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The map label for this gene is nadB [H]

Identifier: 124024884

GI number: 124024884

Start: 164231

End: 165931

Strand: Direct

Name: nadB [H]

Synonym: NATL1_01711

Alternate gene names: 124024884

Gene position: 164231-165931 (Clockwise)

Preceding gene: 124024883

Following gene: 124024892

Centisome position: 8.81

GC content: 39.15

Gene sequence:

>1701_bases
ATGGATTTAAATACTGGGTTTAATAAAAATGATATTTACTCAACTAATTGGGATGTAATTGTTATTGGAGCAGGAGCTGC
AGGTTTGATGTCATCTCTTGAGTTGCCATCAAATCTGAAAATTTTACTTTTAAACCGCAATACCAGTAAGCGTTCTTCTA
GTAGATGGGCACAAGGAGGAATGGCTGCTGTTACTCGAATTGAAGATAGCGAGGATATTCATGCTAACGACACAATCAAA
GCTGGGGCAGGCCTTTGTGATTTAGAAGCAGTTCAGATGTTTGTTCATAGTGCTCCGAGATTGGTAGATAGACTTTTGAA
ACTAGGAATGGAATTTGATAGAACCTCTGGAAAATTATCTACAACTCTTGAAGCTGCTCACACTCATAGAAGAGTGCTTC
ACGTAAAAGATAGAACTGGTAAGGCATTGGTTGATGTCCTTAATGAGCAAGTTGATCAAAGAGGTAATGTTCTGCATCAA
AGAGGAATAAGAGTTACTCAGATTTGGGTTGAAAGAGGAAAATGCTCCGGGGTACAAGTTCTAGATGGACCAGCTTTGCG
TTGGATCAAAGCAAAGGCAGTTGTTTTAGCTACTGGCGGCGGAGGCCATTTATTTGCCAATACTACAAATCCAACTCAAG
CAGCAGGTGAGGGAATTGCTCTAGCTTGGAGATCTGGGGCTTGCATAGAAGATCTCGAATTTTTTCAGTTTCACCCAACT
GCTCTGAAATTGGATAATGCGCCTTCGTTTTTGATTTCTGAAGCGGTAAGGGGAGAGGGCGCAGTTTTAGTGGATTCATT
CGGCGAGAGTCCCGTAGCTCATCTTGAAGGGAAAGATCTTGCATCAAGAGATCAAGTCAGCAGGGCATTGTTTCAAGCGA
TGCAAAAGCAAAAAGTTGATCACATTGGTCTTGATGTTAAATCCATTTCTGTTGAGGATGTAGAAGCGCGCTTTCCGTCA
ATTTTTCAAAGGTGCAGAGAACTTGGCTTAGAACCTTTAAAAGAAGCAATCCCTGTGGCTCCCTCTGCCCATTATTGGAT
GGGTGGTGTCGCTACAAACTTGAAAGCACAAACAAATGTCAAAGGACTTTTCGCGATTGGTGAGGTGGCATGTACTGGCC
TGCATGGTGCCAATAGACTTGCAAGTAATTCATTAATGGAATGTTTGGTCTTTGCAAATCAAATGAGAAATATTGAATTA
AATGATTTTATAACTTCCGATATTTCAGGAAATAATTTAAGTTTTAACAAATCAGATCTTCGCTTTTCTAAGGAGCAAGG
AACTAGTTATTTATCAAAAGAAATTGAAAAACTTAGACAATTATGCTGGCGTGAAGCTGGAGTTGATCGATCACGAAAAG
GAATGAATTCTGCTCTTGTAAAAGTTAAACAAGATTATCAAAATCTTTTAACCGAGCCCTTATTAAATTTGGTTTTTTCT
CAGTCAAAATATGAAATTCATGAATTCGAGGAACTTGCTAGGAGAGACCTTAATTTGCTACTTGATTTGAGTAATCGACA
AATGTCAAGTTTGCTTATGTTGGAAGCTTGTTTGTTTCGTGAAGAAAGTAGAGGAGGTCATTTTAGAGATGATTTCCCTA
CCTCAGTTCCTTTTTGGCAATGTCATACTAGACAAATGAAGGGAAAGAACATTCATACAAGACCCATTGTCGATAAAGCT
GGCTTCCCTAAAAATCTTTAG

Upstream 100 bases:

>100_bases
AGTTCAGCCTTGACAACAACCTTGTGGGTTGATGGCTTATTTTTTGCTACCACATTGATTCAGCCTCAATTAAGTGGATT
GATCTGAAAACTAATCTTTT

Downstream 100 bases:

>100_bases
AGTCTTTGTAATTGGTAAGGTCAGCTAATTCTTCTAGGCTTTTCACTCCTGAATCAATTGAGCCATTAATTTCCCAAGAA
GGGAAACCAGTGATCCCTTT

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO; Quinolinate synthase B [H]

Number of amino acids: Translated: 566; Mature: 566

Protein sequence:

>566_residues
MDLNTGFNKNDIYSTNWDVIVIGAGAAGLMSSLELPSNLKILLLNRNTSKRSSSRWAQGGMAAVTRIEDSEDIHANDTIK
AGAGLCDLEAVQMFVHSAPRLVDRLLKLGMEFDRTSGKLSTTLEAAHTHRRVLHVKDRTGKALVDVLNEQVDQRGNVLHQ
RGIRVTQIWVERGKCSGVQVLDGPALRWIKAKAVVLATGGGGHLFANTTNPTQAAGEGIALAWRSGACIEDLEFFQFHPT
ALKLDNAPSFLISEAVRGEGAVLVDSFGESPVAHLEGKDLASRDQVSRALFQAMQKQKVDHIGLDVKSISVEDVEARFPS
IFQRCRELGLEPLKEAIPVAPSAHYWMGGVATNLKAQTNVKGLFAIGEVACTGLHGANRLASNSLMECLVFANQMRNIEL
NDFITSDISGNNLSFNKSDLRFSKEQGTSYLSKEIEKLRQLCWREAGVDRSRKGMNSALVKVKQDYQNLLTEPLLNLVFS
QSKYEIHEFEELARRDLNLLLDLSNRQMSSLLMLEACLFREESRGGHFRDDFPTSVPFWQCHTRQMKGKNIHTRPIVDKA
GFPKNL

Sequences:

>Translated_566_residues
MDLNTGFNKNDIYSTNWDVIVIGAGAAGLMSSLELPSNLKILLLNRNTSKRSSSRWAQGGMAAVTRIEDSEDIHANDTIK
AGAGLCDLEAVQMFVHSAPRLVDRLLKLGMEFDRTSGKLSTTLEAAHTHRRVLHVKDRTGKALVDVLNEQVDQRGNVLHQ
RGIRVTQIWVERGKCSGVQVLDGPALRWIKAKAVVLATGGGGHLFANTTNPTQAAGEGIALAWRSGACIEDLEFFQFHPT
ALKLDNAPSFLISEAVRGEGAVLVDSFGESPVAHLEGKDLASRDQVSRALFQAMQKQKVDHIGLDVKSISVEDVEARFPS
IFQRCRELGLEPLKEAIPVAPSAHYWMGGVATNLKAQTNVKGLFAIGEVACTGLHGANRLASNSLMECLVFANQMRNIEL
NDFITSDISGNNLSFNKSDLRFSKEQGTSYLSKEIEKLRQLCWREAGVDRSRKGMNSALVKVKQDYQNLLTEPLLNLVFS
QSKYEIHEFEELARRDLNLLLDLSNRQMSSLLMLEACLFREESRGGHFRDDFPTSVPFWQCHTRQMKGKNIHTRPIVDKA
GFPKNL
>Mature_566_residues
MDLNTGFNKNDIYSTNWDVIVIGAGAAGLMSSLELPSNLKILLLNRNTSKRSSSRWAQGGMAAVTRIEDSEDIHANDTIK
AGAGLCDLEAVQMFVHSAPRLVDRLLKLGMEFDRTSGKLSTTLEAAHTHRRVLHVKDRTGKALVDVLNEQVDQRGNVLHQ
RGIRVTQIWVERGKCSGVQVLDGPALRWIKAKAVVLATGGGGHLFANTTNPTQAAGEGIALAWRSGACIEDLEFFQFHPT
ALKLDNAPSFLISEAVRGEGAVLVDSFGESPVAHLEGKDLASRDQVSRALFQAMQKQKVDHIGLDVKSISVEDVEARFPS
IFQRCRELGLEPLKEAIPVAPSAHYWMGGVATNLKAQTNVKGLFAIGEVACTGLHGANRLASNSLMECLVFANQMRNIEL
NDFITSDISGNNLSFNKSDLRFSKEQGTSYLSKEIEKLRQLCWREAGVDRSRKGMNSALVKVKQDYQNLLTEPLLNLVFS
QSKYEIHEFEELARRDLNLLLDLSNRQMSSLLMLEACLFREESRGGHFRDDFPTSVPFWQCHTRQMKGKNIHTRPIVDKA
GFPKNL

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate [H]

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=581, Percent_Identity=30.6368330464716, Blast_Score=194, Evalue=2e-49,
Organism=Escherichia coli, GI1788928, Length=541, Percent_Identity=35.4898336414048, Blast_Score=287, Evalue=1e-78,
Organism=Escherichia coli, GI1790597, Length=523, Percent_Identity=29.4455066921606, Blast_Score=198, Evalue=8e-52,
Organism=Escherichia coli, GI1786942, Length=612, Percent_Identity=27.9411764705882, Blast_Score=184, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17550100, Length=530, Percent_Identity=31.8867924528302, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17505833, Length=585, Percent_Identity=29.5726495726496, Blast_Score=182, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI71986328, Length=421, Percent_Identity=27.790973871734, Blast_Score=97, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6322701, Length=585, Percent_Identity=28.2051282051282, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6322416, Length=577, Percent_Identity=29.4627383015598, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6320788, Length=466, Percent_Identity=27.0386266094421, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI17137288, Length=564, Percent_Identity=31.9148936170213, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24655642, Length=564, Percent_Identity=31.9148936170213, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24655647, Length=564, Percent_Identity=31.9148936170213, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24663005, Length=606, Percent_Identity=29.3729372937294, Blast_Score=178, Evalue=8e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005288 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.4.3.16 [H]

Molecular weight: Translated: 62690; Mature: 62690

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLNTGFNKNDIYSTNWDVIVIGAGAAGLMSSLELPSNLKILLLNRNTSKRSSSRWAQGG
CCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHCCC
MAAVTRIEDSEDIHANDTIKAGAGLCDLEAVQMFVHSAPRLVDRLLKLGMEFDRTSGKLS
CEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCHH
TTLEAAHTHRRVLHVKDRTGKALVDVLNEQVDQRGNVLHQRGIRVTQIWVERGKCSGVQV
HHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHCCHHHHCCCEEEEEEEECCCCCCCEE
LDGPALRWIKAKAVVLATGGGGHLFANTTNPTQAAGEGIALAWRSGACIEDLEFFQFHPT
ECCCHHHEEEEEEEEEEECCCCEEEECCCCCHHHCCCCEEEEECCCCCHHHHHHHEECCC
ALKLDNAPSFLISEAVRGEGAVLVDSFGESPVAHLEGKDLASRDQVSRALFQAMQKQKVD
EEEECCCCHHHHHHHHCCCCEEEEECCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHCHH
HIGLDVKSISVEDVEARFPSIFQRCRELGLEPLKEAIPVAPSAHYWMGGVATNLKAQTNV
HHCCCEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHCCCCCCCCC
KGLFAIGEVACTGLHGANRLASNSLMECLVFANQMRNIELNDFITSDISGNNLSFNKSDL
CCEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHEECCCCCCCCCCCHHHC
RFSKEQGTSYLSKEIEKLRQLCWREAGVDRSRKGMNSALVKVKQDYQNLLTEPLLNLVFS
EECHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHC
QSKYEIHEFEELARRDLNLLLDLSNRQMSSLLMLEACLFREESRGGHFRDDFPTSVPFWQ
CCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
CHTRQMKGKNIHTRPIVDKAGFPKNL
HHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDLNTGFNKNDIYSTNWDVIVIGAGAAGLMSSLELPSNLKILLLNRNTSKRSSSRWAQGG
CCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHCCC
MAAVTRIEDSEDIHANDTIKAGAGLCDLEAVQMFVHSAPRLVDRLLKLGMEFDRTSGKLS
CEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCHH
TTLEAAHTHRRVLHVKDRTGKALVDVLNEQVDQRGNVLHQRGIRVTQIWVERGKCSGVQV
HHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHCCHHHHCCCEEEEEEEECCCCCCCEE
LDGPALRWIKAKAVVLATGGGGHLFANTTNPTQAAGEGIALAWRSGACIEDLEFFQFHPT
ECCCHHHEEEEEEEEEEECCCCEEEECCCCCHHHCCCCEEEEECCCCCHHHHHHHEECCC
ALKLDNAPSFLISEAVRGEGAVLVDSFGESPVAHLEGKDLASRDQVSRALFQAMQKQKVD
EEEECCCCHHHHHHHHCCCCEEEEECCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHCHH
HIGLDVKSISVEDVEARFPSIFQRCRELGLEPLKEAIPVAPSAHYWMGGVATNLKAQTNV
HHCCCEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHCCCCCCCCC
KGLFAIGEVACTGLHGANRLASNSLMECLVFANQMRNIELNDFITSDISGNNLSFNKSDL
CCEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHEECCCCCCCCCCCHHHC
RFSKEQGTSYLSKEIEKLRQLCWREAGVDRSRKGMNSALVKVKQDYQNLLTEPLLNLVFS
EECHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHC
QSKYEIHEFEELARRDLNLLLDLSNRQMSSLLMLEACLFREESRGGHFRDDFPTSVPFWQ
CCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
CHTRQMKGKNIHTRPIVDKAGFPKNL
HHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]