHCCEEEEEECHHHHHHHHCCCCEEEECCHHHHHH
SLVEYFPQNQKGLKLFIPRVQTGGRSILSDSFKLKGAEVTEVAAYESSCPKDIPQKTIDA
HHHHHCCCCCCCEEEEECCCCCCCHHHHCCCHHCCCCCHHHHHHHHHCCCCCCHHHHHHH
LNSGQIDIIAFTSSKTVKNTVSLFTKHFGENWLKLIQKIQLVSIGPQTTISCKNLIRKPD
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC
KEASPHDLEGLLQACLELNFN
CCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8123787 [H]