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The map label for this gene is ilvA [H]

Identifier: 123966224

GI number: 123966224

Start: 885812

End: 887353

Strand: Direct

Name: ilvA [H]

Synonym: P9515_09911

Alternate gene names: 123966224

Gene position: 885812-887353 (Clockwise)

Preceding gene: 123966222

Following gene: 123966225

Centisome position: 51.98

GC content: 31.0

Gene sequence:

>1542_bases
ATGGAAGATTATTTTAAAAAAATACTTCAGGCTCAAGTCTATGAAGTTGCTAAAAAAACACCTTTAGAAAAAGCAAATAA
TTTAAGTAAAGCACTTAAAAATAATATTTTTTTGAAAAGAGAGGATCTTCAAGATGTATTTTCTTTCAAAATAAGAGGAG
CTTTTAATAAAATGAGGCAACTAACTCCATCACAACTTACAAATGGAGTCATAACATCAAGTGCTGGTAATCATGCGCAA
GGGGTTGCATTAAGTGCGTTAAAATTAAATTGTAGTGCAACAATATTGATGCCTATAACAACACCTTTAGTAAAAGTAAA
TGCTGTTAGAAATTTAAAAGCAAAGGTAATCTTATTCGGCGACAATTATGATGAAGCATATAAAGAAGCCATACGTATTA
GTGAAGAGAATAATTTATGTTTTATTCATCCATTTGATGATACGGATGTAATAGCTGGTCAAGGTACTATCGCTATTGAA
TTAGAACAACAACTACAAGATCCACCAGAAGCAATTTACATCGCTGTGGGGGGAGGAGGACTGATAGCTGGTATTTCAAT
ATATATAAAGAAGATTTGGCCTAAAGTACAAATAATTGGTGTAGAGCCTGAAGATGCTGCTGCAATGTCTAAATCCTTAA
AAAGGCTTGAAATAATAGAATTATCTTCAGTTGGTCAGTTTGCTGATGGTGTAGCAGTAAAAAAGGTTGGAGAAAAAACC
TTTGAAATTGGCAAAACACATATAGACAAAATGATAACTGTAAATACCGATGAAATTTGTTCCGCTATTAAGGATGTTTT
CGAAGATACAAGATCAATCTTAGAGCCAGCTGGTGCTTTATCCATTGCTGGCATGAAAAAAGATATATATGAATCCAATT
ACATAAATAAAAATATGATTGCTATTGCCTGTGGAGCAAATATGAATTTTGAAAGGCTTAGATTTGTTGCGGAAAGAGCA
GCACTTGGTGAGTACAAAGAATCAATGTTTGCAGTTGAAATACCAGAAAAGGCAGGTAGTTTAATTGATTTCTGTAGTTT
GTTAAATACTAGAAATTTAACTGAATTTAGTTATAGGATGTCCAACTCAATAAATGCTCAGATTTTTGTAGGCATAGAGG
TTAATGGAGTAAATGACAAAGAAAAACTTTTAAATGAATTCAGGAAATCAAATTATCCTTTTATAGATATCAGTAAAGAT
GAATTATCTAAAAACCATTTAAGACATATGGTAGGTGGGCGACTACCCCAAAAATTTACAAAATTAGACAATTCAAAACA
TATCGAATTGTTATATAGATTTGAGTTTCCAGAAAGACCGGGAGCATTAATAAATTTTCTAAAAAAAATGAAAACAAATT
GGACAATCAGCATATTTCACTATAGAAATCATGGATCTGATGTAGGAAAAATTGTTATAGGAGTGTTAATAGATAATGCT
GAAATTAATTACTGGAATAAATTTGTTGAATTTTTAGGATATAAATATTGGGATGAAACTAATAATCCAACATATAAATT
GTTCCTTGGTGCATCAGAATAA

Upstream 100 bases:

>100_bases
CTTATATAATCTAAGACGTTAAGGTGCAAAATGAGTATTTTTTTTGAAATAGATTATGTAATGTTTTATTAGATTAATAA
TTAATGCTAAAAATATACAT

Downstream 100 bases:

>100_bases
ATATAAGGTAACTTGGGTAAGAGTTAGGTAGAAAAAAATTAATCAAGCTGATCTTATTACTACAAAATCACCAGACATAG
ACTTGGTTACCAGAGTTGAG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MEDYFKKILQAQVYEVAKKTPLEKANNLSKALKNNIFLKREDLQDVFSFKIRGAFNKMRQLTPSQLTNGVITSSAGNHAQ
GVALSALKLNCSATILMPITTPLVKVNAVRNLKAKVILFGDNYDEAYKEAIRISEENNLCFIHPFDDTDVIAGQGTIAIE
LEQQLQDPPEAIYIAVGGGGLIAGISIYIKKIWPKVQIIGVEPEDAAAMSKSLKRLEIIELSSVGQFADGVAVKKVGEKT
FEIGKTHIDKMITVNTDEICSAIKDVFEDTRSILEPAGALSIAGMKKDIYESNYINKNMIAIACGANMNFERLRFVAERA
ALGEYKESMFAVEIPEKAGSLIDFCSLLNTRNLTEFSYRMSNSINAQIFVGIEVNGVNDKEKLLNEFRKSNYPFIDISKD
ELSKNHLRHMVGGRLPQKFTKLDNSKHIELLYRFEFPERPGALINFLKKMKTNWTISIFHYRNHGSDVGKIVIGVLIDNA
EINYWNKFVEFLGYKYWDETNNPTYKLFLGASE

Sequences:

>Translated_513_residues
MEDYFKKILQAQVYEVAKKTPLEKANNLSKALKNNIFLKREDLQDVFSFKIRGAFNKMRQLTPSQLTNGVITSSAGNHAQ
GVALSALKLNCSATILMPITTPLVKVNAVRNLKAKVILFGDNYDEAYKEAIRISEENNLCFIHPFDDTDVIAGQGTIAIE
LEQQLQDPPEAIYIAVGGGGLIAGISIYIKKIWPKVQIIGVEPEDAAAMSKSLKRLEIIELSSVGQFADGVAVKKVGEKT
FEIGKTHIDKMITVNTDEICSAIKDVFEDTRSILEPAGALSIAGMKKDIYESNYINKNMIAIACGANMNFERLRFVAERA
ALGEYKESMFAVEIPEKAGSLIDFCSLLNTRNLTEFSYRMSNSINAQIFVGIEVNGVNDKEKLLNEFRKSNYPFIDISKD
ELSKNHLRHMVGGRLPQKFTKLDNSKHIELLYRFEFPERPGALINFLKKMKTNWTISIFHYRNHGSDVGKIVIGVLIDNA
EINYWNKFVEFLGYKYWDETNNPTYKLFLGASE
>Mature_513_residues
MEDYFKKILQAQVYEVAKKTPLEKANNLSKALKNNIFLKREDLQDVFSFKIRGAFNKMRQLTPSQLTNGVITSSAGNHAQ
GVALSALKLNCSATILMPITTPLVKVNAVRNLKAKVILFGDNYDEAYKEAIRISEENNLCFIHPFDDTDVIAGQGTIAIE
LEQQLQDPPEAIYIAVGGGGLIAGISIYIKKIWPKVQIIGVEPEDAAAMSKSLKRLEIIELSSVGQFADGVAVKKVGEKT
FEIGKTHIDKMITVNTDEICSAIKDVFEDTRSILEPAGALSIAGMKKDIYESNYINKNMIAIACGANMNFERLRFVAERA
ALGEYKESMFAVEIPEKAGSLIDFCSLLNTRNLTEFSYRMSNSINAQIFVGIEVNGVNDKEKLLNEFRKSNYPFIDISKD
ELSKNHLRHMVGGRLPQKFTKLDNSKHIELLYRFEFPERPGALINFLKKMKTNWTISIFHYRNHGSDVGKIVIGVLIDNA
EINYWNKFVEFLGYKYWDETNNPTYKLFLGASE

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=313, Percent_Identity=33.5463258785943, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI33469958, Length=314, Percent_Identity=28.0254777070064, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI19923959, Length=316, Percent_Identity=28.4810126582279, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1790207, Length=508, Percent_Identity=45.6692913385827, Blast_Score=454, Evalue=1e-129,
Organism=Escherichia coli, GI1789505, Length=308, Percent_Identity=37.987012987013, Blast_Score=173, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI71991565, Length=332, Percent_Identity=31.6265060240964, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17537387, Length=384, Percent_Identity=32.2916666666667, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17508781, Length=294, Percent_Identity=27.5510204081633, Blast_Score=119, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320930, Length=525, Percent_Identity=44.952380952381, Blast_Score=435, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6322631, Length=303, Percent_Identity=33.003300330033, Blast_Score=152, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6319788, Length=320, Percent_Identity=25.9375, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21355833, Length=331, Percent_Identity=33.5347432024169, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24645328, Length=252, Percent_Identity=32.1428571428571, Blast_Score=115, Evalue=6e-26,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 57689; Mature: 57689

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDYFKKILQAQVYEVAKKTPLEKANNLSKALKNNIFLKREDLQDVFSFKIRGAFNKMRQ
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHC
LTPSQLTNGVITSSAGNHAQGVALSALKLNCSATILMPITTPLVKVNAVRNLKAKVILFG
CCHHHHCCCEEECCCCCCCCCEEEEEEEECCCEEEEEECCCCCEEEHHHCCCEEEEEEEE
DNYDEAYKEAIRISEENNLCFIHPFDDTDVIAGQGTIAIELEQQLQDPPEAIYIAVGGGG
CCHHHHHHHHHEECCCCCEEEEECCCCCCEEECCCEEEEEEHHHHCCCCCEEEEEECCCC
LIAGISIYIKKIWPKVQIIGVEPEDAAAMSKSLKRLEIIELSSVGQFADGVAVKKVGEKT
HHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHEEEEEECCCCCHHCCHHHHHHHHHH
FEIGKTHIDKMITVNTDEICSAIKDVFEDTRSILEPAGALSIAGMKKDIYESNYINKNMI
HHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHCCCCCCCEE
AIACGANMNFERLRFVAERAALGEYKESMFAVEIPEKAGSLIDFCSLLNTRNLTEFSYRM
EEEECCCCCHHHHHHHHHHHHHHHHHHCEEEEECCHHHCHHHHHHHHHCCCCCHHHHHHH
SNSINAQIFVGIEVNGVNDKEKLLNEFRKSNYPFIDISKDELSKNHLRHMVGGRLPQKFT
CCCCCEEEEEEEEEECCCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHCCCCCHHHH
KLDNSKHIELLYRFEFPERPGALINFLKKMKTNWTISIFHYRNHGSDVGKIVIGVLIDNA
HCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCHHHEEEEEEEECC
EINYWNKFVEFLGYKYWDETNNPTYKLFLGASE
CCHHHHHHHHHHCCEECCCCCCCEEEEEEECCC
>Mature Secondary Structure
MEDYFKKILQAQVYEVAKKTPLEKANNLSKALKNNIFLKREDLQDVFSFKIRGAFNKMRQ
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHC
LTPSQLTNGVITSSAGNHAQGVALSALKLNCSATILMPITTPLVKVNAVRNLKAKVILFG
CCHHHHCCCEEECCCCCCCCCEEEEEEEECCCEEEEEECCCCCEEEHHHCCCEEEEEEEE
DNYDEAYKEAIRISEENNLCFIHPFDDTDVIAGQGTIAIELEQQLQDPPEAIYIAVGGGG
CCHHHHHHHHHEECCCCCEEEEECCCCCCEEECCCEEEEEEHHHHCCCCCEEEEEECCCC
LIAGISIYIKKIWPKVQIIGVEPEDAAAMSKSLKRLEIIELSSVGQFADGVAVKKVGEKT
HHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHEEEEEECCCCCHHCCHHHHHHHHHH
FEIGKTHIDKMITVNTDEICSAIKDVFEDTRSILEPAGALSIAGMKKDIYESNYINKNMI
HHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHCCCCCCCEE
AIACGANMNFERLRFVAERAALGEYKESMFAVEIPEKAGSLIDFCSLLNTRNLTEFSYRM
EEEECCCCCHHHHHHHHHHHHHHHHHHCEEEEECCHHHCHHHHHHHHHCCCCCHHHHHHH
SNSINAQIFVGIEVNGVNDKEKLLNEFRKSNYPFIDISKDELSKNHLRHMVGGRLPQKFT
CCCCCEEEEEEEEEECCCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHCCCCCHHHH
KLDNSKHIELLYRFEFPERPGALINFLKKMKTNWTISIFHYRNHGSDVGKIVIGVLIDNA
HCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCHHHEEEEEEEECC
EINYWNKFVEFLGYKYWDETNNPTYKLFLGASE
CCHHHHHHHHHHCCEECCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA