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The map label for this gene is uvrB [H]

Identifier: 123967072

GI number: 123967072

Start: 1624175

End: 1626214

Strand: Reverse

Name: uvrB [H]

Synonym: P9515_18391

Alternate gene names: 123967072

Gene position: 1626214-1624175 (Counterclockwise)

Preceding gene: 123967073

Following gene: 123967069

Centisome position: 95.43

GC content: 34.17

Gene sequence:

>2040_bases
ATGAATAACTATAAGCTTCAAGCACCCTATGAACCAAATGGTGATCAACCTAAAGCCATTAAAAAGTTAGTTCAAGGAGT
TAATAGTGGTAAAGAGTTTCAAACTCTTTTGGGAGCAACTGGTACTGGAAAAACTTTCACTATTGCTAATGTAATCCAGC
AAACTGGAAGACCAGCGCTTATTTTGGCTCATAATAAAACTTTAGCAGCTCAATTATGTAATGAATTAAGGCAGTTTTTT
CCTAAAAATGCGGTTGAATACTTTATTTCTTACTACGATTATTATCAACCTGAAGCTTATGTTCCAGTAAGTGATACATA
CATAGCAAAAACTGCTTCAATTAATGAAGAAATTGATATGCTTAGGCATTCCGCTACTCGTTCATTATTTGAGAGGAAAG
ATGTAATTGTTGTTGCATCTATTAGTTGTATTTATGGTCTAGGAATACCAAGTGAATATTTAAAAGCTGCTGTTAAATTT
GCAGTTGGTGAATCTATAGATTTACGTTCGTCTTTAAGAGCACTTGTAGATAATCAATACACAAGAAATGATGTAGAAAT
TACTAGAGGCAGATTTAGAATTAAGGGAGATGTATTAGAAATTGGACCAGCTTATGAAGATAGATTGATAAGAATTGAAT
TATTTGGAGATGAGATTGAGGCTATAAGATTTGTTGATCCATTAACTGGAGAGATTCTTGAGAGTCTTGATCAAGTTAGT
GTTTACCCAGCAAAGCATTTTGTTACTCCAAAAGAGAGACTAGAGGCTGCCATTACTGCTATAAGAAATGAATTAAAAGA
ACAACTTGATAAGTTTGCTTGTGAAGGAAAGTTGTTGGAAGCGCAGCGCTTAGAGCAACGCACAAAATATGATTTAGAAA
TGCTAAGAGAAGTTGGATACTGTAATGGCGTTGAAAATTACGCACGACATTTGGCTGGTAGGGAAGAAGGTACACCACCA
GAATGTTTAATAGATTATTTCCCAACAGATTGGTTATTAGTAGTTGATGAAAGTCACGTAACATGTCCTCAATTGCATGC
AATGTATAATGGGGATCAAGCTAGAAAGAAAGTGTTAATAGATCATGGTTTTAGGTTGCCTAGTGCTGCAGATAATAGAC
CTTTAAAATGCGAAGAATTTTGGGAAAAATCTAAACAGACATTGTTCATCAGTGCAACTCCTGGCCAATGGGAGTTGGAT
CAATGCGAAGGCCAGTTTATTGAACAAGTTATTAGACCTACAGGCGTTTTAGATCCCATCATTGATGTGAGGCCTAGTGA
TGGACAAATAGATGATCTTTTATCAGAAATAAGAGTTAGAGCTAAAAAGAATCAAAGAGTACTGGTTACTACTCTTACAA
AAAGGATGGCAGAAGATCTTACTGATTTTTTATCAGATAATAAAGTTAGGGTCAGATATTTACATTCTGAAATCCACTCT
ATTGAAAGGATAGAGATTATTCAAGATCTTAGATTGGGTGAATATGATGTATTAGTAGGAGTTAATTTGCTAAGGGAGGG
ACTTGATCTGCCTGAGGTTTCTTTAGTCGCTATTTTAGACGCAGATAAAGAGGGTTTTTTGAGAGCAGAGCGTTCTCTAA
TTCAAACTATTGGAAGAGCGGCAAGACATGTTGAGGGAGTTGCTTTGCTTTATGCAGATAATTTTACCCAATCAATGAAA
AGAGCGATAGACGAAACTGATAGAAGACGGACTATCCAAAAAAAATATAATCAGATCAACGGCATCACTCCACAACCTGC
AGGTAAAAAAATTGAAAATTCAATATTATCTTTTTTAGAACTTTCCAGAAAATTAGAAACTGGAGGATTCTCTAAAGATT
TGATCAATGTTGTTAGTAATAAAACAGATGAAATTTTAAATGCTAAAGATAATCAATGTTTACTGGAAGAGATGCCTAAT
TTAATTGATAAGTTAGAAAATAAAATGAAAGAAGCAGCAAAAGAACTAAATTTCGAAGAGGCAGCAAATCTTAGAGATAG
AATTAAGAAACTTAGGCAAAAATTATCTAGGAATAATTAA

Upstream 100 bases:

>100_bases
ATCAATGATTGCTGTTGTTAGAGGCCTAAAAGAATCTTTGAAAAATTCAATGATTAAAGAAAAAATTTCCTAACATATAA
AAACTTAAGCTATTAGCTGA

Downstream 100 bases:

>100_bases
TTAATTTTTTTTATTTATCTAATTCGAAATAAGAATGAATAGCATTTACTGCTTGGTCACAATCCTTTTCTAAGACAATA
CAAGAAGTTCTGATTTCACT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 679; Mature: 679

Protein sequence:

>679_residues
MNNYKLQAPYEPNGDQPKAIKKLVQGVNSGKEFQTLLGATGTGKTFTIANVIQQTGRPALILAHNKTLAAQLCNELRQFF
PKNAVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDMLRHSATRSLFERKDVIVVASISCIYGLGIPSEYLKAAVKF
AVGESIDLRSSLRALVDNQYTRNDVEITRGRFRIKGDVLEIGPAYEDRLIRIELFGDEIEAIRFVDPLTGEILESLDQVS
VYPAKHFVTPKERLEAAITAIRNELKEQLDKFACEGKLLEAQRLEQRTKYDLEMLREVGYCNGVENYARHLAGREEGTPP
ECLIDYFPTDWLLVVDESHVTCPQLHAMYNGDQARKKVLIDHGFRLPSAADNRPLKCEEFWEKSKQTLFISATPGQWELD
QCEGQFIEQVIRPTGVLDPIIDVRPSDGQIDDLLSEIRVRAKKNQRVLVTTLTKRMAEDLTDFLSDNKVRVRYLHSEIHS
IERIEIIQDLRLGEYDVLVGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQTIGRAARHVEGVALLYADNFTQSMK
RAIDETDRRRTIQKKYNQINGITPQPAGKKIENSILSFLELSRKLETGGFSKDLINVVSNKTDEILNAKDNQCLLEEMPN
LIDKLENKMKEAAKELNFEEAANLRDRIKKLRQKLSRNN

Sequences:

>Translated_679_residues
MNNYKLQAPYEPNGDQPKAIKKLVQGVNSGKEFQTLLGATGTGKTFTIANVIQQTGRPALILAHNKTLAAQLCNELRQFF
PKNAVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDMLRHSATRSLFERKDVIVVASISCIYGLGIPSEYLKAAVKF
AVGESIDLRSSLRALVDNQYTRNDVEITRGRFRIKGDVLEIGPAYEDRLIRIELFGDEIEAIRFVDPLTGEILESLDQVS
VYPAKHFVTPKERLEAAITAIRNELKEQLDKFACEGKLLEAQRLEQRTKYDLEMLREVGYCNGVENYARHLAGREEGTPP
ECLIDYFPTDWLLVVDESHVTCPQLHAMYNGDQARKKVLIDHGFRLPSAADNRPLKCEEFWEKSKQTLFISATPGQWELD
QCEGQFIEQVIRPTGVLDPIIDVRPSDGQIDDLLSEIRVRAKKNQRVLVTTLTKRMAEDLTDFLSDNKVRVRYLHSEIHS
IERIEIIQDLRLGEYDVLVGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQTIGRAARHVEGVALLYADNFTQSMK
RAIDETDRRRTIQKKYNQINGITPQPAGKKIENSILSFLELSRKLETGGFSKDLINVVSNKTDEILNAKDNQCLLEEMPN
LIDKLENKMKEAAKELNFEEAANLRDRIKKLRQKLSRNN
>Mature_679_residues
MNNYKLQAPYEPNGDQPKAIKKLVQGVNSGKEFQTLLGATGTGKTFTIANVIQQTGRPALILAHNKTLAAQLCNELRQFF
PKNAVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDMLRHSATRSLFERKDVIVVASISCIYGLGIPSEYLKAAVKF
AVGESIDLRSSLRALVDNQYTRNDVEITRGRFRIKGDVLEIGPAYEDRLIRIELFGDEIEAIRFVDPLTGEILESLDQVS
VYPAKHFVTPKERLEAAITAIRNELKEQLDKFACEGKLLEAQRLEQRTKYDLEMLREVGYCNGVENYARHLAGREEGTPP
ECLIDYFPTDWLLVVDESHVTCPQLHAMYNGDQARKKVLIDHGFRLPSAADNRPLKCEEFWEKSKQTLFISATPGQWELD
QCEGQFIEQVIRPTGVLDPIIDVRPSDGQIDDLLSEIRVRAKKNQRVLVTTLTKRMAEDLTDFLSDNKVRVRYLHSEIHS
IERIEIIQDLRLGEYDVLVGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQTIGRAARHVEGVALLYADNFTQSMK
RAIDETDRRRTIQKKYNQINGITPQPAGKKIENSILSFLELSRKLETGGFSKDLINVVSNKTDEILNAKDNQCLLEEMPN
LIDKLENKMKEAAKELNFEEAANLRDRIKKLRQKLSRNN

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=675, Percent_Identity=56, Blast_Score=751, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 77286; Mature: 77286

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNYKLQAPYEPNGDQPKAIKKLVQGVNSGKEFQTLLGATGTGKTFTIANVIQQTGRPAL
CCCCEEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCEE
ILAHNKTLAAQLCNELRQFFPKNAVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDM
EEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEECCCCCCHHEECCCCHHHHHH
LRHSATRSLFERKDVIVVASISCIYGLGIPSEYLKAAVKFAVGESIDLRSSLRALVDNQY
HHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
TRNDVEITRGRFRIKGDVLEIGPAYEDRLIRIELFGDEIEAIRFVDPLTGEILESLDQVS
CCCCHHEECCEEEEECCEEECCCCCCCCEEEEEEECCCHHHHHHCCCHHHHHHHHHHHHC
VYPAKHFVTPKERLEAAITAIRNELKEQLDKFACEGKLLEAQRLEQRTKYDLEMLREVGY
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
CNGVENYARHLAGREEGTPPECLIDYFPTDWLLVVDESHVTCPQLHAMYNGDQARKKVLI
CCCHHHHHHHHCCCCCCCCHHHHHCCCCCCEEEEECCCCCCCHHHHHHHCCCHHHHHHHH
DHGFRLPSAADNRPLKCEEFWEKSKQTLFISATPGQWELDQCEGQFIEQVIRPTGVLDPI
HCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCH
IDVRPSDGQIDDLLSEIRVRAKKNQRVLVTTLTKRMAEDLTDFLSDNKVRVRYLHSEIHS
HCCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHH
IERIEIIQDLRLGEYDVLVGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQTIGRA
HHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
ARHVEGVALLYADNFTQSMKRAIDETDRRRTIQKKYNQINGITPQPAGKKIENSILSFLE
HHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
LSRKLETGGFSKDLINVVSNKTDEILNAKDNQCLLEEMPNLIDKLENKMKEAAKELNFEE
HHHHHHCCCCHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
AANLRDRIKKLRQKLSRNN
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNYKLQAPYEPNGDQPKAIKKLVQGVNSGKEFQTLLGATGTGKTFTIANVIQQTGRPAL
CCCCEEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCEE
ILAHNKTLAAQLCNELRQFFPKNAVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDM
EEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEECCCCCCHHEECCCCHHHHHH
LRHSATRSLFERKDVIVVASISCIYGLGIPSEYLKAAVKFAVGESIDLRSSLRALVDNQY
HHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
TRNDVEITRGRFRIKGDVLEIGPAYEDRLIRIELFGDEIEAIRFVDPLTGEILESLDQVS
CCCCHHEECCEEEEECCEEECCCCCCCCEEEEEEECCCHHHHHHCCCHHHHHHHHHHHHC
VYPAKHFVTPKERLEAAITAIRNELKEQLDKFACEGKLLEAQRLEQRTKYDLEMLREVGY
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
CNGVENYARHLAGREEGTPPECLIDYFPTDWLLVVDESHVTCPQLHAMYNGDQARKKVLI
CCCHHHHHHHHCCCCCCCCHHHHHCCCCCCEEEEECCCCCCCHHHHHHHCCCHHHHHHHH
DHGFRLPSAADNRPLKCEEFWEKSKQTLFISATPGQWELDQCEGQFIEQVIRPTGVLDPI
HCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCH
IDVRPSDGQIDDLLSEIRVRAKKNQRVLVTTLTKRMAEDLTDFLSDNKVRVRYLHSEIHS
HCCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHH
IERIEIIQDLRLGEYDVLVGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQTIGRA
HHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHH
ARHVEGVALLYADNFTQSMKRAIDETDRRRTIQKKYNQINGITPQPAGKKIENSILSFLE
HHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
LSRKLETGGFSKDLINVVSNKTDEILNAKDNQCLLEEMPNLIDKLENKMKEAAKELNFEE
HHHHHHCCCCHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
AANLRDRIKKLRQKLSRNN
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA