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The map label for this gene is menB [H]

Identifier: 123965908

GI number: 123965908

Start: 608742

End: 609599

Strand: Direct

Name: menB [H]

Synonym: P9515_06731

Alternate gene names: 123965908

Gene position: 608742-609599 (Clockwise)

Preceding gene: 123965907

Following gene: 123965909

Centisome position: 35.72

GC content: 36.48

Gene sequence:

>858_bases
ATGAAAATTTTACCTGGAAAAAATAACGCAGATTGGAAAGAATGGAAATCCTATGAAGATATCTTGTTTCATAAGAGTGG
AGATGGAATAGCAAGAATTGCAATTAATCGACCTGAAAAAAGAAATGCATTTCGTCCAAAAACAGTTTGTGAGCTCTTAG
AGGCTTTTAACCTTGTTAGGAATGATAAGAGTATCGGAGTTGTTCTTTTGACAGGGGCTGGCCCAGATAAAAAAGGAATT
TTTTCGTTTTGTTCAGGTGGTGATCAAAGTGTTAGGGGTAAAAATGGATATATAGATGATCAAGGAAATCAAAGGCTGAA
TGTATTGGAATTGCAGAAATTAATAAGAACTATACCAAAAGTAGTTATAGCTTTAGTACCTGGTTTTGCAATAGGAGGAG
GGCAAGTTTTACATTTACTTTGTGATCTAAGTATTGCTTCTGAAAATGCAATATTTGGCCAAACAGGTCCTAGAGTAGGA
AGTTTTGATGCGGGATTTGGATCAAGCTATTTAGCTAGACTGGTTGGACAAAGAAAAGCTAAGGAAATTTGGTTTTTATG
CAGAAAATATAATTCTAAAGAAGCCTTTGAAATGGGATTGGTAAATGCGATTACAAAGATTGAAGAATTAGAAGCTGAGG
GTGTAATCTGGGCAAGAGAGATTCTACAAAATAGTCCTACTGCTATTCGAATACTTAAGGCGTCATTTAATGCTGAATGT
GACGGGATAGCAGGAATCCAGGAATTATCTGGGTATACAACTCAGTTATTTTATTCTACGGACGAAGCTAAAGAGGGTAG
AGATGCTTTCCTTGAGAAACGGCCACCTGATTTTTCTGATTGCGGATGGACTCCTTAA

Upstream 100 bases:

>100_bases
AGTCGATATTAATGTTGATAATGAAATGAAAGAAAGAAGTTTAATCTTAAAAAAAATCCTCAATAATTAATGAAATTGCT
TTTTAAAATTATTTAAATCT

Downstream 100 bases:

>100_bases
TAGCTTATTTCTCTTCAAAAATAACTTTTTAAAATAATGAATCAATGAGAATTCTTCTTGCTGCTGCTGAATGTGCTCCA
ATGATCAAAGTTGGAGGGAT

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MKILPGKNNADWKEWKSYEDILFHKSGDGIARIAINRPEKRNAFRPKTVCELLEAFNLVRNDKSIGVVLLTGAGPDKKGI
FSFCSGGDQSVRGKNGYIDDQGNQRLNVLELQKLIRTIPKVVIALVPGFAIGGGQVLHLLCDLSIASENAIFGQTGPRVG
SFDAGFGSSYLARLVGQRKAKEIWFLCRKYNSKEAFEMGLVNAITKIEELEAEGVIWAREILQNSPTAIRILKASFNAEC
DGIAGIQELSGYTTQLFYSTDEAKEGRDAFLEKRPPDFSDCGWTP

Sequences:

>Translated_285_residues
MKILPGKNNADWKEWKSYEDILFHKSGDGIARIAINRPEKRNAFRPKTVCELLEAFNLVRNDKSIGVVLLTGAGPDKKGI
FSFCSGGDQSVRGKNGYIDDQGNQRLNVLELQKLIRTIPKVVIALVPGFAIGGGQVLHLLCDLSIASENAIFGQTGPRVG
SFDAGFGSSYLARLVGQRKAKEIWFLCRKYNSKEAFEMGLVNAITKIEELEAEGVIWAREILQNSPTAIRILKASFNAEC
DGIAGIQELSGYTTQLFYSTDEAKEGRDAFLEKRPPDFSDCGWTP
>Mature_285_residues
MKILPGKNNADWKEWKSYEDILFHKSGDGIARIAINRPEKRNAFRPKTVCELLEAFNLVRNDKSIGVVLLTGAGPDKKGI
FSFCSGGDQSVRGKNGYIDDQGNQRLNVLELQKLIRTIPKVVIALVPGFAIGGGQVLHLLCDLSIASENAIFGQTGPRVG
SFDAGFGSSYLARLVGQRKAKEIWFLCRKYNSKEAFEMGLVNAITKIEELEAEGVIWAREILQNSPTAIRILKASFNAEC
DGIAGIQELSGYTTQLFYSTDEAKEGRDAFLEKRPPDFSDCGWTP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=277, Percent_Identity=31.0469314079422, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI4502327, Length=259, Percent_Identity=30.1158301158301, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI31542718, Length=262, Percent_Identity=27.4809160305344, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI45643119, Length=219, Percent_Identity=28.310502283105, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI260275230, Length=219, Percent_Identity=28.310502283105, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI260274832, Length=219, Percent_Identity=28.310502283105, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI157694516, Length=229, Percent_Identity=26.2008733624454, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI213417737, Length=229, Percent_Identity=26.2008733624454, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI70995211, Length=238, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1788597, Length=271, Percent_Identity=60.5166051660517, Blast_Score=341, Evalue=3e-95,
Organism=Escherichia coli, GI1787659, Length=249, Percent_Identity=28.9156626506024, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87082183, Length=261, Percent_Identity=27.2030651340996, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787660, Length=267, Percent_Identity=29.2134831460674, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI221142681, Length=264, Percent_Identity=28.030303030303, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI25145438, Length=255, Percent_Identity=32.5490196078431, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17554946, Length=268, Percent_Identity=29.8507462686567, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17540714, Length=220, Percent_Identity=28.1818181818182, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17560910, Length=173, Percent_Identity=30.635838150289, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17534483, Length=284, Percent_Identity=26.7605633802817, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17535521, Length=211, Percent_Identity=25.5924170616114, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17549921, Length=202, Percent_Identity=27.7227722772277, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI20129971, Length=257, Percent_Identity=29.9610894941634, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24653477, Length=257, Percent_Identity=29.9610894941634, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24653139, Length=289, Percent_Identity=28.0276816608997, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24654903, Length=209, Percent_Identity=30.622009569378, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI21357171, Length=191, Percent_Identity=30.8900523560209, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19922422, Length=270, Percent_Identity=23.7037037037037, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24650670, Length=182, Percent_Identity=30.2197802197802, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 31451; Mature: 31451

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILPGKNNADWKEWKSYEDILFHKSGDGIARIAINRPEKRNAFRPKTVCELLEAFNLVR
CCCCCCCCCCCHHHHHCHHHHEEECCCCCEEEEEECCCHHCCCCCHHHHHHHHHHHHHHH
NDKSIGVVLLTGAGPDKKGIFSFCSGGDQSVRGKNGYIDDQGNQRLNVLELQKLIRTIPK
CCCCCEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEECHHHHHHHHHHHHH
VVIALVPGFAIGGGQVLHLLCDLSIASENAIFGQTGPRVGSFDAGFGSSYLARLVGQRKA
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
KEIWFLCRKYNSKEAFEMGLVNAITKIEELEAEGVIWAREILQNSPTAIRILKASFNAEC
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEECCCCCCC
DGIAGIQELSGYTTQLFYSTDEAKEGRDAFLEKRPPDFSDCGWTP
CCCCCHHHHCCCEEEEEEECCHHCCHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MKILPGKNNADWKEWKSYEDILFHKSGDGIARIAINRPEKRNAFRPKTVCELLEAFNLVR
CCCCCCCCCCCHHHHHCHHHHEEECCCCCEEEEEECCCHHCCCCCHHHHHHHHHHHHHHH
NDKSIGVVLLTGAGPDKKGIFSFCSGGDQSVRGKNGYIDDQGNQRLNVLELQKLIRTIPK
CCCCCEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEECHHHHHHHHHHHHH
VVIALVPGFAIGGGQVLHLLCDLSIASENAIFGQTGPRVGSFDAGFGSSYLARLVGQRKA
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHH
KEIWFLCRKYNSKEAFEMGLVNAITKIEELEAEGVIWAREILQNSPTAIRILKASFNAEC
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEECCCCCCC
DGIAGIQELSGYTTQLFYSTDEAKEGRDAFLEKRPPDFSDCGWTP
CCCCCHHHHCCCEEEEEEECCHHCCHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629163; 8566759; 9387221; 9384377 [H]