Click here to switch to the map view.

The map label for this gene is hisD [H]

Identifier: 123966901

GI number: 123966901

Start: 1462212

End: 1463498

Strand: Direct

Name: hisD [H]

Synonym: P9515_16681

Alternate gene names: 123966901

Gene position: 1462212-1463498 (Clockwise)

Preceding gene: 123966888

Following gene: 123966904

Centisome position: 85.8

GC content: 34.73

Gene sequence:

>1287_bases
ATGAAGATTATAAATAATAAACAAAAGGCTTTGGAAGAGTTGAAAAGAATTTCTCAAAGAACTACATCCGGCGACAATAG
AAAAATAAATTCATTAGTTGAAGAAATTCTTGAAGAGGTGAAAATTAATGGAGATAAAGCTGTAGAAAAATATACAAAAA
AGTTTGATGGATTCCATCCTAAACCGATGCAAGTTAGTGCTATGGATTTAAAGTCTGCTTGGGATGAGACAGACCATCAT
TTAAAAAAATCATTAGAAATTGCCTACCAAAGAATTCAAAAATTCCATGAAAAAGAAATACCTGAATCATTCACTATAAA
AGGAGAATATGGTGACTCCGTTCAAAGAAAATGGATGCCTGTAAAAAATGCTGGCTTATACATTCCGGGGGGACGAGCCG
CATATCCAAGTACTGTTTTAATGAATGCGATACCTGCAAAAGTTGCTGGAGTGAAAGAAATTTCAATGGTATCTCCCGGA
AATCAAGAAGGAAAAATAAATAAAACTGTTTTAGCTGCTGCCTACTTATCAGGGATTGATAAAGTTTTTAGAATTGGAGG
AGCACAGGCAATTGGCGCCTTAGCCTTTGGCACAAAGCAAATAAATAGAGTTGATGTTATTTCTGGACCAGGAAATATCT
ATGTTACTGCTGCTAAAAAGTTAATTTATGGATTGACTGGAATTGATTCTTTAGCAGGCCCAAGTGAAATTTTAATCATC
GCGGATAGAACAGCTAAAAGTTCTCAAATAGCATCAGATTTATTAGCCCAAGCAGAGCATGATCCATTAGCCTCCTCAAT
ACTTTTGACTACATCAAAGGGTCAAGCTCAAGAAGTCTTTGATGAGGTCTTTAAGCAATTAGAGCATCACCCCAGAAAAG
AAATTTGTATTCAATCAATTGAAAATTGGGGATTAATTGCTATTTGCGAAAATTTAGAATCATGCATTGAACTCAGCAAT
GAGTTTGCCCCAGAACATCTAGAGATTATTACTATTGATCCAAAAAAGATACTTAAAACTATCGAAAATGCAGGCGCGAT
TTTTTTAGGAAATTGGACACCAGAAGCTGTAGGTGATTATTTGGCTGGACCAAACCATACTTTACCCACATGCGGTAATG
CCAGGTTTAGTGGATCATTAGGTGTTGAAACTTTCATGAAGAATTCATCAATAATTGAATTTAATGAAAAAAGTTTAAAA
ATCAATAGCTCAGATATTATAAACTTGGCAAACAGCGAAGGTCTCCATAGTCATGCGAATTCAGTAAAAATTAGATTTGA
GGATTAA

Upstream 100 bases:

>100_bases
ACTATACCAAAACTTAGTGCACTAATCAATATAATATAATTGGATTTAAATCAATTAATTAGATAATTAATCAATCGAAT
TTCAATTTGGCATTAAGAAA

Downstream 100 bases:

>100_bases
CTCCCCTTGGAAGGTGAAAATAACACTGGAACATTGTTCTCAATCTTACCCACCAAAACCTTATCTGTTAAATTAACAAA
CAATCCATTTTCCAATACTC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MKIINNKQKALEELKRISQRTTSGDNRKINSLVEEILEEVKINGDKAVEKYTKKFDGFHPKPMQVSAMDLKSAWDETDHH
LKKSLEIAYQRIQKFHEKEIPESFTIKGEYGDSVQRKWMPVKNAGLYIPGGRAAYPSTVLMNAIPAKVAGVKEISMVSPG
NQEGKINKTVLAAAYLSGIDKVFRIGGAQAIGALAFGTKQINRVDVISGPGNIYVTAAKKLIYGLTGIDSLAGPSEILII
ADRTAKSSQIASDLLAQAEHDPLASSILLTTSKGQAQEVFDEVFKQLEHHPRKEICIQSIENWGLIAICENLESCIELSN
EFAPEHLEIITIDPKKILKTIENAGAIFLGNWTPEAVGDYLAGPNHTLPTCGNARFSGSLGVETFMKNSSIIEFNEKSLK
INSSDIINLANSEGLHSHANSVKIRFED

Sequences:

>Translated_428_residues
MKIINNKQKALEELKRISQRTTSGDNRKINSLVEEILEEVKINGDKAVEKYTKKFDGFHPKPMQVSAMDLKSAWDETDHH
LKKSLEIAYQRIQKFHEKEIPESFTIKGEYGDSVQRKWMPVKNAGLYIPGGRAAYPSTVLMNAIPAKVAGVKEISMVSPG
NQEGKINKTVLAAAYLSGIDKVFRIGGAQAIGALAFGTKQINRVDVISGPGNIYVTAAKKLIYGLTGIDSLAGPSEILII
ADRTAKSSQIASDLLAQAEHDPLASSILLTTSKGQAQEVFDEVFKQLEHHPRKEICIQSIENWGLIAICENLESCIELSN
EFAPEHLEIITIDPKKILKTIENAGAIFLGNWTPEAVGDYLAGPNHTLPTCGNARFSGSLGVETFMKNSSIIEFNEKSLK
INSSDIINLANSEGLHSHANSVKIRFED
>Mature_428_residues
MKIINNKQKALEELKRISQRTTSGDNRKINSLVEEILEEVKINGDKAVEKYTKKFDGFHPKPMQVSAMDLKSAWDETDHH
LKKSLEIAYQRIQKFHEKEIPESFTIKGEYGDSVQRKWMPVKNAGLYIPGGRAAYPSTVLMNAIPAKVAGVKEISMVSPG
NQEGKINKTVLAAAYLSGIDKVFRIGGAQAIGALAFGTKQINRVDVISGPGNIYVTAAKKLIYGLTGIDSLAGPSEILII
ADRTAKSSQIASDLLAQAEHDPLASSILLTTSKGQAQEVFDEVFKQLEHHPRKEICIQSIENWGLIAICENLESCIELSN
EFAPEHLEIITIDPKKILKTIENAGAIFLGNWTPEAVGDYLAGPNHTLPTCGNARFSGSLGVETFMKNSSIIEFNEKSLK
INSSDIINLANSEGLHSHANSVKIRFED

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=426, Percent_Identity=39.4366197183099, Blast_Score=302, Evalue=2e-83,
Organism=Saccharomyces cerevisiae, GI6319819, Length=427, Percent_Identity=38.1733021077283, Blast_Score=268, Evalue=1e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46981; Mature: 46981

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIINNKQKALEELKRISQRTTSGDNRKINSLVEEILEEVKINGDKAVEKYTKKFDGFHP
CCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
KPMQVSAMDLKSAWDETDHHLKKSLEIAYQRIQKFHEKEIPESFTIKGEYGDSVQRKWMP
CCCEEEHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHCCCC
VKNAGLYIPGGRAAYPSTVLMNAIPAKVAGVKEISMVSPGNQEGKINKTVLAAAYLSGID
CCCCCEECCCCCCCCCHHHHHHHHHHHHCCCHHEEEECCCCCCCCCHHHHHHHHHHHHHH
KVFRIGGAQAIGALAFGTKQINRVDVISGPGNIYVTAAKKLIYGLTGIDSLAGPSEILII
HHHHCCCHHHHHHHHHCCCCCCEEEEEECCCCEEEEEHHHHHHHHCCCCCCCCCCEEEEE
ADRTAKSSQIASDLLAQAEHDPLASSILLTTSKGQAQEVFDEVFKQLEHHPRKEICIQSI
ECCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHH
ENWGLIAICENLESCIELSNEFAPEHLEIITIDPKKILKTIENAGAIFLGNWTPEAVGDY
CCCCEEHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHCCCEEEECCCCHHHHHHH
LAGPNHTLPTCGNARFSGSLGVETFMKNSSIIEFNEKSLKINSSDIINLANSEGLHSHAN
HCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCEEEECCHHHEEECCCCCCCCCCC
SVKIRFED
EEEEEECC
>Mature Secondary Structure
MKIINNKQKALEELKRISQRTTSGDNRKINSLVEEILEEVKINGDKAVEKYTKKFDGFHP
CCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
KPMQVSAMDLKSAWDETDHHLKKSLEIAYQRIQKFHEKEIPESFTIKGEYGDSVQRKWMP
CCCEEEHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHCCCC
VKNAGLYIPGGRAAYPSTVLMNAIPAKVAGVKEISMVSPGNQEGKINKTVLAAAYLSGID
CCCCCEECCCCCCCCCHHHHHHHHHHHHCCCHHEEEECCCCCCCCCHHHHHHHHHHHHHH
KVFRIGGAQAIGALAFGTKQINRVDVISGPGNIYVTAAKKLIYGLTGIDSLAGPSEILII
HHHHCCCHHHHHHHHHCCCCCCEEEEEECCCCEEEEEHHHHHHHHCCCCCCCCCCEEEEE
ADRTAKSSQIASDLLAQAEHDPLASSILLTTSKGQAQEVFDEVFKQLEHHPRKEICIQSI
ECCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHH
ENWGLIAICENLESCIELSNEFAPEHLEIITIDPKKILKTIENAGAIFLGNWTPEAVGDY
CCCCEEHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHCCCEEEECCCCHHHHHHH
LAGPNHTLPTCGNARFSGSLGVETFMKNSSIIEFNEKSLKINSSDIINLANSEGLHSHAN
HCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCEEEECCHHHEEECCCCCCCCCCC
SVKIRFED
EEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]