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The map label for this gene is gap2 [H]

Identifier: 124024735

GI number: 124024735

Start: 24726

End: 25748

Strand: Direct

Name: gap2 [H]

Synonym: NATL1_00221

Alternate gene names: 124024735

Gene position: 24726-25748 (Clockwise)

Preceding gene: 124024731

Following gene: 124024738

Centisome position: 1.33

GC content: 39.2

Gene sequence:

>1023_bases
ATGACTTTGCGTGTAGCGATTAATGGATTCGGAAGAATTGGACGCAATTTTATGCGTTGTTGGCTCAGTAGGGGTGCAAA
TACAAATATTGAGGTGGTCGGCATTAACGTCACTTCTGATCCAAAAACTTGTGCACATTTGCTCAAATATGACTCTATTT
TAGGTGCTATAAAAGACGCCCAAATTTCACATACGGACGATACATTTCAAATTAATGGCAAAACTATAAAATGTTATTCA
GATAGAAACCCTTTAAATCTTCCTTGGAAAGAGTGGGGAATTGATTTAGTAATTGAGTCAACTGGTGTATTCAATACAGA
TGTTGGTGCTAGTAAGCATCTACAAGTTGGTGCTAAGAAGGTCATTCTTACTGCACCTGGGAAGGGTGATGGTGTAGGTA
CTTATGTGGTTGGTGTTAACGCTGATTCATACTCACATGAAGATTTTGATATCCTTAGCAACGCAAGTTGCACCACTAAT
TGTTTAGCGCCAATCGTAAAAGTTTTAGATCAAAAGTTGGGGATTAATAAAGGTTTAATGACCACGATTCATAGTTATAC
GGGAGATCAAAGAATTCTTGACAATGCTCATCGTGATTTACGTCGCGCAAGAGCAGCAGCAATGAATTTGGTCCCTACTT
CAACTGGAGCGGCAAAGGCTGTTGCTCTTGTTTATCCACAAATGAAAGGGAAACTAACTGGTATTGCGATGCGAGTCCCT
ACTCCTAATGTTTCTGCGGTTGATTTGGTTTTTGAATCAGGACGTAAAACTAGTGCTGAAGAGGTCAATTCATTACTTAA
AACCGCTTCACAGGGAGAAATGAAAGGAATCATTAAATATGGTGATTTGCCTCTGGTTTCTACTGACTATGCGGGAACGA
ATGAATCAACCATTGTTGATGAAGCATTAACAATGTGCATCGATGACAATATGGTGAAAGTTTTAGCTTGGTATGACAAT
GAGTGGGGTTACAGTCAAAGGGTTGTTGATTTGGCTGAAATTGTTGCTCAGAAATGGAAGTAA

Upstream 100 bases:

>100_bases
ATTTCCTTAACGCTTCAATTATTTTTCAAAATGCACAGAAAATGATCATCGTTCTGTATGATCAGCGGCCAGTAGTTTGT
GCGGTTTTACCGTTTTTGAA

Downstream 100 bases:

>100_bases
AATTAACTTCTAGAGTTTAAAATGTCTAAATAGACTTGATTGGTCAATTCTAGTTTGTTCTAAATTATCCCAGAAAATAT
TGGGTTTACCTTCTTTGATA

Product: glyceraldehyde 3-phosphate dehydrogenase(NADP+)(phosphorylating)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MTLRVAINGFGRIGRNFMRCWLSRGANTNIEVVGINVTSDPKTCAHLLKYDSILGAIKDAQISHTDDTFQINGKTIKCYS
DRNPLNLPWKEWGIDLVIESTGVFNTDVGASKHLQVGAKKVILTAPGKGDGVGTYVVGVNADSYSHEDFDILSNASCTTN
CLAPIVKVLDQKLGINKGLMTTIHSYTGDQRILDNAHRDLRRARAAAMNLVPTSTGAAKAVALVYPQMKGKLTGIAMRVP
TPNVSAVDLVFESGRKTSAEEVNSLLKTASQGEMKGIIKYGDLPLVSTDYAGTNESTIVDEALTMCIDDNMVKVLAWYDN
EWGYSQRVVDLAEIVAQKWK

Sequences:

>Translated_340_residues
MTLRVAINGFGRIGRNFMRCWLSRGANTNIEVVGINVTSDPKTCAHLLKYDSILGAIKDAQISHTDDTFQINGKTIKCYS
DRNPLNLPWKEWGIDLVIESTGVFNTDVGASKHLQVGAKKVILTAPGKGDGVGTYVVGVNADSYSHEDFDILSNASCTTN
CLAPIVKVLDQKLGINKGLMTTIHSYTGDQRILDNAHRDLRRARAAAMNLVPTSTGAAKAVALVYPQMKGKLTGIAMRVP
TPNVSAVDLVFESGRKTSAEEVNSLLKTASQGEMKGIIKYGDLPLVSTDYAGTNESTIVDEALTMCIDDNMVKVLAWYDN
EWGYSQRVVDLAEIVAQKWK
>Mature_339_residues
TLRVAINGFGRIGRNFMRCWLSRGANTNIEVVGINVTSDPKTCAHLLKYDSILGAIKDAQISHTDDTFQINGKTIKCYSD
RNPLNLPWKEWGIDLVIESTGVFNTDVGASKHLQVGAKKVILTAPGKGDGVGTYVVGVNADSYSHEDFDILSNASCTTNC
LAPIVKVLDQKLGINKGLMTTIHSYTGDQRILDNAHRDLRRARAAAMNLVPTSTGAAKAVALVYPQMKGKLTGIAMRVPT
PNVSAVDLVFESGRKTSAEEVNSLLKTASQGEMKGIIKYGDLPLVSTDYAGTNESTIVDEALTMCIDDNMVKVLAWYDNE
WGYSQRVVDLAEIVAQKWK

Specific function: Second phase of glycolysis; first step. [C]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7657116, Length=331, Percent_Identity=42.9003021148036, Blast_Score=277, Evalue=8e-75,
Organism=Homo sapiens, GI7669492, Length=341, Percent_Identity=41.3489736070381, Blast_Score=259, Evalue=2e-69,
Organism=Escherichia coli, GI1788079, Length=332, Percent_Identity=46.9879518072289, Blast_Score=307, Evalue=7e-85,
Organism=Escherichia coli, GI1789295, Length=330, Percent_Identity=43.030303030303, Blast_Score=281, Evalue=6e-77,
Organism=Caenorhabditis elegans, GI32566163, Length=344, Percent_Identity=43.8953488372093, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17568413, Length=344, Percent_Identity=43.8953488372093, Blast_Score=274, Evalue=4e-74,
Organism=Caenorhabditis elegans, GI17534679, Length=344, Percent_Identity=43.6046511627907, Blast_Score=270, Evalue=5e-73,
Organism=Caenorhabditis elegans, GI17534677, Length=344, Percent_Identity=43.6046511627907, Blast_Score=270, Evalue=6e-73,
Organism=Saccharomyces cerevisiae, GI6321631, Length=339, Percent_Identity=46.9026548672566, Blast_Score=308, Evalue=8e-85,
Organism=Saccharomyces cerevisiae, GI6322468, Length=340, Percent_Identity=46.4705882352941, Blast_Score=305, Evalue=9e-84,
Organism=Saccharomyces cerevisiae, GI6322409, Length=340, Percent_Identity=45.8823529411765, Blast_Score=296, Evalue=4e-81,
Organism=Drosophila melanogaster, GI85725000, Length=340, Percent_Identity=43.8235294117647, Blast_Score=278, Evalue=4e-75,
Organism=Drosophila melanogaster, GI22023983, Length=340, Percent_Identity=43.8235294117647, Blast_Score=278, Evalue=4e-75,
Organism=Drosophila melanogaster, GI17933600, Length=340, Percent_Identity=43.8235294117647, Blast_Score=278, Evalue=4e-75,
Organism=Drosophila melanogaster, GI18110149, Length=340, Percent_Identity=43.8235294117647, Blast_Score=278, Evalue=4e-75,
Organism=Drosophila melanogaster, GI19922412, Length=338, Percent_Identity=42.3076923076923, Blast_Score=258, Evalue=4e-69,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 740 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Min

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 36987; Mature: 36855

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRVAINGFGRIGRNFMRCWLSRGANTNIEVVGINVTSDPKTCAHLLKYDSILGAIKDA
CEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHCC
QISHTDDTFQINGKTIKCYSDRNPLNLPWKEWGIDLVIESTGVFNTDVGASKHLQVGAKK
EECCCCCEEEECCEEEEEECCCCCCCCCHHHCCEEEEEECCCCEECCCCCCCEEECCCEE
VILTAPGKGDGVGTYVVGVNADSYSHEDFDILSNASCTTNCLAPIVKVLDQKLGINKGLM
EEEECCCCCCCCEEEEEEECCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHH
TTIHSYTGDQRILDNAHRDLRRARAAAMNLVPTSTGAAKAVALVYPQMKGKLTGIAMRVP
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCHHEEEEEECCCCCCEEEEEEECC
TPNVSAVDLVFESGRKTSAEEVNSLLKTASQGEMKGIIKYGDLPLVSTDYAGTNESTIVD
CCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCEEECCCCCCCCCHHHH
EALTMCIDDNMVKVLAWYDNEWGYSQRVVDLAEIVAQKWK
HHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TLRVAINGFGRIGRNFMRCWLSRGANTNIEVVGINVTSDPKTCAHLLKYDSILGAIKDA
EEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHCC
QISHTDDTFQINGKTIKCYSDRNPLNLPWKEWGIDLVIESTGVFNTDVGASKHLQVGAKK
EECCCCCEEEECCEEEEEECCCCCCCCCHHHCCEEEEEECCCCEECCCCCCCEEECCCEE
VILTAPGKGDGVGTYVVGVNADSYSHEDFDILSNASCTTNCLAPIVKVLDQKLGINKGLM
EEEECCCCCCCCEEEEEEECCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHH
TTIHSYTGDQRILDNAHRDLRRARAAAMNLVPTSTGAAKAVALVYPQMKGKLTGIAMRVP
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCHHEEEEEECCCCCCEEEEEEECC
TPNVSAVDLVFESGRKTSAEEVNSLLKTASQGEMKGIIKYGDLPLVSTDYAGTNESTIVD
CCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCEEECCCCCCCCCHHHH
EALTMCIDDNMVKVLAWYDNEWGYSQRVVDLAEIVAQKWK
HHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8378350 [H]