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The map label for this gene is guaB [C]

Identifier: 123966385

GI number: 123966385

Start: 1002210

End: 1003511

Strand: Reverse

Name: guaB [C]

Synonym: P9515_11521

Alternate gene names: 123966385

Gene position: 1003511-1002210 (Counterclockwise)

Preceding gene: 123966388

Following gene: 123966384

Centisome position: 58.89

GC content: 35.64

Gene sequence:

>1302_bases
ATGAATAAAATAATGCTAATAATTAATTTTCAAATACTCATATTTCTACAAAATTATAAAAAAACTCTTTTGTTTTTAAG
AAATTATTGGCTTATTACACCTTTAGTTGTTAACTTAATCAGAATAATTAAAAAAACCGTGAATATTGAAATTGGCTTAA
ACAAAAAAGTTAGAAGGGCTTACGGCATTGATGAAATTGCATTAGTGCCAGGAACAAGAACCCTAGATTACGAATTAACA
AATCCTTCTTGGTCAATTGGAAATATTGAAAGAGATATTCCAATTATCGCCAGTGCAATGGATAGTGTTGTTGATGTGAA
TACAGCTGTAGATCTCTCTAAATTAGGAGCTATTGGTGTTCTCAACATGGAAGGTATACAAACTAGGTATGAAAATCCAA
AGGAAATACTAAGTCAAATCTCCTCCGTAGGAAAAAATGAATTCGTACCTTTGATGCAAGAAATATATAAAGAACCCATC
AAGCAAGAACTTATTTTGCAAAGAATTAACGAAATTAAAGAAAAAGATGGAATAGCAGCATTAAGTGGAACACCGCAAGC
AGCTATCAAATTTAAAGAAACACTTGTGAAGTCGAAAATAGATTTATTCTTTCTTCAAGGTACTGTAGTTTCAACCGAAC
ATTTAGGTATGGAGGGGAATGAGACATTAAATATCAAAAGCTTATGTCAATCTTTAAAAGTACCAGTTGTTGCAGGTAAT
TGTGTAACTTATGAAGTTGCAGAACTTCTTATGAAATCAGGTGTTGCAGGTCTTATGGTGGGAATCGGCCCAGGAGCAGC
TTGCACTTCGAGAGGAGTATTGGGAATAGGAATCCCCCAAGCAACAGCAATCTCTGATTGTAGTTCAGCAAGAGATGATT
ATTTTCAAGAAACTGGTCGTTATGTCCCCATAATTGCTGATGGAGGAATTGTTACTGGTGGTGACATTTGCAAATGCATC
GCCTGTGGTGCTGACGCAGTTATGATTGGTTCTCCAATAGCTAAATCAACAAGTGCTCCGGGCAATGGATTTCATTGGGG
TATGGCCACACCAAGTCCTATATTACCTAGAGGTACAAGAATTGAAGTCGGCTCTACAGGTTCCTTAGAGAGAATATTAA
AAGGACCCGCAATACTTGATGATGGGACACACAATTTACTTGGAGCTATTAGGACATCAATGAGTACTCTTGGAGCTAAA
AATATCAAAGAGATGCAAAATGTTGATATTGTAATTGCGCCATCTCTTTTAACAGAGGGAAAAGTATATCAAAAAGCTCA
ACAGCTTGGAATGGGTAAATAA

Upstream 100 bases:

>100_bases
AATGATTCGCTCGTTATTTTCACTCAAACTAGAATCACCAGAATCAACAATATCGGACATATTAAAAACCTTTATTTAAT
AATAATCCCTCATTGTCAGA

Downstream 100 bases:

>100_bases
TATAAAATCTTATCTCCTAAAATATAAAAAATTTCTCATTAGGAGTTATCATTAAATTATGGGGGAAACCCCATACTCCT
CACACACTAAATCGCCCGAT

Product: inosine 5-monophosphate dehydrogenase

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MNKIMLIINFQILIFLQNYKKTLLFLRNYWLITPLVVNLIRIIKKTVNIEIGLNKKVRRAYGIDEIALVPGTRTLDYELT
NPSWSIGNIERDIPIIASAMDSVVDVNTAVDLSKLGAIGVLNMEGIQTRYENPKEILSQISSVGKNEFVPLMQEIYKEPI
KQELILQRINEIKEKDGIAALSGTPQAAIKFKETLVKSKIDLFFLQGTVVSTEHLGMEGNETLNIKSLCQSLKVPVVAGN
CVTYEVAELLMKSGVAGLMVGIGPGAACTSRGVLGIGIPQATAISDCSSARDDYFQETGRYVPIIADGGIVTGGDICKCI
ACGADAVMIGSPIAKSTSAPGNGFHWGMATPSPILPRGTRIEVGSTGSLERILKGPAILDDGTHNLLGAIRTSMSTLGAK
NIKEMQNVDIVIAPSLLTEGKVYQKAQQLGMGK

Sequences:

>Translated_433_residues
MNKIMLIINFQILIFLQNYKKTLLFLRNYWLITPLVVNLIRIIKKTVNIEIGLNKKVRRAYGIDEIALVPGTRTLDYELT
NPSWSIGNIERDIPIIASAMDSVVDVNTAVDLSKLGAIGVLNMEGIQTRYENPKEILSQISSVGKNEFVPLMQEIYKEPI
KQELILQRINEIKEKDGIAALSGTPQAAIKFKETLVKSKIDLFFLQGTVVSTEHLGMEGNETLNIKSLCQSLKVPVVAGN
CVTYEVAELLMKSGVAGLMVGIGPGAACTSRGVLGIGIPQATAISDCSSARDDYFQETGRYVPIIADGGIVTGGDICKCI
ACGADAVMIGSPIAKSTSAPGNGFHWGMATPSPILPRGTRIEVGSTGSLERILKGPAILDDGTHNLLGAIRTSMSTLGAK
NIKEMQNVDIVIAPSLLTEGKVYQKAQQLGMGK
>Mature_433_residues
MNKIMLIINFQILIFLQNYKKTLLFLRNYWLITPLVVNLIRIIKKTVNIEIGLNKKVRRAYGIDEIALVPGTRTLDYELT
NPSWSIGNIERDIPIIASAMDSVVDVNTAVDLSKLGAIGVLNMEGIQTRYENPKEILSQISSVGKNEFVPLMQEIYKEPI
KQELILQRINEIKEKDGIAALSGTPQAAIKFKETLVKSKIDLFFLQGTVVSTEHLGMEGNETLNIKSLCQSLKVPVVAGN
CVTYEVAELLMKSGVAGLMVGIGPGAACTSRGVLGIGIPQATAISDCSSARDDYFQETGRYVPIIADGGIVTGGDICKCI
ACGADAVMIGSPIAKSTSAPGNGFHWGMATPSPILPRGTRIEVGSTGSLERILKGPAILDDGTHNLLGAIRTSMSTLGAK
NIKEMQNVDIVIAPSLLTEGKVYQKAQQLGMGK

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. [C

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family [H]

Homologues:

Organism=Homo sapiens, GI50541954, Length=361, Percent_Identity=24.9307479224377, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI50541952, Length=361, Percent_Identity=24.9307479224377, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI50541948, Length=361, Percent_Identity=24.9307479224377, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI50541956, Length=363, Percent_Identity=24.7933884297521, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI156104880, Length=190, Percent_Identity=31.0526315789474, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI66933016, Length=109, Percent_Identity=45.8715596330275, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI217035150, Length=109, Percent_Identity=44.954128440367, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI217035146, Length=109, Percent_Identity=44.954128440367, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI217035152, Length=109, Percent_Identity=44.954128440367, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI217035148, Length=109, Percent_Identity=44.954128440367, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI34328930, Length=109, Percent_Identity=44.954128440367, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI34328928, Length=109, Percent_Identity=44.954128440367, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI156616279, Length=109, Percent_Identity=44.954128440367, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1786293, Length=184, Percent_Identity=33.695652173913, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788855, Length=199, Percent_Identity=32.1608040201005, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71994385, Length=142, Percent_Identity=39.4366197183099, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71994389, Length=142, Percent_Identity=39.4366197183099, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17560440, Length=183, Percent_Identity=31.6939890710383, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322012, Length=112, Percent_Identity=37.5, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323585, Length=110, Percent_Identity=35.4545454545455, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323464, Length=112, Percent_Identity=33.9285714285714, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI28571163, Length=171, Percent_Identity=35.672514619883, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24641071, Length=171, Percent_Identity=35.672514619883, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24641073, Length=171, Percent_Identity=35.672514619883, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001093
- InterPro:   IPR005992 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: 1.1.1.205

Molecular weight: Translated: 46672; Mature: 46672

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIMLIINFQILIFLQNYKKTLLFLRNYWLITPLVVNLIRIIKKTVNIEIGLNKKVRRA
CCEEEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCHHHHHH
YGIDEIALVPGTRTLDYELTNPSWSIGNIERDIPIIASAMDSVVDVNTAVDLSKLGAIGV
CCCCCEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEE
LNMEGIQTRYENPKEILSQISSVGKNEFVPLMQEIYKEPIKQELILQRINEIKEKDGIAA
EECHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
LSGTPQAAIKFKETLVKSKIDLFFLQGTVVSTEHLGMEGNETLNIKSLCQSLKVPVVAGN
ECCCCHHHHHHHHHHHHHHCEEEEEECEEEEHHHCCCCCCCEECHHHHHHHCCCCEEECC
CVTYEVAELLMKSGVAGLMVGIGPGAACTSRGVLGIGIPQATAISDCSSARDDYFQETGR
CHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCCC
YVPIIADGGIVTGGDICKCIACGADAVMIGSPIAKSTSAPGNGFHWGMATPSPILPRGTR
EEEEEECCCEEECHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCE
IEVGSTGSLERILKGPAILDDGTHNLLGAIRTSMSTLGAKNIKEMQNVDIVIAPSLLTEG
EEECCCCCHHHHHCCCCEECCCHHHHHHHHHHHHHHHCHHHHHHHHCCCEEEECCHHHCC
KVYQKAQQLGMGK
HHHHHHHHHCCCC
>Mature Secondary Structure
MNKIMLIINFQILIFLQNYKKTLLFLRNYWLITPLVVNLIRIIKKTVNIEIGLNKKVRRA
CCEEEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCHHHHHH
YGIDEIALVPGTRTLDYELTNPSWSIGNIERDIPIIASAMDSVVDVNTAVDLSKLGAIGV
CCCCCEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEE
LNMEGIQTRYENPKEILSQISSVGKNEFVPLMQEIYKEPIKQELILQRINEIKEKDGIAA
EECHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
LSGTPQAAIKFKETLVKSKIDLFFLQGTVVSTEHLGMEGNETLNIKSLCQSLKVPVVAGN
ECCCCHHHHHHHHHHHHHHCEEEEEECEEEEHHHCCCCCCCEECHHHHHHHCCCCEEECC
CVTYEVAELLMKSGVAGLMVGIGPGAACTSRGVLGIGIPQATAISDCSSARDDYFQETGR
CHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCCC
YVPIIADGGIVTGGDICKCIACGADAVMIGSPIAKSTSAPGNGFHWGMATPSPILPRGTR
EEEEEECCCEEECHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCE
IEVGSTGSLERILKGPAILDDGTHNLLGAIRTSMSTLGAKNIKEMQNVDIVIAPSLLTEG
EEECCCCCHHHHHCCCCEECCCHHHHHHHHHHHHHHHCHHHHHHHHCCCEEEECCHHHCC
KVYQKAQQLGMGK
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA