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The map label for this gene is thrS

Identifier: 123965897

GI number: 123965897

Start: 597283

End: 599199

Strand: Reverse

Name: thrS

Synonym: P9515_06621

Alternate gene names: 123965897

Gene position: 599199-597283 (Counterclockwise)

Preceding gene: 123965898

Following gene: 123965896

Centisome position: 35.16

GC content: 31.98

Gene sequence:

>1917_bases
ATGCCAAAAATAACACTCCCTGATGGTACTAAAAAAGTTTTCGAAAAAGCTGTAACTACTCTTGATATTGCTAAAAGTAT
TGGAGCAGGGTTAGCCAAAGCAACAATTGCGGGGAAAGTAAATAACGTTCTTTTTGATGCAACTCTGCCAATAAAAAATG
ATTCTAAAGTGGTAATAATTACATCACGAGATAAGGAGGGTATTGAGATAATTAGACATTCTTTTGCTCATTTAATTGGT
CATGCCGTTAAACAAATATATCCAAATATAAAAATGGCTATTGGTCCAGTAATTGAGGATGGATTTTATTATGATATTTT
TTCAGAATATAGGTTTACTCCTGAAGATTTAATCAAAATTGAAGAAAGAATTAATCAACTCATTAGAAAGGATTATGACG
TTGAAGTTTTGCAAGTTTCAAAACAAGAAGCTATTAAAACTTTTAAAGAAAGAGATGAGATTTTCAAATTAAGAATTATT
GAAGAAATCGATGAAAAAGATTCAATAAATTTATATAAACATGAAGAATATATTGATATGTGCAGAGGACCTCATGTCCC
AAACACAAGACATCTTAGACACTTTAAGTTATTAAAATTATCCGGATCATATTGGAGAGGTGACAGCAAAAACGAATCAT
TGCAAAGAATTTATGGTACAGCGTGGAGCAAGGAGAAGGATCTTACTAATTATCTAAAAAGAATTGAAGAAGCCGAAAAA
AGAGACCATAGAAAACTAGGCAAAAAACATTCTCTTTTTCATATACAAGAAGAATCTCCCGGAATGATTTTTTGGCATCC
AAATGGTTGGATAATTTATCAAATCCTTGAAAAATACATAAGAGAAATTCTCAGAAAAAATGAATATCTCGAAATTAAAA
CACCCCAAGCAGTTGATAAATCTCTTTGGGAAAAATCAGGTCACTGGGAAAAATTCAGAGATGATATGTTCACTACTGCC
TCTGAGAATAGAACTTATGCAATTAAGCCGATGAACTGTCCTTGCCATATTCAAGTATTTAATCAAGGGTTGAAAAGTTA
TAAAGATTTACCTCTGCGTCTGGCTGAATTTGGATCTTGCCACAGAAATGAGCCTTCAGGAGCCTTGCACGGTTTGATGA
GAGTTAGAAATTTCACTCAAGATGATGCTCATATATTTTGTACTGAAGAGCAAATTCAAGAAGAGGTCTCAACTTTTATT
GATCTAGTTTTTGAGGTTTATAATACTTTTGGATTTGATGAAATTATCATAAAGTTATCAACCCGTCCAGAAAAAAGAGT
AGGGAGTGAGGATATTTGGGACAAATCTGAGGAAGCTCTAACCGAAGCTTTAAATAATAAAAATCTCAAATGGGAACTCC
AACCAGGGGAAGGAGCATTTTATGGTCCAAAAATTGAATTTTCACTTAAAGATTGTCTTAACAGGATATGGCAATGTGGG
ACGATTCAGGTTGATTTTTCGATGCCTGTTCGATTAGATGCGACTTTTGTAGACATTAATAACGAGAAAAAAAGTCCCGT
CATGTTGCATAGAGCAATATTAGGTTCTTTTGAGAGATTTATAGGAATATTGATAGAACAATACGAAGCTAAATTCCCTA
TTTGGCTAGCTCCAACTCAGATTATTTTATTAAGTATTACTGAAAGAAATATAAAAAAATGTATTGAATTTAATAATTTA
TTAAATACTAAAGGATATCGATCAAAAATTGATATTAGAAACGAAAAGATTGGTTATAAAATTAGAGAATCTACGCTGGC
CAGAATACCATTAATTGGTATTGTTGGAGACAAAGAGCAGGAACTAAATTCAGTTACCTTGAGAGCTTTAGATGGATCGA
ATTTAGGAATTTATGAATTAGATAATCTTTTTAAACTTATGAATACTTTAATTGAGAAAAAGGGAAGAGTAGACTAA

Upstream 100 bases:

>100_bases
GATACTTCTAGAGGGTAAAGAGAAAGCTGAGTTAGTAGCAAACAAAACTCTAAGTAGAGTTAAATCAGAATTAGGTTTCT
TTTCAATGGAAAAATAAATC

Downstream 100 bases:

>100_bases
TTTAATTTTATGAATTTTCTTGCTTGTGATCTTGGGGGTACGAAAGTTCTTGTAGGTATTTATGAAAAAGATCTTGAATC
TGATACTCCTAAATTAATCT

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 638; Mature: 637

Protein sequence:

>638_residues
MPKITLPDGTKKVFEKAVTTLDIAKSIGAGLAKATIAGKVNNVLFDATLPIKNDSKVVIITSRDKEGIEIIRHSFAHLIG
HAVKQIYPNIKMAIGPVIEDGFYYDIFSEYRFTPEDLIKIEERINQLIRKDYDVEVLQVSKQEAIKTFKERDEIFKLRII
EEIDEKDSINLYKHEEYIDMCRGPHVPNTRHLRHFKLLKLSGSYWRGDSKNESLQRIYGTAWSKEKDLTNYLKRIEEAEK
RDHRKLGKKHSLFHIQEESPGMIFWHPNGWIIYQILEKYIREILRKNEYLEIKTPQAVDKSLWEKSGHWEKFRDDMFTTA
SENRTYAIKPMNCPCHIQVFNQGLKSYKDLPLRLAEFGSCHRNEPSGALHGLMRVRNFTQDDAHIFCTEEQIQEEVSTFI
DLVFEVYNTFGFDEIIIKLSTRPEKRVGSEDIWDKSEEALTEALNNKNLKWELQPGEGAFYGPKIEFSLKDCLNRIWQCG
TIQVDFSMPVRLDATFVDINNEKKSPVMLHRAILGSFERFIGILIEQYEAKFPIWLAPTQIILLSITERNIKKCIEFNNL
LNTKGYRSKIDIRNEKIGYKIRESTLARIPLIGIVGDKEQELNSVTLRALDGSNLGIYELDNLFKLMNTLIEKKGRVD

Sequences:

>Translated_638_residues
MPKITLPDGTKKVFEKAVTTLDIAKSIGAGLAKATIAGKVNNVLFDATLPIKNDSKVVIITSRDKEGIEIIRHSFAHLIG
HAVKQIYPNIKMAIGPVIEDGFYYDIFSEYRFTPEDLIKIEERINQLIRKDYDVEVLQVSKQEAIKTFKERDEIFKLRII
EEIDEKDSINLYKHEEYIDMCRGPHVPNTRHLRHFKLLKLSGSYWRGDSKNESLQRIYGTAWSKEKDLTNYLKRIEEAEK
RDHRKLGKKHSLFHIQEESPGMIFWHPNGWIIYQILEKYIREILRKNEYLEIKTPQAVDKSLWEKSGHWEKFRDDMFTTA
SENRTYAIKPMNCPCHIQVFNQGLKSYKDLPLRLAEFGSCHRNEPSGALHGLMRVRNFTQDDAHIFCTEEQIQEEVSTFI
DLVFEVYNTFGFDEIIIKLSTRPEKRVGSEDIWDKSEEALTEALNNKNLKWELQPGEGAFYGPKIEFSLKDCLNRIWQCG
TIQVDFSMPVRLDATFVDINNEKKSPVMLHRAILGSFERFIGILIEQYEAKFPIWLAPTQIILLSITERNIKKCIEFNNL
LNTKGYRSKIDIRNEKIGYKIRESTLARIPLIGIVGDKEQELNSVTLRALDGSNLGIYELDNLFKLMNTLIEKKGRVD
>Mature_637_residues
PKITLPDGTKKVFEKAVTTLDIAKSIGAGLAKATIAGKVNNVLFDATLPIKNDSKVVIITSRDKEGIEIIRHSFAHLIGH
AVKQIYPNIKMAIGPVIEDGFYYDIFSEYRFTPEDLIKIEERINQLIRKDYDVEVLQVSKQEAIKTFKERDEIFKLRIIE
EIDEKDSINLYKHEEYIDMCRGPHVPNTRHLRHFKLLKLSGSYWRGDSKNESLQRIYGTAWSKEKDLTNYLKRIEEAEKR
DHRKLGKKHSLFHIQEESPGMIFWHPNGWIIYQILEKYIREILRKNEYLEIKTPQAVDKSLWEKSGHWEKFRDDMFTTAS
ENRTYAIKPMNCPCHIQVFNQGLKSYKDLPLRLAEFGSCHRNEPSGALHGLMRVRNFTQDDAHIFCTEEQIQEEVSTFID
LVFEVYNTFGFDEIIIKLSTRPEKRVGSEDIWDKSEEALTEALNNKNLKWELQPGEGAFYGPKIEFSLKDCLNRIWQCGT
IQVDFSMPVRLDATFVDINNEKKSPVMLHRAILGSFERFIGILIEQYEAKFPIWLAPTQIILLSITERNIKKCIEFNNLL
NTKGYRSKIDIRNEKIGYKIRESTLARIPLIGIVGDKEQELNSVTLRALDGSNLGIYELDNLFKLMNTLIEKKGRVD

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=613, Percent_Identity=40.6199021207178, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI38570111, Length=619, Percent_Identity=39.4184168012924, Blast_Score=468, Evalue=1e-132,
Organism=Homo sapiens, GI20070344, Length=654, Percent_Identity=36.085626911315, Blast_Score=407, Evalue=1e-113,
Organism=Escherichia coli, GI1788013, Length=635, Percent_Identity=57.1653543307087, Blast_Score=798, Evalue=0.0,
Organism=Escherichia coli, GI1786392, Length=161, Percent_Identity=25.4658385093168, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71984184, Length=631, Percent_Identity=40.4120443740095, Blast_Score=488, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI71984192, Length=631, Percent_Identity=40.4120443740095, Blast_Score=488, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6322112, Length=658, Percent_Identity=37.5379939209726, Blast_Score=447, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6322654, Length=397, Percent_Identity=38.5390428211587, Blast_Score=296, Evalue=7e-81,
Organism=Drosophila melanogaster, GI24583839, Length=612, Percent_Identity=39.2156862745098, Blast_Score=474, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24583842, Length=612, Percent_Identity=39.2156862745098, Blast_Score=474, Evalue=1e-134,
Organism=Drosophila melanogaster, GI28574141, Length=612, Percent_Identity=39.2156862745098, Blast_Score=474, Evalue=1e-134,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_PROM5 (A2BVR0)

Other databases:

- EMBL:   CP000552
- RefSeq:   YP_001010978.1
- ProteinModelPortal:   A2BVR0
- SMR:   A2BVR0
- STRING:   A2BVR0
- GeneID:   4719540
- GenomeReviews:   CP000552_GR
- KEGG:   pmc:P9515_06621
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   GFEYEVE
- ProtClustDB:   PRK00413
- BioCyc:   PMAR167542:P9515ORF_0698-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 74186; Mature: 74055

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKITLPDGTKKVFEKAVTTLDIAKSIGAGLAKATIAGKVNNVLFDATLPIKNDSKVVII
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEECCCCCCCEEEEE
TSRDKEGIEIIRHSFAHLIGHAVKQIYPNIKMAIGPVIEDGFYYDIFSEYRFTPEDLIKI
ECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHCCCEEEEHHHHCCCCHHHHHHH
EERINQLIRKDYDVEVLQVSKQEAIKTFKERDEIFKLRIIEEIDEKDSINLYKHEEYIDM
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHH
CRGPHVPNTRHLRHFKLLKLSGSYWRGDSKNESLQRIYGTAWSKEKDLTNYLKRIEEAEK
HCCCCCCCCCCHHHEEEEEECCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
RDHRKLGKKHSLFHIQEESPGMIFWHPNGWIIYQILEKYIREILRKNEYLEIKTPQAVDK
HHHHHCCCCCCEEEEECCCCCEEEECCCCEEHHHHHHHHHHHHHCCCCEEEEECCHHHHH
SLWEKSGHWEKFRDDMFTTASENRTYAIKPMNCPCHIQVFNQGLKSYKDLPLRLAEFGSC
HHHHCCCCHHHHHHHHHCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHCCCHHHHHHCCC
HRNEPSGALHGLMRVRNFTQDDAHIFCTEEQIQEEVSTFIDLVFEVYNTFGFDEIIIKLS
CCCCCCHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEC
TRPEKRVGSEDIWDKSEEALTEALNNKNLKWELQPGEGAFYGPKIEFSLKDCLNRIWQCG
CCCCHHCCCCHHCCCHHHHHHHHHCCCCCEEEEECCCCCEECCEEEEEHHHHHHHHHCCC
TIQVDFSMPVRLDATFVDINNEKKSPVMLHRAILGSFERFIGILIEQYEAKFPIWLAPTQ
EEEEEECCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCE
IILLSITERNIKKCIEFNNLLNTKGYRSKIDIRNEKIGYKIRESTLARIPLIGIVGDKEQ
EEEEEECHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCEEHHHHHHHCCEEEEECCCHH
ELNSVTLRALDGSNLGIYELDNLFKLMNTLIEKKGRVD
HCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PKITLPDGTKKVFEKAVTTLDIAKSIGAGLAKATIAGKVNNVLFDATLPIKNDSKVVII
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEECCCCCCCEEEEE
TSRDKEGIEIIRHSFAHLIGHAVKQIYPNIKMAIGPVIEDGFYYDIFSEYRFTPEDLIKI
ECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHCCCEEEEHHHHCCCCHHHHHHH
EERINQLIRKDYDVEVLQVSKQEAIKTFKERDEIFKLRIIEEIDEKDSINLYKHEEYIDM
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHH
CRGPHVPNTRHLRHFKLLKLSGSYWRGDSKNESLQRIYGTAWSKEKDLTNYLKRIEEAEK
HCCCCCCCCCCHHHEEEEEECCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
RDHRKLGKKHSLFHIQEESPGMIFWHPNGWIIYQILEKYIREILRKNEYLEIKTPQAVDK
HHHHHCCCCCCEEEEECCCCCEEEECCCCEEHHHHHHHHHHHHHCCCCEEEEECCHHHHH
SLWEKSGHWEKFRDDMFTTASENRTYAIKPMNCPCHIQVFNQGLKSYKDLPLRLAEFGSC
HHHHCCCCHHHHHHHHHCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHCCCHHHHHHCCC
HRNEPSGALHGLMRVRNFTQDDAHIFCTEEQIQEEVSTFIDLVFEVYNTFGFDEIIIKLS
CCCCCCHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEC
TRPEKRVGSEDIWDKSEEALTEALNNKNLKWELQPGEGAFYGPKIEFSLKDCLNRIWQCG
CCCCHHCCCCHHCCCHHHHHHHHHCCCCCEEEEECCCCCEECCEEEEEHHHHHHHHHCCC
TIQVDFSMPVRLDATFVDINNEKKSPVMLHRAILGSFERFIGILIEQYEAKFPIWLAPTQ
EEEEEECCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCE
IILLSITERNIKKCIEFNNLLNTKGYRSKIDIRNEKIGYKIRESTLARIPLIGIVGDKEQ
EEEEEECHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCEEHHHHHHHCCEEEEECCCHH
ELNSVTLRALDGSNLGIYELDNLFKLMNTLIEKKGRVD
HCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA