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The map label for this gene is gltA [H]

Identifier: 123965425

GI number: 123965425

Start: 173702

End: 174847

Strand: Reverse

Name: gltA [H]

Synonym: P9515_01901

Alternate gene names: 123965425

Gene position: 174847-173702 (Counterclockwise)

Preceding gene: 123965426

Following gene: 123965424

Centisome position: 10.26

GC content: 37.61

Gene sequence:

>1146_bases
TTGGACCCTAACAAACTAATTTTAAAACCAGGATTAGAGGGTGTCCCAGTAACTAATTCATCAATATGCGATATTGATGG
ACAAAATGGGAAATTGTTATATAGAGGCTATGCAATTGAAGAATTAGCACAGAAAAGTACTTTCTTAGAAACTGCTTTTT
TATTAATTTGGGGAGAATTGCCATCAGCAATAGAACTGAGGGATTTTGAACAAGAAGTACAGATGCATAGGAGATTAAGT
TTCAGAGTTAGAGATATGATGAAATGTTTTCCTGCGACTGGACATCCTATGGATGCTCTTCAATCGAGTGCTGCGTCTCT
TGGCCTTTTTTATTCAAGGAGAGCCATAGATGACCCGAAATATATATACAACGCTGTAATTAGACTTATAGCCAAAATTC
CTACTATGATTGCCGCTTTCCAACTAATTAGAAAAGGGCAGGATCCAATCCAACCGAGAGATGATTTATCTTACTCATCA
AATTTCCTTTATATGCTCACAGAGAAAGAACAAGATCCAATCGCAGCGAAAGTTTTTGATAGATGCTTAATTCTTCATGC
AGAACACAGCTTAAATGCAAGCACCTTCAGTGCGAGAGTTACAGCAAGTACTCTTACTGATCCATACGCAGTAATTGCAT
CTGCGGTGGGGACACTCGCTGGTCCTCTTCATGGAGGAGCAAATGAAGATGTGATTGCAATGCTAGAAGATATTAAAACG
CCCGAAAAAGCCGGTTGTTTTTTGGATGATGCTATAAAAAATAAAAAGAAAATAATGGGTTTCGGTCACAGGGAATATAA
GGTTAAAGATCCTAGAGCAATTATTCTTCAAAAGTTAGCGGAAGAGCTTTTTATCAGATTTGGTAAAGATGAGATGTATG
AAGTTGCTAAAAATTTAGAGTTAGAAGCCATACCAAGACTAGGGCCAAAAGGCATTTTCCCAAATGTTGATTTCTATTCT
GGTCTTGTTTATCGAAAACTTGGAATACCACGAGACCTTTTTACTCCAATTTTCGCAATATCCAGAGTAGCAGGATGGTT
AGCTCACTGGAGGGAACAATTAGGAGCAAACAGGATTTTTAGACCATCGCAAATTTATACTGGATCAGCTCCAAGAGATT
GGATTAGTTTAGAAAACCGAAAATAA

Upstream 100 bases:

>100_bases
TTGAAAATATTTTAATAATTAAATTTGATTGATATCTTATGGTTAACTAAAAATTATTTGACTATCTTAGATCTATAAAG
AATTTATATCTTATTAAAAT

Downstream 100 bases:

>100_bases
TATTTTCAGCTTTTCAAAAAACACACACATATCGTTTATGGCGAGGTAACCTATAGGGTAAATAACAACAAAACTTTGAA
CACCGGATTAGATCTCGAAT

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MDPNKLILKPGLEGVPVTNSSICDIDGQNGKLLYRGYAIEELAQKSTFLETAFLLIWGELPSAIELRDFEQEVQMHRRLS
FRVRDMMKCFPATGHPMDALQSSAASLGLFYSRRAIDDPKYIYNAVIRLIAKIPTMIAAFQLIRKGQDPIQPRDDLSYSS
NFLYMLTEKEQDPIAAKVFDRCLILHAEHSLNASTFSARVTASTLTDPYAVIASAVGTLAGPLHGGANEDVIAMLEDIKT
PEKAGCFLDDAIKNKKKIMGFGHREYKVKDPRAIILQKLAEELFIRFGKDEMYEVAKNLELEAIPRLGPKGIFPNVDFYS
GLVYRKLGIPRDLFTPIFAISRVAGWLAHWREQLGANRIFRPSQIYTGSAPRDWISLENRK

Sequences:

>Translated_381_residues
MDPNKLILKPGLEGVPVTNSSICDIDGQNGKLLYRGYAIEELAQKSTFLETAFLLIWGELPSAIELRDFEQEVQMHRRLS
FRVRDMMKCFPATGHPMDALQSSAASLGLFYSRRAIDDPKYIYNAVIRLIAKIPTMIAAFQLIRKGQDPIQPRDDLSYSS
NFLYMLTEKEQDPIAAKVFDRCLILHAEHSLNASTFSARVTASTLTDPYAVIASAVGTLAGPLHGGANEDVIAMLEDIKT
PEKAGCFLDDAIKNKKKIMGFGHREYKVKDPRAIILQKLAEELFIRFGKDEMYEVAKNLELEAIPRLGPKGIFPNVDFYS
GLVYRKLGIPRDLFTPIFAISRVAGWLAHWREQLGANRIFRPSQIYTGSAPRDWISLENRK
>Mature_381_residues
MDPNKLILKPGLEGVPVTNSSICDIDGQNGKLLYRGYAIEELAQKSTFLETAFLLIWGELPSAIELRDFEQEVQMHRRLS
FRVRDMMKCFPATGHPMDALQSSAASLGLFYSRRAIDDPKYIYNAVIRLIAKIPTMIAAFQLIRKGQDPIQPRDDLSYSS
NFLYMLTEKEQDPIAAKVFDRCLILHAEHSLNASTFSARVTASTLTDPYAVIASAVGTLAGPLHGGANEDVIAMLEDIKT
PEKAGCFLDDAIKNKKKIMGFGHREYKVKDPRAIILQKLAEELFIRFGKDEMYEVAKNLELEAIPRLGPKGIFPNVDFYS
GLVYRKLGIPRDLFTPIFAISRVAGWLAHWREQLGANRIFRPSQIYTGSAPRDWISLENRK

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=380, Percent_Identity=27.1052631578947, Blast_Score=112, Evalue=7e-25,
Organism=Escherichia coli, GI1786939, Length=384, Percent_Identity=38.5416666666667, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI1786527, Length=380, Percent_Identity=34.7368421052632, Blast_Score=238, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI17555174, Length=377, Percent_Identity=28.3819628647215, Blast_Score=111, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6319850, Length=372, Percent_Identity=25.2688172043011, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6325257, Length=376, Percent_Identity=25, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324328, Length=320, Percent_Identity=24.375, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21356863, Length=389, Percent_Identity=27.5064267352185, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24640126, Length=395, Percent_Identity=27.0886075949367, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24640124, Length=395, Percent_Identity=27.0886075949367, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 42900; Mature: 42900

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPNKLILKPGLEGVPVTNSSICDIDGQNGKLLYRGYAIEELAQKSTFLETAFLLIWGEL
CCCCCEEECCCCCCCCCCCCCEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCC
PSAIELRDFEQEVQMHRRLSFRVRDMMKCFPATGHPMDALQSSAASLGLFYSRRAIDDPK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHH
YIYNAVIRLIAKIPTMIAAFQLIRKGQDPIQPRDDLSYSSNFLYMLTEKEQDPIAAKVFD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHH
RCLILHAEHSLNASTFSARVTASTLTDPYAVIASAVGTLAGPLHGGANEDVIAMLEDIKT
HHHHEECCCCCCCCHHEEEEEHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCC
PEKAGCFLDDAIKNKKKIMGFGHREYKVKDPRAIILQKLAEELFIRFGKDEMYEVAKNLE
CHHCCCHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
LEAIPRLGPKGIFPNVDFYSGLVYRKLGIPRDLFTPIFAISRVAGWLAHWREQLGANRIF
EEECCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RPSQIYTGSAPRDWISLENRK
CCCCEEECCCCCHHCCCCCCC
>Mature Secondary Structure
MDPNKLILKPGLEGVPVTNSSICDIDGQNGKLLYRGYAIEELAQKSTFLETAFLLIWGEL
CCCCCEEECCCCCCCCCCCCCEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCC
PSAIELRDFEQEVQMHRRLSFRVRDMMKCFPATGHPMDALQSSAASLGLFYSRRAIDDPK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHH
YIYNAVIRLIAKIPTMIAAFQLIRKGQDPIQPRDDLSYSSNFLYMLTEKEQDPIAAKVFD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHH
RCLILHAEHSLNASTFSARVTASTLTDPYAVIASAVGTLAGPLHGGANEDVIAMLEDIKT
HHHHEECCCCCCCCHHEEEEEHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCC
PEKAGCFLDDAIKNKKKIMGFGHREYKVKDPRAIILQKLAEELFIRFGKDEMYEVAKNLE
CHHCCCHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
LEAIPRLGPKGIFPNVDFYSGLVYRKLGIPRDLFTPIFAISRVAGWLAHWREQLGANRIF
EEECCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RPSQIYTGSAPRDWISLENRK
CCCCEEECCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]