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The map label for this gene is pyrC [H]

Identifier: 124027007

GI number: 124027007

Start: 95991

End: 97265

Strand: Reverse

Name: pyrC [H]

Synonym: Hbut_0107

Alternate gene names: 124027007

Gene position: 97265-95991 (Counterclockwise)

Preceding gene: 124027008

Following gene: 124027000

Centisome position: 5.83

GC content: 56.71

Gene sequence:

>1275_bases
GTGCCAGAACTAGCCATCTGCGGCCACCTCGTAGATGGCTATGGCGTCTACGGGAGTGGTTGCATCAACATTGAGGGAGA
CAGGATAGCTTCGGTAACAAGTGAGCCCAGGGCGCCGGAGAGGCTCGACTACCGAGATATGGGCGGCATAGTACTGCCCG
GCATGATAGACCTCCACGTTCACCTAAGGGGGCTCAAGCTATCCTACAAGGAGGACGAGGCTACTAGTACACGTGCAGCC
GCAGCCTCGGGCATAACGCTCGTGGCAGACATGCCGAATACCATGCCGCCACTAAGGTCGAAGAGTGCTATTGATGCTAA
GCTTGCCGCGCTAAGGAGGATGAGCCTCGTAGACTATGCTGTCTACGCCGGGGTACCTGACGAGCCCGAAGAGGCGCGGG
GGCTCGCAGAGCTGCCTATTGCAGGGTTCAAGGTTTATCCCGAAGACCTGGAGGAGAGGAGAGGCACACTACGAAGGATA
GCTAGGCTACACAAGCTACTAATCCTTCACGCAGAGCACCCCGTGGCGTTGAAGAGCATAGTAGAAGCCGAGGATACGAG
GGCTGCTATGAGGGGCTGCTGGGCCGAACTCGCTGGGCTCATGGAGGTACTAGATCTTGGTCCGGCGAGGCTCCATGTAA
CCCATGCTAGCTGCCCCAGCACTGTGCTAGCAGCCAAGAAGGTGGGTGCAACAGTTGATGCTACGCCGCACCACCTCTTC
TACAGCCTCCGAGGCAGCGATTGTGGATGGAGGGTTAACCCACCCCTGCGCAGCAAGGCTGAGCGCCTATCCATGCTCAA
ACTCCTAGCAGAAGGCATGGTGGACGCGTTGGCGAGCGATCATGCACCCCACTTGCTGCGGGAGAGGATAGACCCCCTAT
CCTGTAGCCCGGGCTTTGCATGGCTCGACTCATGGCCTCTACTTGCGGCTTGTCTTGTAGCCTCTGGCACTCTAAGTCTC
CAGGATTACGCGCGTTTGACATCTCTAAATCCTGCAAGGATACTCGGCATAGACTCCGTCTACGGCTCCCTGCAGCCGGG
CATGAGGGCGAACATAGTGGTCATCAAGCTCGAGCGTTGGCACCGGCCAGCAAGAATCTACAGCAAGGGTGAAAACCCAA
TAGAGAACATTATCGAGGTATGTGCTGCACTGAAGGCAGTAATCGTGGGAGGCACGCTTGTCTACCTTGATGGCGAGTTT
ACTGGCGAGAAACCTGAAACAGTTAACGCTATAGAATACGCCTCTACTTACCTAGCCTCCTCCTCTCCTCCCTAA

Upstream 100 bases:

>100_bases
GCTTCTGTGGGAGCTGCACCATACCCTGCACAGGCATGCTGCTCTGCCGTGACGGTCCCGTAGTTCCGGCTGTTAGGCTT
GGCTGCTGGGTGGTGAGGGA

Downstream 100 bases:

>100_bases
GCTTCTTTACCTCTTGAGCTATCATACGTAAAGTGTTAAGCTTGGAGCCAACCTTATCCACAACCACTCTTTTACGCTGC
TCCCACCAGCTACGGGGATA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MPELAICGHLVDGYGVYGSGCINIEGDRIASVTSEPRAPERLDYRDMGGIVLPGMIDLHVHLRGLKLSYKEDEATSTRAA
AASGITLVADMPNTMPPLRSKSAIDAKLAALRRMSLVDYAVYAGVPDEPEEARGLAELPIAGFKVYPEDLEERRGTLRRI
ARLHKLLILHAEHPVALKSIVEAEDTRAAMRGCWAELAGLMEVLDLGPARLHVTHASCPSTVLAAKKVGATVDATPHHLF
YSLRGSDCGWRVNPPLRSKAERLSMLKLLAEGMVDALASDHAPHLLRERIDPLSCSPGFAWLDSWPLLAACLVASGTLSL
QDYARLTSLNPARILGIDSVYGSLQPGMRANIVVIKLERWHRPARIYSKGENPIENIIEVCAALKAVIVGGTLVYLDGEF
TGEKPETVNAIEYASTYLASSSPP

Sequences:

>Translated_424_residues
MPELAICGHLVDGYGVYGSGCINIEGDRIASVTSEPRAPERLDYRDMGGIVLPGMIDLHVHLRGLKLSYKEDEATSTRAA
AASGITLVADMPNTMPPLRSKSAIDAKLAALRRMSLVDYAVYAGVPDEPEEARGLAELPIAGFKVYPEDLEERRGTLRRI
ARLHKLLILHAEHPVALKSIVEAEDTRAAMRGCWAELAGLMEVLDLGPARLHVTHASCPSTVLAAKKVGATVDATPHHLF
YSLRGSDCGWRVNPPLRSKAERLSMLKLLAEGMVDALASDHAPHLLRERIDPLSCSPGFAWLDSWPLLAACLVASGTLSL
QDYARLTSLNPARILGIDSVYGSLQPGMRANIVVIKLERWHRPARIYSKGENPIENIIEVCAALKAVIVGGTLVYLDGEF
TGEKPETVNAIEYASTYLASSSPP
>Mature_423_residues
PELAICGHLVDGYGVYGSGCINIEGDRIASVTSEPRAPERLDYRDMGGIVLPGMIDLHVHLRGLKLSYKEDEATSTRAAA
ASGITLVADMPNTMPPLRSKSAIDAKLAALRRMSLVDYAVYAGVPDEPEEARGLAELPIAGFKVYPEDLEERRGTLRRIA
RLHKLLILHAEHPVALKSIVEAEDTRAAMRGCWAELAGLMEVLDLGPARLHVTHASCPSTVLAAKKVGATVDATPHHLFY
SLRGSDCGWRVNPPLRSKAERLSMLKLLAEGMVDALASDHAPHLLRERIDPLSCSPGFAWLDSWPLLAACLVASGTLSLQ
DYARLTSLNPARILGIDSVYGSLQPGMRANIVVIKLERWHRPARIYSKGENPIENIIEVCAALKAVIVGGTLVYLDGEFT
GEKPETVNAIEYASTYLASSSPP

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=363, Percent_Identity=30.8539944903581, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1786722, Length=386, Percent_Identity=26.1658031088083, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI87082175, Length=431, Percent_Identity=24.5939675174014, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI193204318, Length=297, Percent_Identity=30.6397306397306, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24642586, Length=359, Percent_Identity=27.8551532033426, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 45918; Mature: 45786

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELAICGHLVDGYGVYGSGCINIEGDRIASVTSEPRAPERLDYRDMGGIVLPGMIDLHV
CCCHHHHHHHHCCCCCCCCCEEEECCCEEEECCCCCCCCCCCCHHHCCCEECCCEEEEEE
HLRGLKLSYKEDEATSTRAAAASGITLVADMPNTMPPLRSKSAIDAKLAALRRMSLVDYA
EEEEEEEECCCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VYAGVPDEPEEARGLAELPIAGFKVYPEDLEERRGTLRRIARLHKLLILHAEHPVALKSI
HHCCCCCCHHHHCCCHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHH
VEAEDTRAAMRGCWAELAGLMEVLDLGPARLHVTHASCPSTVLAAKKVGATVDATPHHLF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCEEE
YSLRGSDCGWRVNPPLRSKAERLSMLKLLAEGMVDALASDHAPHLLRERIDPLSCSPGFA
EEECCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCH
WLDSWPLLAACLVASGTLSLQDYARLTSLNPARILGIDSVYGSLQPGMRANIVVIKLERW
HHCCHHHHHHHHHHCCCCCHHHHHHHHCCCCHHEEEHHHHHHCCCCCCCCCEEEEEECCC
HRPARIYSKGENPIENIIEVCAALKAVIVGGTLVYLDGEFTGEKPETVNAIEYASTYLAS
CCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHCC
SSPP
CCCC
>Mature Secondary Structure 
PELAICGHLVDGYGVYGSGCINIEGDRIASVTSEPRAPERLDYRDMGGIVLPGMIDLHV
CCHHHHHHHHCCCCCCCCCEEEECCCEEEECCCCCCCCCCCCHHHCCCEECCCEEEEEE
HLRGLKLSYKEDEATSTRAAAASGITLVADMPNTMPPLRSKSAIDAKLAALRRMSLVDYA
EEEEEEEECCCCCHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VYAGVPDEPEEARGLAELPIAGFKVYPEDLEERRGTLRRIARLHKLLILHAEHPVALKSI
HHCCCCCCHHHHCCCHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHH
VEAEDTRAAMRGCWAELAGLMEVLDLGPARLHVTHASCPSTVLAAKKVGATVDATPHHLF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCEEE
YSLRGSDCGWRVNPPLRSKAERLSMLKLLAEGMVDALASDHAPHLLRERIDPLSCSPGFA
EEECCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCH
WLDSWPLLAACLVASGTLSLQDYARLTSLNPARILGIDSVYGSLQPGMRANIVVIKLERW
HHCCHHHHHHHHHHCCCCCHHHHHHHHCCCCHHEEEHHHHHHCCCCCCCCCEEEEEECCC
HRPARIYSKGENPIENIIEVCAALKAVIVGGTLVYLDGEFTGEKPETVNAIEYASTYLAS
CCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHCC
SSPP
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]