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The map label for this gene is 124028500

Identifier: 124028500

GI number: 124028500

Start: 1651962

End: 1653287

Strand: Reverse

Name: 124028500

Synonym: Hbut_1661

Alternate gene names: NA

Gene position: 1653287-1651962 (Counterclockwise)

Preceding gene: 124028501

Following gene: 124028499

Centisome position: 99.17

GC content: 53.09

Gene sequence:

>1326_bases
ATGACTGGTGTACATAGCGACGGCGTTGAGGCAGTAATAACTGGTATTGCTAGCAAAGCTTTGAGGCTCCTAGAGGAGAT
TCCTCTTTGTGACAGTTGCCTCGGTAGAATGTTTGGTCTCCTGGGTAGAGGTTTCAGTAATGAAGAGCGTGGAAGGGCCC
TAAAGACTCTGCTTGTAATGTCGCTGCATGCACGTATACGCGAAGGCGATGCCGGGGCACGTGAGCAGTTGAGAAGGCTT
GCGCCAAATATAGGTGAGCTAGCAGCAAAATTGTATGAAGAGGTTTTCGGGGAAAAGCTGGTTCCTAATCGCTGCTATAT
TTGCGAGTCGCGGCTGCAAGAGATGATCAGTCTTGCTGTTAAACGTGCAAGGCATATGCTTGAAGGACTGGAGTTTCGTG
GGTTTATTGTTGCTGCCCGGGTGAACGATGAGGTTCGGTTTAGGGAGGACGAGGTTAAGAGGAGATTCAGTCTAGAGTAT
GCCGAGTCCATAGGCTCAGAGGTTAAGAGAGAGGTTGGCAAGAAACTGCAGCAGCTCATAGGCGTTAAGCCGGACTTTGA
GAAGCCTGATGTAGTGGTTCTAGTTCACGTTCCTGAAGGCAGAGTTGAGCTACAAGTTATGCCGCTCCTCCTGAGGGGAT
GGTATTGGAAGCTAGCGCGCCGCGTCTCGCAGTCAGCATGGGTTACCAGGAGGGGAGAGCGCCGCTATCCCTTCAGCGTG
GAGGATGGTTTGTTTATACTGGCTGAGGTGTTCGAAGCAGACAACATAGTGATACATGCTTCCGGCCGGGAGGATGCAGA
TGCACGCATGCTGGGGACAGGGCGGCCATTCATAGTTGAAGCTAAACGGCCTAGGAAGAGGATCTCAGGTCTTGCAGTAG
CCGAGGTTGAAGCTAACAGCTATGCTGCAGGCCTTGTCGAGTACAAGCTCTTATCTGAGGCGAGACGCAGCGACGTCGCC
TCGATAAAGGGTGAAACACAGCACCGCGCCAAGCTCTACAAGGCACTTGTAGTTGTCGAGCGGCCAATTTCCGAGGATGA
GCTGAAGGGGCTTGAGGAAGCATTCCACATGAGGTCCATAATGCAGCGTACCCCGCGGAGGGTTAGACACCGGCGGCCTG
ACGTGGTCCGCGAGAAGATAGTCTTCAGCGTTAAGACTAGGCAGCTAGCGGATAACGTGTTTGAGGCAATAATCCATGCT
GAGGGAGGGCTGTACATAAAGGAGCTTGTGAGCGGTGATGGAGGCGATACCAGGCCGAGCTTCGCCGAGTACTTCTCGGC
ACGTGCATACTGTGCCGAGCTGGACGTCCTCGGAGTCTTTAGCTAG

Upstream 100 bases:

>100_bases
CTCTCGCAAAGGAAATGTCCAACTTGCATATCGTTGGAGCCTGTAGAGGGGCTTAGATTTAATGCCTGGTGGCTAGCATC
TGCAGTCATGGTAGTGTATG

Downstream 100 bases:

>100_bases
GAGTCACTCCGTCATGGAAGCTAAGCCTATTTTAGCTAGTTATAGATGCGGGGCGTCGGGGGAGAACAGTGAAGCCGTCC
AAAGGCTTTAGGCACCGTAC

Product: putative pseudouridylate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MTGVHSDGVEAVITGIASKALRLLEEIPLCDSCLGRMFGLLGRGFSNEERGRALKTLLVMSLHARIREGDAGAREQLRRL
APNIGELAAKLYEEVFGEKLVPNRCYICESRLQEMISLAVKRARHMLEGLEFRGFIVAARVNDEVRFREDEVKRRFSLEY
AESIGSEVKREVGKKLQQLIGVKPDFEKPDVVVLVHVPEGRVELQVMPLLLRGWYWKLARRVSQSAWVTRRGERRYPFSV
EDGLFILAEVFEADNIVIHASGREDADARMLGTGRPFIVEAKRPRKRISGLAVAEVEANSYAAGLVEYKLLSEARRSDVA
SIKGETQHRAKLYKALVVVERPISEDELKGLEEAFHMRSIMQRTPRRVRHRRPDVVREKIVFSVKTRQLADNVFEAIIHA
EGGLYIKELVSGDGGDTRPSFAEYFSARAYCAELDVLGVFS

Sequences:

>Translated_441_residues
MTGVHSDGVEAVITGIASKALRLLEEIPLCDSCLGRMFGLLGRGFSNEERGRALKTLLVMSLHARIREGDAGAREQLRRL
APNIGELAAKLYEEVFGEKLVPNRCYICESRLQEMISLAVKRARHMLEGLEFRGFIVAARVNDEVRFREDEVKRRFSLEY
AESIGSEVKREVGKKLQQLIGVKPDFEKPDVVVLVHVPEGRVELQVMPLLLRGWYWKLARRVSQSAWVTRRGERRYPFSV
EDGLFILAEVFEADNIVIHASGREDADARMLGTGRPFIVEAKRPRKRISGLAVAEVEANSYAAGLVEYKLLSEARRSDVA
SIKGETQHRAKLYKALVVVERPISEDELKGLEEAFHMRSIMQRTPRRVRHRRPDVVREKIVFSVKTRQLADNVFEAIIHA
EGGLYIKELVSGDGGDTRPSFAEYFSARAYCAELDVLGVFS
>Mature_440_residues
TGVHSDGVEAVITGIASKALRLLEEIPLCDSCLGRMFGLLGRGFSNEERGRALKTLLVMSLHARIREGDAGAREQLRRLA
PNIGELAAKLYEEVFGEKLVPNRCYICESRLQEMISLAVKRARHMLEGLEFRGFIVAARVNDEVRFREDEVKRRFSLEYA
ESIGSEVKREVGKKLQQLIGVKPDFEKPDVVVLVHVPEGRVELQVMPLLLRGWYWKLARRVSQSAWVTRRGERRYPFSVE
DGLFILAEVFEADNIVIHASGREDADARMLGTGRPFIVEAKRPRKRISGLAVAEVEANSYAAGLVEYKLLSEARRSDVAS
IKGETQHRAKLYKALVVVERPISEDELKGLEEAFHMRSIMQRTPRRVRHRRPDVVREKIVFSVKTRQLADNVFEAIIHAE
GGLYIKELVSGDGGDTRPSFAEYFSARAYCAELDVLGVFS

Specific function: Unknown

COG id: COG1258

COG function: function code J; Predicted pseudouridylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 THUMP domain [H]

Homologues:

Organism=Homo sapiens, GI207113130, Length=235, Percent_Identity=31.4893617021277, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17537241, Length=288, Percent_Identity=31.5972222222222, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19920442, Length=248, Percent_Identity=33.0645161290323, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005912
- InterPro:   IPR020103
- InterPro:   IPR004114 [H]

Pfam domain/function: PF02926 THUMP [H]

EC number: NA

Molecular weight: Translated: 49834; Mature: 49703

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS51165 THUMP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGVHSDGVEAVITGIASKALRLLEEIPLCDSCLGRMFGLLGRGFSNEERGRALKTLLVM
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
SLHARIREGDAGAREQLRRLAPNIGELAAKLYEEVFGEKLVPNRCYICESRLQEMISLAV
HHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
KRARHMLEGLEFRGFIVAARVNDEVRFREDEVKRRFSLEYAESIGSEVKREVGKKLQQLI
HHHHHHHHCCCCCCEEEEEEECCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVKPDFEKPDVVVLVHVPEGRVELQVMPLLLRGWYWKLARRVSQSAWVTRRGERRYPFSV
CCCCCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
EDGLFILAEVFEADNIVIHASGREDADARMLGTGRPFIVEAKRPRKRISGLAVAEVEANS
CCCHHHHHHHHCCCCEEEEECCCCCCCCCEEECCCCEEEECCCHHHHHCCCEEEEECCCC
YAAGLVEYKLLSEARRSDVASIKGETQHRAKLYKALVVVERPISEDELKGLEEAFHMRSI
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
MQRTPRRVRHRRPDVVREKIVFSVKTRQLADNVFEAIIHAEGGLYIKELVSGDGGDTRPS
HHHCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCH
FAEYFSARAYCAELDVLGVFS
HHHHHHHHHHHHHHCEECCCC
>Mature Secondary Structure 
TGVHSDGVEAVITGIASKALRLLEEIPLCDSCLGRMFGLLGRGFSNEERGRALKTLLVM
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
SLHARIREGDAGAREQLRRLAPNIGELAAKLYEEVFGEKLVPNRCYICESRLQEMISLAV
HHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
KRARHMLEGLEFRGFIVAARVNDEVRFREDEVKRRFSLEYAESIGSEVKREVGKKLQQLI
HHHHHHHHCCCCCCEEEEEEECCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVKPDFEKPDVVVLVHVPEGRVELQVMPLLLRGWYWKLARRVSQSAWVTRRGERRYPFSV
CCCCCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
EDGLFILAEVFEADNIVIHASGREDADARMLGTGRPFIVEAKRPRKRISGLAVAEVEANS
CCCHHHHHHHHCCCCEEEEECCCCCCCCCEEECCCCEEEECCCHHHHHCCCEEEEECCCC
YAAGLVEYKLLSEARRSDVASIKGETQHRAKLYKALVVVERPISEDELKGLEEAFHMRSI
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
MQRTPRRVRHRRPDVVREKIVFSVKTRQLADNVFEAIIHAEGGLYIKELVSGDGGDTRPS
HHHCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCH
FAEYFSARAYCAELDVLGVFS
HHHHHHHHHHHHHHCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]