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The map label for this gene is eIF5A

Identifier: 124028502

GI number: 124028502

Start: 1655229

End: 1655639

Strand: Reverse

Name: eIF5A

Synonym: Hbut_1663

Alternate gene names: 124028502

Gene position: 1655639-1655229 (Counterclockwise)

Preceding gene: 124028505

Following gene: 124028501

Centisome position: 99.31

GC content: 50.61

Gene sequence:

>411_bases
GTGAGTGTGACGTATGCGACTCTGGGCGAACTAAAGGTTGGCAGCTACATTGTGATCGATGGTGAGCCTTGTCGTATCGT
GGAGATGAGTAAGGCTAAGACTGGTAAGCATGGTAGTGCTAAGGCCCACGTGGTGGCGGTTTGCCTCTTCTCGGGGAACA
AGAAAACGTTGACTGCGCCAGTTGATGCACGTGTTGAGGTGCCGATTATCGATAAGAGGATTGGCCAGGTTATAGCTGAT
ATGGGTGATATGGTTCAGATAATGGATATGGAGACCTATGAGACCTTCGAGGTTGAGAAGCCCAAGGACGAGGATCTCAA
GTCGAAGCTTCAGCCGGGCGTTGAGGTTGAATACTGGGTAGTTATGGGCCGCTATATGATTACTCGAGTCAGAGGCGCGC
CAAAGAGCTAA

Upstream 100 bases:

>100_bases
CAGGGCGGGGTTTAATAGTTTTGTGTCTTTATTTATGGGGTGCTTGGGCCTAACTTATAAGTAGGGTTTTGTGGTCTGCG
GCGTGGACTGGGTGGGCGCT

Downstream 100 bases:

>100_bases
CCATGGTTTGGAGGCTTCTTCAATATTTTTGTTGTTTTAGCTAGATTTATAATTTCCTATTGCATGTGTTAGTCCATACT
TATTCTTGTGTTATTCGCTA

Product: translation initiation factor IF-5A

Products: NA

Alternate protein names: Hypusine-containing protein; eIF-5A

Number of amino acids: Translated: 136; Mature: 135

Protein sequence:

>136_residues
MSVTYATLGELKVGSYIVIDGEPCRIVEMSKAKTGKHGSAKAHVVAVCLFSGNKKTLTAPVDARVEVPIIDKRIGQVIAD
MGDMVQIMDMETYETFEVEKPKDEDLKSKLQPGVEVEYWVVMGRYMITRVRGAPKS

Sequences:

>Translated_136_residues
MSVTYATLGELKVGSYIVIDGEPCRIVEMSKAKTGKHGSAKAHVVAVCLFSGNKKTLTAPVDARVEVPIIDKRIGQVIAD
MGDMVQIMDMETYETFEVEKPKDEDLKSKLQPGVEVEYWVVMGRYMITRVRGAPKS
>Mature_135_residues
SVTYATLGELKVGSYIVIDGEPCRIVEMSKAKTGKHGSAKAHVVAVCLFSGNKKTLTAPVDARVEVPIIDKRIGQVIADM
GDMVQIMDMETYETFEVEKPKDEDLKSKLQPGVEVEYWVVMGRYMITRVRGAPKS

Specific function: Functions by promoting the formation of the first peptide bond

COG id: COG0231

COG function: function code J; Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-5A family

Homologues:

Organism=Homo sapiens, GI219555712, Length=69, Percent_Identity=42.0289855072464, Blast_Score=64, Evalue=3e-11,
Organism=Homo sapiens, GI219555710, Length=69, Percent_Identity=42.0289855072464, Blast_Score=64, Evalue=3e-11,
Organism=Homo sapiens, GI4503545, Length=69, Percent_Identity=42.0289855072464, Blast_Score=64, Evalue=3e-11,
Organism=Homo sapiens, GI219555707, Length=69, Percent_Identity=42.0289855072464, Blast_Score=64, Evalue=4e-11,
Organism=Homo sapiens, GI9966867, Length=97, Percent_Identity=38.1443298969072, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17534327, Length=105, Percent_Identity=34.2857142857143, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71990399, Length=112, Percent_Identity=32.1428571428571, Blast_Score=66, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320801, Length=106, Percent_Identity=35.8490566037736, Blast_Score=69, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322507, Length=132, Percent_Identity=31.8181818181818, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF5A_HYPBU (A2BNB6)

Other databases:

- EMBL:   CP000493
- RefSeq:   YP_001013822.1
- ProteinModelPortal:   A2BNB6
- SMR:   A2BNB6
- STRING:   A2BNB6
- GeneID:   4782642
- GenomeReviews:   CP000493_GR
- KEGG:   hbu:Hbut_1663
- eggNOG:   arNOG10602
- HOGENOM:   HBG497107
- OMA:   CRIVEMS
- PhylomeDB:   A2BNB6
- ProtClustDB:   PRK03999
- BioCyc:   HBUT415426:HBUT_1663-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00085
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR019769
- InterPro:   IPR001884
- InterPro:   IPR022847
- InterPro:   IPR020189
- InterPro:   IPR013185
- InterPro:   IPR014722
- InterPro:   IPR008991
- Gene3D:   G3DSA:2.40.50.140
- Gene3D:   G3DSA:2.30.30.30
- PANTHER:   PTHR11673
- PIRSF:   PIRSF003025
- TIGRFAMs:   TIGR00037

Pfam domain/function: PF08207 EFP_N; PF01287 eIF-5a; SSF50249 Nucleic_acid_OB; SSF50104 Transl_SH3_like

EC number: NA

Molecular weight: Translated: 15038; Mature: 14907

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS00302 IF5A_HYPUSINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTYATLGELKVGSYIVIDGEPCRIVEMSKAKTGKHGSAKAHVVAVCLFSGNKKTLTAP
CCEEEEECCCEECCCEEEECCCCCEEEEECCCCCCCCCCCCEEEEEEEEECCCCEEEECC
VDARVEVPIIDKRIGQVIADMGDMVQIMDMETYETFEVEKPKDEDLKSKLQPGVEVEYWV
CCCEEECCCHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCCCHHHHCCCCCCEEEEE
VMGRYMITRVRGAPKS
EHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SVTYATLGELKVGSYIVIDGEPCRIVEMSKAKTGKHGSAKAHVVAVCLFSGNKKTLTAP
CEEEEECCCEECCCEEEECCCCCEEEEECCCCCCCCCCCCEEEEEEEEECCCCEEEECC
VDARVEVPIIDKRIGQVIADMGDMVQIMDMETYETFEVEKPKDEDLKSKLQPGVEVEYWV
CCCEEECCCHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCCCHHHHCCCCCCEEEEE
VMGRYMITRVRGAPKS
EHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA