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The map label for this gene is purK [H]

Identifier: 123965991

GI number: 123965991

Start: 685655

End: 686845

Strand: Direct

Name: purK [H]

Synonym: P9515_07561

Alternate gene names: 123965991

Gene position: 685655-686845 (Clockwise)

Preceding gene: 123965989

Following gene: 123965994

Centisome position: 40.23

GC content: 30.73

Gene sequence:

>1191_bases
ATGACTCAAAAAAGAAATATAAAAAATATTAGTAAAAATTATTCACTAGGAATAATTGGAGGAGGTCAATTAGCCTTAAT
GCTTACTGAAGCGGCAAACAAAAGAGGAATAAAAGTATGCGTTCAAACTAAATCTTCCAATGACCCAGCAGGCTCAAAAG
CAGATTGTGTTATTGAGGCTGATCCTCTTAAGATAAAAGGAAATAAGGATCTAATTAAAAAGTGCGAAAAAATTATTTTT
GAAAATGAATGGATTAGAATCGAAAAATTAAATTTAATTGAATCTAATAATATTTTTGTACCAAGCCTGCAATCGATTCA
ACCTTTGGTAGATAGAATTTCTCAAAAAAAATTAATAGAGAAAATGGGCCTGCCCTCACCAAGATGGATTTCAATAAAGG
ATTTTAAAATTCTTGAGCATAAAGAAATTGAGGATTGGAATTTTCCCTTAATGGTTAAATCTCTTAAAGGAGGATATGAC
GGTAAAGGAAATAAAAAAATTAATAACAAAGAAGATTTGAATTCCTTTTTGGTTGGAGCGGAATCAGACGATTGGCTAAT
TGAAGAATGGATTGACTATAAAAAGGAGCTTGCTCTGGTTGGATCAAGAGATTTTGATGGCAAAATAAGGCTATTTCCCA
TTGTTGAGACATTTCAAAAAAATAACGTTTGTGATTGGGTTTTGTCTCCAGCTGAAATTAATTATGACTTGAAAACTTTT
GTGATTAATATTTTTTCCTCAATAGTAAATGAACTCAATTATGTTGGAGTAATGGGAATTGAATTCTTTTATGGTGATAA
AGGACTATTAATTAATGAAATTGCCCCTAGAACTCATAATTCTGCTCACTTTTCTATAGAGGCTTGTACTTCAAGCCAGT
TCGATCAATATATTTGTATATCTTCAGGTGCCAAGCCCCCAGATATTAATTTGAATTCTCATGGCTCCTTAATGATAAAT
TTATTAGGTTTGAAAAAAGATTTCCCTTTGTCAATAGAAAAAAGGATAGAGTTTTTAACACAAATTAAGGGGTCTAACCT
TCATTGGTATGGAAAATCTAAAGAAAGTGTTGGACGGAAAATGGGTCATATAACTTTTTTACTGAATGAGAATAATTATT
TGAAAAGGAATGAAAAATCAAGAGAAATATTAAATAAGGTAAGAGAGATTTGGCCATCTCCAAATGAATAA

Upstream 100 bases:

>100_bases
ATATTAAAATTTTATTTTTTTATTCTAACCTCATGGTGACTTAAAAATTAGATTAAAATAATCTGTTGTTAAGAATTAAA
AATCATAATAAGATCATCAT

Downstream 100 bases:

>100_bases
AAAAATAAGTTAATATTTAAGTACTGGATCTTTGGTTAAGTTCTTCTTTATGTGCTCTGATCTGACTCTTTTTCGACTTG
AGGAGACTGTCGTGATGTAG

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MTQKRNIKNISKNYSLGIIGGGQLALMLTEAANKRGIKVCVQTKSSNDPAGSKADCVIEADPLKIKGNKDLIKKCEKIIF
ENEWIRIEKLNLIESNNIFVPSLQSIQPLVDRISQKKLIEKMGLPSPRWISIKDFKILEHKEIEDWNFPLMVKSLKGGYD
GKGNKKINNKEDLNSFLVGAESDDWLIEEWIDYKKELALVGSRDFDGKIRLFPIVETFQKNNVCDWVLSPAEINYDLKTF
VINIFSSIVNELNYVGVMGIEFFYGDKGLLINEIAPRTHNSAHFSIEACTSSQFDQYICISSGAKPPDINLNSHGSLMIN
LLGLKKDFPLSIEKRIEFLTQIKGSNLHWYGKSKESVGRKMGHITFLLNENNYLKRNEKSREILNKVREIWPSPNE

Sequences:

>Translated_396_residues
MTQKRNIKNISKNYSLGIIGGGQLALMLTEAANKRGIKVCVQTKSSNDPAGSKADCVIEADPLKIKGNKDLIKKCEKIIF
ENEWIRIEKLNLIESNNIFVPSLQSIQPLVDRISQKKLIEKMGLPSPRWISIKDFKILEHKEIEDWNFPLMVKSLKGGYD
GKGNKKINNKEDLNSFLVGAESDDWLIEEWIDYKKELALVGSRDFDGKIRLFPIVETFQKNNVCDWVLSPAEINYDLKTF
VINIFSSIVNELNYVGVMGIEFFYGDKGLLINEIAPRTHNSAHFSIEACTSSQFDQYICISSGAKPPDINLNSHGSLMIN
LLGLKKDFPLSIEKRIEFLTQIKGSNLHWYGKSKESVGRKMGHITFLLNENNYLKRNEKSREILNKVREIWPSPNE
>Mature_395_residues
TQKRNIKNISKNYSLGIIGGGQLALMLTEAANKRGIKVCVQTKSSNDPAGSKADCVIEADPLKIKGNKDLIKKCEKIIFE
NEWIRIEKLNLIESNNIFVPSLQSIQPLVDRISQKKLIEKMGLPSPRWISIKDFKILEHKEIEDWNFPLMVKSLKGGYDG
KGNKKINNKEDLNSFLVGAESDDWLIEEWIDYKKELALVGSRDFDGKIRLFPIVETFQKNNVCDWVLSPAEINYDLKTFV
INIFSSIVNELNYVGVMGIEFFYGDKGLLINEIAPRTHNSAHFSIEACTSSQFDQYICISSGAKPPDINLNSHGSLMINL
LGLKKDFPLSIEKRIEFLTQIKGSNLHWYGKSKESVGRKMGHITFLLNENNYLKRNEKSREILNKVREIWPSPNE

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=362, Percent_Identity=28.4530386740331, Blast_Score=129, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6324702, Length=371, Percent_Identity=30.4582210242588, Blast_Score=160, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 45128; Mature: 44996

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQKRNIKNISKNYSLGIIGGGQLALMLTEAANKRGIKVCVQTKSSNDPAGSKADCVIEA
CCCCCCCHHHCCCCEEEEEECCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCEEEEC
DPLKIKGNKDLIKKCEKIIFENEWIRIEKLNLIESNNIFVPSLQSIQPLVDRISQKKLIE
CCEEEECCHHHHHHHHHHHCCCCCEEEEEEEEEECCCEECCCHHHHHHHHHHHHHHHHHH
KMGLPSPRWISIKDFKILEHKEIEDWNFPLMVKSLKGGYDGKGNKKINNKEDLNSFLVGA
HHCCCCCCEEEEECEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHEECC
ESDDWLIEEWIDYKKELALVGSRDFDGKIRLFPIVETFQKNNVCDWVLSPAEINYDLKTF
CCCCHHHHHHHHHHHHEEEECCCCCCCCEEEEEEHHHHCCCCCEEEEECCHHCCCHHHHH
VINIFSSIVNELNYVGVMGIEFFYGDKGLLINEIAPRTHNSAHFSIEACTSSQFDQYICI
HHHHHHHHHHHHCCEEEEEEEEEECCCCEEEECCCCCCCCCCEEEEEECCCCCCCCEEEE
SSGAKPPDINLNSHGSLMINLLGLKKDFPLSIEKRIEFLTQIKGSNLHWYGKSKESVGRK
ECCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHH
MGHITFLLNENNYLKRNEKSREILNKVREIWPSPNE
CCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TQKRNIKNISKNYSLGIIGGGQLALMLTEAANKRGIKVCVQTKSSNDPAGSKADCVIEA
CCCCCCHHHCCCCEEEEEECCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCEEEEC
DPLKIKGNKDLIKKCEKIIFENEWIRIEKLNLIESNNIFVPSLQSIQPLVDRISQKKLIE
CCEEEECCHHHHHHHHHHHCCCCCEEEEEEEEEECCCEECCCHHHHHHHHHHHHHHHHHH
KMGLPSPRWISIKDFKILEHKEIEDWNFPLMVKSLKGGYDGKGNKKINNKEDLNSFLVGA
HHCCCCCCEEEEECEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHEECC
ESDDWLIEEWIDYKKELALVGSRDFDGKIRLFPIVETFQKNNVCDWVLSPAEINYDLKTF
CCCCHHHHHHHHHHHHEEEECCCCCCCCEEEEEEHHHHCCCCCEEEEECCHHCCCHHHHH
VINIFSSIVNELNYVGVMGIEFFYGDKGLLINEIAPRTHNSAHFSIEACTSSQFDQYICI
HHHHHHHHHHHHCCEEEEEEEEEECCCCEEEECCCCCCCCCCEEEEEECCCCCCCCEEEE
SSGAKPPDINLNSHGSLMINLLGLKKDFPLSIEKRIEFLTQIKGSNLHWYGKSKESVGRK
ECCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHH
MGHITFLLNENNYLKRNEKSREILNKVREIWPSPNE
CCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA