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The map label for this gene is ugd [H]

Identifier: 123966654

GI number: 123966654

Start: 1258958

End: 1260355

Strand: Reverse

Name: ugd [H]

Synonym: P9515_14211

Alternate gene names: 123966654

Gene position: 1260355-1258958 (Counterclockwise)

Preceding gene: 123966656

Following gene: 123966652

Centisome position: 73.96

GC content: 30.33

Gene sequence:

>1398_bases
ATGAATATTACAAAAACTAGTAATATTAAAAATATCTGTTGTATTGGAGCTGGTTATGTTGGAGGTCCAACAATGGCAGT
AATTGCAGCGAATTGTCCAGATTTAATAATCAATGTAGTAGATATTAATATTGATAGGATAAATTCTTGGAATATTGATG
ATTTATCTAAGTTACCAGTTTTTGAACCAGGATTGAAGGATATTGTTGAAAAGTGTAGAGGTAAAAATCTATTTTTCTCA
TCAAATGTTGAAGAAAATATCGCAAATGCAGATATTATTTTTATTTCAGTTAATACTCCTACAAAAACTAAGGGTATAGG
AGCTGGTTATGCGAGTGACTTGAAGTGGATTGAATCTTCAACAAGGACAATAGCGAAATTTGCAAGAAATCATACGATTG
TTGTAGAAAAAAGTACTTTACCTGTTAAAACTGCTGAAACAATAAAAAATATTTTGCTTTCATCAGATGAATCGTTAGAT
AAAAACGTAAAAAAAACTTTTTCTATCTTATCAAACCCCGAATTTCTTGCAGAGGGATCAGCAATAAATGATCTTCAGAA
TCCTGATAGAGTTTTGATTGGAGGGGATGATAATTATGCTATTAATCTGCTGGTAAATATATATGAGAAATGGGTTGATA
CAAAAAAAATTATCACTACAAACTTATGGAGTTCTGAATTATCCAAATTAGTAGCAAATGCTTTTTTGGCCCAGAGAATA
TCTTCTGTTAATTCTATTTCTGCTCTATGCGAATCAACTGGAGCTAATATTCAAGAGGTAAAAGAGGCTATTGGAAGTGA
TACTAGAATTGGAAATAAGTTTCTTAATGCAGGTCCAGGCTTTGGAGGGAGCTGCTTTAAAAAGGATATTTTAAACCTTG
TTTATTTATGCAGATATTATGGACTCAATGAGGTTGCTGCATATTGGGAGCAAATAGTTCAAATTAATTTATGGCAACAA
AAAAGAATATCTGCATTAGTTATAAAGAATTTATTTGGTACTCTTTCAAATAAAAAATTAGTAATATTAGGATTTTCATT
TAAAGCCAATACAAATGATACGAGAGAGTCTCCTAGTATTAATATCTCTAAAGAGTTTTTAAAGGAAGGAGCAGAATTAA
ATTTTTATGACCCTAAAGTTGAAAAAAAGCAAATTTTAAGAGAATTTGATGATTTTAAAGACTCAAAAATATCAGTATCT
AAATCAGCTTTAGGAGCTGCTGAAGGCGCAGATGCAGTTTTAGTAATGACTGATTGGGAAGACTTTAAATATTTAGATTG
GATTAGTATTTATAAAGTCATGAGAAAACCTGCATGGGTTTTTGATACTCGAATTTGCTTAAATCGAGAAGAAATAAGTA
ATATTGGGTTTAATATATGGACTTTGGGAAGGATATAA

Upstream 100 bases:

>100_bases
ATATTTTTGTAATTATTATTTTCTTCTCATGTATTTTAATATTAATGAAACTTCCTTATAATAAGTTGATATTTTTAGAA
AATTGTTTGTTTAGAATCAT

Downstream 100 bases:

>100_bases
TAATAAATAGACCTATAAATGAAGTTTAATAATTAAGGCATTTTTTTAAGTGAAATTTATCAAATGAAGAATGTTAAACA
ATCTCCAAATAAATAAACAA

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MNITKTSNIKNICCIGAGYVGGPTMAVIAANCPDLIINVVDINIDRINSWNIDDLSKLPVFEPGLKDIVEKCRGKNLFFS
SNVEENIANADIIFISVNTPTKTKGIGAGYASDLKWIESSTRTIAKFARNHTIVVEKSTLPVKTAETIKNILLSSDESLD
KNVKKTFSILSNPEFLAEGSAINDLQNPDRVLIGGDDNYAINLLVNIYEKWVDTKKIITTNLWSSELSKLVANAFLAQRI
SSVNSISALCESTGANIQEVKEAIGSDTRIGNKFLNAGPGFGGSCFKKDILNLVYLCRYYGLNEVAAYWEQIVQINLWQQ
KRISALVIKNLFGTLSNKKLVILGFSFKANTNDTRESPSINISKEFLKEGAELNFYDPKVEKKQILREFDDFKDSKISVS
KSALGAAEGADAVLVMTDWEDFKYLDWISIYKVMRKPAWVFDTRICLNREEISNIGFNIWTLGRI

Sequences:

>Translated_465_residues
MNITKTSNIKNICCIGAGYVGGPTMAVIAANCPDLIINVVDINIDRINSWNIDDLSKLPVFEPGLKDIVEKCRGKNLFFS
SNVEENIANADIIFISVNTPTKTKGIGAGYASDLKWIESSTRTIAKFARNHTIVVEKSTLPVKTAETIKNILLSSDESLD
KNVKKTFSILSNPEFLAEGSAINDLQNPDRVLIGGDDNYAINLLVNIYEKWVDTKKIITTNLWSSELSKLVANAFLAQRI
SSVNSISALCESTGANIQEVKEAIGSDTRIGNKFLNAGPGFGGSCFKKDILNLVYLCRYYGLNEVAAYWEQIVQINLWQQ
KRISALVIKNLFGTLSNKKLVILGFSFKANTNDTRESPSINISKEFLKEGAELNFYDPKVEKKQILREFDDFKDSKISVS
KSALGAAEGADAVLVMTDWEDFKYLDWISIYKVMRKPAWVFDTRICLNREEISNIGFNIWTLGRI
>Mature_465_residues
MNITKTSNIKNICCIGAGYVGGPTMAVIAANCPDLIINVVDINIDRINSWNIDDLSKLPVFEPGLKDIVEKCRGKNLFFS
SNVEENIANADIIFISVNTPTKTKGIGAGYASDLKWIESSTRTIAKFARNHTIVVEKSTLPVKTAETIKNILLSSDESLD
KNVKKTFSILSNPEFLAEGSAINDLQNPDRVLIGGDDNYAINLLVNIYEKWVDTKKIITTNLWSSELSKLVANAFLAQRI
SSVNSISALCESTGANIQEVKEAIGSDTRIGNKFLNAGPGFGGSCFKKDILNLVYLCRYYGLNEVAAYWEQIVQINLWQQ
KRISALVIKNLFGTLSNKKLVILGFSFKANTNDTRESPSINISKEFLKEGAELNFYDPKVEKKQILREFDDFKDSKISVS
KSALGAAEGADAVLVMTDWEDFKYLDWISIYKVMRKPAWVFDTRICLNREEISNIGFNIWTLGRI

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=471, Percent_Identity=54.7770700636943, Blast_Score=521, Evalue=1e-148,
Organism=Homo sapiens, GI296040438, Length=374, Percent_Identity=52.4064171122995, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI296040443, Length=333, Percent_Identity=53.1531531531532, Blast_Score=350, Evalue=2e-96,
Organism=Escherichia coli, GI48994968, Length=434, Percent_Identity=24.8847926267281, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI1788340, Length=388, Percent_Identity=25, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17560350, Length=464, Percent_Identity=52.801724137931, Blast_Score=499, Evalue=1e-141,
Organism=Drosophila melanogaster, GI17136908, Length=468, Percent_Identity=51.9230769230769, Blast_Score=498, Evalue=1e-141,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 51794; Mature: 51794

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNITKTSNIKNICCIGAGYVGGPTMAVIAANCPDLIINVVDINIDRINSWNIDDLSKLPV
CCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCHHEEEEEEEEEEECCCCCCCCCCCCCC
FEPGLKDIVEKCRGKNLFFSSNVEENIANADIIFISVNTPTKTKGIGAGYASDLKWIESS
CCCCHHHHHHHHCCCCEEEECCCHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHH
TRTIAKFARNHTIVVEKSTLPVKTAETIKNILLSSDESLDKNVKKTFSILSNPEFLAEGS
HHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHCCCC
AINDLQNPDRVLIGGDDNYAINLLVNIYEKWVDTKKIITTNLWSSELSKLVANAFLAQRI
CCCCCCCCCEEEEECCCCEEEHHHHHHHHHHCCCHHHEEECCCHHHHHHHHHHHHHHHHH
SSVNSISALCESTGANIQEVKEAIGSDTRIGNKFLNAGPGFGGSCFKKDILNLVYLCRYY
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
GLNEVAAYWEQIVQINLWQQKRISALVIKNLFGTLSNKKLVILGFSFKANTNDTRESPSI
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCC
NISKEFLKEGAELNFYDPKVEKKQILREFDDFKDSKISVSKSALGAAEGADAVLVMTDWE
CCCHHHHHCCCCEECCCCCHHHHHHHHHHHCCCCCCEEEHHHHCCCCCCCCEEEEEECCC
DFKYLDWISIYKVMRKPAWVFDTRICLNREEISNIGFNIWTLGRI
CCCHHHHHHHHHHHHCCCCEEHHHHHCCHHHHHHCCCEEEEECCC
>Mature Secondary Structure
MNITKTSNIKNICCIGAGYVGGPTMAVIAANCPDLIINVVDINIDRINSWNIDDLSKLPV
CCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCHHEEEEEEEEEEECCCCCCCCCCCCCC
FEPGLKDIVEKCRGKNLFFSSNVEENIANADIIFISVNTPTKTKGIGAGYASDLKWIESS
CCCCHHHHHHHHCCCCEEEECCCHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHH
TRTIAKFARNHTIVVEKSTLPVKTAETIKNILLSSDESLDKNVKKTFSILSNPEFLAEGS
HHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHCCCC
AINDLQNPDRVLIGGDDNYAINLLVNIYEKWVDTKKIITTNLWSSELSKLVANAFLAQRI
CCCCCCCCCEEEEECCCCEEEHHHHHHHHHHCCCHHHEEECCCHHHHHHHHHHHHHHHHH
SSVNSISALCESTGANIQEVKEAIGSDTRIGNKFLNAGPGFGGSCFKKDILNLVYLCRYY
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
GLNEVAAYWEQIVQINLWQQKRISALVIKNLFGTLSNKKLVILGFSFKANTNDTRESPSI
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCC
NISKEFLKEGAELNFYDPKVEKKQILREFDDFKDSKISVSKSALGAAEGADAVLVMTDWE
CCCHHHHHCCCCEECCCCCHHHHHHHHHHHCCCCCCEEEHHHHCCCCCCCCEEEEEECCC
DFKYLDWISIYKVMRKPAWVFDTRICLNREEISNIGFNIWTLGRI
CCCHHHHHHHHHHHHCCCCEEHHHHHCCHHHHHHCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]