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The map label for this gene is hemE [H]

Identifier: 123965883

GI number: 123965883

Start: 578956

End: 579996

Strand: Reverse

Name: hemE [H]

Synonym: P9515_06481

Alternate gene names: 123965883

Gene position: 579996-578956 (Counterclockwise)

Preceding gene: 123965884

Following gene: 123965882

Centisome position: 34.03

GC content: 34.87

Gene sequence:

>1041_bases
ATGGGTGAGAATTTACCACTTTTACTATCTGCTGCTTTAGGCAAGAAAGTTAATAGGCCTCCAGTATGGATGATGAGACA
AGCAGGTAGGTATATGAAGATTTATAGAGATTTAAGAGAGCGCTATCCAAGTTTTAGGGAAAGATCTGAGAACCCAGAAC
TCTCTTATCAAATTTCAATGCAACCTTTTAAGGCTTTCAAGCCGGATGGAGTGATTCTTTTTTCAGATATTCTTACCCCT
CTGCCTGGAATGGGTATCAATTTTGAAATAATAGAAAGTAAGGGGCCAATCATAGAGAATCCCATAAAAAATATTCATCA
GATAGAAAATTTGAAAGAATTAGTTCCGAGCGAAAGTTTAAGTTTTGTTGGAGAAGTCCTATCCTCATTAAAAAAAGATG
TAAATAATGAAGCTACTGTTCTTGGATTCGTTGGAGCACCTTGGACTCTTGCTGCGTATGTAGTTGAAGGCAAAAGCAGT
AAAAATTATTCTTTAATAAAGTCAATGGCTTTCAAAGAGCCTGATTTGCTACACAAGCTTCTTGATCATTTTGCAAAATC
CATAGGTGAGTATTTAAAATATCAAATCAAATCTGGTGCTCAGGTTGTACAAATTTTTGACTCTTGGGCAGGACAATTAA
GTCCTCAAGACTACGATATTTTTGCTGGTCCTTATCAAAAAAAAGTGGTTGATATAGTTAAGGAAAAATACCCAGAAACT
CCTATTATTTTATATATATCAGGAAGTGCTGGGCTATTAGAAAGAATGGCAAGAACTGGGGTAGACATAATTTCATTAGA
CTGGACTGTAGATATCGAGGAAGCATGCAAGAGAATTCCTGAAGGTATTGGTATTCAGGGTAATGTTGATCCAGGTCTAT
TATTCGGAAATAAAGAATCCATAAAAGAGAGGATAGATATTACTTTTAACAAATCAAAAGGAAGAAAGTATATTCTTAAT
TTAGGCCATGGAATTTTACCAGGTACACCTGAAGAAAATGCTCAAACATTTTTTGAACACGGGAAAAAACTTACTTATTA
A

Upstream 100 bases:

>100_bases
TTAATTCTTCACATCAACGATTTTAATCTGCTCCACGTTGTAAACTTTTTAAGTTAAAGATTTTTTATTTTTTCTTTTAA
AAACATATTGAACTCTAAAA

Downstream 100 bases:

>100_bases
TTAATATTTTGGCAACTAAAAACTTATTAATAACAGGCTCTAACGGATGTGTTGGTCAATATTTAATTGATTGGTTTTTA
AAAAATACTCGATTTAGGCT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MGENLPLLLSAALGKKVNRPPVWMMRQAGRYMKIYRDLRERYPSFRERSENPELSYQISMQPFKAFKPDGVILFSDILTP
LPGMGINFEIIESKGPIIENPIKNIHQIENLKELVPSESLSFVGEVLSSLKKDVNNEATVLGFVGAPWTLAAYVVEGKSS
KNYSLIKSMAFKEPDLLHKLLDHFAKSIGEYLKYQIKSGAQVVQIFDSWAGQLSPQDYDIFAGPYQKKVVDIVKEKYPET
PIILYISGSAGLLERMARTGVDIISLDWTVDIEEACKRIPEGIGIQGNVDPGLLFGNKESIKERIDITFNKSKGRKYILN
LGHGILPGTPEENAQTFFEHGKKLTY

Sequences:

>Translated_346_residues
MGENLPLLLSAALGKKVNRPPVWMMRQAGRYMKIYRDLRERYPSFRERSENPELSYQISMQPFKAFKPDGVILFSDILTP
LPGMGINFEIIESKGPIIENPIKNIHQIENLKELVPSESLSFVGEVLSSLKKDVNNEATVLGFVGAPWTLAAYVVEGKSS
KNYSLIKSMAFKEPDLLHKLLDHFAKSIGEYLKYQIKSGAQVVQIFDSWAGQLSPQDYDIFAGPYQKKVVDIVKEKYPET
PIILYISGSAGLLERMARTGVDIISLDWTVDIEEACKRIPEGIGIQGNVDPGLLFGNKESIKERIDITFNKSKGRKYILN
LGHGILPGTPEENAQTFFEHGKKLTY
>Mature_345_residues
GENLPLLLSAALGKKVNRPPVWMMRQAGRYMKIYRDLRERYPSFRERSENPELSYQISMQPFKAFKPDGVILFSDILTPL
PGMGINFEIIESKGPIIENPIKNIHQIENLKELVPSESLSFVGEVLSSLKKDVNNEATVLGFVGAPWTLAAYVVEGKSSK
NYSLIKSMAFKEPDLLHKLLDHFAKSIGEYLKYQIKSGAQVVQIFDSWAGQLSPQDYDIFAGPYQKKVVDIVKEKYPETP
IILYISGSAGLLERMARTGVDIISLDWTVDIEEACKRIPEGIGIQGNVDPGLLFGNKESIKERIDITFNKSKGRKYILNL
GHGILPGTPEENAQTFFEHGKKLTY

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=339, Percent_Identity=33.0383480825959, Blast_Score=210, Evalue=1e-54,
Organism=Escherichia coli, GI2367337, Length=340, Percent_Identity=38.5294117647059, Blast_Score=259, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6320252, Length=356, Percent_Identity=34.2696629213483, Blast_Score=220, Evalue=2e-58,
Organism=Drosophila melanogaster, GI19921920, Length=340, Percent_Identity=35.2941176470588, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI221330099, Length=340, Percent_Identity=35.2941176470588, Blast_Score=219, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 38913; Mature: 38782

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGENLPLLLSAALGKKVNRPPVWMMRQAGRYMKIYRDLRERYPSFRERSENPELSYQISM
CCCCCHHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCHHHHCCCCCCEEEEEEC
QPFKAFKPDGVILFSDILTPLPGMGINFEIIESKGPIIENPIKNIHQIENLKELVPSESL
CHHHCCCCCCEEEEHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHH
SFVGEVLSSLKKDVNNEATVLGFVGAPWTLAAYVVEGKSSKNYSLIKSMAFKEPDLLHKL
HHHHHHHHHHHHCCCCCEEEEEECCCCHHEEEEEEECCCCCCHHHHHHHHCCCHHHHHHH
LDHFAKSIGEYLKYQIKSGAQVVQIFDSWAGQLSPQDYDIFAGPYQKKVVDIVKEKYPET
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHCCCC
PIILYISGSAGLLERMARTGVDIISLDWTVDIEEACKRIPEGIGIQGNVDPGLLFGNKES
CEEEEECCCHHHHHHHHHCCCEEEEEEEEECHHHHHHHCCCCCCCCCCCCCCEEECCHHH
IKERIDITFNKSKGRKYILNLGHGILPGTPEENAQTFFEHGKKLTY
HHHHHCEEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GENLPLLLSAALGKKVNRPPVWMMRQAGRYMKIYRDLRERYPSFRERSENPELSYQISM
CCCCHHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCHHHHCCCCCCEEEEEEC
QPFKAFKPDGVILFSDILTPLPGMGINFEIIESKGPIIENPIKNIHQIENLKELVPSESL
CHHHCCCCCCEEEEHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHH
SFVGEVLSSLKKDVNNEATVLGFVGAPWTLAAYVVEGKSSKNYSLIKSMAFKEPDLLHKL
HHHHHHHHHHHHCCCCCEEEEEECCCCHHEEEEEEECCCCCCHHHHHHHHCCCHHHHHHH
LDHFAKSIGEYLKYQIKSGAQVVQIFDSWAGQLSPQDYDIFAGPYQKKVVDIVKEKYPET
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHCCCC
PIILYISGSAGLLERMARTGVDIISLDWTVDIEEACKRIPEGIGIQGNVDPGLLFGNKES
CEEEEECCCHHHHHHHHHCCCEEEEEEEEECHHHHHHHCCCCCCCCCCCCCCEEECCHHH
IKERIDITFNKSKGRKYILNLGHGILPGTPEENAQTFFEHGKKLTY
HHHHHCEEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA