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The map label for this gene is argD [H]

Identifier: 123966695

GI number: 123966695

Start: 1298206

End: 1299459

Strand: Direct

Name: argD [H]

Synonym: P9515_14621

Alternate gene names: 123966695

Gene position: 1298206-1299459 (Clockwise)

Preceding gene: 123966694

Following gene: 123966696

Centisome position: 76.18

GC content: 35.81

Gene sequence:

>1254_bases
GTGGAATTGGTAGACGCACCGCACTCAAAATGCGGCACCTTCGGGTTTGTCGGTTCAAGTCCGACCGCTCCCACTTTAAT
GAATACCTATACAAGGTTTAATATATCTTTTAAAAAGGGCGAAGGATGCTGGCTTTGGGACACAAGAGGTAAGAAATATC
TTGATGCAGTTGCTGGGATAGCAACATGTAGTCTTGGGCATAGCGATAGAATCCTTAGAAAAAAGTTAGTAGCTCAACTA
AAAAAACTACAACATATTTCTAATCTCTATAAAATTGAAGAGCAAGAAGAATTAAGTAAATATCTTACTAAGCAGAGTTG
TGCAGAAAGTGTTTTTTTCTGTAACAGTGGAGCCGAGGCGAATGAGTCAGCAATTAAATTAATTAAAAAATTCGGCAACA
AAATATATACAGGTAAAGAGACTTTTATTCTTGCAGCTGAGTCAAGTTTTCATGGAAGAACACTCGCGACTTTAAGTGCA
ACTGGTCAGCCCAAATACCAAAAAGGTTTTGAGCCAATGGTAAAAGGATTTAAGTTTTTTAAATATAACGATATTGCTTC
AGTGAAAAAATTATTTGATGAATGTCAAAAAAACGACCAAAAAGTTTCCGGAGTTTTAATTGAACCTATCCAAGGAGAAG
GAGGAGTAATACCTGGAGATAAATTATTTTTCAAAGATTTAAGAAAACTTTGCACTCAAAATAATTCTCTTTTAATTCTC
GATGAAGTTCAGAGTGGGGTAGGAAGAACTGGCAAAATGTGGGGGTATGAGACTCTAGGAATCGAACCTGATGGATTCAC
ACTAGCCAAAGGATTAGGAGGAGGTCATGCCATTGGTGCTCTCTTAGTAAAAGAAAAAGCTAACATTTTCTCTCCCGGGG
ATCATGCAAGTACCTTTGGGGGCAATCCCTTTGCTTGTAGAGCTGCTCTGACCGTTTTGGAAGAAATTACACGACGTAAA
ATTCTTAATAATGTTATTTCAAGAGGTAACCAATTAAATGAAGGGTTTATAAAACTTTCAGATAAATTTCCTAATATTAT
TAATGGGATTAGAGGAATTGGATTAATACAAGGTCTAGTTATAAATAATTCATATACTGATCCAAAAACGATTACCCTCA
AAGCTTTTGATAAAGGTTTACTTTTGGTACCCGCCGGAGGAAATGTGGTTAGGTTTGTTCCACCATTGATAATTTCGCGA
AATGAAATCAAAATACTTCTTAAGAAGTTGAATTTAATTTTTGAAGAACTGTAA

Upstream 100 bases:

>100_bases
ACAAACAAGATAAATTTGTATAAAGCAGAGAAAGTAGTCAATAAATTAAATTTTGTTATAATAAAAAAGTTGTTTATTCT
TCAAAAGCCTTGGGAGCGTG

Downstream 100 bases:

>100_bases
GCTTTAGAGGATTTGAAAAAAGAAAACTTTAAGAATTTTGATTTGCTTTCACCTAAATTTGAGAGACAAAATATTCACTT
AGGATTATCAAGAATTAAAA

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MELVDAPHSKCGTFGFVGSSPTAPTLMNTYTRFNISFKKGEGCWLWDTRGKKYLDAVAGIATCSLGHSDRILRKKLVAQL
KKLQHISNLYKIEEQEELSKYLTKQSCAESVFFCNSGAEANESAIKLIKKFGNKIYTGKETFILAAESSFHGRTLATLSA
TGQPKYQKGFEPMVKGFKFFKYNDIASVKKLFDECQKNDQKVSGVLIEPIQGEGGVIPGDKLFFKDLRKLCTQNNSLLIL
DEVQSGVGRTGKMWGYETLGIEPDGFTLAKGLGGGHAIGALLVKEKANIFSPGDHASTFGGNPFACRAALTVLEEITRRK
ILNNVISRGNQLNEGFIKLSDKFPNIINGIRGIGLIQGLVINNSYTDPKTITLKAFDKGLLLVPAGGNVVRFVPPLIISR
NEIKILLKKLNLIFEEL

Sequences:

>Translated_417_residues
MELVDAPHSKCGTFGFVGSSPTAPTLMNTYTRFNISFKKGEGCWLWDTRGKKYLDAVAGIATCSLGHSDRILRKKLVAQL
KKLQHISNLYKIEEQEELSKYLTKQSCAESVFFCNSGAEANESAIKLIKKFGNKIYTGKETFILAAESSFHGRTLATLSA
TGQPKYQKGFEPMVKGFKFFKYNDIASVKKLFDECQKNDQKVSGVLIEPIQGEGGVIPGDKLFFKDLRKLCTQNNSLLIL
DEVQSGVGRTGKMWGYETLGIEPDGFTLAKGLGGGHAIGALLVKEKANIFSPGDHASTFGGNPFACRAALTVLEEITRRK
ILNNVISRGNQLNEGFIKLSDKFPNIINGIRGIGLIQGLVINNSYTDPKTITLKAFDKGLLLVPAGGNVVRFVPPLIISR
NEIKILLKKLNLIFEEL
>Mature_417_residues
MELVDAPHSKCGTFGFVGSSPTAPTLMNTYTRFNISFKKGEGCWLWDTRGKKYLDAVAGIATCSLGHSDRILRKKLVAQL
KKLQHISNLYKIEEQEELSKYLTKQSCAESVFFCNSGAEANESAIKLIKKFGNKIYTGKETFILAAESSFHGRTLATLSA
TGQPKYQKGFEPMVKGFKFFKYNDIASVKKLFDECQKNDQKVSGVLIEPIQGEGGVIPGDKLFFKDLRKLCTQNNSLLIL
DEVQSGVGRTGKMWGYETLGIEPDGFTLAKGLGGGHAIGALLVKEKANIFSPGDHASTFGGNPFACRAALTVLEEITRRK
ILNNVISRGNQLNEGFIKLSDKFPNIINGIRGIGLIQGLVINNSYTDPKTITLKAFDKGLLLVPAGGNVVRFVPPLIISR
NEIKILLKKLNLIFEEL

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=392, Percent_Identity=31.8877551020408, Blast_Score=224, Evalue=8e-59,
Organism=Homo sapiens, GI284507298, Length=305, Percent_Identity=33.7704918032787, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI13994255, Length=373, Percent_Identity=29.4906166219839, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI37574042, Length=418, Percent_Identity=27.9904306220096, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI226442705, Length=418, Percent_Identity=27.511961722488, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI226442709, Length=338, Percent_Identity=29.585798816568, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI24119277, Length=417, Percent_Identity=23.021582733813, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI188536080, Length=435, Percent_Identity=25.0574712643678, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI38679950, Length=435, Percent_Identity=25.0574712643678, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI38679946, Length=435, Percent_Identity=25.0574712643678, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1788044, Length=381, Percent_Identity=42.5196850393701, Blast_Score=304, Evalue=7e-84,
Organism=Escherichia coli, GI1789759, Length=367, Percent_Identity=37.6021798365123, Blast_Score=258, Evalue=6e-70,
Organism=Escherichia coli, GI145693181, Length=389, Percent_Identity=33.4190231362468, Blast_Score=215, Evalue=5e-57,
Organism=Escherichia coli, GI1789016, Length=406, Percent_Identity=31.5270935960591, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1787560, Length=407, Percent_Identity=30.2211302211302, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1786349, Length=331, Percent_Identity=27.7945619335347, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786991, Length=398, Percent_Identity=26.1306532663317, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25144271, Length=381, Percent_Identity=34.9081364829396, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI25144274, Length=273, Percent_Identity=35.8974358974359, Blast_Score=175, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI32564660, Length=433, Percent_Identity=30.0230946882217, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71992977, Length=414, Percent_Identity=24.8792270531401, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17541228, Length=441, Percent_Identity=25.8503401360544, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71981843, Length=166, Percent_Identity=33.1325301204819, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324432, Length=385, Percent_Identity=39.2207792207792, Blast_Score=247, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6323470, Length=397, Percent_Identity=32.4937027707809, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6324386, Length=450, Percent_Identity=24.6666666666667, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321456, Length=372, Percent_Identity=25.5376344086022, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21357415, Length=381, Percent_Identity=33.0708661417323, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI28574759, Length=440, Percent_Identity=30, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI161085790, Length=439, Percent_Identity=29.6127562642369, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI281366494, Length=436, Percent_Identity=27.7522935779816, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24667139, Length=436, Percent_Identity=27.7522935779816, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24667143, Length=436, Percent_Identity=27.7522935779816, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21356575, Length=399, Percent_Identity=26.8170426065163, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 45824; Mature: 45824

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELVDAPHSKCGTFGFVGSSPTAPTLMNTYTRFNISFKKGEGCWLWDTRGKKYLDAVAGI
CCCCCCCCCCCCCEECCCCCCCCCHHHHHHEEEEEEEECCCCEEEECCCCHHHHHHHHHH
ATCSLGHSDRILRKKLVAQLKKLQHISNLYKIEEQEELSKYLTKQSCAESVFFCNSGAEA
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEECCCCCC
NESAIKLIKKFGNKIYTGKETFILAAESSFHGRTLATLSATGQPKYQKGFEPMVKGFKFF
CHHHHHHHHHHCCEEECCCCEEEEEECCCCCCCEEEEEECCCCCHHHCCHHHHHHHHHEE
KYNDIASVKKLFDECQKNDQKVSGVLIEPIQGEGGVIPGDKLFFKDLRKLCTQNNSLLIL
ECCCHHHHHHHHHHHHCCCCEECCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEE
DEVQSGVGRTGKMWGYETLGIEPDGFTLAKGLGGGHAIGALLVKEKANIFSPGDHASTFG
ECHHCCCCCCCCCCCCEECCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCC
GNPFACRAALTVLEEITRRKILNNVISRGNQLNEGFIKLSDKFPNIINGIRGIGLIQGLV
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHEEE
INNSYTDPKTITLKAFDKGLLLVPAGGNVVRFVPPLIISRNEIKILLKKLNLIFEEL
EECCCCCCCEEEEEEECCCEEEEECCCCEEEECCCHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MELVDAPHSKCGTFGFVGSSPTAPTLMNTYTRFNISFKKGEGCWLWDTRGKKYLDAVAGI
CCCCCCCCCCCCCEECCCCCCCCCHHHHHHEEEEEEEECCCCEEEECCCCHHHHHHHHHH
ATCSLGHSDRILRKKLVAQLKKLQHISNLYKIEEQEELSKYLTKQSCAESVFFCNSGAEA
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEECCCCCC
NESAIKLIKKFGNKIYTGKETFILAAESSFHGRTLATLSATGQPKYQKGFEPMVKGFKFF
CHHHHHHHHHHCCEEECCCCEEEEEECCCCCCCEEEEEECCCCCHHHCCHHHHHHHHHEE
KYNDIASVKKLFDECQKNDQKVSGVLIEPIQGEGGVIPGDKLFFKDLRKLCTQNNSLLIL
ECCCHHHHHHHHHHHHCCCCEECCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEE
DEVQSGVGRTGKMWGYETLGIEPDGFTLAKGLGGGHAIGALLVKEKANIFSPGDHASTFG
ECHHCCCCCCCCCCCCEECCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCC
GNPFACRAALTVLEEITRRKILNNVISRGNQLNEGFIKLSDKFPNIINGIRGIGLIQGLV
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHEEE
INNSYTDPKTITLKAFDKGLLLVPAGGNVVRFVPPLIISRNEIKILLKKLNLIFEEL
EECCCCCCCEEEEEEECCCEEEEECCCCEEEECCCHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]