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The map label for this gene is srp54

Identifier: 124028501

GI number: 124028501

Start: 1653713

End: 1655056

Strand: Reverse

Name: srp54

Synonym: Hbut_1662

Alternate gene names: 124028501

Gene position: 1655056-1653713 (Counterclockwise)

Preceding gene: 124028502

Following gene: 124028500

Centisome position: 99.27

GC content: 50.3

Gene sequence:

>1344_bases
ATGCCTGGGCTTGACGATATCCGCAGGGCTGTCAGCAAACTGTTAAAGCGTAGTGGGCCCTACGAGAACATTGTAAATGA
ATTCATCCGTGACCTTCAGAGGGCCCTCATCTCAGCTGATGTCAATGTGAGGCTCGTCTTCAACCTCACCAAGCGTATTC
GCGAGCGGGCTCTGAAGGAGCAGCCCCCGCCCGGCCTTAGTAGGAGGGAATGGCTAGTTAAGCTCACCTATGATGAGCTT
GTGAAACTATTTGGCGGCGAGTATGAGCCAGAGGTTAAGCCGCCCTATACACCCTATGTAATCATGATGGTTGGTGTGCA
GGGTAGCGGTAAGACCACAACTGTCGGCAAGCTAGCAAAGTTCTATCGTGGCATGGGCTACCGTGTAGGTGTTGTTGCTG
CAGATACCTACCGTCCCGGCGCCTACGAGCAACTTAAACAGCTGGCCGATAGGGCTGGTGCAATGTTCTACGGTGAGCCC
GGCTCTAAGGATCCAGTTGGCATCGCCCGAAGGGGGGTTGAGGAGCTCAAGCAGCGTGGCGCAGACATAGTAATCGTCGA
TACTGCTGGCCGCCACGGCTACGGCGAGGAGGAAGCTCTGTTAGATGAGATGAAGCGTATTGCAGAAGCAATTAAGCCCG
ATGAGGTCGTACTTGTTATTGACGCTGCCATGGGACAGAAGAGCTACGACTTGGCTAAGAGATTCCATGAAGCCACACCC
GTAGGTAGCATCATAGTGACAAAGATGGATGGTACAGCAAAGGGTGGCGGTGCGCTGTCAGCTGTAGCGGCTACGGGTGC
TCGGATAAAATTCATCGGTACAGGCGAGGACATTGATGAGATCGAGGTGTTTAGACCCAAGAGGTTTGTAGCGAGACTTC
TTGGCATGGGTGATCTAGAGTCACTACTAGAGAAGATTGAGAGACTTAGGGGTGTTGAAGAATTTGAGAAGACCGTTGCC
GAGATGATGTCCGGTAAGATAACGTTTAGAACAATCTATAAGCAGTTGCAGCAAGTTACTAAGCTTGGTCCATTCCGGAA
AATACTACAAATGATACCCGGTATATCGACTATGCTTGAGAGCCTTGACGAAGCTGCAAGGCTTAGCGAGGAGAAGGTCA
AGAAGTGGCTCACAATAATGAACTCTATGACCTATGAAGAGCTTGATAACCCCAACCTATTAGAGGAAAGGAGTAGAGTC
AAGAGGATAGCAGTTGGTGCTGGCGTCGAGCCTAGCGAGGTTAGAGAGCTATACAACTACTACAAGTCAGTCAAGAAGAT
GATGAGACAGCTCAAGAAGAGGAAAGATTTGTTAGAGAGGTTTGCTAGGCTTGGAGGAGTGTAA

Upstream 100 bases:

>100_bases
TCCATACTTATTCTTGTGTTATTCGCTATTCTTGTGTAGCCTGGTCCACTGGCGTTATTAGGGCTAGTTCCATGTTTCCC
AGTGTCTTATGGGGCTGTAA

Downstream 100 bases:

>100_bases
GGTAACGATATGTTATAATGCTGGCTGCGGAAAAGATTCGCCGCTAGTTGCAGGGCTTGTTGTTGCTGCCTCCCTACTCC
TATCCAATAACATCCGTCGC

Product: Signal recognition particle GTPase

Products: NA

Alternate protein names: SRP54

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MPGLDDIRRAVSKLLKRSGPYENIVNEFIRDLQRALISADVNVRLVFNLTKRIRERALKEQPPPGLSRREWLVKLTYDEL
VKLFGGEYEPEVKPPYTPYVIMMVGVQGSGKTTTVGKLAKFYRGMGYRVGVVAADTYRPGAYEQLKQLADRAGAMFYGEP
GSKDPVGIARRGVEELKQRGADIVIVDTAGRHGYGEEEALLDEMKRIAEAIKPDEVVLVIDAAMGQKSYDLAKRFHEATP
VGSIIVTKMDGTAKGGGALSAVAATGARIKFIGTGEDIDEIEVFRPKRFVARLLGMGDLESLLEKIERLRGVEEFEKTVA
EMMSGKITFRTIYKQLQQVTKLGPFRKILQMIPGISTMLESLDEAARLSEEKVKKWLTIMNSMTYEELDNPNLLEERSRV
KRIAVGAGVEPSEVRELYNYYKSVKKMMRQLKKRKDLLERFARLGGV

Sequences:

>Translated_447_residues
MPGLDDIRRAVSKLLKRSGPYENIVNEFIRDLQRALISADVNVRLVFNLTKRIRERALKEQPPPGLSRREWLVKLTYDEL
VKLFGGEYEPEVKPPYTPYVIMMVGVQGSGKTTTVGKLAKFYRGMGYRVGVVAADTYRPGAYEQLKQLADRAGAMFYGEP
GSKDPVGIARRGVEELKQRGADIVIVDTAGRHGYGEEEALLDEMKRIAEAIKPDEVVLVIDAAMGQKSYDLAKRFHEATP
VGSIIVTKMDGTAKGGGALSAVAATGARIKFIGTGEDIDEIEVFRPKRFVARLLGMGDLESLLEKIERLRGVEEFEKTVA
EMMSGKITFRTIYKQLQQVTKLGPFRKILQMIPGISTMLESLDEAARLSEEKVKKWLTIMNSMTYEELDNPNLLEERSRV
KRIAVGAGVEPSEVRELYNYYKSVKKMMRQLKKRKDLLERFARLGGV
>Mature_446_residues
PGLDDIRRAVSKLLKRSGPYENIVNEFIRDLQRALISADVNVRLVFNLTKRIRERALKEQPPPGLSRREWLVKLTYDELV
KLFGGEYEPEVKPPYTPYVIMMVGVQGSGKTTTVGKLAKFYRGMGYRVGVVAADTYRPGAYEQLKQLADRAGAMFYGEPG
SKDPVGIARRGVEELKQRGADIVIVDTAGRHGYGEEEALLDEMKRIAEAIKPDEVVLVIDAAMGQKSYDLAKRFHEATPV
GSIIVTKMDGTAKGGGALSAVAATGARIKFIGTGEDIDEIEVFRPKRFVARLLGMGDLESLLEKIERLRGVEEFEKTVAE
MMSGKITFRTIYKQLQQVTKLGPFRKILQMIPGISTMLESLDEAARLSEEKVKKWLTIMNSMTYEELDNPNLLEERSRVK
RIAVGAGVEPSEVRELYNYYKSVKKMMRQLKKRKDLLERFARLGGV

Specific function: Binds to the signal sequence of presecretory protein when they emerge from the ribosomes

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family

Homologues:

Organism=Homo sapiens, GI4507215, Length=442, Percent_Identity=41.1764705882353, Blast_Score=328, Evalue=5e-90,
Organism=Homo sapiens, GI226371618, Length=389, Percent_Identity=43.1876606683805, Blast_Score=306, Evalue=4e-83,
Organism=Homo sapiens, GI89061728, Length=147, Percent_Identity=53.0612244897959, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI23308697, Length=221, Percent_Identity=31.6742081447964, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI295424842, Length=221, Percent_Identity=31.6742081447964, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1788963, Length=424, Percent_Identity=33.9622641509434, Blast_Score=244, Evalue=7e-66,
Organism=Escherichia coli, GI1789874, Length=266, Percent_Identity=35.3383458646617, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17539958, Length=443, Percent_Identity=39.9548532731377, Blast_Score=322, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI193206261, Length=216, Percent_Identity=31.0185185185185, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6325345, Length=418, Percent_Identity=40.9090909090909, Blast_Score=310, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6320498, Length=226, Percent_Identity=31.4159292035398, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17647949, Length=443, Percent_Identity=40.4063205417607, Blast_Score=305, Evalue=5e-83,
Organism=Drosophila melanogaster, GI24641198, Length=221, Percent_Identity=28.0542986425339, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SRP54_HYPBU (A2BNB5)

Other databases:

- EMBL:   CP000493
- RefSeq:   YP_001013821.1
- ProteinModelPortal:   A2BNB5
- SMR:   A2BNB5
- STRING:   A2BNB5
- GeneID:   4782384
- GenomeReviews:   CP000493_GR
- KEGG:   hbu:Hbut_1662
- eggNOG:   arNOG04631
- HOGENOM:   HBG562580
- OMA:   SKKEHII
- PhylomeDB:   A2BNB5
- ProtClustDB:   PRK00771
- BioCyc:   HBUT415426:HBUT_1662-MONOMER
- HAMAP:   MF_00306
- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004125
- InterPro:   IPR022941
- Gene3D:   G3DSA:1.20.120.140
- Gene3D:   G3DSA:1.10.260.30
- SMART:   SM00382
- SMART:   SM00962
- SMART:   SM00963

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB; SSF47446 Signal_recog_particle_SRP54_M; SSF47364 SRP54

EC number: NA

Molecular weight: Translated: 50217; Mature: 50086

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGLDDIRRAVSKLLKRSGPYENIVNEFIRDLQRALISADVNVRLVFNLTKRIRERALKE
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHC
QPPPGLSRREWLVKLTYDELVKLFGGEYEPEVKPPYTPYVIMMVGVQGSGKTTTVGKLAK
CCCCCCCHHHHHHEECHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHH
FYRGMGYRVGVVAADTYRPGAYEQLKQLADRAGAMFYGEPGSKDPVGIARRGVEELKQRG
HHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHCC
ADIVIVDTAGRHGYGEEEALLDEMKRIAEAIKPDEVVLVIDAAMGQKSYDLAKRFHEATP
CCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCC
VGSIIVTKMDGTAKGGGALSAVAATGARIKFIGTGEDIDEIEVFRPKRFVARLLGMGDLE
CCCEEEEECCCCCCCCCHHHHHHHCCCEEEEEECCCCHHHHHHCCHHHHHHHHHCCCCHH
SLLEKIERLRGVEEFEKTVAEMMSGKITFRTIYKQLQQVTKLGPFRKILQMIPGISTMLE
HHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHH
SLDEAARLSEEKVKKWLTIMNSMTYEELDNPNLLEERSRVKRIAVGAGVEPSEVRELYNY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
YKSVKKMMRQLKKRKDLLERFARLGGV
HHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PGLDDIRRAVSKLLKRSGPYENIVNEFIRDLQRALISADVNVRLVFNLTKRIRERALKE
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHC
QPPPGLSRREWLVKLTYDELVKLFGGEYEPEVKPPYTPYVIMMVGVQGSGKTTTVGKLAK
CCCCCCCHHHHHHEECHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHH
FYRGMGYRVGVVAADTYRPGAYEQLKQLADRAGAMFYGEPGSKDPVGIARRGVEELKQRG
HHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHCC
ADIVIVDTAGRHGYGEEEALLDEMKRIAEAIKPDEVVLVIDAAMGQKSYDLAKRFHEATP
CCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCC
VGSIIVTKMDGTAKGGGALSAVAATGARIKFIGTGEDIDEIEVFRPKRFVARLLGMGDLE
CCCEEEEECCCCCCCCCHHHHHHHCCCEEEEEECCCCHHHHHHCCHHHHHHHHHCCCCHH
SLLEKIERLRGVEEFEKTVAEMMSGKITFRTIYKQLQQVTKLGPFRKILQMIPGISTMLE
HHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHH
SLDEAARLSEEKVKKWLTIMNSMTYEELDNPNLLEERSRVKRIAVGAGVEPSEVRELYNY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
YKSVKKMMRQLKKRKDLLERFARLGGV
HHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA