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The map label for this gene is ogt [H]

Identifier: 124027983

GI number: 124027983

Start: 1133960

End: 1134316

Strand: Reverse

Name: ogt [H]

Synonym: Hbut_1117

Alternate gene names: 124027983

Gene position: 1134316-1133960 (Counterclockwise)

Preceding gene: 124027986

Following gene: 124027982

Centisome position: 68.04

GC content: 53.78

Gene sequence:

>357_bases
GTGAGCTGGAAGGACCCCCGTAGCCTTCGCGACATAGTCTACGTGTTATTGTCGGCTGTGCCGCTGGGGTATACCGTTAC
GTACTCGGTGCTGGCTAGACTGGCCGGCACGTCGCCTAGAGCGATAGGGGTGTTCATGAGGCAAAACCGTGACCTGATAG
TTGTCCCGTGTCATCGCGTAGTGAGTGTTAGAGGGCTTGGAGGTTACAGTAGAGGGCTCAGTTTTAAGGAGAAGCTCCTA
AGGCTCGAGGGAGCCCTTAGCAGTGATGGTGGAGTATTGAGGCGCATCACCAGCGTAGAGGACTACTGGAGAGTGTTAGA
GGAGCAAGGCTATACGTGTTGTAGTATTGATGTTTAG

Upstream 100 bases:

>100_bases
TAGCATAGCTATATTCACGGGCGGTAAGTAGTTAATATATAATATGTGGGGGTGACTGGCCTCCCCGTCAGACTGAATGT
TCTTGTATGGTGATGACTGG

Downstream 100 bases:

>100_bases
GAATGTTTAGGGAGAGACTGGCCTCAGCCCACAGGGAACTCATCACGCTGCTCATTGGCCTCAGCTAGGTGTTAGCTCAG
CATATCCAATGATGAGGATC

Product: 6-O-methylguanine DNA methyltransferase

Products: NA

Alternate protein names: 6-O-methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA-alkyltransferase [H]

Number of amino acids: Translated: 118; Mature: 117

Protein sequence:

>118_residues
MSWKDPRSLRDIVYVLLSAVPLGYTVTYSVLARLAGTSPRAIGVFMRQNRDLIVVPCHRVVSVRGLGGYSRGLSFKEKLL
RLEGALSSDGGVLRRITSVEDYWRVLEEQGYTCCSIDV

Sequences:

>Translated_118_residues
MSWKDPRSLRDIVYVLLSAVPLGYTVTYSVLARLAGTSPRAIGVFMRQNRDLIVVPCHRVVSVRGLGGYSRGLSFKEKLL
RLEGALSSDGGVLRRITSVEDYWRVLEEQGYTCCSIDV
>Mature_117_residues
SWKDPRSLRDIVYVLLSAVPLGYTVTYSVLARLAGTSPRAIGVFMRQNRDLIVVPCHRVVSVRGLGGYSRGLSFKEKLLR
LEGALSSDGGVLRRITSVEDYWRVLEEQGYTCCSIDV

Specific function: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a sui

COG id: COG0350

COG function: function code L; Methylated DNA-protein cysteine methyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MGMT family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001497
- InterPro:   IPR014048
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01035 DNA_binding_1 [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 13166; Mature: 13035

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS00374 MGMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWKDPRSLRDIVYVLLSAVPLGYTVTYSVLARLAGTSPRAIGVFMRQNRDLIVVPCHRV
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEHEEECCCCEEEECCHHE
VSVRGLGGYSRGLSFKEKLLRLEGALSSDGGVLRRITSVEDYWRVLEEQGYTCCSIDV
EEECCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECC
>Mature Secondary Structure 
SWKDPRSLRDIVYVLLSAVPLGYTVTYSVLARLAGTSPRAIGVFMRQNRDLIVVPCHRV
CCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEHEEECCCCEEEECCHHE
VSVRGLGGYSRGLSFKEKLLRLEGALSSDGGVLRRITSVEDYWRVLEEQGYTCCSIDV
EEECCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA