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The map label for this gene is dys [H]

Identifier: 124026943

GI number: 124026943

Start: 32612

End: 33574

Strand: Direct

Name: dys [H]

Synonym: Hbut_0040

Alternate gene names: 124026943

Gene position: 32612-33574 (Clockwise)

Preceding gene: 124026940

Following gene: 124026945

Centisome position: 1.96

GC content: 49.12

Gene sequence:

>963_bases
TTGGTACAAAGAGAGGATCTCCTACGTGAACAAGTGACTGATGTCGAGTTGAAGCCTGGAATGACGCTGGACGAGCTAAT
AGATGCCTACGGTGAAATATACGGGTTCATGGCTGGTCATTTGAGGAGAGCAATAGAGATTCTATCTAGGTGCCTCCGCG
ACGCAGACCTCCGCGTACTATCATTTACAGCTAACATTGTTGCAACCGGGGTTAGGGGTATACTAGCCCAACTAATCCGC
GAGAAACTATTCAACCTTGTCGTAACAACTTGTGGCACTATAGATCATGACGTAGCTAGGGGCCTCGGCTATAACTACTA
CAAGGGATACTTCGAAGCAGACGACAAGATGCTCAGAGAGCTTGAGATACACAGACTCGGCAATATATACATCCCGGTTG
AAAACTATGGCGAGCCAATAGAGAAGTTTACACATAGAGTACTATCAGATCTCGCTGGGAGGAAGAAGAGGTGGGCAGTC
TACGAAGTTCTCTGGGAGATGGGTGCAAGAATAAATGATAAACACAGCATCCTACGGGCAGCCTACGAGGCTAAGACACC
AGTAATAGTTCCAGGGTTTGTGGATGGAGCTTTTGGGACAGCGGTATTCACGTTTACACAGCTAAACCGTGACTTCGCCA
TAGATATAATGCTTGACGAGGAGCTGCTAGCAGACCGCTTCTTCAGAGCCAAGAAGGCAGCAGCGCTGCTCATAGGCGGT
GGTATAAGCAAGCACCACTCAATATGGTGGGCTCAGTTCCGCGGCGGATTTGATTGTGCAGTATACGTTACAACAGCTGT
AGAGTATGATGGAAGCTTGAGTGGGGCACAGCCACGTGAGGCAATTTCATGGGGTAAGATTAAGCCTAGCGGCGAGCACG
TGGTAGTCTATGGTGATGCGACGATATTGCTACCGCTAATAGCCTATGGCCTGCTTAGGTCTCTGAGATGGGGGAGCGGG
TAG

Upstream 100 bases:

>100_bases
CACCCTTTGCTAGCATCGCCCAGGGTTAGGCTTCTAGCAGCGGGTAAGCCCTAATACTTCCATTAGCCAGACATAGCGCT
ACCCGGGGTGGAGTACAAGT

Downstream 100 bases:

>100_bases
GCTTAATATCGCTAACCCCTCTTATATAGAGGTAGAGTGTGCGCACAAGCCCGGCAATGTAGTATCTCTCGACGTGTACG
GGTTTCCAGCCTGGTATAGC

Product: putative deoxyhypusine synthase

Products: NA

Alternate protein names: DHS [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MVQREDLLREQVTDVELKPGMTLDELIDAYGEIYGFMAGHLRRAIEILSRCLRDADLRVLSFTANIVATGVRGILAQLIR
EKLFNLVVTTCGTIDHDVARGLGYNYYKGYFEADDKMLRELEIHRLGNIYIPVENYGEPIEKFTHRVLSDLAGRKKRWAV
YEVLWEMGARINDKHSILRAAYEAKTPVIVPGFVDGAFGTAVFTFTQLNRDFAIDIMLDEELLADRFFRAKKAAALLIGG
GISKHHSIWWAQFRGGFDCAVYVTTAVEYDGSLSGAQPREAISWGKIKPSGEHVVVYGDATILLPLIAYGLLRSLRWGSG

Sequences:

>Translated_320_residues
MVQREDLLREQVTDVELKPGMTLDELIDAYGEIYGFMAGHLRRAIEILSRCLRDADLRVLSFTANIVATGVRGILAQLIR
EKLFNLVVTTCGTIDHDVARGLGYNYYKGYFEADDKMLRELEIHRLGNIYIPVENYGEPIEKFTHRVLSDLAGRKKRWAV
YEVLWEMGARINDKHSILRAAYEAKTPVIVPGFVDGAFGTAVFTFTQLNRDFAIDIMLDEELLADRFFRAKKAAALLIGG
GISKHHSIWWAQFRGGFDCAVYVTTAVEYDGSLSGAQPREAISWGKIKPSGEHVVVYGDATILLPLIAYGLLRSLRWGSG
>Mature_320_residues
MVQREDLLREQVTDVELKPGMTLDELIDAYGEIYGFMAGHLRRAIEILSRCLRDADLRVLSFTANIVATGVRGILAQLIR
EKLFNLVVTTCGTIDHDVARGLGYNYYKGYFEADDKMLRELEIHRLGNIYIPVENYGEPIEKFTHRVLSDLAGRKKRWAV
YEVLWEMGARINDKHSILRAAYEAKTPVIVPGFVDGAFGTAVFTFTQLNRDFAIDIMLDEELLADRFFRAKKAAALLIGG
GISKHHSIWWAQFRGGFDCAVYVTTAVEYDGSLSGAQPREAISWGKIKPSGEHVVVYGDATILLPLIAYGLLRSLRWGSG

Specific function: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine

COG id: COG1899

COG function: function code O; Deoxyhypusine synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deoxyhypusine synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503325, Length=324, Percent_Identity=30.5555555555556, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI7108338, Length=324, Percent_Identity=25.3086419753086, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI7108340, Length=234, Percent_Identity=25.2136752136752, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17536927, Length=317, Percent_Identity=31.2302839116719, Blast_Score=157, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6321859, Length=276, Percent_Identity=31.8840579710145, Blast_Score=151, Evalue=1e-37,
Organism=Drosophila melanogaster, GI45550569, Length=337, Percent_Identity=30.2670623145401, Blast_Score=157, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002773
- InterPro:   IPR022899 [H]

Pfam domain/function: PF01916 DS [H]

EC number: =2.5.1.46 [H]

Molecular weight: Translated: 35937; Mature: 35937

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQREDLLREQVTDVELKPGMTLDELIDAYGEIYGFMAGHLRRAIEILSRCLRDADLRVL
CCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
SFTANIVATGVRGILAQLIREKLFNLVVTTCGTIDHDVARGLGYNYYKGYFEADDKMLRE
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHCCEEHHHHHHHHH
LEIHRLGNIYIPVENYGEPIEKFTHRVLSDLAGRKKRWAVYEVLWEMGARINDKHSILRA
HHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHH
AYEAKTPVIVPGFVDGAFGTAVFTFTQLNRDFAIDIMLDEELLADRFFRAKKAAALLIGG
HHHCCCCEEECCCCCCHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHEEEEEC
GISKHHSIWWAQFRGGFDCAVYVTTAVEYDGSLSGAQPREAISWGKIKPSGEHVVVYGDA
CCCCCCCEEEEECCCCCEEEEEEEEEEEECCCCCCCCCHHHCCCCCCCCCCCEEEEEECH
TILLPLIAYGLLRSLRWGSG
HHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVQREDLLREQVTDVELKPGMTLDELIDAYGEIYGFMAGHLRRAIEILSRCLRDADLRVL
CCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
SFTANIVATGVRGILAQLIREKLFNLVVTTCGTIDHDVARGLGYNYYKGYFEADDKMLRE
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHCCEEHHHHHHHHH
LEIHRLGNIYIPVENYGEPIEKFTHRVLSDLAGRKKRWAVYEVLWEMGARINDKHSILRA
HHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHH
AYEAKTPVIVPGFVDGAFGTAVFTFTQLNRDFAIDIMLDEELLADRFFRAKKAAALLIGG
HHHCCCCEEECCCCCCHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHEEEEEC
GISKHHSIWWAQFRGGFDCAVYVTTAVEYDGSLSGAQPREAISWGKIKPSGEHVVVYGDA
CCCCCCCEEEEECCCCCEEEEEEEEEEEECCCCCCCCCHHHCCCCCCCCCCCEEEEEECH
TILLPLIAYGLLRSLRWGSG
HHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA