Click here to switch to the map view.

The map label for this gene is uvrD [H]

Identifier: 123965572

GI number: 123965572

Start: 310235

End: 312643

Strand: Reverse

Name: uvrD [H]

Synonym: P9515_03371

Alternate gene names: 123965572

Gene position: 312643-310235 (Counterclockwise)

Preceding gene: 123965573

Following gene: 123965571

Centisome position: 18.35

GC content: 33.17

Gene sequence:

>2409_bases
GTGTCTCAAACTCACAACTTCCTTTTTAACTCTTTAAATAATGCACAACTAAAAGCAGTCAATCATATCAATGGGCCACT
GCTAGTTGTAGCAGGTGCAGGTAGTGGGAAAACTAAGGCTCTTACTCATCGAATTGCTAATTTAATAGAAAATCACTCAG
TAGATCCTCATAATATCTTGGCAGTAACTTTTACAAATAAAGCTGCAAAAGAAATGAAAGCAAGACTTCAAGTACTACTT
GCACAAGAACTAGCTTTCAATCAATTTGGGCAGCCTTGGGCAACTCTCAAAGAATTTGATCAAAACCAATTAAGAACAAA
TATTGATCAAGAAAGGCTCAAGGACCTATGGATAGGAACTTTTCATTCACTATTTTCAAGGCTGTTAAGATACGATATTG
AAAAATATCAAGATCCTGAAGGGTTAAGATGGACGAGGCAATTTTCTATTTATGACGAGACAGATTCTCAGACCTTGGTA
AAGGAAATTATTAGTCAAGATATGAGTCTTGATCCAAAAAGATTTGATCCCAAGAAAATAAAGAGAGCAATTAGTAACGC
AAAAAATCAATGTTTTACAGCTAAGGAACTCGAAGAGAAAGCTGATAATCATTTTGATAAAGTTATTGCAGATGCTTATA
GAAGATACAAAATATCTCTCTCTAAAAATAATGCTTTAGATTTTGATGATCTTTTACTACTTCCGGTTTTTTTATTAAGG
CAAAATGATTTAGTTAGGGATTACTGGCATAAAAGATTCCAGCATGTTTTAGTTGATGAATATCAAGATACAAATAGGAC
ACAATATGAACTTATCAAATTAATTACGGCTGGTAATACTAAACCAAATAAATTTTGCGAATGGAATAATCGATCAATTT
TTGTTGTTGGAGATGCTGATCAAAGTATTTATAGTTTTAGAGCAGCCGATTTTAGAATATTAATTGGATTTCAAGAAGAT
TTTAAAGGTCCATCTAATAATGATAAGAAAGCATCTTTGGTGAAATTAGAAGAAAACTATAGATCTTCATCAAATATTCT
TAACGCTGCAAATTCTTTAATTGAAAATAATACTGAAAGAATTGATAAAGTTTTAAAGCCTACAAAGGAAGAAGGAGAAC
TTTTAAAGTTGCTTAGCTGTGATGATGAAATATCTGAAGCTGAAGCAATAACAACAAAATTAAGATCTCTAAACAATTAT
AATAATCAACCAATTTGGAGAAATTTCGCAATCCTATATAGGACTAGGGCTCAATCTAGGGTATTAGAAGAATCACTAGT
AAGATGGAGAATACCTTATACAATCTTTGGCGGATTACGTTTTTATGACAGAAGAGAAGTTAAAGATGCAGTTGCCTATT
TAAAAGTATTAGTAAATTCTTCAGATAATGTAAGCCTTTTGAGAATCATAAATGTGCCGAGAAGAGGCATAGGAAAAACA
ACTATTCAAAAGCTTAGTGATCTATCAATTAAGTTAAACATTCCTTTATGGGAGGTCATAAATGACAAACAAAGTTTAGA
TGAGACTATAGGTAGATCGTCAAAGGGCATTAATAAATTCACAGACCTGATGAATGACCTTCTTTGCTACGTAGAGAACT
CAGGACCTGCTCAAATTCTTCAATTAATTTTAGAAAAAAGCGGTTATTTAAATGAATTGTTAAGGTCTGGTTCAGAGGAA
TCTGAAGACAGACGAAATAATCTGCAGGAATTAATAAATGCTGCTACTCAATTCGAAGAAGAGACAGAGAATGCAAATGT
AGAAGGATTCTTGTCAACAGCAGCTTTAACAACAGATAATGATACGAAAAAAAATCATCCCAACTCTGTTACTTTAATGA
CTCTCCATAACAGTAAAGGATTAGAATTTCAAAATGTATTTATAACTGGACTCGAACAAGGTTTGTTCCCAAGCCATAGG
TCCATTGATACGCCTTCTCTTCTAGAAGAAGAAAGAAGATTATGCTATGTAGGTATAACAAGAGCTAAAGAGAGAGTTTT
CTTATCACATGCAAGGGAGAGGAGATTGTGGGGAGGTATGCGAGAACCAACAATTCCGTCAATCTTTCTCTCAGAAATAC
CAGAGGAATTAATTGATGGCGAATTACCTCAATCTGGTGGTGCTTCTATTAGAAGGGATCGACATCTTGACCGTTTAACA
AGAGTAGATAGGAACAATTCAAATGAATTTTTAAATAAACCTATCAATGCAGTGAGAAAGCTATATTCCGGACCCAGCAA
AGGTAAAAGTTGGATAATAGGAGATAAAGTAATTCACTCCAAATTTGGTAAGGGAGAAATTATACATATTTTTGGTAGTG
GAGAAAAAATATCGTTAGCAGTTAAATTTGGAGATAAAGGTAGCAAAATTTTAGACCCAAGATTAGCTCCAATAAGAGCA
ATAAACTGA

Upstream 100 bases:

>100_bases
TGAACTAATAAATTTAAAAAAAGCATTAGAAGAATTAGAGTCTAAAACTCAATCTTCAAATTAAAGTAAGTTCAAACTTT
GATCATACAACCTACAGAAA

Downstream 100 bases:

>100_bases
AATTGAAATGAATGATATTTCGGCTCATATAAATCAATCAATATTAAAAATTCCTTTTGACTTATTTAATATAATTTCTA
ATTATATTAAATTGCATAGC

Product: UvrD/REP helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 802; Mature: 801

Protein sequence:

>802_residues
MSQTHNFLFNSLNNAQLKAVNHINGPLLVVAGAGSGKTKALTHRIANLIENHSVDPHNILAVTFTNKAAKEMKARLQVLL
AQELAFNQFGQPWATLKEFDQNQLRTNIDQERLKDLWIGTFHSLFSRLLRYDIEKYQDPEGLRWTRQFSIYDETDSQTLV
KEIISQDMSLDPKRFDPKKIKRAISNAKNQCFTAKELEEKADNHFDKVIADAYRRYKISLSKNNALDFDDLLLLPVFLLR
QNDLVRDYWHKRFQHVLVDEYQDTNRTQYELIKLITAGNTKPNKFCEWNNRSIFVVGDADQSIYSFRAADFRILIGFQED
FKGPSNNDKKASLVKLEENYRSSSNILNAANSLIENNTERIDKVLKPTKEEGELLKLLSCDDEISEAEAITTKLRSLNNY
NNQPIWRNFAILYRTRAQSRVLEESLVRWRIPYTIFGGLRFYDRREVKDAVAYLKVLVNSSDNVSLLRIINVPRRGIGKT
TIQKLSDLSIKLNIPLWEVINDKQSLDETIGRSSKGINKFTDLMNDLLCYVENSGPAQILQLILEKSGYLNELLRSGSEE
SEDRRNNLQELINAATQFEEETENANVEGFLSTAALTTDNDTKKNHPNSVTLMTLHNSKGLEFQNVFITGLEQGLFPSHR
SIDTPSLLEEERRLCYVGITRAKERVFLSHARERRLWGGMREPTIPSIFLSEIPEELIDGELPQSGGASIRRDRHLDRLT
RVDRNNSNEFLNKPINAVRKLYSGPSKGKSWIIGDKVIHSKFGKGEIIHIFGSGEKISLAVKFGDKGSKILDPRLAPIRA
IN

Sequences:

>Translated_802_residues
MSQTHNFLFNSLNNAQLKAVNHINGPLLVVAGAGSGKTKALTHRIANLIENHSVDPHNILAVTFTNKAAKEMKARLQVLL
AQELAFNQFGQPWATLKEFDQNQLRTNIDQERLKDLWIGTFHSLFSRLLRYDIEKYQDPEGLRWTRQFSIYDETDSQTLV
KEIISQDMSLDPKRFDPKKIKRAISNAKNQCFTAKELEEKADNHFDKVIADAYRRYKISLSKNNALDFDDLLLLPVFLLR
QNDLVRDYWHKRFQHVLVDEYQDTNRTQYELIKLITAGNTKPNKFCEWNNRSIFVVGDADQSIYSFRAADFRILIGFQED
FKGPSNNDKKASLVKLEENYRSSSNILNAANSLIENNTERIDKVLKPTKEEGELLKLLSCDDEISEAEAITTKLRSLNNY
NNQPIWRNFAILYRTRAQSRVLEESLVRWRIPYTIFGGLRFYDRREVKDAVAYLKVLVNSSDNVSLLRIINVPRRGIGKT
TIQKLSDLSIKLNIPLWEVINDKQSLDETIGRSSKGINKFTDLMNDLLCYVENSGPAQILQLILEKSGYLNELLRSGSEE
SEDRRNNLQELINAATQFEEETENANVEGFLSTAALTTDNDTKKNHPNSVTLMTLHNSKGLEFQNVFITGLEQGLFPSHR
SIDTPSLLEEERRLCYVGITRAKERVFLSHARERRLWGGMREPTIPSIFLSEIPEELIDGELPQSGGASIRRDRHLDRLT
RVDRNNSNEFLNKPINAVRKLYSGPSKGKSWIIGDKVIHSKFGKGEIIHIFGSGEKISLAVKFGDKGSKILDPRLAPIRA
IN
>Mature_801_residues
SQTHNFLFNSLNNAQLKAVNHINGPLLVVAGAGSGKTKALTHRIANLIENHSVDPHNILAVTFTNKAAKEMKARLQVLLA
QELAFNQFGQPWATLKEFDQNQLRTNIDQERLKDLWIGTFHSLFSRLLRYDIEKYQDPEGLRWTRQFSIYDETDSQTLVK
EIISQDMSLDPKRFDPKKIKRAISNAKNQCFTAKELEEKADNHFDKVIADAYRRYKISLSKNNALDFDDLLLLPVFLLRQ
NDLVRDYWHKRFQHVLVDEYQDTNRTQYELIKLITAGNTKPNKFCEWNNRSIFVVGDADQSIYSFRAADFRILIGFQEDF
KGPSNNDKKASLVKLEENYRSSSNILNAANSLIENNTERIDKVLKPTKEEGELLKLLSCDDEISEAEAITTKLRSLNNYN
NQPIWRNFAILYRTRAQSRVLEESLVRWRIPYTIFGGLRFYDRREVKDAVAYLKVLVNSSDNVSLLRIINVPRRGIGKTT
IQKLSDLSIKLNIPLWEVINDKQSLDETIGRSSKGINKFTDLMNDLLCYVENSGPAQILQLILEKSGYLNELLRSGSEES
EDRRNNLQELINAATQFEEETENANVEGFLSTAALTTDNDTKKNHPNSVTLMTLHNSKGLEFQNVFITGLEQGLFPSHRS
IDTPSLLEEERRLCYVGITRAKERVFLSHARERRLWGGMREPTIPSIFLSEIPEELIDGELPQSGGASIRRDRHLDRLTR
VDRNNSNEFLNKPINAVRKLYSGPSKGKSWIIGDKVIHSKFGKGEIIHIFGSGEKISLAVKFGDKGSKILDPRLAPIRAI
N

Specific function: Essential helicase [H]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=800, Percent_Identity=34.5, Blast_Score=431, Evalue=1e-121,
Organism=Escherichia coli, GI48994965, Length=693, Percent_Identity=36.5079365079365, Blast_Score=363, Evalue=1e-101,
Organism=Escherichia coli, GI1787196, Length=365, Percent_Identity=27.1232876712329, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6322369, Length=783, Percent_Identity=28.735632183908, Blast_Score=212, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6324477, Length=728, Percent_Identity=23.6263736263736, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 91829; Mature: 91698

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTHNFLFNSLNNAQLKAVNHINGPLLVVAGAGSGKTKALTHRIANLIENHSVDPHNIL
CCCCHHHHHHCCCCCCEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEE
AVTFTNKAAKEMKARLQVLLAQELAFNQFGQPWATLKEFDQNQLRTNIDQERLKDLWIGT
EEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
FHSLFSRLLRYDIEKYQDPEGLRWTRQFSIYDETDSQTLVKEIISQDMSLDPKRFDPKKI
HHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCHHHH
KRAISNAKNQCFTAKELEEKADNHFDKVIADAYRRYKISLSKNNALDFDDLLLLPVFLLR
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHH
QNDLVRDYWHKRFQHVLVDEYQDTNRTQYELIKLITAGNTKPNKFCEWNNRSIFVVGDAD
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEECCCEEEEEECCC
QSIYSFRAADFRILIGFQEDFKGPSNNDKKASLVKLEENYRSSSNILNAANSLIENNTER
CHHHHHHCCCEEEEEEEHHHCCCCCCCCCCHHEEEEHHHCCHHHHHHHHHHHHHHCCHHH
IDKVLKPTKEEGELLKLLSCDDEISEAEAITTKLRSLNNYNNQPIWRNFAILYRTRAQSR
HHHHHCCCCCCCCEEHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
VLEESLVRWRIPYTIFGGLRFYDRREVKDAVAYLKVLVNSSDNVSLLRIINVPRRGIGKT
HHHHHHHHEECCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHH
TIQKLSDLSIKLNIPLWEVINDKQSLDETIGRSSKGINKFTDLMNDLLCYVENSGPAQIL
HHHHHHCCEEEECCCHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHH
QLILEKSGYLNELLRSGSEESEDRRNNLQELINAATQFEEETENANVEGFLSTAALTTDN
HHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCC
DTKKNHPNSVTLMTLHNSKGLEFQNVFITGLEQGLFPSHRSIDTPSLLEEERRLCYVGIT
CCCCCCCCEEEEEEEECCCCCEEHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCEEEEEHH
RAKERVFLSHARERRLWGGMREPTIPSIFLSEIPEELIDGELPQSGGASIRRDRHLDRLT
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHH
RVDRNNSNEFLNKPINAVRKLYSGPSKGKSWIIGDKVIHSKFGKGEIIHIFGSGEKISLA
HHCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECHHHHHHCCCCCCEEEEEECCCEEEEE
VKFGDKGSKILDPRLAPIRAIN
EEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SQTHNFLFNSLNNAQLKAVNHINGPLLVVAGAGSGKTKALTHRIANLIENHSVDPHNIL
CCCHHHHHHCCCCCCEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEE
AVTFTNKAAKEMKARLQVLLAQELAFNQFGQPWATLKEFDQNQLRTNIDQERLKDLWIGT
EEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
FHSLFSRLLRYDIEKYQDPEGLRWTRQFSIYDETDSQTLVKEIISQDMSLDPKRFDPKKI
HHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCHHHH
KRAISNAKNQCFTAKELEEKADNHFDKVIADAYRRYKISLSKNNALDFDDLLLLPVFLLR
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHH
QNDLVRDYWHKRFQHVLVDEYQDTNRTQYELIKLITAGNTKPNKFCEWNNRSIFVVGDAD
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEECCCEEEEEECCC
QSIYSFRAADFRILIGFQEDFKGPSNNDKKASLVKLEENYRSSSNILNAANSLIENNTER
CHHHHHHCCCEEEEEEEHHHCCCCCCCCCCHHEEEEHHHCCHHHHHHHHHHHHHHCCHHH
IDKVLKPTKEEGELLKLLSCDDEISEAEAITTKLRSLNNYNNQPIWRNFAILYRTRAQSR
HHHHHCCCCCCCCEEHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
VLEESLVRWRIPYTIFGGLRFYDRREVKDAVAYLKVLVNSSDNVSLLRIINVPRRGIGKT
HHHHHHHHEECCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHH
TIQKLSDLSIKLNIPLWEVINDKQSLDETIGRSSKGINKFTDLMNDLLCYVENSGPAQIL
HHHHHHCCEEEECCCHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHH
QLILEKSGYLNELLRSGSEESEDRRNNLQELINAATQFEEETENANVEGFLSTAALTTDN
HHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCC
DTKKNHPNSVTLMTLHNSKGLEFQNVFITGLEQGLFPSHRSIDTPSLLEEERRLCYVGIT
CCCCCCCCEEEEEEEECCCCCEEHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCEEEEEHH
RAKERVFLSHARERRLWGGMREPTIPSIFLSEIPEELIDGELPQSGGASIRRDRHLDRLT
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHH
RVDRNNSNEFLNKPINAVRKLYSGPSKGKSWIIGDKVIHSKFGKGEIIHIFGSGEKISLA
HHCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEECHHHHHHCCCCCCEEEEEECCCEEEEE
VKFGDKGSKILDPRLAPIRAIN
EEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA