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The map label for this gene is eIF2A

Identifier: 124028479

GI number: 124028479

Start: 1638373

End: 1639176

Strand: Reverse

Name: eIF2A

Synonym: Hbut_1640

Alternate gene names: 124028479

Gene position: 1639176-1638373 (Counterclockwise)

Preceding gene: 124028480

Following gene: 297616209

Centisome position: 98.32

GC content: 50.0

Gene sequence:

>804_bases
GTGCCGATTCAGAGGAAGGAGCTGCCAGACGTGGGAGAACTCGTGGTTGCGACTGTAAAGGAGGTATACGACTACGGTGC
ATACCTTACACTCGACGAATACGGTGGTCTCGAGGCATACCTGCCATGGAGCGAGGTTGCTTCCCGTTGGGTTCGCAGCA
TACACGATGTTGTTAAGCCTGGTCAGAAGATAGTTGTCAAGGTTATAAGGGTTAACAAGAGGAAAAAGCAGGTTGACGTC
TCGCTAAAACGTGTAACCGATAGCGAACGCCGCAGGAAGATGATGGAATGGAAAAGAGCTCAGAAAGCTGAGAGGATACT
AGAGCTGGTCGCGCAAAAGCTCGGTAAGAGCCTCGAGGAGGCCTATGAGGCTGTGGGGAAGAAGCTTGAGGACTACTATG
GAGAACTCATGGCAGCCTTTGAGGAGGTTGTCATTCGCGGCGAGCAAGCGTTGCGCGAGGCAGGAGTCCCAGAGGAGTGG
GTTCAACCGCTACTTGAGGAAATTAAGAGGCATGTGGAGGTTAAGCGTGTAAAGATAGCTGGCGTTCTCACTGTTAGAAG
TCTGGCTGGCGATGGTATTGAGAGAGTTAAAAAGGTGTTGCTAACAGTGAAAGATGCTATTGAGAACTCGTCTCCCGACA
TAAAGGTTAAACTATACACTGTAGGAGCACCAAGGTATAGGCTTGAGTTGGAAGCATACGACTATAAGACGCTTGAGAAG
GCGTTAGCTAAGGCTCTTGAGGAGGGTGAGGAGACTGCTAAGAGCTTGGGTGTAGAGTTTAGCTTTACGAGGGAGAAGCA
GTAA

Upstream 100 bases:

>100_bases
ACTACCGCCTCCTCTAGTCTGGGTTTTAGTCTCAGCTACGGATACGCATCCAATATTTTAGGGCTCCCAGCTCTCTATCC
AGCTTTCTCGGTGAAACAGG

Downstream 100 bases:

>100_bases
GCCCGGGTGAACCCCGTGCAGTGGCTCATGAGGAAGTGTACAGTCTGTGGCAGGTACACGCTGCAACGTGACCGCTGCCC
AGTCTGTGGGGGCCCCGTAG

Product: translation initiation factor IF-2 subunit alpha

Products: NA

Alternate protein names: aIF2-alpha; eIF-2-alpha

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MPIQRKELPDVGELVVATVKEVYDYGAYLTLDEYGGLEAYLPWSEVASRWVRSIHDVVKPGQKIVVKVIRVNKRKKQVDV
SLKRVTDSERRRKMMEWKRAQKAERILELVAQKLGKSLEEAYEAVGKKLEDYYGELMAAFEEVVIRGEQALREAGVPEEW
VQPLLEEIKRHVEVKRVKIAGVLTVRSLAGDGIERVKKVLLTVKDAIENSSPDIKVKLYTVGAPRYRLELEAYDYKTLEK
ALAKALEEGEETAKSLGVEFSFTREKQ

Sequences:

>Translated_267_residues
MPIQRKELPDVGELVVATVKEVYDYGAYLTLDEYGGLEAYLPWSEVASRWVRSIHDVVKPGQKIVVKVIRVNKRKKQVDV
SLKRVTDSERRRKMMEWKRAQKAERILELVAQKLGKSLEEAYEAVGKKLEDYYGELMAAFEEVVIRGEQALREAGVPEEW
VQPLLEEIKRHVEVKRVKIAGVLTVRSLAGDGIERVKKVLLTVKDAIENSSPDIKVKLYTVGAPRYRLELEAYDYKTLEK
ALAKALEEGEETAKSLGVEFSFTREKQ
>Mature_266_residues
PIQRKELPDVGELVVATVKEVYDYGAYLTLDEYGGLEAYLPWSEVASRWVRSIHDVVKPGQKIVVKVIRVNKRKKQVDVS
LKRVTDSERRRKMMEWKRAQKAERILELVAQKLGKSLEEAYEAVGKKLEDYYGELMAAFEEVVIRGEQALREAGVPEEWV
QPLLEEIKRHVEVKRVKIAGVLTVRSLAGDGIERVKKVLLTVKDAIENSSPDIKVKLYTVGAPRYRLELEAYDYKTLEKA
LAKALEEGEETAKSLGVEFSFTREKQ

Specific function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA

COG id: COG1093

COG function: function code J; Translation initiation factor 2, alpha subunit (eIF-2alpha)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain

Homologues:

Organism=Homo sapiens, GI4758256, Length=227, Percent_Identity=26.8722466960352, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17509871, Length=236, Percent_Identity=28.3898305084746, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6322466, Length=253, Percent_Identity=27.2727272727273, Blast_Score=92, Evalue=6e-20,
Organism=Drosophila melanogaster, GI18860087, Length=246, Percent_Identity=26.0162601626016, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF2A_HYPBU (A2BN93)

Other databases:

- EMBL:   CP000493
- RefSeq:   YP_001013799.1
- ProteinModelPortal:   A2BN93
- SMR:   A2BN93
- STRING:   A2BN93
- GeneID:   4782352
- GenomeReviews:   CP000493_GR
- KEGG:   hbu:Hbut_1640
- eggNOG:   arNOG06306
- HOGENOM:   HBG496806
- OMA:   EYPGKEG
- PhylomeDB:   A2BN93
- ProtClustDB:   PRK03987
- BioCyc:   HBUT415426:HBUT_1640-MONOMER
- HAMAP:   MF_00231
- InterPro:   IPR011488
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR022964
- Gene3D:   G3DSA:2.40.50.140
- SMART:   SM00316

Pfam domain/function: PF07541 EIF_2_alpha; PF00575 S1; SSF50249 Nucleic_acid_OB

EC number: NA

Molecular weight: Translated: 30534; Mature: 30403

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS50126 S1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIQRKELPDVGELVVATVKEVYDYGAYLTLDEYGGLEAYLPWSEVASRWVRSIHDVVKP
CCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCEEECCHHHHHHHHHHHHHHHHCC
GQKIVVKVIRVNKRKKQVDVSLKRVTDSERRRKMMEWKRAQKAERILELVAQKLGKSLEE
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYEAVGKKLEDYYGELMAAFEEVVIRGEQALREAGVPEEWVQPLLEEIKRHVEVKRVKIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
GVLTVRSLAGDGIERVKKVLLTVKDAIENSSPDIKVKLYTVGAPRYRLELEAYDYKTLEK
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEEEEHHHHHHHHHH
ALAKALEEGEETAKSLGVEFSFTREKQ
HHHHHHHHHHHHHHHHCCCEEECCCCC
>Mature Secondary Structure 
PIQRKELPDVGELVVATVKEVYDYGAYLTLDEYGGLEAYLPWSEVASRWVRSIHDVVKP
CCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCEEECCHHHHHHHHHHHHHHHHCC
GQKIVVKVIRVNKRKKQVDVSLKRVTDSERRRKMMEWKRAQKAERILELVAQKLGKSLEE
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYEAVGKKLEDYYGELMAAFEEVVIRGEQALREAGVPEEWVQPLLEEIKRHVEVKRVKIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
GVLTVRSLAGDGIERVKKVLLTVKDAIENSSPDIKVKLYTVGAPRYRLELEAYDYKTLEK
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEEEEHHHHHHHHHH
ALAKALEEGEETAKSLGVEFSFTREKQ
HHHHHHHHHHHHHHHHCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA