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The map label for this gene is ndk

Identifier: 124027434

GI number: 124027434

Start: 526845

End: 527273

Strand: Direct

Name: ndk

Synonym: Hbut_0549

Alternate gene names: 124027434

Gene position: 526845-527273 (Clockwise)

Preceding gene: 124027432

Following gene: 124027435

Centisome position: 31.6

GC content: 51.28

Gene sequence:

>429_bases
ATGCCTGTAGAACGTACGTTCGTCATGATAAAGCCTGATGGTGTCAAGAGGGGGCTCGTAGGCGAGATAATAGCCAGGTT
TGAGAGGAAGGGCCTCAAGATAAAGGCTCTCAAGATGAAGTGGCTAACCCGGGAGGAAGCCGAGAAGCTTTACGAGGTAC
ACCGTGGCAAACCGTTCTTCGAGGATCTTGTCAACTTTGTCACGAGTGGGCCCGTCGTAGCAATGATACTTGAGGGTGAC
AGTGCTATAGAGGTTGTAAGGCTAATGATAGGCCCAACCGACGGTAGAAAGGCACCGCCGGGCACCATTAGGGGCGACTA
CGCCCTAGACATTGGCGCTAATGTAATACATGCTAGCGACAGCAAGGAGTCCTATGAACGTGAGTACAAGGTATTCTTCA
GCGACGACGAGATAGTGGGTGACTACTAA

Upstream 100 bases:

>100_bases
TATCGTGGAGTTACTAGCTTAAAGGCCTAGAGGTCTCCAGTGGTAGCATCAAGCACTTATCCCGCAGCTTCCAATGGGTA
GCGCTTGGTGGAGGAAATCC

Downstream 100 bases:

>100_bases
CCATCGATTCAAGGCACATAGCTTATCGATATGATGTTATACATAATGCTAATGGAGTAGTCTCGCTCCACTTTTCTTCC
CTACAGCTTACTCCTACCCG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 142; Mature: 141

Protein sequence:

>142_residues
MPVERTFVMIKPDGVKRGLVGEIIARFERKGLKIKALKMKWLTREEAEKLYEVHRGKPFFEDLVNFVTSGPVVAMILEGD
SAIEVVRLMIGPTDGRKAPPGTIRGDYALDIGANVIHASDSKESYEREYKVFFSDDEIVGDY

Sequences:

>Translated_142_residues
MPVERTFVMIKPDGVKRGLVGEIIARFERKGLKIKALKMKWLTREEAEKLYEVHRGKPFFEDLVNFVTSGPVVAMILEGD
SAIEVVRLMIGPTDGRKAPPGTIRGDYALDIGANVIHASDSKESYEREYKVFFSDDEIVGDY
>Mature_141_residues
PVERTFVMIKPDGVKRGLVGEIIARFERKGLKIKALKMKWLTREEAEKLYEVHRGKPFFEDLVNFVTSGPVVAMILEGDS
AIEVVRLMIGPTDGRKAPPGTIRGDYALDIGANVIHASDSKESYEREYKVFFSDDEIVGDY

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=49.2647058823529, Blast_Score=139, Evalue=8e-34,
Organism=Homo sapiens, GI66392203, Length=140, Percent_Identity=47.8571428571429, Blast_Score=137, Evalue=3e-33,
Organism=Homo sapiens, GI66392227, Length=140, Percent_Identity=47.8571428571429, Blast_Score=137, Evalue=3e-33,
Organism=Homo sapiens, GI66392205, Length=140, Percent_Identity=47.8571428571429, Blast_Score=137, Evalue=3e-33,
Organism=Homo sapiens, GI4505409, Length=140, Percent_Identity=47.8571428571429, Blast_Score=137, Evalue=3e-33,
Organism=Homo sapiens, GI66392192, Length=140, Percent_Identity=47.8571428571429, Blast_Score=137, Evalue=3e-33,
Organism=Homo sapiens, GI38045913, Length=140, Percent_Identity=47.8571428571429, Blast_Score=136, Evalue=7e-33,
Organism=Homo sapiens, GI4557797, Length=140, Percent_Identity=47.8571428571429, Blast_Score=135, Evalue=9e-33,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=47.7941176470588, Blast_Score=134, Evalue=2e-32,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=36.0902255639098, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=36.0902255639098, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI5031951, Length=138, Percent_Identity=34.7826086956522, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=31.1111111111111, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI4505413, Length=137, Percent_Identity=32.8467153284672, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI148839372, Length=140, Percent_Identity=30, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1788866, Length=139, Percent_Identity=46.7625899280576, Blast_Score=132, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI17506807, Length=140, Percent_Identity=46.4285714285714, Blast_Score=132, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6322783, Length=137, Percent_Identity=45.985401459854, Blast_Score=135, Evalue=2e-33,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=50.7352941176471, Blast_Score=150, Evalue=2e-37,
Organism=Drosophila melanogaster, GI18860097, Length=143, Percent_Identity=32.1678321678322, Blast_Score=79, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_HYPBU (A2BK98)

Other databases:

- EMBL:   CP000493
- RefSeq:   YP_001012754.1
- ProteinModelPortal:   A2BK98
- SMR:   A2BK98
- STRING:   A2BK98
- GeneID:   4782069
- GenomeReviews:   CP000493_GR
- KEGG:   hbu:Hbut_0549
- eggNOG:   arNOG07660
- HOGENOM:   HBG445152
- OMA:   IRAEFAE
- PhylomeDB:   A2BK98
- ProtClustDB:   PRK00668
- BioCyc:   HBUT415426:HBUT_0549-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 16008; Mature: 15877

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVERTFVMIKPDGVKRGLVGEIIARFERKGLKIKALKMKWLTREEAEKLYEVHRGKPFF
CCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCCCHH
EDLVNFVTSGPVVAMILEGDSAIEVVRLMIGPTDGRKAPPGTIRGDYALDIGANVIHASD
HHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCEEEECCC
SKESYEREYKVFFSDDEIVGDY
CCHHHCCEEEEEECCCCCCCCC
>Mature Secondary Structure 
PVERTFVMIKPDGVKRGLVGEIIARFERKGLKIKALKMKWLTREEAEKLYEVHRGKPFF
CCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCCCHH
EDLVNFVTSGPVVAMILEGDSAIEVVRLMIGPTDGRKAPPGTIRGDYALDIGANVIHASD
HHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCEEEECCC
SKESYEREYKVFFSDDEIVGDY
CCHHHCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA