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The map label for this gene is trxA [H]

Identifier: 123966384

GI number: 123966384

Start: 1001678

End: 1002001

Strand: Reverse

Name: trxA [H]

Synonym: P9515_11511

Alternate gene names: 123966384

Gene position: 1002001-1001678 (Counterclockwise)

Preceding gene: 123966385

Following gene: 123966383

Centisome position: 58.8

GC content: 39.51

Gene sequence:

>324_bases
ATGTCATCAGCTCCCGCCGTAACTGATTCTTCATTTGACAAAGAAGTTTTGCAAAGTGATCTGCCAGTCCTAGTTGATTT
TTGGGCTCCATGGTGTGGTCCTTGCAGGATGGTCGCCCCTGTTGTTGAGGAAATTTCAAAAGACTTTGAAGGTAAAATCA
AGGTATTTAAGTTGAATACAGATGAGAATCCAAATGTTGCAAGTCAATATGGAATAAGAAGTATTCCGACCTTAATGATA
TTTAAAGGTGGTCAAAAGGTTGATACTGTCGTTGGAGCTGTTCCAAAAGCGACTCTTTCAAGTACCTTGTCTAAGCACTT
ATAA

Upstream 100 bases:

>100_bases
CTTTTTTTAAGACATTTTGTTACTTAAATGTGTTTATCTGTAATGAAATCATCACTTAAAAGAATAGCCTGCTAAATTTT
CTAAAAGGAATATCTAAATT

Downstream 100 bases:

>100_bases
ATTAAAGAATTGTCTAAAATAGGACTTATAGATTACGGAATGGGTAACATTCATTCCGTGACGAAAGCCTTAGAAAATCT
TGAAGAAGAAATACTTTTAA

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MSSAPAVTDSSFDKEVLQSDLPVLVDFWAPWCGPCRMVAPVVEEISKDFEGKIKVFKLNTDENPNVASQYGIRSIPTLMI
FKGGQKVDTVVGAVPKATLSSTLSKHL

Sequences:

>Translated_107_residues
MSSAPAVTDSSFDKEVLQSDLPVLVDFWAPWCGPCRMVAPVVEEISKDFEGKIKVFKLNTDENPNVASQYGIRSIPTLMI
FKGGQKVDTVVGAVPKATLSSTLSKHL
>Mature_106_residues
SSAPAVTDSSFDKEVLQSDLPVLVDFWAPWCGPCRMVAPVVEEISKDFEGKIKVFKLNTDENPNVASQYGIRSIPTLMIF
KGGQKVDTVVGAVPKATLSSTLSKHL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=94, Percent_Identity=35.1063829787234, Blast_Score=74, Evalue=2e-14,
Organism=Homo sapiens, GI5031973, Length=83, Percent_Identity=40.9638554216867, Blast_Score=73, Evalue=5e-14,
Organism=Homo sapiens, GI42794771, Length=85, Percent_Identity=37.6470588235294, Blast_Score=70, Evalue=5e-13,
Organism=Homo sapiens, GI224493972, Length=85, Percent_Identity=37.6470588235294, Blast_Score=69, Evalue=6e-13,
Organism=Homo sapiens, GI21361657, Length=102, Percent_Identity=30.3921568627451, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI87082331, Length=101, Percent_Identity=52.4752475247525, Blast_Score=125, Evalue=8e-31,
Organism=Escherichia coli, GI1788936, Length=100, Percent_Identity=52, Blast_Score=116, Evalue=3e-28,
Organism=Escherichia coli, GI87081747, Length=96, Percent_Identity=32.2916666666667, Blast_Score=68, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=88, Percent_Identity=38.6363636363636, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71998175, Length=99, Percent_Identity=35.3535353535354, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17507705, Length=84, Percent_Identity=35.7142857142857, Blast_Score=71, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17556044, Length=78, Percent_Identity=38.4615384615385, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17510299, Length=84, Percent_Identity=38.0952380952381, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI115532378, Length=74, Percent_Identity=37.8378378378378, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=72, Percent_Identity=38.8888888888889, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI115532380, Length=74, Percent_Identity=37.8378378378378, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=74, Percent_Identity=37.8378378378378, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=86, Percent_Identity=31.3953488372093, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71980562, Length=86, Percent_Identity=31.3953488372093, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=90, Percent_Identity=44.4444444444444, Blast_Score=84, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6321648, Length=88, Percent_Identity=42.0454545454545, Blast_Score=83, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6324862, Length=78, Percent_Identity=35.8974358974359, Blast_Score=65, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319925, Length=96, Percent_Identity=27.0833333333333, Blast_Score=64, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24639826, Length=103, Percent_Identity=33.0097087378641, Blast_Score=83, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28573567, Length=98, Percent_Identity=34.6938775510204, Blast_Score=79, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24664269, Length=99, Percent_Identity=38.3838383838384, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19921434, Length=83, Percent_Identity=38.5542168674699, Blast_Score=75, Evalue=6e-15,
Organism=Drosophila melanogaster, GI17648013, Length=74, Percent_Identity=41.8918918918919, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24583090, Length=74, Percent_Identity=41.8918918918919, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21358065, Length=81, Percent_Identity=39.5061728395062, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=26.8817204301075, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11611; Mature: 11480

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAPAVTDSSFDKEVLQSDLPVLVDFWAPWCGPCRMVAPVVEEISKDFEGKIKVFKLNT
CCCCCCCCCCCCHHHHHHCCCCEEEHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECC
DENPNVASQYGIRSIPTLMIFKGGQKVDTVVGAVPKATLSSTLSKHL
CCCCCHHHHCCCCCCCEEEEEECCCHHHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SSAPAVTDSSFDKEVLQSDLPVLVDFWAPWCGPCRMVAPVVEEISKDFEGKIKVFKLNT
CCCCCCCCCCCHHHHHHCCCCEEEHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECC
DENPNVASQYGIRSIPTLMIFKGGQKVDTVVGAVPKATLSSTLSKHL
CCCCCHHHHCCCCCCCEEEEEECCCHHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096973; 3926769 [H]