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The map label for this gene is tdcB [H]

Identifier: 124027113

GI number: 124027113

Start: 198151

End: 199410

Strand: Reverse

Name: tdcB [H]

Synonym: Hbut_0216

Alternate gene names: 124027113

Gene position: 199410-198151 (Counterclockwise)

Preceding gene: 124027114

Following gene: 124027111

Centisome position: 11.96

GC content: 59.6

Gene sequence:

>1260_bases
GTGGCTGAAGCAGTCCCGAGCGATACGCGTGAGCTTGTGAGGCTCGTCTACGAGGAGTCGCTGAAGGCTCGGGAGATAGT
GTCGCAGTATGCTCACCATACGCCTCTCGATCCCAGCGCCACGTTTAGCAGGCTCACCCGCGCAAGAGTCTACCTGAAGT
ATGAGAACCTCCAGAAAACGGGGAGCTTCAAGATACGTGGCGCTCTATATAAGATATACAGCATCAAGAACGAGGCCAGG
GGTGTTGTAGCAGCATCTGCTGGGAATCACGCGCAGGGCGTGGCCTATGCAGCCTCTGTCTTTGGGCTACCAGCTGTCAT
AGTTATGCCGGAGACTGCCAGCATAGCTAAGGTCGAGGCTACAAAGGGGTATGGGGCCGAGGTGGTGCTCTACGGGAGGG
TTTTCGACGACGCAGAGGCTAAGGCGTTGGAGATAGCTCGAGAGAGAGGATACACGTTCATCCCCGCGTTCGACGACGTG
AAGATAATAGCCGGGCAGGGCACGATAGCCCACGAACTCATCCAGGACCTAGGCGACTTCGACGCTGTAGTGGTGCCCGT
CGGTGGCGGCGGCCTTATCTCCGGTATAGCCTCGGTGCTTAAGACGGTTAAGCCCGGCATAAAGGTCTATGGCGTGGAGC
CAGAGAATGCCCCGAAGTTTACCAAGTCCCTGGAGGCTGGGAGACCGGTCCGGGTCGAGATTAGGCCAACAATAGCTGAT
GGGCTCGCCGTGAAAAGGCCTGGGGATATAACGTTCCGCATCGTCCGGGAGCTGGTAGATGATATCGTCACTGTTAGTGA
GGAGGAGATAGCACACGCGATATACATGCTCCTGGAGAGGGGTAAGGTGCTGGCAGAGGGCGCAGGCGCCGCCGCGCTAG
CAGCGCTGCTCACTGGTAAGCTGCCGGTTGAGGGGAGGAAGGTTGTAGCCATAGTCTCGGGCGGCAATATAGACCTCACA
GCGCTCTACCGCGTGCTCATCCGCGGCCTGGCAGCTAGCGGGAGGATAGTCACGCTGGAGGGCTACGTGCCGGACATCCC
TGGCACCCTGGCAGACGTAGCAGCTGTGATAGCGAGGCACCGGGGCAACATACTCGAGGTGGTTCATGACCGCAGCGACC
TGGGAGCGCCAGCATGGCATACACGGCTCCGGGTAACACTGGAGGTTCCGGGGCCAGCTGAGGCCGAGGCATTGCTCAAC
GAGCTGGCGGAGAGGGGGTACAGGCTTAGGTTGAAGGGGCAGAAGCCCGAAGCCCCCTAG

Upstream 100 bases:

>100_bases
AGGGAGAACCCTCCGGCAAGGGTCGTGGTTGAGGTTTCCAATTTGCCGAAGAATGCGGAGCTAGAGGTTGAGGCCATAGC
CTACCTGGGTGACGGGAAGC

Downstream 100 bases:

>100_bases
GGTATAACCTCGGTGGACTCTAGCTCCGGGGTGTAGGAGAGGTAAGCCAGGTCGATCTCGCCCCTCTCCACGGCTTTCTC
AACCGCCGGGACAACCTCCT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MAEAVPSDTRELVRLVYEESLKAREIVSQYAHHTPLDPSATFSRLTRARVYLKYENLQKTGSFKIRGALYKIYSIKNEAR
GVVAASAGNHAQGVAYAASVFGLPAVIVMPETASIAKVEATKGYGAEVVLYGRVFDDAEAKALEIARERGYTFIPAFDDV
KIIAGQGTIAHELIQDLGDFDAVVVPVGGGGLISGIASVLKTVKPGIKVYGVEPENAPKFTKSLEAGRPVRVEIRPTIAD
GLAVKRPGDITFRIVRELVDDIVTVSEEEIAHAIYMLLERGKVLAEGAGAAALAALLTGKLPVEGRKVVAIVSGGNIDLT
ALYRVLIRGLAASGRIVTLEGYVPDIPGTLADVAAVIARHRGNILEVVHDRSDLGAPAWHTRLRVTLEVPGPAEAEALLN
ELAERGYRLRLKGQKPEAP

Sequences:

>Translated_419_residues
MAEAVPSDTRELVRLVYEESLKAREIVSQYAHHTPLDPSATFSRLTRARVYLKYENLQKTGSFKIRGALYKIYSIKNEAR
GVVAASAGNHAQGVAYAASVFGLPAVIVMPETASIAKVEATKGYGAEVVLYGRVFDDAEAKALEIARERGYTFIPAFDDV
KIIAGQGTIAHELIQDLGDFDAVVVPVGGGGLISGIASVLKTVKPGIKVYGVEPENAPKFTKSLEAGRPVRVEIRPTIAD
GLAVKRPGDITFRIVRELVDDIVTVSEEEIAHAIYMLLERGKVLAEGAGAAALAALLTGKLPVEGRKVVAIVSGGNIDLT
ALYRVLIRGLAASGRIVTLEGYVPDIPGTLADVAAVIARHRGNILEVVHDRSDLGAPAWHTRLRVTLEVPGPAEAEALLN
ELAERGYRLRLKGQKPEAP
>Mature_418_residues
AEAVPSDTRELVRLVYEESLKAREIVSQYAHHTPLDPSATFSRLTRARVYLKYENLQKTGSFKIRGALYKIYSIKNEARG
VVAASAGNHAQGVAYAASVFGLPAVIVMPETASIAKVEATKGYGAEVVLYGRVFDDAEAKALEIARERGYTFIPAFDDVK
IIAGQGTIAHELIQDLGDFDAVVVPVGGGGLISGIASVLKTVKPGIKVYGVEPENAPKFTKSLEAGRPVRVEIRPTIADG
LAVKRPGDITFRIVRELVDDIVTVSEEEIAHAIYMLLERGKVLAEGAGAAALAALLTGKLPVEGRKVVAIVSGGNIDLTA
LYRVLIRGLAASGRIVTLEGYVPDIPGTLADVAAVIARHRGNILEVVHDRSDLGAPAWHTRLRVTLEVPGPAEAEALLNE
LAERGYRLRLKGQKPEAP

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=299, Percent_Identity=40.133779264214, Blast_Score=195, Evalue=8e-50,
Organism=Homo sapiens, GI19923959, Length=295, Percent_Identity=33.2203389830508, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI33469958, Length=318, Percent_Identity=34.5911949685535, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1789505, Length=312, Percent_Identity=47.7564102564103, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1790207, Length=345, Percent_Identity=39.4202898550725, Blast_Score=207, Evalue=8e-55,
Organism=Escherichia coli, GI1789235, Length=198, Percent_Identity=27.7777777777778, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71991565, Length=368, Percent_Identity=41.8478260869565, Blast_Score=257, Evalue=8e-69,
Organism=Caenorhabditis elegans, GI17537387, Length=385, Percent_Identity=37.4025974025974, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17508781, Length=310, Percent_Identity=32.258064516129, Blast_Score=161, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6322631, Length=316, Percent_Identity=41.7721518987342, Blast_Score=229, Evalue=8e-61,
Organism=Saccharomyces cerevisiae, GI6320930, Length=368, Percent_Identity=36.1413043478261, Blast_Score=189, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6319788, Length=268, Percent_Identity=27.2388059701493, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21355833, Length=392, Percent_Identity=39.7959183673469, Blast_Score=215, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24645328, Length=295, Percent_Identity=40.6779661016949, Blast_Score=155, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 44832; Mature: 44701

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAVPSDTRELVRLVYEESLKAREIVSQYAHHTPLDPSATFSRLTRARVYLKYENLQKT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEEEEECCCCCC
GSFKIRGALYKIYSIKNEARGVVAASAGNHAQGVAYAASVFGLPAVIVMPETASIAKVEA
CCEEEEHEEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCEEEEEE
TKGYGAEVVLYGRVFDDAEAKALEIARERGYTFIPAFDDVKIIAGQGTIAHELIQDLGDF
CCCCCCEEEEEEEEECCCHHHHHHHHHHCCCEEEECCCCEEEEECCCHHHHHHHHHCCCC
DAVVVPVGGGGLISGIASVLKTVKPGIKVYGVEPENAPKFTKSLEAGRPVRVEIRPTIAD
CEEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHCCCCCEEEEEECCCCC
GLAVKRPGDITFRIVRELVDDIVTVSEEEIAHAIYMLLERGKVLAEGAGAAALAALLTGK
CEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHCC
LPVEGRKVVAIVSGGNIDLTALYRVLIRGLAASGRIVTLEGYVPDIPGTLADVAAVIARH
CCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHH
RGNILEVVHDRSDLGAPAWHTRLRVTLEVPGPAEAEALLNELAERGYRLRLKGQKPEAP
CCCEEEEEECCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHCCEEEEECCCCCCCC
>Mature Secondary Structure 
AEAVPSDTRELVRLVYEESLKAREIVSQYAHHTPLDPSATFSRLTRARVYLKYENLQKT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEEEEECCCCCC
GSFKIRGALYKIYSIKNEARGVVAASAGNHAQGVAYAASVFGLPAVIVMPETASIAKVEA
CCEEEEHEEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCEEEEEE
TKGYGAEVVLYGRVFDDAEAKALEIARERGYTFIPAFDDVKIIAGQGTIAHELIQDLGDF
CCCCCCEEEEEEEEECCCHHHHHHHHHHCCCEEEECCCCEEEEECCCHHHHHHHHHCCCC
DAVVVPVGGGGLISGIASVLKTVKPGIKVYGVEPENAPKFTKSLEAGRPVRVEIRPTIAD
CEEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHCCCCCEEEEEECCCCC
GLAVKRPGDITFRIVRELVDDIVTVSEEEIAHAIYMLLERGKVLAEGAGAAALAALLTGK
CEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHCC
LPVEGRKVVAIVSGGNIDLTALYRVLIRGLAASGRIVTLEGYVPDIPGTLADVAAVIARH
CCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHH
RGNILEVVHDRSDLGAPAWHTRLRVTLEVPGPAEAEALLNELAERGYRLRLKGQKPEAP
CCCEEEEEECCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA