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The map label for this gene is murC [H]

Identifier: 123965256

GI number: 123965256

Start: 22542

End: 23951

Strand: Reverse

Name: murC [H]

Synonym: P9515_00211

Alternate gene names: 123965256

Gene position: 23951-22542 (Counterclockwise)

Preceding gene: 123965258

Following gene: 123965255

Centisome position: 1.41

GC content: 25.74

Gene sequence:

>1410_bases
TTGAATACAAATTTAATTGTCAGAGGTCATTTTCATTTTATTGGCATTGGTGGTATTGGAATGTCTGCGATCGCTTTGGC
ATTAATAAAAAAGGGATACTCAGTTTCTGGTTCTGATTTAGTCAAAAATGAAGAAACGAATAAATTAAAAGAATTTGGAG
CAATAATTTTTGATTCTCAAATAAGTACTAATATTCAATTTGTGCTTTCACAATTTCAAAATCAAACAATTAATTTTGTT
ATTAGCTCAGCAATCAAAGATGATAATGAAGAATTATGCTTTTGCAAAAAAAATAATTTATTAATCAAACATCGTTCTGA
AATTCTTGCGATGATAATGAAATCATACATTACATTATCCATAGCAGGAAGTCATGGAAAAACTTCAACTAGTACTTTCC
TTTCTACTTTATTAGAGTTATGTACTCATGATTCTTCTTCAATAACTGGTGGGATAATCCCAATTTATAAATCCAATGCT
CATATCGAAAATACAAAATACCTAGTAACAGAAATAGATGAATCTGACGGAACAATTAATAATTACACTTCCAACATTGG
AATAATTAATAATATTGATTTCGATCATTGTGACCATTATTCTAATATCGATGAAATACTATCCTCATTTAAACAATTTG
CCTCTAATTCCAAAAAATTATTAATTAATTACGATTGTAAAATTACTAGAGAAAATTTTACTTCACATAATCAATGGTCT
ATTAAAGAAAAAAATAATATTACTTATTCAATAATTCCAAATACCATAAATAAAGATATAACCATTGGAAAATATTATGA
ACATGGCGATTTCGTTGACAGTATAAATATCCCAATTCCAGGGTTACATAATCTTTCAAATATTACTGCTGCAATAGCAG
CCTGTAGAATGATTGGAGTAAGTTTTAAAGAGATAAAAAAAAATATCAAATCTCTAGAATTACCAAAAAAAAGGTTTGAA
TTTAGAGGTGAACTGAATCAAAGAGTTTTTTATGATGATTATGCACATCATCCAAACGAAATTAAAGCCACGATTGATTT
GGCAAGGTTATTTATTATAGATAATAATATAAATAAAAATCAAAAAGGAAGATTAATTGCTATTTTTCAACCACATAGAT
TTACTAGAGTAAAACAATTTATTCATGAGTTTGTCCAAGAATTATCAAAAGCCGATGTTATCTACTTAACAAATATTTTT
GGTGCTGGAGAAGAAAATATAGATAACATTAATTCGCAAGTAATTGCAAACCTTATTTATAAAAAAAATAAAAATGTTAC
ATGTTTAAAAAACAATTATGAAATAAAAGATAAATTTTTTAAATTAACGAAAGAAAATGATTTTATATTAAATATGGGTG
CTGGAGATTGTCATAAACTATGGTCAATATTAAATAATAAAAATACTTAA

Upstream 100 bases:

>100_bases
TTTTTGTATTAATTCATAAAAAAACAAACATTTTTTGTAAAAATTAAATGTCAAAATAATTACTTAGAAGTTATCTTGAT
TTTAAGTATAAAGTTCATAA

Downstream 100 bases:

>100_bases
AAGATTAAAAAAATAATGGAAAATATTAATTTAGAAGAGAAAATAAACCTTTCAAATTATACAACTATAAAAGTTGGTGG
ATTTGCAGAATATTTTTCAC

Product: UDP-N-acetylmuramate-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MNTNLIVRGHFHFIGIGGIGMSAIALALIKKGYSVSGSDLVKNEETNKLKEFGAIIFDSQISTNIQFVLSQFQNQTINFV
ISSAIKDDNEELCFCKKNNLLIKHRSEILAMIMKSYITLSIAGSHGKTSTSTFLSTLLELCTHDSSSITGGIIPIYKSNA
HIENTKYLVTEIDESDGTINNYTSNIGIINNIDFDHCDHYSNIDEILSSFKQFASNSKKLLINYDCKITRENFTSHNQWS
IKEKNNITYSIIPNTINKDITIGKYYEHGDFVDSINIPIPGLHNLSNITAAIAACRMIGVSFKEIKKNIKSLELPKKRFE
FRGELNQRVFYDDYAHHPNEIKATIDLARLFIIDNNINKNQKGRLIAIFQPHRFTRVKQFIHEFVQELSKADVIYLTNIF
GAGEENIDNINSQVIANLIYKKNKNVTCLKNNYEIKDKFFKLTKENDFILNMGAGDCHKLWSILNNKNT

Sequences:

>Translated_469_residues
MNTNLIVRGHFHFIGIGGIGMSAIALALIKKGYSVSGSDLVKNEETNKLKEFGAIIFDSQISTNIQFVLSQFQNQTINFV
ISSAIKDDNEELCFCKKNNLLIKHRSEILAMIMKSYITLSIAGSHGKTSTSTFLSTLLELCTHDSSSITGGIIPIYKSNA
HIENTKYLVTEIDESDGTINNYTSNIGIINNIDFDHCDHYSNIDEILSSFKQFASNSKKLLINYDCKITRENFTSHNQWS
IKEKNNITYSIIPNTINKDITIGKYYEHGDFVDSINIPIPGLHNLSNITAAIAACRMIGVSFKEIKKNIKSLELPKKRFE
FRGELNQRVFYDDYAHHPNEIKATIDLARLFIIDNNINKNQKGRLIAIFQPHRFTRVKQFIHEFVQELSKADVIYLTNIF
GAGEENIDNINSQVIANLIYKKNKNVTCLKNNYEIKDKFFKLTKENDFILNMGAGDCHKLWSILNNKNT
>Mature_469_residues
MNTNLIVRGHFHFIGIGGIGMSAIALALIKKGYSVSGSDLVKNEETNKLKEFGAIIFDSQISTNIQFVLSQFQNQTINFV
ISSAIKDDNEELCFCKKNNLLIKHRSEILAMIMKSYITLSIAGSHGKTSTSTFLSTLLELCTHDSSSITGGIIPIYKSNA
HIENTKYLVTEIDESDGTINNYTSNIGIINNIDFDHCDHYSNIDEILSSFKQFASNSKKLLINYDCKITRENFTSHNQWS
IKEKNNITYSIIPNTINKDITIGKYYEHGDFVDSINIPIPGLHNLSNITAAIAACRMIGVSFKEIKKNIKSLELPKKRFE
FRGELNQRVFYDDYAHHPNEIKATIDLARLFIIDNNINKNQKGRLIAIFQPHRFTRVKQFIHEFVQELSKADVIYLTNIF
GAGEENIDNINSQVIANLIYKKNKNVTCLKNNYEIKDKFFKLTKENDFILNMGAGDCHKLWSILNNKNT

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=480, Percent_Identity=28.3333333333333, Blast_Score=167, Evalue=9e-43,
Organism=Escherichia coli, GI1790680, Length=397, Percent_Identity=24.9370277078086, Blast_Score=130, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 53279; Mature: 53279

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTNLIVRGHFHFIGIGGIGMSAIALALIKKGYSVSGSDLVKNEETNKLKEFGAIIFDSQ
CCCCEEEEEEEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHCCEEECCC
ISTNIQFVLSQFQNQTINFVISSAIKDDNEELCFCKKNNLLIKHRSEILAMIMKSYITLS
CCCHHHHHHHHHCCCCEEEEEEHHHCCCCCCEEEEECCCEEEEHHHHHHHHHHHHHEEEE
IAGSHGKTSTSTFLSTLLELCTHDSSSITGGIIPIYKSNAHIENTKYLVTEIDESDGTIN
EECCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCEEEEEEECCCCCCCC
NYTSNIGIINNIDFDHCDHYSNIDEILSSFKQFASNSKKLLINYDCKITRENFTSHNQWS
CCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECEEEEECCCCCCCCEE
IKEKNNITYSIIPNTINKDITIGKYYEHGDFVDSINIPIPGLHNLSNITAAIAACRMIGV
EEECCCEEEEEECCCCCCCEEEEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCC
SFKEIKKNIKSLELPKKRFEFRGELNQRVFYDDYAHHPNEIKATIDLARLFIIDNNINKN
CHHHHHHHHHHCCCCHHHHHHHCCCCCEEEECHHCCCCCHHHHHEEEEEEEEEECCCCCC
QKGRLIAIFQPHRFTRVKQFIHEFVQELSKADVIYLTNIFGAGEENIDNINSQVIANLIY
CCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHH
KKNKNVTCLKNNYEIKDKFFKLTKENDFILNMGAGDCHKLWSILNNKNT
HCCCCEEEEECCCCHHHHHEEEECCCCEEEECCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MNTNLIVRGHFHFIGIGGIGMSAIALALIKKGYSVSGSDLVKNEETNKLKEFGAIIFDSQ
CCCCEEEEEEEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHCCEEECCC
ISTNIQFVLSQFQNQTINFVISSAIKDDNEELCFCKKNNLLIKHRSEILAMIMKSYITLS
CCCHHHHHHHHHCCCCEEEEEEHHHCCCCCCEEEEECCCEEEEHHHHHHHHHHHHHEEEE
IAGSHGKTSTSTFLSTLLELCTHDSSSITGGIIPIYKSNAHIENTKYLVTEIDESDGTIN
EECCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCEEEEEEECCCCCCCC
NYTSNIGIINNIDFDHCDHYSNIDEILSSFKQFASNSKKLLINYDCKITRENFTSHNQWS
CCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECEEEEECCCCCCCCEE
IKEKNNITYSIIPNTINKDITIGKYYEHGDFVDSINIPIPGLHNLSNITAAIAACRMIGV
EEECCCEEEEEECCCCCCCEEEEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCC
SFKEIKKNIKSLELPKKRFEFRGELNQRVFYDDYAHHPNEIKATIDLARLFIIDNNINKN
CHHHHHHHHHHCCCCHHHHHHHCCCCCEEEECHHCCCCCHHHHHEEEEEEEEEECCCCCC
QKGRLIAIFQPHRFTRVKQFIHEFVQELSKADVIYLTNIFGAGEENIDNINSQVIANLIY
CCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHH
KKNKNVTCLKNNYEIKDKFFKLTKENDFILNMGAGDCHKLWSILNNKNT
HCCCCEEEEECCCCHHHHHEEEECCCCEEEECCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]