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The map label for this gene is hisI [H]

Identifier: 123965878

GI number: 123965878

Start: 573676

End: 574338

Strand: Reverse

Name: hisI [H]

Synonym: P9515_06431

Alternate gene names: 123965878

Gene position: 574338-573676 (Counterclockwise)

Preceding gene: 123965880

Following gene: 123965877

Centisome position: 33.7

GC content: 30.92

Gene sequence:

>663_bases
ATGGCTTATTCAACTAATTTTTCGATAGAAGATCTTCACTTTGACAATAATGGATTAATCCCTGCAATAGCGCAAGATTG
GTTAGACGGTTCAATTCTTATGTTTGCTTGGATGAATAAAGAATCTTTAAACAAAACACTTCAGACAAAAAATGTCCATT
ACTGGAGCCGATCAAGATCTGAAATTTGGAGAAAAGGCGCAACAAGCGGTAGTACCCAAATTCTTAAAGAAATTAGATTT
GATTGTGATAATGATGCACTTCTTCTCTCTATAGAGCAAAATGGCTCCGGAGCATGCCATACAGGTGAAAAAAGTTGTTT
TTTCAACAAAATAGATAATAATTTTATTAATAAAAAAGAAAAGAGAAAGAAGCCTTTGTCTAATGTTTGTTCAGAATTAT
TTAATACTCTTAATGAAAGATCAATTAATCCTTCTGAAAAAAGTTACACCAATCTTTTATTAACAAAAGGTAGTAATACT
ATCTTAAAAAAAATAGGAGAAGAAACTGCTGAATTTATAATGGCTTGCAAAGATAATGACAAAAATTCAATCTCAAATGA
AGCTGCAGATATAATATATCATCTCCAAGTTGCTTTGCTGTATAAGGGGGTTGAGTGGAGAGATGTGCTAAATATTCTTG
AATCAAGAAGAAAAAAAAGATAA

Upstream 100 bases:

>100_bases
CTTTTAGAGCAAGAAAATTTCGAAGAATGAATATTCATTAATTAGCTGTTAAGATGATTTCTAGTCAAACAAAGAGTAAA
GAGTTAACACATTTAATATA

Downstream 100 bases:

>100_bases
TCAAATATCTATATATGAAAACTATAAATTAAGAAATTTCATCAAATTAAGAAATAATAATTATTAATTAAATATTAATT
AATTATTACATGTGTAGCTT

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MAYSTNFSIEDLHFDNNGLIPAIAQDWLDGSILMFAWMNKESLNKTLQTKNVHYWSRSRSEIWRKGATSGSTQILKEIRF
DCDNDALLLSIEQNGSGACHTGEKSCFFNKIDNNFINKKEKRKKPLSNVCSELFNTLNERSINPSEKSYTNLLLTKGSNT
ILKKIGEETAEFIMACKDNDKNSISNEAADIIYHLQVALLYKGVEWRDVLNILESRRKKR

Sequences:

>Translated_220_residues
MAYSTNFSIEDLHFDNNGLIPAIAQDWLDGSILMFAWMNKESLNKTLQTKNVHYWSRSRSEIWRKGATSGSTQILKEIRF
DCDNDALLLSIEQNGSGACHTGEKSCFFNKIDNNFINKKEKRKKPLSNVCSELFNTLNERSINPSEKSYTNLLLTKGSNT
ILKKIGEETAEFIMACKDNDKNSISNEAADIIYHLQVALLYKGVEWRDVLNILESRRKKR
>Mature_219_residues
AYSTNFSIEDLHFDNNGLIPAIAQDWLDGSILMFAWMNKESLNKTLQTKNVHYWSRSRSEIWRKGATSGSTQILKEIRFD
CDNDALLLSIEQNGSGACHTGEKSCFFNKIDNNFINKKEKRKKPLSNVCSELFNTLNERSINPSEKSYTNLLLTKGSNTI
LKKIGEETAEFIMACKDNDKNSISNEAADIIYHLQVALLYKGVEWRDVLNILESRRKKR

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=205, Percent_Identity=34.6341463414634, Blast_Score=124, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6319819, Length=187, Percent_Identity=33.6898395721925, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 25208; Mature: 25077

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYSTNFSIEDLHFDNNGLIPAIAQDWLDGSILMFAWMNKESLNKTLQTKNVHYWSRSRS
CCCCCCCCEEEEEECCCCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCHHHHCCHH
EIWRKGATSGSTQILKEIRFDCDNDALLLSIEQNGSGACHTGEKSCFFNKIDNNFINKKE
HHHHCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHCCHHCCCHH
KRKKPLSNVCSELFNTLNERSINPSEKSYTNLLLTKGSNTILKKIGEETAEFIMACKDND
HHCCHHHHHHHHHHHHHHHCCCCCCHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHCCCC
KNSISNEAADIIYHLQVALLYKGVEWRDVLNILESRRKKR
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AYSTNFSIEDLHFDNNGLIPAIAQDWLDGSILMFAWMNKESLNKTLQTKNVHYWSRSRS
CCCCCCCEEEEEECCCCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCHHHHCCHH
EIWRKGATSGSTQILKEIRFDCDNDALLLSIEQNGSGACHTGEKSCFFNKIDNNFINKKE
HHHHCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHCCHHCCCHH
KRKKPLSNVCSELFNTLNERSINPSEKSYTNLLLTKGSNTILKKIGEETAEFIMACKDND
HHCCHHHHHHHHHHHHHHHCCCCCCHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHCCCC
KNSISNEAADIIYHLQVALLYKGVEWRDVLNILESRRKKR
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]