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The map label for this gene is fumC [H]

Identifier: 123966879

GI number: 123966879

Start: 1436452

End: 1437837

Strand: Direct

Name: fumC [H]

Synonym: P9515_16461

Alternate gene names: 123966879

Gene position: 1436452-1437837 (Clockwise)

Preceding gene: 123966878

Following gene: 123966881

Centisome position: 84.29

GC content: 31.39

Gene sequence:

>1386_bases
ATGACCAAAAACTTTAGATTTGAAAAAGATAGTATGGGAAAAATTAAAGTTCCCGCTGAGGCTCTTTGGGGAGCTCAAAC
GCAAAGATCAATTATAAATTTTTCTATTGGCGAGGAATTAATCCCATTAGAACTGATCTATTCAATTACATTAATTAAAA
AAGCAGCAGCAATTGCTAATTTTAAATTGGGTCTAATTAATGATGTAAAAAAAGATCTAATTATTGAAGCTTGCACTGAA
ATACTTGATGGATATCATGATTCTCAGTTCCCTTTAAAAATATGGCAAACAGGTAGTGGTACTCAAACAAATATGAATAT
AAATGAAGTCATATCTAATATTGCTGCATTAAAAACAAATTCAGAACTTGGAACTCATAATCCTATTCATCCAAATGACG
ATGTTAATAAATCTCAATCTACAAATGATACTTTTCCTGCTGCTATTCAGATATCAGTGGTTACTGAAATAATTAAAAAA
TTAGTTCCTTCAATAAAGGAACTTACTAAGGTTCTTGATAAAAAAAGTAATGAGTGGAAAAATCTTATAAAAATAGGAAG
AACCCATTTTCAAGATGCCGTTCCAATTTCACTTGGGCAAGAAGTTTCTGCATGGTCAAAACAACTAAAAGATGCTGAAG
ATACTCTCTTAGTAAGTCTTGATGAATTATGTTTTTTGCCACTAGGTGGTACTGCAGTTGGTACAGGAATTAATTGTCCA
AAAGATTTTCCAGAAGAATCTATAAAATCAATTTCAGATGACACTAATGTAGTGTTTTATAAATCAAATAATCATTTCTC
TTTAATGGCATCTCATGATCGATTAGCAAACGTAATGGGTCAAATAAAAATACTTGCGAGTGCATTATTTAAGATTTCTA
ATGATATAAAAATATTATCCTCAGGCCCTAGATCAGGTATTTATGAGTTAATAATTCCTCAGAATGAACCTGGCAGCTCA
ATCATGCCTGGGAAAGTAAATCCTACCCAATGTGAAGCATTATCCATGGTATGTACTCAAGTAATGGGTTTTGAATATGC
AGTATCAATAGCCAATGCCAGCGGTACTTTACAAATGAACGAATATAAGCCACTAATTGGATTTAATATTCTGAGGAGTA
TAAAATTACTGAATAATGCAATAAGTAACTTTAGATTAAAGTTAATTGAAGGTATACAACCTAATCCTGAGACTATAAAA
GCGAATCTTGAAAATTCACTAATGCTTGTAACAGCATTAGTACCCAAAATAGGTTACGAAAAAGCAGCAGAAATTGCGAA
TCTTGCTTTTAATGAATCAATTAACTTAAAAGAGGCAACACTAAAATTAGGCTATTTAAGTGCCAATGATTTTGAGGATG
CTATAAATACTGATCAAATGATCTGA

Upstream 100 bases:

>100_bases
CAACATTCATCTAAATAATTTAAATGTAATATGGGAAAAATTAAGTATTTAAATCACCTAAATATTATTTGAATTTTAAC
CACAGTTTTTTTTACAACTA

Downstream 100 bases:

>100_bases
TTTTTGTACTCTTAGTAATTATTATCAATTCTTTTTGTTGCTGGATTTATATTATCAGAGACTTTTAACAAGTCATTCGA
TTCAGAGACAGGAAATCTAT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MTKNFRFEKDSMGKIKVPAEALWGAQTQRSIINFSIGEELIPLELIYSITLIKKAAAIANFKLGLINDVKKDLIIEACTE
ILDGYHDSQFPLKIWQTGSGTQTNMNINEVISNIAALKTNSELGTHNPIHPNDDVNKSQSTNDTFPAAIQISVVTEIIKK
LVPSIKELTKVLDKKSNEWKNLIKIGRTHFQDAVPISLGQEVSAWSKQLKDAEDTLLVSLDELCFLPLGGTAVGTGINCP
KDFPEESIKSISDDTNVVFYKSNNHFSLMASHDRLANVMGQIKILASALFKISNDIKILSSGPRSGIYELIIPQNEPGSS
IMPGKVNPTQCEALSMVCTQVMGFEYAVSIANASGTLQMNEYKPLIGFNILRSIKLLNNAISNFRLKLIEGIQPNPETIK
ANLENSLMLVTALVPKIGYEKAAEIANLAFNESINLKEATLKLGYLSANDFEDAINTDQMI

Sequences:

>Translated_461_residues
MTKNFRFEKDSMGKIKVPAEALWGAQTQRSIINFSIGEELIPLELIYSITLIKKAAAIANFKLGLINDVKKDLIIEACTE
ILDGYHDSQFPLKIWQTGSGTQTNMNINEVISNIAALKTNSELGTHNPIHPNDDVNKSQSTNDTFPAAIQISVVTEIIKK
LVPSIKELTKVLDKKSNEWKNLIKIGRTHFQDAVPISLGQEVSAWSKQLKDAEDTLLVSLDELCFLPLGGTAVGTGINCP
KDFPEESIKSISDDTNVVFYKSNNHFSLMASHDRLANVMGQIKILASALFKISNDIKILSSGPRSGIYELIIPQNEPGSS
IMPGKVNPTQCEALSMVCTQVMGFEYAVSIANASGTLQMNEYKPLIGFNILRSIKLLNNAISNFRLKLIEGIQPNPETIK
ANLENSLMLVTALVPKIGYEKAAEIANLAFNESINLKEATLKLGYLSANDFEDAINTDQMI
>Mature_460_residues
TKNFRFEKDSMGKIKVPAEALWGAQTQRSIINFSIGEELIPLELIYSITLIKKAAAIANFKLGLINDVKKDLIIEACTEI
LDGYHDSQFPLKIWQTGSGTQTNMNINEVISNIAALKTNSELGTHNPIHPNDDVNKSQSTNDTFPAAIQISVVTEIIKKL
VPSIKELTKVLDKKSNEWKNLIKIGRTHFQDAVPISLGQEVSAWSKQLKDAEDTLLVSLDELCFLPLGGTAVGTGINCPK
DFPEESIKSISDDTNVVFYKSNNHFSLMASHDRLANVMGQIKILASALFKISNDIKILSSGPRSGIYELIIPQNEPGSSI
MPGKVNPTQCEALSMVCTQVMGFEYAVSIANASGTLQMNEYKPLIGFNILRSIKLLNNAISNFRLKLIEGIQPNPETIKA
NLENSLMLVTALVPKIGYEKAAEIANLAFNESINLKEATLKLGYLSANDFEDAINTDQMI

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=46.7391304347826, Blast_Score=417, Evalue=1e-116,
Organism=Escherichia coli, GI1787896, Length=456, Percent_Identity=48.4649122807018, Blast_Score=441, Evalue=1e-125,
Organism=Escherichia coli, GI87082375, Length=464, Percent_Identity=36.4224137931034, Blast_Score=295, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI17553882, Length=458, Percent_Identity=47.1615720524017, Blast_Score=427, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI32565146, Length=324, Percent_Identity=45.9876543209877, Blast_Score=295, Evalue=3e-80,
Organism=Saccharomyces cerevisiae, GI6324993, Length=463, Percent_Identity=45.3563714902808, Blast_Score=416, Evalue=1e-117,
Organism=Drosophila melanogaster, GI78710009, Length=461, Percent_Identity=49.2407809110629, Blast_Score=443, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24640177, Length=463, Percent_Identity=48.8120950323974, Blast_Score=438, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24640179, Length=463, Percent_Identity=48.8120950323974, Blast_Score=437, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24662684, Length=461, Percent_Identity=47.939262472885, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24583245, Length=460, Percent_Identity=43.695652173913, Blast_Score=403, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50672; Mature: 50541

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKNFRFEKDSMGKIKVPAEALWGAQTQRSIINFSIGEELIPLELIYSITLIKKAAAIAN
CCCCCCCCCCCCCEEECCHHHHHCCHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHH
FKLGLINDVKKDLIIEACTEILDGYHDSQFPLKIWQTGSGTQTNMNINEVISNIAALKTN
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCC
SELGTHNPIHPNDDVNKSQSTNDTFPAAIQISVVTEIIKKLVPSIKELTKVLDKKSNEWK
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
NLIKIGRTHFQDAVPISLGQEVSAWSKQLKDAEDTLLVSLDELCFLPLGGTAVGTGINCP
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHEEEHHHHEEECCCCEEECCCCCCC
KDFPEESIKSISDDTNVVFYKSNNHFSLMASHDRLANVMGQIKILASALFKISNDIKILS
CCCCHHHHHHCCCCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
SGPRSGIYELIIPQNEPGSSIMPGKVNPTQCEALSMVCTQVMGFEYAVSIANASGTLQMN
CCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEC
EYKPLIGFNILRSIKLLNNAISNFRLKLIEGIQPNPETIKANLENSLMLVTALVPKIGYE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEECCCCCEEHHHHHHHHCCHH
KAAEIANLAFNESINLKEATLKLGYLSANDFEDAINTDQMI
HHHHHHHHHHCCCCCCEEHEEEEEEECCCCHHHHCCCCCCC
>Mature Secondary Structure 
TKNFRFEKDSMGKIKVPAEALWGAQTQRSIINFSIGEELIPLELIYSITLIKKAAAIAN
CCCCCCCCCCCCEEECCHHHHHCCHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHH
FKLGLINDVKKDLIIEACTEILDGYHDSQFPLKIWQTGSGTQTNMNINEVISNIAALKTN
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCC
SELGTHNPIHPNDDVNKSQSTNDTFPAAIQISVVTEIIKKLVPSIKELTKVLDKKSNEWK
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
NLIKIGRTHFQDAVPISLGQEVSAWSKQLKDAEDTLLVSLDELCFLPLGGTAVGTGINCP
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHHEEEHHHHEEECCCCEEECCCCCCC
KDFPEESIKSISDDTNVVFYKSNNHFSLMASHDRLANVMGQIKILASALFKISNDIKILS
CCCCHHHHHHCCCCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
SGPRSGIYELIIPQNEPGSSIMPGKVNPTQCEALSMVCTQVMGFEYAVSIANASGTLQMN
CCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEC
EYKPLIGFNILRSIKLLNNAISNFRLKLIEGIQPNPETIKANLENSLMLVTALVPKIGYE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEECCCCCEEHHHHHHHHCCHH
KAAEIANLAFNESINLKEATLKLGYLSANDFEDAINTDQMI
HHHHHHHHHHCCCCCCEEHEEEEEEECCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]