Click here to switch to the map view.

The map label for this gene is ribE [H]

Identifier: 123965739

GI number: 123965739

Start: 452294

End: 452953

Strand: Direct

Name: ribE [H]

Synonym: P9515_05041

Alternate gene names: 123965739

Gene position: 452294-452953 (Clockwise)

Preceding gene: 123965737

Following gene: 123965744

Centisome position: 26.54

GC content: 29.39

Gene sequence:

>660_bases
ATGTTTACAGGAATAATTCAGTCAGTAGGAAAACTTAAAAAAGAAAAAGATTTCTTAATTATTGAAATTCTTGATGAACC
TTTTGATATGCAAATAGGCGATAGTATCGCAGTTAATGGGATTTGTTTAACGGTAAAAGAAATTTCAAATAATCAATTTA
AAGTAGATGTAAGTGAAGAAACTTTTAAAAAAACTACTTTAGGAGATAAATCAAGTATCAATCAAATAGTTAATTTGGAA
CCAGCTATCCGTCTTTCAGATCGTCTTGGGGGGCACATAGTAAGTGGACATATAGATGGTTTGGGAAAAGTTGAAAATAT
AGAAAAACTAGAAAAATCATGGATGTTAAAAATTAAGTGGCAAAATAAAAAATTTTCCAAATACATAGTTGATAAAGGAA
GTATATGCGTAAACGGAATTAGTCTGACAATTGCAAAATCTGAGAATCAAGGAGAAATTTTTACGATCGCAATTATCCCT
CATACCTGGGATAACACGAATCTGAAAAATTTATCAATTGGCGATAGTGTAAATCTTGAAGGAGATGCATTAATTAAATA
CGTCGAAAAATTACTTCTATTTAACAAAAATAGAGAATCAGATAACTTTTCTGAAGAAATCTCTTCAAATTGGCTTAAAG
AAAATGGCTGGGATAAATAA

Upstream 100 bases:

>100_bases
TAATTTCTACTAAATAATTCTTTTATTTATTTATAGTTGATATTGGTTTAAAGTAAATTAAAATTAATATTTATTCTAAA
AAAAATCTTTATTTAAAGTT

Downstream 100 bases:

>100_bases
TTTTTAATTAATTGGAATTAGGGAAATAGTTTTAGTATCTTTTTTGAGATCAATTTTATATTCTTGACCAGGCTCTAATC
CTAATTTCTTTGTATAGGCA

Product: riboflavin synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MFTGIIQSVGKLKKEKDFLIIEILDEPFDMQIGDSIAVNGICLTVKEISNNQFKVDVSEETFKKTTLGDKSSINQIVNLE
PAIRLSDRLGGHIVSGHIDGLGKVENIEKLEKSWMLKIKWQNKKFSKYIVDKGSICVNGISLTIAKSENQGEIFTIAIIP
HTWDNTNLKNLSIGDSVNLEGDALIKYVEKLLLFNKNRESDNFSEEISSNWLKENGWDK

Sequences:

>Translated_219_residues
MFTGIIQSVGKLKKEKDFLIIEILDEPFDMQIGDSIAVNGICLTVKEISNNQFKVDVSEETFKKTTLGDKSSINQIVNLE
PAIRLSDRLGGHIVSGHIDGLGKVENIEKLEKSWMLKIKWQNKKFSKYIVDKGSICVNGISLTIAKSENQGEIFTIAIIP
HTWDNTNLKNLSIGDSVNLEGDALIKYVEKLLLFNKNRESDNFSEEISSNWLKENGWDK
>Mature_219_residues
MFTGIIQSVGKLKKEKDFLIIEILDEPFDMQIGDSIAVNGICLTVKEISNNQFKVDVSEETFKKTTLGDKSSINQIVNLE
PAIRLSDRLGGHIVSGHIDGLGKVENIEKLEKSWMLKIKWQNKKFSKYIVDKGSICVNGISLTIAKSENQGEIFTIAIIP
HTWDNTNLKNLSIGDSVNLEGDALIKYVEKLLLFNKNRESDNFSEEISSNWLKENGWDK

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The alpha subunit catalyze

COG id: COG0307

COG function: function code H; Riboflavin synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 lumazine-binding repeats [H]

Homologues:

Organism=Escherichia coli, GI1787952, Length=207, Percent_Identity=37.1980676328502, Blast_Score=117, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6319733, Length=231, Percent_Identity=36.3636363636364, Blast_Score=127, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001783
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00677 Lum_binding [H]

EC number: =2.5.1.9 [H]

Molecular weight: Translated: 24675; Mature: 24675

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTGIIQSVGKLKKEKDFLIIEILDEPFDMQIGDSIAVNGICLTVKEISNNQFKVDVSEE
CCHHHHHHHHHHHCCCCEEEEEEECCCCCEECCCEEEECEEEEEEEECCCCEEEEEECHH
TFKKTTLGDKSSINQIVNLEPAIRLSDRLGGHIVSGHIDGLGKVENIEKLEKSWMLKIKW
HHHHHCCCCHHHHHHHCCCCCCEEECCCCCCEEEEECCCCCCCHHHHHHHHHCEEEEEEE
QNKKFSKYIVDKGSICVNGISLTIAKSENQGEIFTIAIIPHTWDNTNLKNLSIGDSVNLE
CCCCCEEEEECCCCEEEECEEEEEEECCCCCCEEEEEEEECCCCCCCCCEEECCCCCCCC
GDALIKYVEKLLLFNKNRESDNFSEEISSNWLKENGWDK
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFTGIIQSVGKLKKEKDFLIIEILDEPFDMQIGDSIAVNGICLTVKEISNNQFKVDVSEE
CCHHHHHHHHHHHCCCCEEEEEEECCCCCEECCCEEEECEEEEEEEECCCCEEEEEECHH
TFKKTTLGDKSSINQIVNLEPAIRLSDRLGGHIVSGHIDGLGKVENIEKLEKSWMLKIKW
HHHHHCCCCHHHHHHHCCCCCCEEECCCCCCEEEEECCCCCCCHHHHHHHHHCEEEEEEE
QNKKFSKYIVDKGSICVNGISLTIAKSENQGEIFTIAIIPHTWDNTNLKNLSIGDSVNLE
CCCCCEEEEECCCCEEEECEEEEEEECCCCCCEEEEEEEECCCCCCCCCEEECCCCCCCC
GDALIKYVEKLLLFNKNRESDNFSEEISSNWLKENGWDK
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8522537 [H]