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The map label for this gene is nadC [H]

Identifier: 124027560

GI number: 124027560

Start: 660733

End: 661608

Strand: Reverse

Name: nadC [H]

Synonym: Hbut_0679

Alternate gene names: 124027560

Gene position: 661608-660733 (Counterclockwise)

Preceding gene: 124027561

Following gene: 124027559

Centisome position: 39.68

GC content: 60.5

Gene sequence:

>876_bases
TTGTTCCTCGACCCCTACACCGTTGCGGAAAAGCTGCTTGAATGGGTTGAGGAGGACGCGCCCTTCGGCGACCTGACTAC
GGGCTACACGGTACCCCGCGGGCTCTGGGCTCGTGCAGTCGTCGTGCTCAAGTCTCGGGCTGTGCCCGCCTGCCTAGAGC
CAGTTGTGGAGGCCCTACGCATACTAGGCTTCAATGCCAAGCCGCTTGTTGAGGAAGCTGCCTGGGTCGAGCCGCCAAGG
GGGGTTCTGGAGGTTGCTGGCGAGGCTAGACGGATACTACTCTTCGAGCGTACCCTGCTAAACCTCCTCATATACACGTT
TAGTGTAGCTACTACAACCAGGATGATGGTCGAGGCTGCCCACCGTATAAACCCCCGCGTAAGGATCGCGGCAACTAGGA
AGACTCCGCCCGGCCTACGCTACTTTGCCAAGTGTGCTGTCGCAGTTGGCGGCGGCGATACCCACAGGTTATCCCTTAGC
GACGCCGTGCTAGTCAAGGACAACCACGTACGCATAGCCGGCAGCGTGGCAGAGGCTGTACGACGGGCCAAGGCTAGGAC
GAGCTTCGCACATCGCGTCGAGGTGGAGGTCTCTAGCCTCGAGGAGGCTGTAGAGGCCATAGAGGCTGGCGCCGATATCG
TGATGATCGACAATCAGCCCCCCGAAGTGGTCGCGGAGATAGTGGGGGAGCTGGGTAGGAGGGGGCTCCGGGACCGCGTA
CTCATAGAGGCCAGTGGTGGGATAGACCTGTCCAACGTGGCTGACTACGCTGCCACCGGAGTTGACATTATTAGCTCGAG
CATGCTGACCATGAGCCCGGTGCGTGTAGACCTAAGCCTACGGGTTGTAGAGGTGAGGGAGCTACGCTCCGCGTAG

Upstream 100 bases:

>100_bases
TGAAGCCCAGGGTAGTCGTACCAGAGCCAATTGCGAGGCGCGTCCGCGAAATCCTTGAGCGCTCCCTGGAGATGGTAAGG
TAGCCTTGTGGGTGGCTGGG

Downstream 100 bases:

>100_bases
CAGTCATAGGATGCGGCAACATAGGCACAGTACTCGCCAAGGCAGTGGATGAGGGTGTCGTGGAGAACGCGGAGCTGGTA
GCCCTCTACGACGTTGCTAG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MFLDPYTVAEKLLEWVEEDAPFGDLTTGYTVPRGLWARAVVVLKSRAVPACLEPVVEALRILGFNAKPLVEEAAWVEPPR
GVLEVAGEARRILLFERTLLNLLIYTFSVATTTRMMVEAAHRINPRVRIAATRKTPPGLRYFAKCAVAVGGGDTHRLSLS
DAVLVKDNHVRIAGSVAEAVRRAKARTSFAHRVEVEVSSLEEAVEAIEAGADIVMIDNQPPEVVAEIVGELGRRGLRDRV
LIEASGGIDLSNVADYAATGVDIISSSMLTMSPVRVDLSLRVVEVRELRSA

Sequences:

>Translated_291_residues
MFLDPYTVAEKLLEWVEEDAPFGDLTTGYTVPRGLWARAVVVLKSRAVPACLEPVVEALRILGFNAKPLVEEAAWVEPPR
GVLEVAGEARRILLFERTLLNLLIYTFSVATTTRMMVEAAHRINPRVRIAATRKTPPGLRYFAKCAVAVGGGDTHRLSLS
DAVLVKDNHVRIAGSVAEAVRRAKARTSFAHRVEVEVSSLEEAVEAIEAGADIVMIDNQPPEVVAEIVGELGRRGLRDRV
LIEASGGIDLSNVADYAATGVDIISSSMLTMSPVRVDLSLRVVEVRELRSA
>Mature_291_residues
MFLDPYTVAEKLLEWVEEDAPFGDLTTGYTVPRGLWARAVVVLKSRAVPACLEPVVEALRILGFNAKPLVEEAAWVEPPR
GVLEVAGEARRILLFERTLLNLLIYTFSVATTTRMMVEAAHRINPRVRIAATRKTPPGLRYFAKCAVAVGGGDTHRLSLS
DAVLVKDNHVRIAGSVAEAVRRAKARTSFAHRVEVEVSSLEEAVEAIEAGADIVMIDNQPPEVVAEIVGELGRRGLRDRV
LIEASGGIDLSNVADYAATGVDIISSSMLTMSPVRVDLSLRVVEVRELRSA

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=287, Percent_Identity=37.6306620209059, Blast_Score=149, Evalue=3e-36,
Organism=Escherichia coli, GI1786299, Length=215, Percent_Identity=40.4651162790698, Blast_Score=113, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6321162, Length=280, Percent_Identity=34.6428571428571, Blast_Score=164, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31673; Mature: 31673

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLDPYTVAEKLLEWVEEDAPFGDLTTGYTVPRGLWARAVVVLKSRAVPACLEPVVEALR
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ILGFNAKPLVEEAAWVEPPRGVLEVAGEARRILLFERTLLNLLIYTFSVATTTRMMVEAA
HHCCCCCHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HRINPRVRIAATRKTPPGLRYFAKCAVAVGGGDTHRLSLSDAVLVKDNHVRIAGSVAEAV
HHCCCEEEEEEECCCCCCHHHHHHHHEEECCCCCEEEECCCEEEEECCCEEEEHHHHHHH
RRAKARTSFAHRVEVEVSSLEEAVEAIEAGADIVMIDNQPPEVVAEIVGELGRRGLRDRV
HHHHHHHHHHHHEEEHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEE
LIEASGGIDLSNVADYAATGVDIISSSMLTMSPVRVDLSLRVVEVRELRSA
EEEECCCCCHHHHHHHHHHHHHHHHCCHHEECCEEEEEEEEEEEHHHHHCC
>Mature Secondary Structure
MFLDPYTVAEKLLEWVEEDAPFGDLTTGYTVPRGLWARAVVVLKSRAVPACLEPVVEALR
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ILGFNAKPLVEEAAWVEPPRGVLEVAGEARRILLFERTLLNLLIYTFSVATTTRMMVEAA
HHCCCCCHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HRINPRVRIAATRKTPPGLRYFAKCAVAVGGGDTHRLSLSDAVLVKDNHVRIAGSVAEAV
HHCCCEEEEEEECCCCCCHHHHHHHHEEECCCCCEEEECCCEEEEECCCEEEEHHHHHHH
RRAKARTSFAHRVEVEVSSLEEAVEAIEAGADIVMIDNQPPEVVAEIVGELGRRGLRDRV
HHHHHHHHHHHHEEEHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEE
LIEASGGIDLSNVADYAATGVDIISSSMLTMSPVRVDLSLRVVEVRELRSA
EEEECCCCCHHHHHHHHHHHHHHHHCCHHEECCEEEEEEEEEEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]