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The map label for this gene is mre11 [H]

Identifier: 124028051

GI number: 124028051

Start: 1200734

End: 1201957

Strand: Direct

Name: mre11 [H]

Synonym: Hbut_1192

Alternate gene names: 124028051

Gene position: 1200734-1201957 (Clockwise)

Preceding gene: 124028050

Following gene: 124028052

Centisome position: 72.02

GC content: 49.92

Gene sequence:

>1224_bases
ATGACGGAGGCTGACTATAGCGTGGAGCATCTACACTTGCTTCACGTGTCTGATACTCATCTTGGCTACCGACAGTACGG
CATTATAGAGCGAGAAATGGACTTCTACCAGGTGTTCGAGGAGGTAATCGATATAGCAATCCGCGAACATGTAGATGCAG
TCATACATACTGGCGACCTATTTGACTCTACAAGGCCACCAGCACAAGCCATAAGGGCTGCAATAAGAGCGCTTAAGAAA
CTAAGAGGACATGGTATACCCTTCATAGTTCTCGCGGGTGACCACGACACTCCTAAGCGTGCAAACCTCTCACCCCTCAC
CGAGCTCGATGAGGTCGGGCTGGCATACACTATAGGAGCCATCGGAGATAAGCCGACAACCATACAAATTGATACAAGAC
ATGGTCGCTTACTTGTTAGCGGTATAAGGAGCCAGAAGGGACTCCATGCCAGGAAACATTTGCTTGATGCGTTTAAACAG
CTTGTCCCCCGCGATAGGAGCACTGTGAACATACTCTTGCTCCACCAGGCTCTCCGCGAGGTCGCCCCCAACTACGAGGT
TGAACTGGGCGAACTTCCCAAGGGATTCTCATACTACGCGCTAGGACACATACATCTCTACCGCGAGTTTAGGCTAGGAG
ATGCTGCAGTGGTATACCCTGGCTCGCCCGAAGTCCTAAGGATTGATGAGGCTCGCGAACAGCCTCAGCGCTATGTTGTA
CTCGTAGAGGTAGACCAACGTTCAACAAAATCACTTGAAAGAATAAGGCTGGAGATGCCAAGGCCCATAGTTTACAAGGA
GATCATCTATCAAGGCCTTGCCGAGTTTAAGAGCTTGCTCGTGGAGCTTCGGGAGAAGCTTGCAAAGATGGCAGCTAAGG
GAGTGAAGAAGCCTCTACTATACATGTACGTGAAGCGGTTACCAAGGGGCTCGAAGACAGATATCTACACACTCGTCGAG
AGGATTCTGGGAAGCTACATCCTAGACTACAAGCTTAACATTGAGACAGTGATAGAGAATGTGCCGAAGACTGTGCAGAG
TGCAGCCGCCACTATAAACATTGAGAATATACTCCGGGAGCTTCTCGGAAACGACGAGCTAGCACAGCTAGCAGTAAAAC
TCATTGAAATCCTTGGAGGCGAGTCCGAGAAGCATGCGCTCAAGGAGGCCTACAGTATTGTTGCGCAAGAGTTTGGCCTT
GATAGGGAGGCTGGTCTACTATGA

Upstream 100 bases:

>100_bases
CCGAGTGGCAGAACCATATGAGCCAGGAATCCGAGGCCGAAGAGTCCACAATAGAAGATGTACTATCAAACCTCATGTAG
TAACACCCCTAGGAGGGGAT

Downstream 100 bases:

>100_bases
TCATAGAGGCTGTTGAGCTGGAGAACTTCCTCAGCCATCGCTACACCAAAGTCGAGCTTGGCAGAGGCATAGTAGCCGTA
GTTGGACCCAATGGTGCAGG

Product: DNA repair exonuclease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MTEADYSVEHLHLLHVSDTHLGYRQYGIIEREMDFYQVFEEVIDIAIREHVDAVIHTGDLFDSTRPPAQAIRAAIRALKK
LRGHGIPFIVLAGDHDTPKRANLSPLTELDEVGLAYTIGAIGDKPTTIQIDTRHGRLLVSGIRSQKGLHARKHLLDAFKQ
LVPRDRSTVNILLLHQALREVAPNYEVELGELPKGFSYYALGHIHLYREFRLGDAAVVYPGSPEVLRIDEAREQPQRYVV
LVEVDQRSTKSLERIRLEMPRPIVYKEIIYQGLAEFKSLLVELREKLAKMAAKGVKKPLLYMYVKRLPRGSKTDIYTLVE
RILGSYILDYKLNIETVIENVPKTVQSAAATINIENILRELLGNDELAQLAVKLIEILGGESEKHALKEAYSIVAQEFGL
DREAGLL

Sequences:

>Translated_407_residues
MTEADYSVEHLHLLHVSDTHLGYRQYGIIEREMDFYQVFEEVIDIAIREHVDAVIHTGDLFDSTRPPAQAIRAAIRALKK
LRGHGIPFIVLAGDHDTPKRANLSPLTELDEVGLAYTIGAIGDKPTTIQIDTRHGRLLVSGIRSQKGLHARKHLLDAFKQ
LVPRDRSTVNILLLHQALREVAPNYEVELGELPKGFSYYALGHIHLYREFRLGDAAVVYPGSPEVLRIDEAREQPQRYVV
LVEVDQRSTKSLERIRLEMPRPIVYKEIIYQGLAEFKSLLVELREKLAKMAAKGVKKPLLYMYVKRLPRGSKTDIYTLVE
RILGSYILDYKLNIETVIENVPKTVQSAAATINIENILRELLGNDELAQLAVKLIEILGGESEKHALKEAYSIVAQEFGL
DREAGLL
>Mature_406_residues
TEADYSVEHLHLLHVSDTHLGYRQYGIIEREMDFYQVFEEVIDIAIREHVDAVIHTGDLFDSTRPPAQAIRAAIRALKKL
RGHGIPFIVLAGDHDTPKRANLSPLTELDEVGLAYTIGAIGDKPTTIQIDTRHGRLLVSGIRSQKGLHARKHLLDAFKQL
VPRDRSTVNILLLHQALREVAPNYEVELGELPKGFSYYALGHIHLYREFRLGDAAVVYPGSPEVLRIDEAREQPQRYVVL
VEVDQRSTKSLERIRLEMPRPIVYKEIIYQGLAEFKSLLVELREKLAKMAAKGVKKPLLYMYVKRLPRGSKTDIYTLVER
ILGSYILDYKLNIETVIENVPKTVQSAAATINIENILRELLGNDELAQLAVKLIEILGGESEKHALKEAYSIVAQEFGLD
REAGLL

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity [H]

COG id: COG0420

COG function: function code L; DNA repair exonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MRE11/RAD32 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: NA

Molecular weight: Translated: 46060; Mature: 45929

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEADYSVEHLHLLHVSDTHLGYRQYGIIEREMDFYQVFEEVIDIAIREHVDAVIHTGDL
CCCCCCCCCEEEEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FDSTRPPAQAIRAAIRALKKLRGHGIPFIVLAGDHDTPKRANLSPLTELDEVGLAYTIGA
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHCCCEEEECC
IGDKPTTIQIDTRHGRLLVSGIRSQKGLHARKHLLDAFKQLVPRDRSTVNILLLHQALRE
CCCCCCEEEEECCCCEEHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
VAPNYEVELGELPKGFSYYALGHIHLYREFRLGDAAVVYPGSPEVLRIDEAREQPQRYVV
HCCCCEEEECCCCCCCCEEEEHHEEEEEEEECCCEEEEECCCCCEEEECHHHCCCCEEEE
LVEVDQRSTKSLERIRLEMPRPIVYKEIIYQGLAEFKSLLVELREKLAKMAAKGVKKPLL
EEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
YMYVKRLPRGSKTDIYTLVERILGSYILDYKLNIETVIENVPKTVQSAAATINIENILRE
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEHHHHHHH
LLGNDELAQLAVKLIEILGGESEKHALKEAYSIVAQEFGLDREAGLL
HHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TEADYSVEHLHLLHVSDTHLGYRQYGIIEREMDFYQVFEEVIDIAIREHVDAVIHTGDL
CCCCCCCCEEEEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FDSTRPPAQAIRAAIRALKKLRGHGIPFIVLAGDHDTPKRANLSPLTELDEVGLAYTIGA
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHCCCEEEECC
IGDKPTTIQIDTRHGRLLVSGIRSQKGLHARKHLLDAFKQLVPRDRSTVNILLLHQALRE
CCCCCCEEEEECCCCEEHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
VAPNYEVELGELPKGFSYYALGHIHLYREFRLGDAAVVYPGSPEVLRIDEAREQPQRYVV
HCCCCEEEECCCCCCCCEEEEHHEEEEEEEECCCEEEEECCCCCEEEECHHHCCCCEEEE
LVEVDQRSTKSLERIRLEMPRPIVYKEIIYQGLAEFKSLLVELREKLAKMAAKGVKKPLL
EEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
YMYVKRLPRGSKTDIYTLVERILGSYILDYKLNIETVIENVPKTVQSAAATINIENILRE
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEHHHHHHH
LLGNDELAQLAVKLIEILGGESEKHALKEAYSIVAQEFGLDREAGLL
HHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]