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The map label for this gene is ilvC [H]

Identifier: 123966709

GI number: 123966709

Start: 1313324

End: 1314313

Strand: Direct

Name: ilvC [H]

Synonym: P9515_14761

Alternate gene names: 123966709

Gene position: 1313324-1314313 (Clockwise)

Preceding gene: 123966708

Following gene: 123966710

Centisome position: 77.07

GC content: 36.46

Gene sequence:

>990_bases
ATGACACAACTCTTTTATGACACGGATGCTGACTTAAGTCTATTAAATAATAAAACAATTGCAATAATAGGTTATGGTTC
ACAAGGTCATGCACATGCTTTAAATCTTAAAGACAGTGGAATGGATGTAATTGTTGGTTTATATAAAGGTAGTAAATCAG
AAAGCAAAGCTATTAATGATGGTTTAGAAGTATTTACTGTTTCTGAGGCTTGTGAAAAAGCTGATTGGATTATGATATTG
CTTCCCGATGAGTTCCAAAAAGATGTTTATATTAAAGAGATCGAACCAAATTTAAAAGAGGGGAAGATATTAAGTTTTGC
TCATGGATTTAATATTAGATTCGGCCTCATAAAACCACCCAGTTTTGTCGATGTTGTGATGATTGCGCCAAAAGGCCCCG
GTCACACTGTTAGATGGGAATATCAGAATGGCCAGGGAGTGCCTGCTCTTTTCGCAGTAGAACAGGATTATTCGAGCAAT
GCGAGATCATTAGCCATGGCTTATGCCAAGGGTATTGGAGGTACAAGAGCTGGGATTCTTGAAACAAATTTCAAAGAAGA
AACTGAAACTGATCTATTTGGTGAACAAGCTGTTCTCTGTGGTGGTCTATCAGAACTTGTTAAGTCAGGATTTGAAACTC
TCGTTGAGGCAGGATATCAACCCGAACTTGCATATTTCGAGTGTTTACACGAAGTGAAGCTAATTGTAGATCTAATGGTC
AAGGGAGGTTTATCACAAATGAGAGATTCAATTTCAAATACCGCAGAATATGGTGATTATGTAAGCGGTAAAAGACTTAT
AAATAGTGATACGAAAAAAGAAATGCAGAAAATATTAAAAGATATCCAAGATGGCACTTTCGCTAAGAACTTTGTAGAAG
AGTGTGATAGGGATAAACCATTAATGACTAAATTAAGAGCAGAAAATTCGCAACATGAGATAGAAAAAGTTGGGAAAGGT
CTTCGTGCAATGTTCAGTTGGCTGAAATAA

Upstream 100 bases:

>100_bases
ATAATATTTAAATATTAATTTTTAAATGAGCAATTATATGGTTTATTTACACATTTAATGTCTAAAATAATAACTATCAA
AAGTTAAGAAACTACAACTA

Downstream 100 bases:

>100_bases
ATTTATTTTATATATTTATTGGATCGATTGGTTTTGATCTTTTAATTGGTGATCCAAGATTTATCATCCATCCTGTTCAA
ATAATAGGGTTCTATATTAA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MTQLFYDTDADLSLLNNKTIAIIGYGSQGHAHALNLKDSGMDVIVGLYKGSKSESKAINDGLEVFTVSEACEKADWIMIL
LPDEFQKDVYIKEIEPNLKEGKILSFAHGFNIRFGLIKPPSFVDVVMIAPKGPGHTVRWEYQNGQGVPALFAVEQDYSSN
ARSLAMAYAKGIGGTRAGILETNFKEETETDLFGEQAVLCGGLSELVKSGFETLVEAGYQPELAYFECLHEVKLIVDLMV
KGGLSQMRDSISNTAEYGDYVSGKRLINSDTKKEMQKILKDIQDGTFAKNFVEECDRDKPLMTKLRAENSQHEIEKVGKG
LRAMFSWLK

Sequences:

>Translated_329_residues
MTQLFYDTDADLSLLNNKTIAIIGYGSQGHAHALNLKDSGMDVIVGLYKGSKSESKAINDGLEVFTVSEACEKADWIMIL
LPDEFQKDVYIKEIEPNLKEGKILSFAHGFNIRFGLIKPPSFVDVVMIAPKGPGHTVRWEYQNGQGVPALFAVEQDYSSN
ARSLAMAYAKGIGGTRAGILETNFKEETETDLFGEQAVLCGGLSELVKSGFETLVEAGYQPELAYFECLHEVKLIVDLMV
KGGLSQMRDSISNTAEYGDYVSGKRLINSDTKKEMQKILKDIQDGTFAKNFVEECDRDKPLMTKLRAENSQHEIEKVGKG
LRAMFSWLK
>Mature_328_residues
TQLFYDTDADLSLLNNKTIAIIGYGSQGHAHALNLKDSGMDVIVGLYKGSKSESKAINDGLEVFTVSEACEKADWIMILL
PDEFQKDVYIKEIEPNLKEGKILSFAHGFNIRFGLIKPPSFVDVVMIAPKGPGHTVRWEYQNGQGVPALFAVEQDYSSNA
RSLAMAYAKGIGGTRAGILETNFKEETETDLFGEQAVLCGGLSELVKSGFETLVEAGYQPELAYFECLHEVKLIVDLMVK
GGLSQMRDSISNTAEYGDYVSGKRLINSDTKKEMQKILKDIQDGTFAKNFVEECDRDKPLMTKLRAENSQHEIEKVGKGL
RAMFSWLK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=301, Percent_Identity=36.8770764119601, Blast_Score=159, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6323387, Length=324, Percent_Identity=33.9506172839506, Blast_Score=150, Evalue=3e-37,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 36504; Mature: 36373

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLFYDTDADLSLLNNKTIAIIGYGSQGHAHALNLKDSGMDVIVGLYKGSKSESKAIND
CCEEEECCCCCCEEECCCEEEEEEECCCCCEEEECCCCCCCEEEEEEECCCCCHHHHHHC
GLEVFTVSEACEKADWIMILLPDEFQKDVYIKEIEPNLKEGKILSFAHGFNIRFGLIKPP
CCCEEEHHHHHHCCCEEEEEECCCCCCCEEEEECCCCCCCCCEEEEECCCEEEEEEECCC
SFVDVVMIAPKGPGHTVRWEYQNGQGVPALFAVEQDYSSNARSLAMAYAKGIGGTRAGIL
CCEEEEEEECCCCCCCEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCEE
ETNFKEETETDLFGEQAVLCGGLSELVKSGFETLVEAGYQPELAYFECLHEVKLIVDLMV
ECCCCCHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KGGLSQMRDSISNTAEYGDYVSGKRLINSDTKKEMQKILKDIQDGTFAKNFVEECDRDKP
HCCHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCH
LMTKLRAENSQHEIEKVGKGLRAMFSWLK
HHHHHHCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQLFYDTDADLSLLNNKTIAIIGYGSQGHAHALNLKDSGMDVIVGLYKGSKSESKAIND
CEEEECCCCCCEEECCCEEEEEEECCCCCEEEECCCCCCCEEEEEEECCCCCHHHHHHC
GLEVFTVSEACEKADWIMILLPDEFQKDVYIKEIEPNLKEGKILSFAHGFNIRFGLIKPP
CCCEEEHHHHHHCCCEEEEEECCCCCCCEEEEECCCCCCCCCEEEEECCCEEEEEEECCC
SFVDVVMIAPKGPGHTVRWEYQNGQGVPALFAVEQDYSSNARSLAMAYAKGIGGTRAGIL
CCEEEEEEECCCCCCCEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCEE
ETNFKEETETDLFGEQAVLCGGLSELVKSGFETLVEAGYQPELAYFECLHEVKLIVDLMV
ECCCCCHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KGGLSQMRDSISNTAEYGDYVSGKRLINSDTKKEMQKILKDIQDGTFAKNFVEECDRDKP
HCCHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCH
LMTKLRAENSQHEIEKVGKGLRAMFSWLK
HHHHHHCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA