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The map label for this gene is pyrG [H]

Identifier: 123967113

GI number: 123967113

Start: 1669388

End: 1670998

Strand: Direct

Name: pyrG [H]

Synonym: P9515_18801

Alternate gene names: 123967113

Gene position: 1669388-1670998 (Clockwise)

Preceding gene: 123967112

Following gene: 123967114

Centisome position: 97.96

GC content: 34.64

Gene sequence:

>1611_bases
ATGTCAAAATTTGTTTTTGTTACTGGGGGAGTTGTTTCTAGCATTGGTAAAGGTATTGTTGCCGCAAGCTTAGGAAGATT
ATTAAAGTCAAGAGGATATAGCGTTTCAATACTCAAATTAGATCCTTATCTCAATGTTGACCCTGGAACAATGAGCCCTT
TTCAGCATGGTGAAGTTTTCGTGACAGAAGATGGGGCTGAAACAGATTTAGATTTAGGACACTATGAAAGATTTACTGAC
ACTGCAATGACTCGCTTAAATAGTGTCACAACAGGATCTATATATCAAGCAGTCATTAATAAAGAAAGAAGAGGTAGTTA
CAATGGGGGCACAGTGCAAGTTATTCCTCACATAACAGGTGAAATAAGAGAAAGGATTCATAGAGTAGCATCTAACAGCA
ATGCTGATATTGTTATCACTGAAATTGGTGGAACAGTAGGAGATATTGAATCTCTGCCATTTTTAGAGGCAATAAGAGAA
TTTAAAAATGACGTTAATAAAAATGATGTTACGTATATCCATGTAACTTTACTCCCATATATCAAAACTTCAGGTGAAAT
AAAAACTAAACCTACTCAACATTCTGTTAAAGAATTAAGATCAATCGGCATACAACCAGATTTACTTGTATGCAGAAGTG
ATAAAGAAATTAACGACAGTCTTAAAAGAAAACTTAGTGGTTTCTGCGGAGTTAATCTTAATTGTGTAATTGAAGCATTG
GATGCTGACAGTATTTATTCTGTCCCACTTTCATTAAAAAAAGAGGGTTTATGTAAAGAGACTTTGAGATGTCTAGATCT
AGAGGATAAGGAATGTGATTTAGAAAGTTGGGAAAAAATAATTCATAATCTTAGAAATCCTGGTAACCCTATAAAAGTTG
CTTTAGTTGGAAAATATATAGAACTTGGTGACGCATATCTTTCAGTAGTGGAAGCATTAAGACATGCTTGCATTGAACAA
AAGGCTTTCTTAGATTTGCATTGGGTCAGTGCTGAAATGATCGAAGAGAAATCAGCCGAAGAGTATTTACATGATGTTGA
TGCAATTGTTGTACCGGGAGGATTTGGAAATAGAGGAGTAAATGGAAAGATTGCATCAATAAAATTTGCAAGAGAAAAAA
AAATTCCTTTCCTAGGTTTATGTTTAGGTATGCAATGTGCAGTAATAGAGTGGGCCAGAAATGTGGTCCAATTACCGGGC
GCATCTAGCTCGGAATTAGACCCAGAGTCTGAGAATCCTGTTATACATTTATTACCAGAACAAGAAGATATTGTTGATCT
AGGAGGCACTATGAGATTAGGAGTTTATCCTTGCAGACTTCAAAAAAATACAACTGGTAAGGAACTTTATAATGAAGATG
TTATATATGAGAGACATAGACATAGATACGAATTTAATAATTTCTACAAACAAATTTTTGTAGATTCTGGATACAAAATC
AGTGGTACATCACCTGATGGCAGATTAGTAGAGTTGATTGAGTTAGTTAATCATCCATATTTTTTAGCATGCCAATACCA
TCCTGAATTCTTATCGAGACCAGGAAAGCCCCATCCTTTATTTAAAGGCTTGATAAAAGCATCTCGAGAAAAATTAGAGC
AATCAAAATAA

Upstream 100 bases:

>100_bases
ATATTGAAATAACAATTGATGAATAAACTATTTATGGATGATCAATAATTTTTTTGTTTAAATAAAATATAAGGAGGTTG
TGCTTAATTAAAAATATTTA

Downstream 100 bases:

>100_bases
TATTATTTATTTTTTTGCATTAAATAATGACAAATTTCTTACCATTAGTAGAAAAATTTCATTCATTACAAGGGGAGGGC
TTTCATACAGGTCAAAGTGC

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 536; Mature: 535

Protein sequence:

>536_residues
MSKFVFVTGGVVSSIGKGIVAASLGRLLKSRGYSVSILKLDPYLNVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFTD
TAMTRLNSVTTGSIYQAVINKERRGSYNGGTVQVIPHITGEIRERIHRVASNSNADIVITEIGGTVGDIESLPFLEAIRE
FKNDVNKNDVTYIHVTLLPYIKTSGEIKTKPTQHSVKELRSIGIQPDLLVCRSDKEINDSLKRKLSGFCGVNLNCVIEAL
DADSIYSVPLSLKKEGLCKETLRCLDLEDKECDLESWEKIIHNLRNPGNPIKVALVGKYIELGDAYLSVVEALRHACIEQ
KAFLDLHWVSAEMIEEKSAEEYLHDVDAIVVPGGFGNRGVNGKIASIKFAREKKIPFLGLCLGMQCAVIEWARNVVQLPG
ASSSELDPESENPVIHLLPEQEDIVDLGGTMRLGVYPCRLQKNTTGKELYNEDVIYERHRHRYEFNNFYKQIFVDSGYKI
SGTSPDGRLVELIELVNHPYFLACQYHPEFLSRPGKPHPLFKGLIKASREKLEQSK

Sequences:

>Translated_536_residues
MSKFVFVTGGVVSSIGKGIVAASLGRLLKSRGYSVSILKLDPYLNVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFTD
TAMTRLNSVTTGSIYQAVINKERRGSYNGGTVQVIPHITGEIRERIHRVASNSNADIVITEIGGTVGDIESLPFLEAIRE
FKNDVNKNDVTYIHVTLLPYIKTSGEIKTKPTQHSVKELRSIGIQPDLLVCRSDKEINDSLKRKLSGFCGVNLNCVIEAL
DADSIYSVPLSLKKEGLCKETLRCLDLEDKECDLESWEKIIHNLRNPGNPIKVALVGKYIELGDAYLSVVEALRHACIEQ
KAFLDLHWVSAEMIEEKSAEEYLHDVDAIVVPGGFGNRGVNGKIASIKFAREKKIPFLGLCLGMQCAVIEWARNVVQLPG
ASSSELDPESENPVIHLLPEQEDIVDLGGTMRLGVYPCRLQKNTTGKELYNEDVIYERHRHRYEFNNFYKQIFVDSGYKI
SGTSPDGRLVELIELVNHPYFLACQYHPEFLSRPGKPHPLFKGLIKASREKLEQSK
>Mature_535_residues
SKFVFVTGGVVSSIGKGIVAASLGRLLKSRGYSVSILKLDPYLNVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFTDT
AMTRLNSVTTGSIYQAVINKERRGSYNGGTVQVIPHITGEIRERIHRVASNSNADIVITEIGGTVGDIESLPFLEAIREF
KNDVNKNDVTYIHVTLLPYIKTSGEIKTKPTQHSVKELRSIGIQPDLLVCRSDKEINDSLKRKLSGFCGVNLNCVIEALD
ADSIYSVPLSLKKEGLCKETLRCLDLEDKECDLESWEKIIHNLRNPGNPIKVALVGKYIELGDAYLSVVEALRHACIEQK
AFLDLHWVSAEMIEEKSAEEYLHDVDAIVVPGGFGNRGVNGKIASIKFAREKKIPFLGLCLGMQCAVIEWARNVVQLPGA
SSSELDPESENPVIHLLPEQEDIVDLGGTMRLGVYPCRLQKNTTGKELYNEDVIYERHRHRYEFNNFYKQIFVDSGYKIS
GTSPDGRLVELIELVNHPYFLACQYHPEFLSRPGKPHPLFKGLIKASREKLEQSK

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=551, Percent_Identity=45.5535390199637, Blast_Score=479, Evalue=1e-135,
Organism=Homo sapiens, GI28559085, Length=553, Percent_Identity=45.3887884267631, Blast_Score=455, Evalue=1e-128,
Organism=Homo sapiens, GI28559083, Length=553, Percent_Identity=45.3887884267631, Blast_Score=455, Evalue=1e-128,
Organism=Homo sapiens, GI221316689, Length=553, Percent_Identity=45.3887884267631, Blast_Score=455, Evalue=1e-128,
Organism=Escherichia coli, GI1789142, Length=539, Percent_Identity=52.3191094619666, Blast_Score=564, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI25148299, Length=605, Percent_Identity=39.0082644628099, Blast_Score=424, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6322563, Length=564, Percent_Identity=44.1489361702128, Blast_Score=457, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6319432, Length=558, Percent_Identity=42.2939068100358, Blast_Score=435, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24664469, Length=556, Percent_Identity=45.863309352518, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI21357815, Length=501, Percent_Identity=44.7105788423154, Blast_Score=408, Evalue=1e-114,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 59806; Mature: 59675

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKFVFVTGGVVSSIGKGIVAASLGRLLKSRGYSVSILKLDPYLNVDPGTMSPFQHGEVF
CCCEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFTDTAMTRLNSVTTGSIYQAVINKERRGSYNGGTVQVIPHITG
EECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHH
EIRERIHRVASNSNADIVITEIGGTVGDIESLPFLEAIREFKNDVNKNDVTYIHVTLLPY
HHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEEEE
IKTSGEIKTKPTQHSVKELRSIGIQPDLLVCRSDKEINDSLKRKLSGFCGVNLNCVIEAL
ECCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEC
DADSIYSVPLSLKKEGLCKETLRCLDLEDKECDLESWEKIIHNLRNPGNPIKVALVGKYI
CCCCEEECCCHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECHH
ELGDAYLSVVEALRHACIEQKAFLDLHWVSAEMIEEKSAEEYLHDVDAIVVPGGFGNRGV
HHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCC
NGKIASIKFAREKKIPFLGLCLGMQCAVIEWARNVVQLPGASSSELDPESENPVIHLLPE
CCEEEEEEEHHHCCCCEEEHHHCCHHHHHHHHHHHEECCCCCCCCCCCCCCCCEEEECCC
QEDIVDLGGTMRLGVYPCRLQKNTTGKELYNEDVIYERHRHRYEFNNFYKQIFVDSGYKI
CCHHHHCCCEEEECEEEEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEE
SGTSPDGRLVELIELVNHPYFLACQYHPEFLSRPGKPHPLFKGLIKASREKLEQSK
ECCCCCHHHHHHHHHHCCCEEEEEEECHHHHCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKFVFVTGGVVSSIGKGIVAASLGRLLKSRGYSVSILKLDPYLNVDPGTMSPFQHGEVF
CCEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFTDTAMTRLNSVTTGSIYQAVINKERRGSYNGGTVQVIPHITG
EECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHH
EIRERIHRVASNSNADIVITEIGGTVGDIESLPFLEAIREFKNDVNKNDVTYIHVTLLPY
HHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEEEE
IKTSGEIKTKPTQHSVKELRSIGIQPDLLVCRSDKEINDSLKRKLSGFCGVNLNCVIEAL
ECCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEC
DADSIYSVPLSLKKEGLCKETLRCLDLEDKECDLESWEKIIHNLRNPGNPIKVALVGKYI
CCCCEEECCCHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECHH
ELGDAYLSVVEALRHACIEQKAFLDLHWVSAEMIEEKSAEEYLHDVDAIVVPGGFGNRGV
HHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCC
NGKIASIKFAREKKIPFLGLCLGMQCAVIEWARNVVQLPGASSSELDPESENPVIHLLPE
CCEEEEEEEHHHCCCCEEEHHHCCHHHHHHHHHHHEECCCCCCCCCCCCCCCCEEEECCC
QEDIVDLGGTMRLGVYPCRLQKNTTGKELYNEDVIYERHRHRYEFNNFYKQIFVDSGYKI
CCHHHHCCCEEEECEEEEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEE
SGTSPDGRLVELIELVNHPYFLACQYHPEFLSRPGKPHPLFKGLIKASREKLEQSK
ECCCCCHHHHHHHHHHCCCEEEEEEECHHHHCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA