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The map label for this gene is gadB [H]

Identifier: 123966233

GI number: 123966233

Start: 894303

End: 895685

Strand: Reverse

Name: gadB [H]

Synonym: P9515_10001

Alternate gene names: 123966233

Gene position: 895685-894303 (Counterclockwise)

Preceding gene: 123966235

Following gene: 123966227

Centisome position: 52.56

GC content: 31.09

Gene sequence:

>1383_bases
ATGACTGTAGATTCAATTAATAAAAAAGAAAAACTATTCCCTACATATTCAGGAAGTAACGATAGTTTTATTGCTCTTCT
CAATAAAACCTCCAAAGTTATTTGCAATTGGTTTTCAAATGCTGAAAAATTAGGCCCTTTACCAATAGATAATAATTTCA
AGTGTTCAGTTCCAGATGAAACTGGAAAGTCAACAGATGTATTATTCTCTGAGATTGAAAGTCTCATTTATAGCTCTTTT
AATCCAGTACACCCAGGATCACTAGCACACCTCGATCCCCCACCTCTGATTATCTCTATTTTGGGAGATTTAATAGCTGC
TAGCTTAAATAATAATCTTCTCGCACATGAACTATCACCAAGTATTTCTCTTCTTGAGGAATCAATTTGTAAATGGTTCT
CAAAAAAAATTGGCTTTACTGAATCTTCTGGAGGGATAGCAGCAAGCGGTGGGACTTTAAGTAATTTAAATGCATTAGTG
GCCGCACGGAATCAAGCTGGACTTGCATCAGATCATAACGCTGTTTTTTTAATTAGTGAAGATGCCCATTCATCATTCAT
AAAATGTACCTTAATTATGGGTTTAGACAAAAACAATCTAATAAAGGTCAAAACAGATAATGATGGTTGTATGGATATTA
TTGATCTCAAAAAGATTATTGATAAATGTTATAGGGAAGGTAAAAAAATATTTTCCATAGTTGCTACTCTTGGCACAACA
ATACGTGGAGCAATAGATCCTATTGAGAAGATAAGCAGAATTTGTAAAGAGAGAAATATTTGGCTACATATTGATGGTTC
TATTGGTGGTATTTTTGCGATTACTAAAATCCCAATTAATGGAATTAGTCATGTTAATTTTGCTAATTCAATAACTATTA
ATCCTCAGAAAATTCTTGGGATTGCAAAAACTTCATCTATATTATTAGTCTCAGATATAGAAGTACTTAAGAATACCTTT
GCTACAGGATTACCTTATATTTCTTCTGAAGATAATTTTTTAAATAGAGGTGAACTTGGAATTCAAGGATCTAGACCTGC
TGAAATTATAAAACTTTGGTTAGGTTTAAGATATCTTGGAATGAAAGGCATAGAGGATGTCTTAAGTTCGTCCATTGAGA
AAAGGAAATTTTTTGAAGATAATTTAAGTAAAGAACAATATGAATTATGTTCAGGTCCCTTGCATATAGTTTCATTTCTA
CCAAAAAGTATGAATAAAAATGAATCAGATGCATGGACTTTAGATAAAAGAATAAGTCTTATGAAAAATAATTTTATGCT
TTCTAGACCTCTTATTAAAAATAGATATTTTTTAAGAGCAGTGTTAGGGAATTTCAATACTGATAGAACTCATATCAAAG
AACTCTTGAAATTACTTCATTAA

Upstream 100 bases:

>100_bases
GTAATTTCTCTATGTTGAATTTCAAAATCATGATTCATTATTATTAGTAGTAATTCCCATTTATAAATATCATAAATTAC
TTAAATAAATTTTTTATAGA

Downstream 100 bases:

>100_bases
AACTTATGAATATTAGCAGATCAAAATTTATAGCGATCATTACGGGTTTTATTTCAATAATAATATGTATTATGTACTTA
CTCTTAATAACAGTTTTTGA

Product: pyridoxal-dependent decarboxylase family protein

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MTVDSINKKEKLFPTYSGSNDSFIALLNKTSKVICNWFSNAEKLGPLPIDNNFKCSVPDETGKSTDVLFSEIESLIYSSF
NPVHPGSLAHLDPPPLIISILGDLIAASLNNNLLAHELSPSISLLEESICKWFSKKIGFTESSGGIAASGGTLSNLNALV
AARNQAGLASDHNAVFLISEDAHSSFIKCTLIMGLDKNNLIKVKTDNDGCMDIIDLKKIIDKCYREGKKIFSIVATLGTT
IRGAIDPIEKISRICKERNIWLHIDGSIGGIFAITKIPINGISHVNFANSITINPQKILGIAKTSSILLVSDIEVLKNTF
ATGLPYISSEDNFLNRGELGIQGSRPAEIIKLWLGLRYLGMKGIEDVLSSSIEKRKFFEDNLSKEQYELCSGPLHIVSFL
PKSMNKNESDAWTLDKRISLMKNNFMLSRPLIKNRYFLRAVLGNFNTDRTHIKELLKLLH

Sequences:

>Translated_460_residues
MTVDSINKKEKLFPTYSGSNDSFIALLNKTSKVICNWFSNAEKLGPLPIDNNFKCSVPDETGKSTDVLFSEIESLIYSSF
NPVHPGSLAHLDPPPLIISILGDLIAASLNNNLLAHELSPSISLLEESICKWFSKKIGFTESSGGIAASGGTLSNLNALV
AARNQAGLASDHNAVFLISEDAHSSFIKCTLIMGLDKNNLIKVKTDNDGCMDIIDLKKIIDKCYREGKKIFSIVATLGTT
IRGAIDPIEKISRICKERNIWLHIDGSIGGIFAITKIPINGISHVNFANSITINPQKILGIAKTSSILLVSDIEVLKNTF
ATGLPYISSEDNFLNRGELGIQGSRPAEIIKLWLGLRYLGMKGIEDVLSSSIEKRKFFEDNLSKEQYELCSGPLHIVSFL
PKSMNKNESDAWTLDKRISLMKNNFMLSRPLIKNRYFLRAVLGNFNTDRTHIKELLKLLH
>Mature_459_residues
TVDSINKKEKLFPTYSGSNDSFIALLNKTSKVICNWFSNAEKLGPLPIDNNFKCSVPDETGKSTDVLFSEIESLIYSSFN
PVHPGSLAHLDPPPLIISILGDLIAASLNNNLLAHELSPSISLLEESICKWFSKKIGFTESSGGIAASGGTLSNLNALVA
ARNQAGLASDHNAVFLISEDAHSSFIKCTLIMGLDKNNLIKVKTDNDGCMDIIDLKKIIDKCYREGKKIFSIVATLGTTI
RGAIDPIEKISRICKERNIWLHIDGSIGGIFAITKIPINGISHVNFANSITINPQKILGIAKTSSILLVSDIEVLKNTFA
TGLPYISSEDNFLNRGELGIQGSRPAEIIKLWLGLRYLGMKGIEDVLSSSIEKRKFFEDNLSKEQYELCSGPLHIVSFLP
KSMNKNESDAWTLDKRISLMKNNFMLSRPLIKNRYFLRAVLGNFNTDRTHIKELLKLLH

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI197276620, Length=389, Percent_Identity=27.7634961439589, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI4503875, Length=389, Percent_Identity=27.7634961439589, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI197383062, Length=366, Percent_Identity=27.3224043715847, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI194294551, Length=410, Percent_Identity=28.2926829268293, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI58331246, Length=339, Percent_Identity=27.4336283185841, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI92110055, Length=380, Percent_Identity=26.5789473684211, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI4503281, Length=427, Percent_Identity=23.8875878220141, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI132814448, Length=427, Percent_Identity=23.8875878220141, Blast_Score=96, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71993058, Length=347, Percent_Identity=26.8011527377522, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI17555682, Length=347, Percent_Identity=26.8011527377522, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71993062, Length=319, Percent_Identity=27.2727272727273, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17534819, Length=393, Percent_Identity=25.9541984732824, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17534817, Length=393, Percent_Identity=25.9541984732824, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17543922, Length=224, Percent_Identity=26.7857142857143, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI17136594, Length=364, Percent_Identity=28.8461538461538, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI21356415, Length=373, Percent_Identity=26.5415549597855, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24657193, Length=386, Percent_Identity=28.7564766839378, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24657185, Length=386, Percent_Identity=28.7564766839378, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24657188, Length=386, Percent_Identity=28.7564766839378, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI28573972, Length=386, Percent_Identity=27.4611398963731, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24652373, Length=367, Percent_Identity=27.2479564032698, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24586044, Length=407, Percent_Identity=23.8329238329238, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136190, Length=386, Percent_Identity=24.8704663212435, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24585135, Length=366, Percent_Identity=25.1366120218579, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI221476190, Length=419, Percent_Identity=23.6276849642005, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24585143, Length=419, Percent_Identity=23.6276849642005, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24585139, Length=418, Percent_Identity=23.6842105263158, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 50770; Mature: 50639

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVDSINKKEKLFPTYSGSNDSFIALLNKTSKVICNWFSNAEKLGPLPIDNNFKCSVPDE
CCCCCCCCHHHCCCCCCCCCCCEEEEECCCHHHHHHHHCCHHHCCCCCCCCCCEECCCCC
TGKSTDVLFSEIESLIYSSFNPVHPGSLAHLDPPPLIISILGDLIAASLNNNLLAHELSP
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCC
SISLLEESICKWFSKKIGFTESSGGIAASGGTLSNLNALVAARNQAGLASDHNAVFLISE
HHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHEECCCCCCCCCCCEEEEEEC
DAHSSFIKCTLIMGLDKNNLIKVKTDNDGCMDIIDLKKIIDKCYREGKKIFSIVATLGTT
CCCCCEEEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRGAIDPIEKISRICKERNIWLHIDGSIGGIFAITKIPINGISHVNFANSITINPQKILG
HHHHCCHHHHHHHHHHHCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCEEEECHHHHEE
IAKTSSILLVSDIEVLKNTFATGLPYISSEDNFLNRGELGIQGSRPAEIIKLWLGLRYLG
EECCCCEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
MKGIEDVLSSSIEKRKFFEDNLSKEQYELCSGPLHIVSFLPKSMNKNESDAWTLDKRISL
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHH
MKNNFMLSRPLIKNRYFLRAVLGNFNTDRTHIKELLKLLH
HHCCCEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
>Mature Secondary Structure 
TVDSINKKEKLFPTYSGSNDSFIALLNKTSKVICNWFSNAEKLGPLPIDNNFKCSVPDE
CCCCCCCHHHCCCCCCCCCCCEEEEECCCHHHHHHHHCCHHHCCCCCCCCCCEECCCCC
TGKSTDVLFSEIESLIYSSFNPVHPGSLAHLDPPPLIISILGDLIAASLNNNLLAHELSP
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCC
SISLLEESICKWFSKKIGFTESSGGIAASGGTLSNLNALVAARNQAGLASDHNAVFLISE
HHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHEECCCCCCCCCCCEEEEEEC
DAHSSFIKCTLIMGLDKNNLIKVKTDNDGCMDIIDLKKIIDKCYREGKKIFSIVATLGTT
CCCCCEEEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRGAIDPIEKISRICKERNIWLHIDGSIGGIFAITKIPINGISHVNFANSITINPQKILG
HHHHCCHHHHHHHHHHHCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCEEEECHHHHEE
IAKTSSILLVSDIEVLKNTFATGLPYISSEDNFLNRGELGIQGSRPAEIIKLWLGLRYLG
EECCCCEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
MKGIEDVLSSSIEKRKFFEDNLSKEQYELCSGPLHIVSFLPKSMNKNESDAWTLDKRISL
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHH
MKNNFMLSRPLIKNRYFLRAVLGNFNTDRTHIKELLKLLH
HHCCCEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11274118; 11481432 [H]