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The map label for this gene is bioF [C]

Identifier: 123966881

GI number: 123966881

Start: 1440715

End: 1441860

Strand: Direct

Name: bioF [C]

Synonym: P9515_16481

Alternate gene names: 123966881

Gene position: 1440715-1441860 (Clockwise)

Preceding gene: 123966879

Following gene: 123966882

Centisome position: 84.54

GC content: 32.81

Gene sequence:

>1146_bases
ATGAATAAAGTAAAAATCCCAAAAAATAGGCTTCGTAAATTAGAAACATTCACGTTAGGTCATAAACCCTATGAACTTCA
AAGTTTAAATCCAGAGAAAGTTAAAAAAAATCTTATTGACTTATGTAGTAATGATTATTTTGGATTAAGTAGAGATAATG
ATGTATTAAAAGCCTCTTATGAAATTAGCTTATCTGAAGGTCTTGGTTCGGGTGGTTCAAGATTTATAACGGGCTCAAGA
CCAATTCATCAATTATTAGAGACACAACTTGCGGAATGGCTTAATCAAGAAAAAGTTCTTTTGTTTCCTAGCGGGTTCCA
AGCTAATATAGCTGCGGTACAATCTTTAGCTGACAGAAATAGTATTGTAATAGCAGATAAATTGATTCATAATTCTTTAT
TAGTTGGTGTAAAAGCTTCAGGATCAAAACTAGTAAGATTCGTACATAATGATTTGAAAGACTTAGAAAATAAAATTCTT
AAATTTAATTCAACACAAAAGTCCATTCTTATAATTGTTGAATCCCTTTATAGTATGGAAGGCTCAATTGCTCCTCTCAA
AGAAATTGCGGGAATTTGTAAAAAATATAATGTTAAATTATTAGTTGACGAAGCTCACGCCCTTGGAATTTTAGGACATG
AAGGCAAAGGTTTAAGTTTTGATGTATCTGATGAAATCACTATGCTTACTGGAACCTTTGGTAAATCGTTTGGCAGTGGC
GGGGCATTCATCGCTTGCAACTCAATAATTGGTGAATACCTTATTCAAACGAGCGGGGCATTTAGATATACAACTGCTCT
TTCCCCAGCTTTATCTGCAGGCGCACTTAAATCTCTTCAAAAAATCAAAAACAACAAAAAATGGGGTATTGATTTATTGA
TTTCTTCTGAAAAGTGGAAGAAAGAAATTATTCGAAATATTAGTTACCCAGTTAAGGGAGACTCTCAAATCTTATCAATA
ATTGTTGGGCAAGAAAAAAAGGCAATACTGCTTCAAAAACATCTTGAAAAAAATGGTTTTTTGGCGATTGCTATTAGACC
TCCAACTGTGCCTGTGAACAAATCAAGAATAAGGTTAACAATCAGGAGAGATTTAAATCTAGAGATACTCGAAAATTTCA
CTTCTGTTTTGAAAGCTTTCAAATGA

Upstream 100 bases:

>100_bases
TATGATCTATATAGATATTAATAAACAATACCTACCTTGCACACTTTAATAGTAAATCTAGATCATTTTATAAAAGTCAA
TTAGTTTAAATTTTTTAAAA

Downstream 100 bases:

>100_bases
AACAAGTTATTACCCAACATGGTTGGGGTTTAGATCAAAGTTTTTGGGATAATTATAAAATTGAATTTAAAAAAAATGGA
TGGCATTGGCAAGATAATGA

Product: putative 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MNKVKIPKNRLRKLETFTLGHKPYELQSLNPEKVKKNLIDLCSNDYFGLSRDNDVLKASYEISLSEGLGSGGSRFITGSR
PIHQLLETQLAEWLNQEKVLLFPSGFQANIAAVQSLADRNSIVIADKLIHNSLLVGVKASGSKLVRFVHNDLKDLENKIL
KFNSTQKSILIIVESLYSMEGSIAPLKEIAGICKKYNVKLLVDEAHALGILGHEGKGLSFDVSDEITMLTGTFGKSFGSG
GAFIACNSIIGEYLIQTSGAFRYTTALSPALSAGALKSLQKIKNNKKWGIDLLISSEKWKKEIIRNISYPVKGDSQILSI
IVGQEKKAILLQKHLEKNGFLAIAIRPPTVPVNKSRIRLTIRRDLNLEILENFTSVLKAFK

Sequences:

>Translated_381_residues
MNKVKIPKNRLRKLETFTLGHKPYELQSLNPEKVKKNLIDLCSNDYFGLSRDNDVLKASYEISLSEGLGSGGSRFITGSR
PIHQLLETQLAEWLNQEKVLLFPSGFQANIAAVQSLADRNSIVIADKLIHNSLLVGVKASGSKLVRFVHNDLKDLENKIL
KFNSTQKSILIIVESLYSMEGSIAPLKEIAGICKKYNVKLLVDEAHALGILGHEGKGLSFDVSDEITMLTGTFGKSFGSG
GAFIACNSIIGEYLIQTSGAFRYTTALSPALSAGALKSLQKIKNNKKWGIDLLISSEKWKKEIIRNISYPVKGDSQILSI
IVGQEKKAILLQKHLEKNGFLAIAIRPPTVPVNKSRIRLTIRRDLNLEILENFTSVLKAFK
>Mature_381_residues
MNKVKIPKNRLRKLETFTLGHKPYELQSLNPEKVKKNLIDLCSNDYFGLSRDNDVLKASYEISLSEGLGSGGSRFITGSR
PIHQLLETQLAEWLNQEKVLLFPSGFQANIAAVQSLADRNSIVIADKLIHNSLLVGVKASGSKLVRFVHNDLKDLENKIL
KFNSTQKSILIIVESLYSMEGSIAPLKEIAGICKKYNVKLLVDEAHALGILGHEGKGLSFDVSDEITMLTGTFGKSFGSG
GAFIACNSIIGEYLIQTSGAFRYTTALSPALSAGALKSLQKIKNNKKWGIDLLISSEKWKKEIIRNISYPVKGDSQILSI
IVGQEKKAILLQKHLEKNGFLAIAIRPPTVPVNKSRIRLTIRRDLNLEILENFTSVLKAFK

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=349, Percent_Identity=31.2320916905444, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI83977440, Length=349, Percent_Identity=31.2320916905444, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI83977444, Length=349, Percent_Identity=31.2320916905444, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI7657118, Length=334, Percent_Identity=27.8443113772455, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI284448556, Length=329, Percent_Identity=27.9635258358663, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI119220554, Length=370, Percent_Identity=27.5675675675676, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI4758668, Length=358, Percent_Identity=28.4916201117318, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI4502025, Length=349, Percent_Identity=28.6532951289398, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI40316939, Length=349, Percent_Identity=28.6532951289398, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI5454084, Length=248, Percent_Identity=27.4193548387097, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI1786993, Length=347, Percent_Identity=33.1412103746398, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1790046, Length=349, Percent_Identity=28.9398280802292, Blast_Score=170, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71994529, Length=330, Percent_Identity=30, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI32566772, Length=354, Percent_Identity=29.3785310734463, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17560912, Length=349, Percent_Identity=29.512893982808, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17560914, Length=349, Percent_Identity=29.512893982808, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71982625, Length=246, Percent_Identity=24.390243902439, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71982617, Length=249, Percent_Identity=25.3012048192771, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320438, Length=389, Percent_Identity=31.3624678663239, Blast_Score=156, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6320267, Length=352, Percent_Identity=26.9886363636364, Blast_Score=135, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6323954, Length=269, Percent_Identity=24.5353159851301, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24662918, Length=331, Percent_Identity=28.7009063444109, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI17137420, Length=356, Percent_Identity=30.0561797752809, Blast_Score=147, Evalue=9e-36,
Organism=Drosophila melanogaster, GI17136286, Length=354, Percent_Identity=29.3785310734463, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24653280, Length=290, Percent_Identity=24.1379310344828, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24653276, Length=290, Percent_Identity=24.1379310344828, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24653278, Length=290, Percent_Identity=24.1379310344828, Blast_Score=122, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 42131; Mature: 42131

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVKIPKNRLRKLETFTLGHKPYELQSLNPEKVKKNLIDLCSNDYFGLSRDNDVLKASY
CCCCCCCHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEE
EISLSEGLGSGGSRFITGSRPIHQLLETQLAEWLNQEKVLLFPSGFQANIAAVQSLADRN
EEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCC
SIVIADKLIHNSLLVGVKASGSKLVRFVHNDLKDLENKILKFNSTQKSILIIVESLYSME
CEEEEHHHHHCEEEEEEECCCHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHCC
GSIAPLKEIAGICKKYNVKLLVDEAHALGILGHEGKGLSFDVSDEITMLTGTFGKSFGSG
CCCCCHHHHHHHHHHCCEEEEEECCCEEEEEECCCCCCEEECCCCEEEEEECCCCCCCCC
GAFIACNSIIGEYLIQTSGAFRYTTALSPALSAGALKSLQKIKNNKKWGIDLLISSEKWK
CCEEEEHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHH
KEIIRNISYPVKGDSQILSIIVGQEKKAILLQKHLEKNGFLAIAIRPPTVPVNKSRIRLT
HHHHHHCCCCCCCCHHEEEEEECCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEE
IRRDLNLEILENFTSVLKAFK
EECCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKVKIPKNRLRKLETFTLGHKPYELQSLNPEKVKKNLIDLCSNDYFGLSRDNDVLKASY
CCCCCCCHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEE
EISLSEGLGSGGSRFITGSRPIHQLLETQLAEWLNQEKVLLFPSGFQANIAAVQSLADRN
EEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCC
SIVIADKLIHNSLLVGVKASGSKLVRFVHNDLKDLENKILKFNSTQKSILIIVESLYSME
CEEEEHHHHHCEEEEEEECCCHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHCC
GSIAPLKEIAGICKKYNVKLLVDEAHALGILGHEGKGLSFDVSDEITMLTGTFGKSFGSG
CCCCCHHHHHHHHHHCCEEEEEECCCEEEEEECCCCCCEEECCCCEEEEEECCCCCCCCC
GAFIACNSIIGEYLIQTSGAFRYTTALSPALSAGALKSLQKIKNNKKWGIDLLISSEKWK
CCEEEEHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHH
KEIIRNISYPVKGDSQILSIIVGQEKKAILLQKHLEKNGFLAIAIRPPTVPVNKSRIRLT
HHHHHHCCCCCCCCHHEEEEEECCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEE
IRRDLNLEILENFTSVLKAFK
EECCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA