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The map label for this gene is tyrS [H]

Identifier: 124027763

GI number: 124027763

Start: 891061

End: 892149

Strand: Direct

Name: tyrS [H]

Synonym: Hbut_0889

Alternate gene names: 124027763

Gene position: 891061-892149 (Clockwise)

Preceding gene: 124027762

Following gene: 124027764

Centisome position: 53.45

GC content: 49.49

Gene sequence:

>1089_bases
ATGGATGTGGAGGAAAGGCTAAAGCTCATCACGAGGAACACTGTTGAAGTTGTAACAGTTGAAGAGCTAAGGGAGAAGCT
TGAGTCTGGCGAGAAGCTAAAGGGTTACATAGGCTTCGAGCCCAGCGGACTCTTCCACATAGGCTGGCTAGTATGGGCCT
TTAAGGTAAAAGACATGGTTGAAGCAGGTATCGACTTCTACCTGCTGGCAGCCACCTGGCACGCTTGGATCAACGACAAG
TTTGGAGGTAATATGGAGCTGATAAGAAAAGCTGCTCGTCACGTAGTAGATGTTCTCGAAGCAATAGGTGTTGAGAGGTC
AAAAGTAAAAGTCGTCGATGCCGAGGATCTCGTATCCGATAAGGAGTACTGGGCTATACTGCTAAAGGTTGCAAAGTCTA
ACACTCTTGCACGTATGAAGCGAGCGCTAACCATAATGGGTAGGCGTGCTGAGGAGGCTGAGCTAGACTTCTCAAAGCTA
ATCTACCCAGCAATGCAGGTTACCGACATCTTCTACCTTGACCTGGACATAGCGTTGGGTGGTATAGACCAGAGAAAGGC
TCACATGCTTGCAAGAGACACAGCGGAGAAGCTGGGCAGGAAGAAGGTCATAGCGGTACATACACCACTCATAACGAGCC
TACAGGGCCTGGGCAGGATGAATCCCGACCAGGTAGACGAGGAGACTCATGCTGTCGAGTTTAAGATGAGTAAGTCTAAG
CCAGAGACAGCACTCTTTGTCTACGATCCGCCCGAAGAGATAGAGAGAAAGATACTGAGAGCATATTGTCCAGCTCGCAT
AGTGAGGTACAATCCGATAATAGAGATAAACAAGTACCTCCTCTTCAGCAGGCCAGGATTCAAGCTGGTGGTTGAGAGGC
CTGAGAAGTACGGCGGGACGGTAGTGATTGAGAGCTATGAGGAACTCGAGAAGCTCTACGTGGAGGGCAAGCTCCACCCA
CTAGACCTCAAGAAGGCTACAGCTAAGGCATTGATAGAGCTACTTGAACCCGTGAGACGGTACTTTGAGTCCAATCGGGA
GGCGCGCGAACTACTAGAAGAACTAAAAAAGGCTACGGTGACGAGGTAA

Upstream 100 bases:

>100_bases
GCACACCCTCCCCGGATATATTTATCAGAGCCTATTTTCAGGGCTGCAACCGAGCAGCTCTCTCAGCAAAGGTCACAATT
ACGGCCTAGGTGTAGGGTCT

Downstream 100 bases:

>100_bases
CGAAGTTGGTAGGATAGAGCCCTAAACTTAGGCTGGGCTGTGCAGTACTGGAGGCAGATATGCTGGCTAGCTATACTCAA
CAGTCTTTGACTGGGAAGCG

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MDVEERLKLITRNTVEVVTVEELREKLESGEKLKGYIGFEPSGLFHIGWLVWAFKVKDMVEAGIDFYLLAATWHAWINDK
FGGNMELIRKAARHVVDVLEAIGVERSKVKVVDAEDLVSDKEYWAILLKVAKSNTLARMKRALTIMGRRAEEAELDFSKL
IYPAMQVTDIFYLDLDIALGGIDQRKAHMLARDTAEKLGRKKVIAVHTPLITSLQGLGRMNPDQVDEETHAVEFKMSKSK
PETALFVYDPPEEIERKILRAYCPARIVRYNPIIEINKYLLFSRPGFKLVVERPEKYGGTVVIESYEELEKLYVEGKLHP
LDLKKATAKALIELLEPVRRYFESNREARELLEELKKATVTR

Sequences:

>Translated_362_residues
MDVEERLKLITRNTVEVVTVEELREKLESGEKLKGYIGFEPSGLFHIGWLVWAFKVKDMVEAGIDFYLLAATWHAWINDK
FGGNMELIRKAARHVVDVLEAIGVERSKVKVVDAEDLVSDKEYWAILLKVAKSNTLARMKRALTIMGRRAEEAELDFSKL
IYPAMQVTDIFYLDLDIALGGIDQRKAHMLARDTAEKLGRKKVIAVHTPLITSLQGLGRMNPDQVDEETHAVEFKMSKSK
PETALFVYDPPEEIERKILRAYCPARIVRYNPIIEINKYLLFSRPGFKLVVERPEKYGGTVVIESYEELEKLYVEGKLHP
LDLKKATAKALIELLEPVRRYFESNREARELLEELKKATVTR
>Mature_362_residues
MDVEERLKLITRNTVEVVTVEELREKLESGEKLKGYIGFEPSGLFHIGWLVWAFKVKDMVEAGIDFYLLAATWHAWINDK
FGGNMELIRKAARHVVDVLEAIGVERSKVKVVDAEDLVSDKEYWAILLKVAKSNTLARMKRALTIMGRRAEEAELDFSKL
IYPAMQVTDIFYLDLDIALGGIDQRKAHMLARDTAEKLGRKKVIAVHTPLITSLQGLGRMNPDQVDEETHAVEFKMSKSK
PETALFVYDPPEEIERKILRAYCPARIVRYNPIIEINKYLLFSRPGFKLVVERPEKYGGTVVIESYEELEKLYVEGKLHP
LDLKKATAKALIELLEPVRRYFESNREARELLEELKKATVTR

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507947, Length=345, Percent_Identity=31.8840579710145, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71992775, Length=360, Percent_Identity=25.8333333333333, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321624, Length=366, Percent_Identity=30.327868852459, Blast_Score=164, Evalue=2e-41,
Organism=Drosophila melanogaster, GI21357223, Length=352, Percent_Identity=31.5340909090909, Blast_Score=146, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002307
- InterPro:   IPR015624 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 41576; Mature: 41576

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVEERLKLITRNTVEVVTVEELREKLESGEKLKGYIGFEPSGLFHIGWLVWAFKVKDMV
CCHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHH
EAGIDFYLLAATWHAWINDKFGGNMELIRKAARHVVDVLEAIGVERSKVKVVDAEDLVSD
HCCCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHCC
KEYWAILLKVAKSNTLARMKRALTIMGRRAEEAELDFSKLIYPAMQVTDIFYLDLDIALG
HHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHEEEEEEEEEEC
GIDQRKAHMLARDTAEKLGRKKVIAVHTPLITSLQGLGRMNPDQVDEETHAVEFKMSKSK
CCCHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHCCCCCCHHCCCCHHEEEEEECCCC
PETALFVYDPPEEIERKILRAYCPARIVRYNPIIEINKYLLFSRPGFKLVVERPEKYGGT
CCEEEEEECCHHHHHHHHHHHHCCHHHEECCCEEEECCEEEECCCCCEEEEECCHHCCCE
VVIESYEELEKLYVEGKLHPLDLKKATAKALIELLEPVRRYFESNREARELLEELKKATV
EEEECHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHC
TR
CC
>Mature Secondary Structure
MDVEERLKLITRNTVEVVTVEELREKLESGEKLKGYIGFEPSGLFHIGWLVWAFKVKDMV
CCHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHH
EAGIDFYLLAATWHAWINDKFGGNMELIRKAARHVVDVLEAIGVERSKVKVVDAEDLVSD
HCCCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHCC
KEYWAILLKVAKSNTLARMKRALTIMGRRAEEAELDFSKLIYPAMQVTDIFYLDLDIALG
HHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHEEEEEEEEEEC
GIDQRKAHMLARDTAEKLGRKKVIAVHTPLITSLQGLGRMNPDQVDEETHAVEFKMSKSK
CCCHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHCCCCCCHHCCCCHHEEEEEECCCC
PETALFVYDPPEEIERKILRAYCPARIVRYNPIIEINKYLLFSRPGFKLVVERPEKYGGT
CCEEEEEECCHHHHHHHHHHHHCCHHHEECCCEEEECCEEEECCCCCEEEEECCHHCCCE
VVIESYEELEKLYVEGKLHPLDLKKATAKALIELLEPVRRYFESNREARELLEELKKATV
EEEECHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHC
TR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]