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The map label for this gene is gcp

Identifier: 124027325

GI number: 124027325

Start: 421592

End: 422683

Strand: Reverse

Name: gcp

Synonym: Hbut_0434

Alternate gene names: 124027325

Gene position: 422683-421592 (Counterclockwise)

Preceding gene: 124027326

Following gene: 124027324

Centisome position: 25.35

GC content: 55.49

Gene sequence:

>1092_bases
GTGGTAAGTGTGGACACACCGAGTTCGTTAGGGAAGCCAAGAGGTGATCCACGCCAACTATACCGTGTTGGGGGCTGGGA
CGAGGAGATATACGTTTTAGGGATAGAATCTACAGCACACACTTTTGGTGTGGGTATAGCCTCGACGAAGCCTCCCTATA
TTCTCGTTAGCGTGCGTGATACTTACCATCCGCCAAAGGGTGGTATTCATCCCCGGGAGGCTGCTAGCCATCACGCCCGT
GTAGCGTCAGAAGTTATACTCGATGCGCTCCGCACCGTCGGCCTATCGATACGGGATATTGATGCTGTGGCTGTCGCGCT
GGGTCCTGGTCTTGGGCCAGCGCTAAGGGTTGGTGCCACTATTGCTCGAGGGCTAGCGGCATACTATGGCAAGCCGCTGG
TGCCAGTAAACCATGCCGTGGCGCACATAGAGATTGCGAGACTCTACACCGGGCTCGGCGACCCAGTAGTCCTCTATGTA
TCCGGCGGAAATACCGTCGTGGCTGCTTATGCCAAGGCCAGGTATAGGGTGTTCGGGGAGACCCTCGACATAGCACTTGG
GAACCTCCTAGACACCTTTGCTAGGGACGCCGGAATAGCGCCACCATATATTGTCTCGGGTCTACACATTGTCGACCGCT
GTGCAGAAGCAGCCTCGAAGCCAGCGGATCTGCCATACGTTGTCAAGGGTATGGATGTCTCGTTCTCGGGGCTCCTAACA
GCGGCTCTACGGCTATGGACTAAGGCTGGTAGCGAGGATGAGAAGGCTGCGGTATGTCTAGGCCTACGCGAGGTAGCCTA
TGGTAGTGTTGTCGAGGTTACTGAAAGGGCGCTGGCTCACACGAGGAAGAAATCGGTGATGTTAACGGGCGGTGTAGCAG
CAAGCCCAATACTTCGCAACAAGGTTAGAAGCATGGCATCATACCACGGTGCTGTAGCGGATTGGCCGCCACCACAGCTA
GCTGGTGATAACGGTGCAATGATAGCCTGGACAGGTCTTCTCAACTATCTTGCAGGGATAACGGTTGATGTCGAGGAGTC
GGTGGTGAAGCAGCGATGGAGACTAGATGTGGTGGAGATCCCGTGGAGGTAG

Upstream 100 bases:

>100_bases
TACGACTACAACACTGGCACAATAAAGAGGAAGAACAAGATATGTCCACGCTGCGGTAGCTTCATGGCGTTCCACAAGTG
GCCGGTGCCGAGGTGGCATT

Downstream 100 bases:

>100_bases
AACAGCTAGTCGAGACGCTAGGAGAGCCCATTGCTCGGGGTGCTGAGGCCTACCTCTACCTCATAGACTGGCTCGGAGAA
AGAGCGGTGCTAAAGCTTCG

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MVSVDTPSSLGKPRGDPRQLYRVGGWDEEIYVLGIESTAHTFGVGIASTKPPYILVSVRDTYHPPKGGIHPREAASHHAR
VASEVILDALRTVGLSIRDIDAVAVALGPGLGPALRVGATIARGLAAYYGKPLVPVNHAVAHIEIARLYTGLGDPVVLYV
SGGNTVVAAYAKARYRVFGETLDIALGNLLDTFARDAGIAPPYIVSGLHIVDRCAEAASKPADLPYVVKGMDVSFSGLLT
AALRLWTKAGSEDEKAAVCLGLREVAYGSVVEVTERALAHTRKKSVMLTGGVAASPILRNKVRSMASYHGAVADWPPPQL
AGDNGAMIAWTGLLNYLAGITVDVEESVVKQRWRLDVVEIPWR

Sequences:

>Translated_363_residues
MVSVDTPSSLGKPRGDPRQLYRVGGWDEEIYVLGIESTAHTFGVGIASTKPPYILVSVRDTYHPPKGGIHPREAASHHAR
VASEVILDALRTVGLSIRDIDAVAVALGPGLGPALRVGATIARGLAAYYGKPLVPVNHAVAHIEIARLYTGLGDPVVLYV
SGGNTVVAAYAKARYRVFGETLDIALGNLLDTFARDAGIAPPYIVSGLHIVDRCAEAASKPADLPYVVKGMDVSFSGLLT
AALRLWTKAGSEDEKAAVCLGLREVAYGSVVEVTERALAHTRKKSVMLTGGVAASPILRNKVRSMASYHGAVADWPPPQL
AGDNGAMIAWTGLLNYLAGITVDVEESVVKQRWRLDVVEIPWR
>Mature_363_residues
MVSVDTPSSLGKPRGDPRQLYRVGGWDEEIYVLGIESTAHTFGVGIASTKPPYILVSVRDTYHPPKGGIHPREAASHHAR
VASEVILDALRTVGLSIRDIDAVAVALGPGLGPALRVGATIARGLAAYYGKPLVPVNHAVAHIEIARLYTGLGDPVVLYV
SGGNTVVAAYAKARYRVFGETLDIALGNLLDTFARDAGIAPPYIVSGLHIVDRCAEAASKPADLPYVVKGMDVSFSGLLT
AALRLWTKAGSEDEKAAVCLGLREVAYGSVVEVTERALAHTRKKSVMLTGGVAASPILRNKVRSMASYHGAVADWPPPQL
AGDNGAMIAWTGLLNYLAGITVDVEESVVKQRWRLDVVEIPWR

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI8923380, Length=341, Percent_Identity=41.6422287390029, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI116812636, Length=311, Percent_Identity=27.6527331189711, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI1789445, Length=344, Percent_Identity=31.9767441860465, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71995670, Length=339, Percent_Identity=40.117994100295, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17557464, Length=340, Percent_Identity=27.9411764705882, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6322891, Length=370, Percent_Identity=38.6486486486486, Blast_Score=210, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6320099, Length=339, Percent_Identity=28.023598820059, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI21357207, Length=352, Percent_Identity=39.7727272727273, Blast_Score=241, Evalue=8e-64,
Organism=Drosophila melanogaster, GI20129063, Length=365, Percent_Identity=28.2191780821918, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_HYPBU (A2BJY9)

Other databases:

- EMBL:   CP000493
- RefSeq:   YP_001012645.1
- ProteinModelPortal:   A2BJY9
- SMR:   A2BJY9
- STRING:   A2BJY9
- MEROPS:   M22.003
- GeneID:   4781871
- GenomeReviews:   CP000493_GR
- KEGG:   hbu:Hbut_0434
- eggNOG:   arNOG04080
- HOGENOM:   HBG304663
- OMA:   TQRFRTD
- PhylomeDB:   A2BJY9
- ProtClustDB:   PRK14878
- BioCyc:   HBUT415426:HBUT_0434-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01446
- InterPro:   IPR022449
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03722
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 38596; Mature: 38596

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSVDTPSSLGKPRGDPRQLYRVGGWDEEIYVLGIESTAHTFGVGIASTKPPYILVSVRD
CCCCCCCHHCCCCCCCHHHHHCCCCCCCEEEEEEECCCCHHHEEECCCCCCCEEEEEEEC
TYHPPKGGIHPREAASHHARVASEVILDALRTVGLSIRDIDAVAVALGPGLGPALRVGAT
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHEEEECCCCCCHHHHHHHH
IARGLAAYYGKPLVPVNHAVAHIEIARLYTGLGDPVVLYVSGGNTVVAAYAKARYRVFGE
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEHHHHHHHHHH
TLDIALGNLLDTFARDAGIAPPYIVSGLHIVDRCAEAASKPADLPYVVKGMDVSFSGLLT
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHH
AALRLWTKAGSEDEKAAVCLGLREVAYGSVVEVTERALAHTRKKSVMLTGGVAASPILRN
HHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHH
KVRSMASYHGAVADWPPPQLAGDNGAMIAWTGLLNYLAGITVDVEESVVKQRWRLDVVEI
HHHHHHHHCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHCCEEEHHHHHHHHHHCCCEEEC
PWR
CCC
>Mature Secondary Structure
MVSVDTPSSLGKPRGDPRQLYRVGGWDEEIYVLGIESTAHTFGVGIASTKPPYILVSVRD
CCCCCCCHHCCCCCCCHHHHHCCCCCCCEEEEEEECCCCHHHEEECCCCCCCEEEEEEEC
TYHPPKGGIHPREAASHHARVASEVILDALRTVGLSIRDIDAVAVALGPGLGPALRVGAT
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHEEEECCCCCCHHHHHHHH
IARGLAAYYGKPLVPVNHAVAHIEIARLYTGLGDPVVLYVSGGNTVVAAYAKARYRVFGE
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEHHHHHHHHHH
TLDIALGNLLDTFARDAGIAPPYIVSGLHIVDRCAEAASKPADLPYVVKGMDVSFSGLLT
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHH
AALRLWTKAGSEDEKAAVCLGLREVAYGSVVEVTERALAHTRKKSVMLTGGVAASPILRN
HHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHH
KVRSMASYHGAVADWPPPQLAGDNGAMIAWTGLLNYLAGITVDVEESVVKQRWRLDVVEI
HHHHHHHHCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHCCEEEHHHHHHHHHHCCCEEEC
PWR
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA