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The map label for this gene is trpC

Identifier: 123966691

GI number: 123966691

Start: 1292912

End: 1293799

Strand: Reverse

Name: trpC

Synonym: P9515_14581

Alternate gene names: 123966691

Gene position: 1293799-1292912 (Counterclockwise)

Preceding gene: 123966692

Following gene: 123966690

Centisome position: 75.92

GC content: 30.07

Gene sequence:

>888_bases
ATGGAAATAAGACGTAGGCCACCAAATCCAACAGTTAGGGTAGAAAATTTAGAGTATGCCGTTCCTCATAGAGAGGCAAA
AGCAAAAAATATTCTTGAAGAAATTGTTTGGTACAAAGATATTGAAATCAAGAATTTCAAGAAAATAGTCTCACTTGAAG
ATCTGATAAAAAAGCTTGATAAACTTCCCCCAACAAAAGATTTTGGTAAAAGTATTTTACAATCCAAAATCAAACCGGGA
GTAATTGCTGAGATTAAAAAAGCTAGTCCTAGTAAAGGGGTGATTAGAGAAGACTTTAGACCAAATGAAATTGCTTTTAG
TTATGAAAGATCTGGGGCCTCATGTATCTCTGTGCTTACTGATAAAAGATTTTTTCAAGGGAGTTATGAAATACTTCAAG
ATGTCCGAGGAGCTACTAATCTGCCTTTGCTCTGCAAAGATTTTATTATTTCTGCTTATCAAATATATAAAGCGAGAGTA
TCTGGTGCTGATGCAATATTATTAATTGCCGCAATATTAAGCGATGATGATTTATTTTATTTGAAGAAAATTGCAGACAA
TTTAGGGATGAGTGTTTTAGTTGAAGTTCATGATGAGCAAGAACTTAAAAGAATATTGAGTTTTAAATTATTTGATTTAA
TAGGAATTAATAATAGAGACTTGAAGACTTTTAAAACTGATCTAAAAACATCAATAGAAATGATGAGTAAATATTCCGAT
ATATTTTCAAAACATAATATTATTCCTATTAGTGAATCTGGAATAAACAACTCTGAAGAGTTAAAAAAGCTTGTTTCAAT
TGGAATTAAGGGAGTTTTAATTGGAGAAAGGTTTATGAGGGAATGTGATATTGAACACTCTTTTAAAAAATTATTTAAAT
CAATTTAA

Upstream 100 bases:

>100_bases
ATTCAGCTAGCTTCTGAAGTACATACTCACCCTACTCTTAGTGAAGTCGTTGAGGTCGCCTATAAACAGGCAGCTTCTCA
AGTAAAGTAATTGATTTTTT

Downstream 100 bases:

>100_bases
TTTAGGGTTGATATTTGTGCTATAAATCTGAGTATTATAAGGTTGTATTTTATTTATAAATGCAGGTTGTAATAGTAACT
GGAATCATTGCTGGATTTGT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MEIRRRPPNPTVRVENLEYAVPHREAKAKNILEEIVWYKDIEIKNFKKIVSLEDLIKKLDKLPPTKDFGKSILQSKIKPG
VIAEIKKASPSKGVIREDFRPNEIAFSYERSGASCISVLTDKRFFQGSYEILQDVRGATNLPLLCKDFIISAYQIYKARV
SGADAILLIAAILSDDDLFYLKKIADNLGMSVLVEVHDEQELKRILSFKLFDLIGINNRDLKTFKTDLKTSIEMMSKYSD
IFSKHNIIPISESGINNSEELKKLVSIGIKGVLIGERFMRECDIEHSFKKLFKSI

Sequences:

>Translated_295_residues
MEIRRRPPNPTVRVENLEYAVPHREAKAKNILEEIVWYKDIEIKNFKKIVSLEDLIKKLDKLPPTKDFGKSILQSKIKPG
VIAEIKKASPSKGVIREDFRPNEIAFSYERSGASCISVLTDKRFFQGSYEILQDVRGATNLPLLCKDFIISAYQIYKARV
SGADAILLIAAILSDDDLFYLKKIADNLGMSVLVEVHDEQELKRILSFKLFDLIGINNRDLKTFKTDLKTSIEMMSKYSD
IFSKHNIIPISESGINNSEELKKLVSIGIKGVLIGERFMRECDIEHSFKKLFKSI
>Mature_295_residues
MEIRRRPPNPTVRVENLEYAVPHREAKAKNILEEIVWYKDIEIKNFKKIVSLEDLIKKLDKLPPTKDFGKSILQSKIKPG
VIAEIKKASPSKGVIREDFRPNEIAFSYERSGASCISVLTDKRFFQGSYEILQDVRGATNLPLLCKDFIISAYQIYKARV
SGADAILLIAAILSDDDLFYLKKIADNLGMSVLVEVHDEQELKRILSFKLFDLIGINNRDLKTFKTDLKTSIEMMSKYSD
IFSKHNIIPISESGINNSEELKKLVSIGIKGVLIGERFMRECDIEHSFKKLFKSI

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=264, Percent_Identity=39.0151515151515, Blast_Score=163, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6322638, Length=275, Percent_Identity=34.5454545454545, Blast_Score=140, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_PROM5 (A2BY04)

Other databases:

- EMBL:   CP000552
- RefSeq:   YP_001011772.1
- ProteinModelPortal:   A2BY04
- SMR:   A2BY04
- STRING:   A2BY04
- GeneID:   4720103
- GenomeReviews:   CP000552_GR
- KEGG:   pmc:P9515_14581
- eggNOG:   COG0134
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- ProtClustDB:   PRK00278
- BioCyc:   PMAR167542:P9515ORF_1522-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 33702; Mature: 33702

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIRRRPPNPTVRVENLEYAVPHREAKAKNILEEIVWYKDIEIKNFKKIVSLEDLIKKLD
CCCCCCCCCCCEEEECCEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
KLPPTKDFGKSILQSKIKPGVIAEIKKASPSKGVIREDFRPNEIAFSYERSGASCISVLT
CCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHCCCCCCCEEEEECCCCHHHHHHHH
DKRFFQGSYEILQDVRGATNLPLLCKDFIISAYQIYKARVSGADAILLIAAILSDDDLFY
HHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHH
LKKIADNLGMSVLVEVHDEQELKRILSFKLFDLIGINNRDLKTFKTDLKTSIEMMSKYSD
HHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
IFSKHNIIPISESGINNSEELKKLVSIGIKGVLIGERFMRECDIEHSFKKLFKSI
HHHCCCCEECCCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure
MEIRRRPPNPTVRVENLEYAVPHREAKAKNILEEIVWYKDIEIKNFKKIVSLEDLIKKLD
CCCCCCCCCCCEEEECCEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
KLPPTKDFGKSILQSKIKPGVIAEIKKASPSKGVIREDFRPNEIAFSYERSGASCISVLT
CCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHCCCCCCCEEEEECCCCHHHHHHHH
DKRFFQGSYEILQDVRGATNLPLLCKDFIISAYQIYKARVSGADAILLIAAILSDDDLFY
HHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHH
LKKIADNLGMSVLVEVHDEQELKRILSFKLFDLIGINNRDLKTFKTDLKTSIEMMSKYSD
HHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
IFSKHNIIPISESGINNSEELKKLVSIGIKGVLIGERFMRECDIEHSFKKLFKSI
HHHCCCCEECCCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA