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The map label for this gene is folP [H]

Identifier: 123966138

GI number: 123966138

Start: 805626

End: 806468

Strand: Direct

Name: folP [H]

Synonym: P9515_09051

Alternate gene names: 123966138

Gene position: 805626-806468 (Clockwise)

Preceding gene: 123966137

Following gene: 123966140

Centisome position: 47.27

GC content: 29.89

Gene sequence:

>843_bases
TTGCAAATTACGAATAATAATTATCCTTGGCCTGATTATTGGGGACGAAAAACTTCAATAATGGGGATTATAAATTTAAC
TCCCGATTCATTTAGTGATGGAGGTGAATTTTGCTCAACTGAAAAAGTTTTAGAACAAGTAAATAATTTTGTATCTAATG
GAGTAGATGTTATAGATCTTGGTGCTCAAAGTACCAGACCTGGTGCTTTAGAAATTGGAGCAAAAAAAGAATCAAAAATT
TTAATACCTTATTTAAAAAAAATTAGAAGCCAATTTCCCAGTATTCTCATATCTATTGATACATTTAATTCTGAAGTTGC
TCATGACGCTCTCCTAAATGGAGCTGACTGGATTAACGATGTCACTGGAGGTAGGAGAGATGAGGAGATATTAGATGTTG
TTTCAGAATTTAATTGCCCTTTTGTAATTACTCATAGTAGAGGAAATAGCCAAAACATGAATAATTTGACAAATTATGAT
GATTTAATAAGGAATATAATAGATTCTCTTGAAAATTTGAGCAATATAGCAACAAGTAAAAATGTTCCTAAAGATAAAAT
AATTTGGGATCCTGGTATGGGATTTTCAAAAGATACTAATCAAAACTTAGAAATTTTAAGAAATATTGATGCCTTCAAAA
ATTATGGGTTCCCTCTTTTGATTGGTGCTTCTAGAAAAAGATTTATTGGAGATATACTTGAGGAAGATAATCCAAAGGAA
AGAGACATAGGAACTCTTGCTATTAGTTGTTTTTGTTCTCAAAAAAACTTACATCTTGTAAGGGTTCATAATGTAAAAAT
AAATTATCAAGTTTTAAAAGTCTCAGATCAAATTTTTAGGTAA

Upstream 100 bases:

>100_bases
TCTGTTAAGCCTAATAATATTGACGAGATTATGTCGATGAGCGATATTAATGGAGTATTGGTAGGGGGCTCTTCTCTAGA
TCCAATTAGTTTTTCAAGAA

Downstream 100 bases:

>100_bases
AAAATATTAAAATTTATTCTTTAACTCCTTCAATTTTATCTTCTACCTCTTGATAAAGTTCTTTTAATTGTTCAATATTT
TCATCTGATGTTTCCCAATA

Product: putative dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MQITNNNYPWPDYWGRKTSIMGIINLTPDSFSDGGEFCSTEKVLEQVNNFVSNGVDVIDLGAQSTRPGALEIGAKKESKI
LIPYLKKIRSQFPSILISIDTFNSEVAHDALLNGADWINDVTGGRRDEEILDVVSEFNCPFVITHSRGNSQNMNNLTNYD
DLIRNIIDSLENLSNIATSKNVPKDKIIWDPGMGFSKDTNQNLEILRNIDAFKNYGFPLLIGASRKRFIGDILEEDNPKE
RDIGTLAISCFCSQKNLHLVRVHNVKINYQVLKVSDQIFR

Sequences:

>Translated_280_residues
MQITNNNYPWPDYWGRKTSIMGIINLTPDSFSDGGEFCSTEKVLEQVNNFVSNGVDVIDLGAQSTRPGALEIGAKKESKI
LIPYLKKIRSQFPSILISIDTFNSEVAHDALLNGADWINDVTGGRRDEEILDVVSEFNCPFVITHSRGNSQNMNNLTNYD
DLIRNIIDSLENLSNIATSKNVPKDKIIWDPGMGFSKDTNQNLEILRNIDAFKNYGFPLLIGASRKRFIGDILEEDNPKE
RDIGTLAISCFCSQKNLHLVRVHNVKINYQVLKVSDQIFR
>Mature_280_residues
MQITNNNYPWPDYWGRKTSIMGIINLTPDSFSDGGEFCSTEKVLEQVNNFVSNGVDVIDLGAQSTRPGALEIGAKKESKI
LIPYLKKIRSQFPSILISIDTFNSEVAHDALLNGADWINDVTGGRRDEEILDVVSEFNCPFVITHSRGNSQNMNNLTNYD
DLIRNIIDSLENLSNIATSKNVPKDKIIWDPGMGFSKDTNQNLEILRNIDAFKNYGFPLLIGASRKRFIGDILEEDNPKE
RDIGTLAISCFCSQKNLHLVRVHNVKINYQVLKVSDQIFR

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=261, Percent_Identity=33.7164750957854, Blast_Score=166, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6324073, Length=318, Percent_Identity=33.0188679245283, Blast_Score=160, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31557; Mature: 31557

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQITNNNYPWPDYWGRKTSIMGIINLTPDSFSDGGEFCSTEKVLEQVNNFVSNGVDVIDL
CCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEC
GAQSTRPGALEIGAKKESKILIPYLKKIRSQFPSILISIDTFNSEVAHDALLNGADWIND
CCCCCCCCEEEECCCCCCCEEHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHCCHHHHHH
VTGGRRDEEILDVVSEFNCPFVITHSRGNSQNMNNLTNYDDLIRNIIDSLENLSNIATSK
HCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
NVPKDKIIWDPGMGFSKDTNQNLEILRNIDAFKNYGFPLLIGASRKRFIGDILEEDNPKE
CCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCCCC
RDIGTLAISCFCSQKNLHLVRVHNVKINYQVLKVSDQIFR
HHHHEEEEEEEECCCCEEEEEEEEEEEEEEEEECCHHHCC
>Mature Secondary Structure
MQITNNNYPWPDYWGRKTSIMGIINLTPDSFSDGGEFCSTEKVLEQVNNFVSNGVDVIDL
CCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEC
GAQSTRPGALEIGAKKESKILIPYLKKIRSQFPSILISIDTFNSEVAHDALLNGADWIND
CCCCCCCCEEEECCCCCCCEEHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHCCHHHHHH
VTGGRRDEEILDVVSEFNCPFVITHSRGNSQNMNNLTNYDDLIRNIIDSLENLSNIATSK
HCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
NVPKDKIIWDPGMGFSKDTNQNLEILRNIDAFKNYGFPLLIGASRKRFIGDILEEDNPKE
CCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCCCC
RDIGTLAISCFCSQKNLHLVRVHNVKINYQVLKVSDQIFR
HHHHEEEEEEEECCCCEEEEEEEEEEEEEEEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]