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The map label for this gene is rad50 [H]

Identifier: 124028052

GI number: 124028052

Start: 1201954

End: 1204617

Strand: Direct

Name: rad50 [H]

Synonym: Hbut_1193

Alternate gene names: 124028052

Gene position: 1201954-1204617 (Clockwise)

Preceding gene: 124028051

Following gene: 124028054

Centisome position: 72.1

GC content: 49.66

Gene sequence:

>2664_bases
ATGATCATAGAGGCTGTTGAGCTGGAGAACTTCCTCAGCCATCGCTACACCAAAGTCGAGCTTGGCAGAGGCATAGTAGC
CGTAGTTGGACCCAATGGTGCAGGCAAGACAAGCATCGTTGACGCCATAACATATGCACTATTCAACATACACTCGCGCG
ATACTCGCAACAAGAAGGAGCCCCTCATACGCCTCGGTGCTCCTGCTGCAAAAATAATAGTAGAGTTCAGCGTTGGCAAG
AAACGTTACCGTGTACATAAAACAGTGTATCGTGGCGCAACACCTACTCAGGCAACTCTCTACCTTCTCGAGGATGGTAA
GCCCCGGCTTGTTGCGCGCGGAGTTGAGAGTGTTTCTAGAGAGATAGCCAGAATTGTTGGTTTTGACCCACAGCTAGCAG
ATGTGATCATGGTTACTAGGCAGGGTGAGATAGAAAAGATACTCGTAGACAAGAAGGCTCGGATAGAGGCGATTAATACT
CTTCTAAAGCTGCGAGCAATGGAGAAAACCTATGATAGAATGCGGGATCTCATAAGCAGGGTTTCTAGGAGGCTAGAATA
CTACCGTGGAAGACACATTGAGCTTGAGAGGGAGTTGAAGAGGCTACGAGAGGAGGCTGCAAGGTATGAAGAGGCAAGGA
GGGAGCTGGAGAGGGTTAGTGCTGAGCTGGAGGAGGTACGTAGAAAGCTCGATGAGGCCAAGCACGAGCTTGAAAGAGTT
GAAGAGCTTAGGAGAGAGTACGAGGATCTCAACTATCGTCTCGGGTTGCTCGAGGCGGCTATTAAGAGGGATAAGGAGCG
TCTTGCTGAGCTTGAGAGAGAGTATAGGGAGGCAAGAGCAGCTGAGGAAGAACTTGAAGCTCTTCGTGGCGCTTTAGAGG
TTGCGAGGAAAGTGCGTGAGGTTAGGCAACTGCTAGTGAAGCGGAGACAACTTGAAGCTCACCTTGAGGCCATCGAGAAA
GGACTTGAAAACTTTGAAGCTGATGAGGATATGTTAAGAAATCTCGAAGAGGTTGTTAGGAGGTATGAAGAGCTAGAGGA
GAAGCTCCGGGAGCTAGAAGATGTAAATAGGGAGTACATGATTGTGGAAAAACAACTGGAGAATATTGAGAAAGACATTA
GGCGCGTTGAAGAGGAGCGAGATAAGGCTAGGTCAAAGCTATATGCTCTGCTTCAGTCAAGCCTGCCCGTGGAACCACCC
AGCGAAGTCTCCAAGCTACTTGAGTTTATAGACTCTCTTGTACACGACATTGATAAGAGAATCGAGCAGCTGCGAGCAAG
GAAGGAGGCTGTTGTAGGCCAAGTTAGTGCTAAGCTGAACGAGAAGGAGTACATTGAGGGCATACTGTTGAAGCTTACGA
GTGCTAGTGGAAGGTGCCCTCTCTGCGGCCGCCCCCTAACGGAGGAGCACCGAATGACGCTTATCTCGAAGTTTAGGAGT
GAAAAAAGAGGCGTGGAGACCGAGATTAAGAGACTTGAAGCGCAAAAGCAGACCATAGAGGCAGAGATAACGAGGCTTGA
ACAACAGAGGGAGCGTATAAGGGAGCTTGGGAAGAAGATTCGCGAGCTTGTTAGCCAGGTTAGCCAGCTCGAGGCTAGGC
TTGAGGAGTTACGTACTGAGCAGGCTAAGCTTAGCGAGAGGCGACTCGAACTCTTTGAAAAGCATAAAGAGTACGAGGAG
GCTAGGAAGGAGCTGGAGAAGCTTGGGCAGGCAGTTGTAGAGTATAGGGTTCTCAAGCGTAGGCTTGAAGAGCTTGAGAA
GCGTAGGGTAGAAGCTGAGCGACTCCGCGAGGAGCTTAGGAGACTTGATGAGAAGATTGGTACTTTACTTGGAGAGCTTG
GGGTTGATGCTAGTGGCCTGGATGAGCTTGAGGAAAGGGTTTCACACCTTCTCGAGATGGTGGCTGAGCTGAGGAGTAAG
GCTTCAAGGAGACCCGAGCTTGAAAGGAGACTTGACGAGGTTAGGAGGAGGCTTGAGGACTACGAGGAGGAATATAACAG
TGTTGCTGGGAGGCTTGAGGAGCTTAAGGGCATCGAAGAGGAGTATGAGAAGTTGAGAAGCCTCGTCGAGAGCCTTGAGG
AGAGGTATCGTGAGAAGGTAGCTGAGTACTCAAAGCTCCGCGGGATAGTGGACGAGCTGGAGAAGAGTGTAAAAAGGCTT
AAGCTCGTTGAGGAAGAGTATAGACGTGTTAGCGAGAAGCTCGAGCGTTATAGCCATGCAAAGAGAGCGCTGGAGCGTAT
CCGTGCCGTTATAGGCCCTGAGGGCTTACAGAGGATTGTCCGTCAGGCCATCCGTAATAGTCTTGAGTACCATTTGCGCC
AGATACTCTCAGCCTTTAACATAGACTTTGTCGATGTAAAACTGGACGATGAGTACAGTGTTACGCTGATTACGAGGGCT
GGCGAGAAGACCGTCTCGATGCTCAGTGGAGGTGAAAAGATAGCGCTAGCTATAGCATATAGGCTGGCTCTAGCAAGGCT
AGTTGGGAGCCGCATAGAGTCACTCATAATGGATGAGCCCACTGTACACCTTGACGCTGAGAAGCGTAGAGAGCTAGTGA
ACATCATTAAGCAGAGTCTGAGTGTTACAGGGCTAGCACAAATGATAGTTGTTACGCATGACCGGGAGGTTGAGGATGTT
GCTGATAGAGTTATAGAGGTTTAA

Upstream 100 bases:

>100_bases
TCATTGAAATCCTTGGAGGCGAGTCCGAGAAGCATGCGCTCAAGGAGGCCTACAGTATTGTTGCGCAAGAGTTTGGCCTT
GATAGGGAGGCTGGTCTACT

Downstream 100 bases:

>100_bases
GGAGCCGTGAGGGGCACAGCGTTGTACAAGTGCTAGGCTAGCCGTCGCTTTCCACATTCCCATATTCTATGATAGGCTCC
CAGCATTCCTTACAGAGGAC

Product: Rad50

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 887; Mature: 887

Protein sequence:

>887_residues
MIIEAVELENFLSHRYTKVELGRGIVAVVGPNGAGKTSIVDAITYALFNIHSRDTRNKKEPLIRLGAPAAKIIVEFSVGK
KRYRVHKTVYRGATPTQATLYLLEDGKPRLVARGVESVSREIARIVGFDPQLADVIMVTRQGEIEKILVDKKARIEAINT
LLKLRAMEKTYDRMRDLISRVSRRLEYYRGRHIELERELKRLREEAARYEEARRELERVSAELEEVRRKLDEAKHELERV
EELRREYEDLNYRLGLLEAAIKRDKERLAELEREYREARAAEEELEALRGALEVARKVREVRQLLVKRRQLEAHLEAIEK
GLENFEADEDMLRNLEEVVRRYEELEEKLRELEDVNREYMIVEKQLENIEKDIRRVEEERDKARSKLYALLQSSLPVEPP
SEVSKLLEFIDSLVHDIDKRIEQLRARKEAVVGQVSAKLNEKEYIEGILLKLTSASGRCPLCGRPLTEEHRMTLISKFRS
EKRGVETEIKRLEAQKQTIEAEITRLEQQRERIRELGKKIRELVSQVSQLEARLEELRTEQAKLSERRLELFEKHKEYEE
ARKELEKLGQAVVEYRVLKRRLEELEKRRVEAERLREELRRLDEKIGTLLGELGVDASGLDELEERVSHLLEMVAELRSK
ASRRPELERRLDEVRRRLEDYEEEYNSVAGRLEELKGIEEEYEKLRSLVESLEERYREKVAEYSKLRGIVDELEKSVKRL
KLVEEEYRRVSEKLERYSHAKRALERIRAVIGPEGLQRIVRQAIRNSLEYHLRQILSAFNIDFVDVKLDDEYSVTLITRA
GEKTVSMLSGGEKIALAIAYRLALARLVGSRIESLIMDEPTVHLDAEKRRELVNIIKQSLSVTGLAQMIVVTHDREVEDV
ADRVIEV

Sequences:

>Translated_887_residues
MIIEAVELENFLSHRYTKVELGRGIVAVVGPNGAGKTSIVDAITYALFNIHSRDTRNKKEPLIRLGAPAAKIIVEFSVGK
KRYRVHKTVYRGATPTQATLYLLEDGKPRLVARGVESVSREIARIVGFDPQLADVIMVTRQGEIEKILVDKKARIEAINT
LLKLRAMEKTYDRMRDLISRVSRRLEYYRGRHIELERELKRLREEAARYEEARRELERVSAELEEVRRKLDEAKHELERV
EELRREYEDLNYRLGLLEAAIKRDKERLAELEREYREARAAEEELEALRGALEVARKVREVRQLLVKRRQLEAHLEAIEK
GLENFEADEDMLRNLEEVVRRYEELEEKLRELEDVNREYMIVEKQLENIEKDIRRVEEERDKARSKLYALLQSSLPVEPP
SEVSKLLEFIDSLVHDIDKRIEQLRARKEAVVGQVSAKLNEKEYIEGILLKLTSASGRCPLCGRPLTEEHRMTLISKFRS
EKRGVETEIKRLEAQKQTIEAEITRLEQQRERIRELGKKIRELVSQVSQLEARLEELRTEQAKLSERRLELFEKHKEYEE
ARKELEKLGQAVVEYRVLKRRLEELEKRRVEAERLREELRRLDEKIGTLLGELGVDASGLDELEERVSHLLEMVAELRSK
ASRRPELERRLDEVRRRLEDYEEEYNSVAGRLEELKGIEEEYEKLRSLVESLEERYREKVAEYSKLRGIVDELEKSVKRL
KLVEEEYRRVSEKLERYSHAKRALERIRAVIGPEGLQRIVRQAIRNSLEYHLRQILSAFNIDFVDVKLDDEYSVTLITRA
GEKTVSMLSGGEKIALAIAYRLALARLVGSRIESLIMDEPTVHLDAEKRRELVNIIKQSLSVTGLAQMIVVTHDREVEDV
ADRVIEV
>Mature_887_residues
MIIEAVELENFLSHRYTKVELGRGIVAVVGPNGAGKTSIVDAITYALFNIHSRDTRNKKEPLIRLGAPAAKIIVEFSVGK
KRYRVHKTVYRGATPTQATLYLLEDGKPRLVARGVESVSREIARIVGFDPQLADVIMVTRQGEIEKILVDKKARIEAINT
LLKLRAMEKTYDRMRDLISRVSRRLEYYRGRHIELERELKRLREEAARYEEARRELERVSAELEEVRRKLDEAKHELERV
EELRREYEDLNYRLGLLEAAIKRDKERLAELEREYREARAAEEELEALRGALEVARKVREVRQLLVKRRQLEAHLEAIEK
GLENFEADEDMLRNLEEVVRRYEELEEKLRELEDVNREYMIVEKQLENIEKDIRRVEEERDKARSKLYALLQSSLPVEPP
SEVSKLLEFIDSLVHDIDKRIEQLRARKEAVVGQVSAKLNEKEYIEGILLKLTSASGRCPLCGRPLTEEHRMTLISKFRS
EKRGVETEIKRLEAQKQTIEAEITRLEQQRERIRELGKKIRELVSQVSQLEARLEELRTEQAKLSERRLELFEKHKEYEE
ARKELEKLGQAVVEYRVLKRRLEELEKRRVEAERLREELRRLDEKIGTLLGELGVDASGLDELEERVSHLLEMVAELRSK
ASRRPELERRLDEVRRRLEDYEEEYNSVAGRLEELKGIEEEYEKLRSLVESLEERYREKVAEYSKLRGIVDELEKSVKRL
KLVEEEYRRVSEKLERYSHAKRALERIRAVIGPEGLQRIVRQAIRNSLEYHLRQILSAFNIDFVDVKLDDEYSVTLITRA
GEKTVSMLSGGEKIALAIAYRLALARLVGSRIESLIMDEPTVHLDAEKRRELVNIIKQSLSVTGLAQMIVVTHDREVEDV
ADRVIEV

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of mre11 by unwinding and

COG id: COG0419

COG function: function code L; ATPase involved in DNA repair

Gene ontology:

Cell location: Inner Membrane-Associated [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 zinc-hook domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR022982
- InterPro:   IPR007517
- InterPro:   IPR003395
- InterPro:   IPR013134 [H]

Pfam domain/function: PF04423 Rad50_zn_hook; PF02463 SMC_N [H]

EC number: NA

Molecular weight: Translated: 103947; Mature: 103947

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS51131 ZN_HOOK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIEAVELENFLSHRYTKVELGRGIVAVVGPNGAGKTSIVDAITYALFNIHSRDTRNKKE
CCCHHHHHHHHHHHCCHHEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
PLIRLGAPAAKIIVEFSVGKKRYRVHKTVYRGATPTQATLYLLEDGKPRLVARGVESVSR
CCEECCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHEEEEEECCCCHHHHHHHHHHHH
EIARIVGFDPQLADVIMVTRQGEIEKILVDKKARIEAINTLLKLRAMEKTYDRMRDLISR
HHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSRRLEYYRGRHIELERELKRLREEAARYEEARRELERVSAELEEVRRKLDEAKHELERV
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EELRREYEDLNYRLGLLEAAIKRDKERLAELEREYREARAAEEELEALRGALEVARKVRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRQLLVKRRQLEAHLEAIEKGLENFEADEDMLRNLEEVVRRYEELEEKLRELEDVNREYM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
IVEKQLENIEKDIRRVEEERDKARSKLYALLQSSLPVEPPSEVSKLLEFIDSLVHDIDKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
IEQLRARKEAVVGQVSAKLNEKEYIEGILLKLTSASGRCPLCGRPLTEEHRMTLISKFRS
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
EKRGVETEIKRLEAQKQTIEAEITRLEQQRERIRELGKKIRELVSQVSQLEARLEELRTE
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAKLSERRLELFEKHKEYEEARKELEKLGQAVVEYRVLKRRLEELEKRRVEAERLREELR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLDEKIGTLLGELGVDASGLDELEERVSHLLEMVAELRSKASRRPELERRLDEVRRRLED
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
YEEEYNSVAGRLEELKGIEEEYEKLRSLVESLEERYREKVAEYSKLRGIVDELEKSVKRL
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLVEEEYRRVSEKLERYSHAKRALERIRAVIGPEGLQRIVRQAIRNSLEYHLRQILSAFN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IDFVDVKLDDEYSVTLITRAGEKTVSMLSGGEKIALAIAYRLALARLVGSRIESLIMDEP
CCEEEEEECCCCEEEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TVHLDAEKRRELVNIIKQSLSVTGLAQMIVVTHDREVEDVADRVIEV
CEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure
MIIEAVELENFLSHRYTKVELGRGIVAVVGPNGAGKTSIVDAITYALFNIHSRDTRNKKE
CCCHHHHHHHHHHHCCHHEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
PLIRLGAPAAKIIVEFSVGKKRYRVHKTVYRGATPTQATLYLLEDGKPRLVARGVESVSR
CCEECCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHEEEEEECCCCHHHHHHHHHHHH
EIARIVGFDPQLADVIMVTRQGEIEKILVDKKARIEAINTLLKLRAMEKTYDRMRDLISR
HHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSRRLEYYRGRHIELERELKRLREEAARYEEARRELERVSAELEEVRRKLDEAKHELERV
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EELRREYEDLNYRLGLLEAAIKRDKERLAELEREYREARAAEEELEALRGALEVARKVRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRQLLVKRRQLEAHLEAIEKGLENFEADEDMLRNLEEVVRRYEELEEKLRELEDVNREYM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
IVEKQLENIEKDIRRVEEERDKARSKLYALLQSSLPVEPPSEVSKLLEFIDSLVHDIDKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
IEQLRARKEAVVGQVSAKLNEKEYIEGILLKLTSASGRCPLCGRPLTEEHRMTLISKFRS
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
EKRGVETEIKRLEAQKQTIEAEITRLEQQRERIRELGKKIRELVSQVSQLEARLEELRTE
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAKLSERRLELFEKHKEYEEARKELEKLGQAVVEYRVLKRRLEELEKRRVEAERLREELR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLDEKIGTLLGELGVDASGLDELEERVSHLLEMVAELRSKASRRPELERRLDEVRRRLED
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
YEEEYNSVAGRLEELKGIEEEYEKLRSLVESLEERYREKVAEYSKLRGIVDELEKSVKRL
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLVEEEYRRVSEKLERYSHAKRALERIRAVIGPEGLQRIVRQAIRNSLEYHLRQILSAFN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IDFVDVKLDDEYSVTLITRAGEKTVSMLSGGEKIALAIAYRLALARLVGSRIESLIMDEP
CCEEEEEECCCCEEEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TVHLDAEKRRELVNIIKQSLSVTGLAQMIVVTHDREVEDVADRVIEV
CEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]