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The map label for this gene is cysG [H]

Identifier: 123967118

GI number: 123967118

Start: 1674518

End: 1675285

Strand: Reverse

Name: cysG [H]

Synonym: P9515_18851

Alternate gene names: 123967118

Gene position: 1675285-1674518 (Counterclockwise)

Preceding gene: 123967123

Following gene: 123967107

Centisome position: 98.3

GC content: 32.29

Gene sequence:

>768_bases
GTGCCCGGAATAGTTTATTTAGTTGGCGCAGGGCCTGGTGATCCTGAGCTGTTGACACTAAAAGCCTTACGACTTATAAA
AAGTTGTGATGTATTAGTGCATGATGCTCTGATCTCTGCAGAAATAATAAAAGAAACTAATAAAAAGGCTGAAATATTTA
ATGTAGGGAAGAGGGCTGGTAAGTGTTCAGTTCCCCAATCTGATACAAATTCCCTAATTTTAAAATTAGCAAAAGAAGGA
AAGACAGTTGTAAGACTCAAAGGAGGAGATCCATTTGTTTTTTCAAGAGGAGGTGAAGAAGTATCTTTCTTAGAAAAAAA
TGGGATTTCAATCGAAATAGTACCAGGTATAACTTCAGGTATAGCGGCTCCTACTTATTATGGAATTCCATTAACTCATC
GAGAAGCAGGCAGCTCAATAACTTTCGTGACAGGTCATGAACATATAAATAAGGATAAAAAGAATGTTAACTGGAGAGCA
TTATCTCAATCATCTGATGGTTTAGTAATTTATATGGGAATAAGAAATATTGAATTTATTGTTAGTGAATTAATTTTAGG
TGGTTTGGATAAAAATACCAAATGTGCTGTTATTCAAGAAGCAACTTTGAATAATCAAAAATGCTTAATTTCAGAATTAA
AAAACCTAGTAGAGAATATTAGGCTAAAAGGTTTTACTTCACCATCAATTGTTGTTATTGGTAGGATTGTTGATTTTAAA
GTTAATAATTATATAACTAATCTACCTAATGCTTTTTTAACAGATTAA

Upstream 100 bases:

>100_bases
ATAATGTGAATTTCCTACTTGGCTTAAATAAACTTTTTTTCACGATATTTATCTACAATACGATTTTCTTCTACTACCAT
ACTTGTTAATGGAGATTAAT

Downstream 100 bases:

>100_bases
AAATAATATTAATTATATAATAATTCCCAGAAATATTTTGGATCAAAAGTTGATATAAATTCTATCTCATTAACTTTTTT
AATTTGTCTACAAGATAAGC

Product: putative uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MPGIVYLVGAGPGDPELLTLKALRLIKSCDVLVHDALISAEIIKETNKKAEIFNVGKRAGKCSVPQSDTNSLILKLAKEG
KTVVRLKGGDPFVFSRGGEEVSFLEKNGISIEIVPGITSGIAAPTYYGIPLTHREAGSSITFVTGHEHINKDKKNVNWRA
LSQSSDGLVIYMGIRNIEFIVSELILGGLDKNTKCAVIQEATLNNQKCLISELKNLVENIRLKGFTSPSIVVIGRIVDFK
VNNYITNLPNAFLTD

Sequences:

>Translated_255_residues
MPGIVYLVGAGPGDPELLTLKALRLIKSCDVLVHDALISAEIIKETNKKAEIFNVGKRAGKCSVPQSDTNSLILKLAKEG
KTVVRLKGGDPFVFSRGGEEVSFLEKNGISIEIVPGITSGIAAPTYYGIPLTHREAGSSITFVTGHEHINKDKKNVNWRA
LSQSSDGLVIYMGIRNIEFIVSELILGGLDKNTKCAVIQEATLNNQKCLISELKNLVENIRLKGFTSPSIVVIGRIVDFK
VNNYITNLPNAFLTD
>Mature_254_residues
PGIVYLVGAGPGDPELLTLKALRLIKSCDVLVHDALISAEIIKETNKKAEIFNVGKRAGKCSVPQSDTNSLILKLAKEGK
TVVRLKGGDPFVFSRGGEEVSFLEKNGISIEIVPGITSGIAAPTYYGIPLTHREAGSSITFVTGHEHINKDKKNVNWRAL
SQSSDGLVIYMGIRNIEFIVSELILGGLDKNTKCAVIQEATLNNQKCLISELKNLVENIRLKGFTSPSIVVIGRIVDFKV
NNYITNLPNAFLTD

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=246, Percent_Identity=41.4634146341463, Blast_Score=186, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6322922, Length=246, Percent_Identity=29.2682926829268, Blast_Score=110, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 27676; Mature: 27544

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGIVYLVGAGPGDPELLTLKALRLIKSCDVLVHDALISAEIIKETNKKAEIFNVGKRAG
CCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCC
KCSVPQSDTNSLILKLAKEGKTVVRLKGGDPFVFSRGGEEVSFLEKNGISIEIVPGITSG
CCCCCCCCCCCEEEEEECCCCEEEEEECCCCEEECCCCCEEEEEECCCCEEEEECCCCCC
IAAPTYYGIPLTHREAGSSITFVTGHEHINKDKKNVNWRALSQSSDGLVIYMGIRNIEFI
CCCCEEECCEEEECCCCCEEEEEECHHHHCCCCCCCCEEEECCCCCCEEEEEECCCHHHH
VSELILGGLDKNTKCAVIQEATLNNQKCLISELKNLVENIRLKGFTSPSIVVIGRIVDFK
HHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCEECCCCCCCEEEEEEEEEEE
VNNYITNLPNAFLTD
ECCEECCCCCHHCCC
>Mature Secondary Structure 
PGIVYLVGAGPGDPELLTLKALRLIKSCDVLVHDALISAEIIKETNKKAEIFNVGKRAG
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCC
KCSVPQSDTNSLILKLAKEGKTVVRLKGGDPFVFSRGGEEVSFLEKNGISIEIVPGITSG
CCCCCCCCCCCEEEEEECCCCEEEEEECCCCEEECCCCCEEEEEECCCCEEEEECCCCCC
IAAPTYYGIPLTHREAGSSITFVTGHEHINKDKKNVNWRALSQSSDGLVIYMGIRNIEFI
CCCCEEECCEEEECCCCCEEEEEECHHHHCCCCCCCCEEEECCCCCCEEEEEECCCHHHH
VSELILGGLDKNTKCAVIQEATLNNQKCLISELKNLVENIRLKGFTSPSIVVIGRIVDFK
HHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCEECCCCCCCEEEEEEEEEEE
VNNYITNLPNAFLTD
ECCEECCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]