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The map label for this gene is lexA [H]

Identifier: 123966656

GI number: 123966656

Start: 1261473

End: 1262105

Strand: Reverse

Name: lexA [H]

Synonym: P9515_14231

Alternate gene names: 123966656

Gene position: 1262105-1261473 (Counterclockwise)

Preceding gene: 123966657

Following gene: 123966654

Centisome position: 74.06

GC content: 34.44

Gene sequence:

>633_bases
GTGTATATTTGTTTTATGTTAAATACATCTCAAGATAATCTTACAGATGCTCAAAATGAGCTATATGAGTGGATAAAGGA
GTATATGAAAGATTTTCAACATAGTCCATCAATAAGACAGATGATGCAGGCGATGGGATTAAAATCTCCAGCTCCAATAC
AAAGCCGTTTGAAGCATTTGCAAGAAAAGGGTTACATATCATGGCAAGAAGGTAAAGCTAGAACACTTCAACTAATAGAT
GAAGTAATAGAGGGTATTCCTGTTATGGGATCCGTTGCGGCAGGAGGCTTAATTGAAACTTATTCTGATGTTAATGAAAA
CTTAGATATTTCTGAGGTCTTGAAAAAGAAAAATGTTTTTGCGTTAACTGTTAATGGAGATTCAATGATTGATGCATGTA
TCGCAGATGGTGATATGGTTTTGATGGAACCTATTATAGATTCAAACAGTCTAAGAAATGGAACGATTGTAAGTGCCATG
GTTCCTGGTCTAGGAACAACTTTAAAATATTTTTCTAAGAGAGGAGCTAAAATATTTCTTGAAGCGGCAAATCCAGCTTA
TGAACCAATTGAATTGAACCTAGACCAAGTTGTTTTTCAGGGAAAACTTTTAGCTGTTTGGAGAAAAATTTAA

Upstream 100 bases:

>100_bases
TCAAGCAGAAAATAGATTACATGCTCAACAAGCCCTTTTATCTTGTCTTCTCCACTAGGAATACTTGCAAACTAATCAAT
AAAAGGGTACAAATGTATTA

Downstream 100 bases:

>100_bases
ATTTTAAAAATCATAATTAACTAATCAAATTTTTTATAAATTATATTTAAACCATTCTATTGTTTTTAAAAGCCCTTCTT
TTAATTCAACTTTAGGCTCC

Product: SOS function regulatory protein, LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MYICFMLNTSQDNLTDAQNELYEWIKEYMKDFQHSPSIRQMMQAMGLKSPAPIQSRLKHLQEKGYISWQEGKARTLQLID
EVIEGIPVMGSVAAGGLIETYSDVNENLDISEVLKKKNVFALTVNGDSMIDACIADGDMVLMEPIIDSNSLRNGTIVSAM
VPGLGTTLKYFSKRGAKIFLEAANPAYEPIELNLDQVVFQGKLLAVWRKI

Sequences:

>Translated_210_residues
MYICFMLNTSQDNLTDAQNELYEWIKEYMKDFQHSPSIRQMMQAMGLKSPAPIQSRLKHLQEKGYISWQEGKARTLQLID
EVIEGIPVMGSVAAGGLIETYSDVNENLDISEVLKKKNVFALTVNGDSMIDACIADGDMVLMEPIIDSNSLRNGTIVSAM
VPGLGTTLKYFSKRGAKIFLEAANPAYEPIELNLDQVVFQGKLLAVWRKI
>Mature_210_residues
MYICFMLNTSQDNLTDAQNELYEWIKEYMKDFQHSPSIRQMMQAMGLKSPAPIQSRLKHLQEKGYISWQEGKARTLQLID
EVIEGIPVMGSVAAGGLIETYSDVNENLDISEVLKKKNVFALTVNGDSMIDACIADGDMVLMEPIIDSNSLRNGTIVSAM
VPGLGTTLKYFSKRGAKIFLEAANPAYEPIELNLDQVVFQGKLLAVWRKI

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=194, Percent_Identity=32.4742268041237, Blast_Score=93, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 23483; Mature: 23483

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYICFMLNTSQDNLTDAQNELYEWIKEYMKDFQHSPSIRQMMQAMGLKSPAPIQSRLKHL
CEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHH
QEKGYISWQEGKARTLQLIDEVIEGIPVMGSVAAGGLIETYSDVNENLDISEVLKKKNVF
HHCCCEEECCCCHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHCCCCCHHHHHHHCCEE
ALTVNGDSMIDACIADGDMVLMEPIIDSNSLRNGTIVSAMVPGLGTTLKYFSKRGAKIFL
EEEECCCHHHHHHHCCCCEEEEECCCCCCCCCCCEEHHHHHCCCHHHHHHHHCCCCEEEE
EAANPAYEPIELNLDQVVFQGKLLAVWRKI
EECCCCCCCEECCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYICFMLNTSQDNLTDAQNELYEWIKEYMKDFQHSPSIRQMMQAMGLKSPAPIQSRLKHL
CEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHH
QEKGYISWQEGKARTLQLIDEVIEGIPVMGSVAAGGLIETYSDVNENLDISEVLKKKNVF
HHCCCEEECCCCHHHHHHHHHHHCCCCCCCHHHCCCHHHHHHHHCCCCCHHHHHHHCCEE
ALTVNGDSMIDACIADGDMVLMEPIIDSNSLRNGTIVSAMVPGLGTTLKYFSKRGAKIFL
EEEECCCHHHHHHHCCCCEEEEECCCCCCCCCCCEEHHHHHCCCHHHHHHHHCCCCEEEE
EAANPAYEPIELNLDQVVFQGKLLAVWRKI
EECCCCCCCEECCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA