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The map label for this gene is mrdB [H]

Identifier: 123969319

GI number: 123969319

Start: 1521222

End: 1522490

Strand: Reverse

Name: mrdB [H]

Synonym: A9601_17871

Alternate gene names: 123969319

Gene position: 1522490-1521222 (Counterclockwise)

Preceding gene: 123969320

Following gene: 123969318

Centisome position: 91.17

GC content: 30.42

Gene sequence:

>1269_bases
ATGTTTAGGAGAATTTCTTTATTAAATAAGAGAGGATTTTTCCCAAAAAAAGAAAACTTTAAGAGAGGTTTTTTATTTTC
TCCACTACTTATAATTCCTCTGTTTTTGGTTATTATTTCGGGTTTATTAATAAAAAGTATTCAGGGTGATTTTTTAGTAT
CGAATTATTTGAGTCATATTTTTACTGGTTTTTTAGGTTATTTTTTAGCATTTTTTATTTCTTATATACCGTTAGAGAGA
CTAAGAAAGTACTTAGTACCATTTTATTTGTGTACTTTAATATCCTTATTACTAATATATTTCTTTGGGATATCAGTTTC
TGGAGCTCAAAGGTGGTTAAACTTGGGTATCTTTTCTTTTCAGCCTTCAGAAGTAGCTAAACTAAGTACTGTATTAACTC
TTGCTTTAGTACTCGACAAAAAAATAATTTGCACAATAAGGGACTTAATTTTGCCCTTATTAGTAGTAGTTATTCCTTGG
TTATTGGTTTTCTTTCAGCCGGACTTAGGTACCTCTTTAGTTTTAATTGTTTTGACAGGTGTGATGCTCTACTGGTCGCA
AATGCCCATAGAGTGGATTTTGTTATTAGTATTTTGTCTTGTCACTTCTATATTGTATTTGACCTTACCAAATCTTCTTG
TTTTCTGGATTCCATTTATAGGATATCTTGCTTATAGATCTTCGAGAAAGAAAATTATTTTTCCTGCTATCGCGATTTCT
TTTCATTTATTAGTGGCAAAATTGACACCATTTTTGTGGCAATATGGCTTAAAAGAATATCAAAAAGATAGATTAGTTTT
ATTTTTAGATCCAAATAGAGATCCATTAGGTGGTGGATATCATTTGATACAGAGTCAAATTGCAATTGGTTCTGGAGGAT
TATTTGGTACTGGTTTGCTAAAAGGTAAGCTGACTAATTTGCAATTTATACCAGAACAACATACTGATTTTATATTCAGT
GCTTTAGGCGAAGAATTGGGTTTTGTGGGGTGCATAGTAGTTTTATTTTTGTTCTTTTTTTTGATAAAAAAACTTATTAA
TACTGCAACAATTGCCAGGACTAACTTTGAATCTCTAATTGTTATTGGAATAGCCTCAACTTTTTTGTTCCAAATAATTA
TTAACTTATTTATGACTATTGGATTAGGACCAGTTACTGGAATCCCCCTTCCTTTTATGAGCTATGGTCGAACGTCATTG
GTGACCAATTTTATATCCATTGGATTTGTTTTATCTATATTAAAACGTTCTAGATCACTAAGAATTTGA

Upstream 100 bases:

>100_bases
GGGTGTACCAATATCAATAAGCCAGCCCAATAAAAATAGTTCTATTGCTTTTAGTAATTTAGCTCAATTAATTAAGAGTC
AATTTGTTAATAGATAATTG

Downstream 100 bases:

>100_bases
TGAAATCACAAATAACCATAAAAAAAATTCAAGAGCTTTTGATTAAAGGAGTTAAAAAAATATATGTGGATGATGATACA
TCCAGAAGAATGTGGTGGGC

Product: cell division membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MFRRISLLNKRGFFPKKENFKRGFLFSPLLIIPLFLVIISGLLIKSIQGDFLVSNYLSHIFTGFLGYFLAFFISYIPLER
LRKYLVPFYLCTLISLLLIYFFGISVSGAQRWLNLGIFSFQPSEVAKLSTVLTLALVLDKKIICTIRDLILPLLVVVIPW
LLVFFQPDLGTSLVLIVLTGVMLYWSQMPIEWILLLVFCLVTSILYLTLPNLLVFWIPFIGYLAYRSSRKKIIFPAIAIS
FHLLVAKLTPFLWQYGLKEYQKDRLVLFLDPNRDPLGGGYHLIQSQIAIGSGGLFGTGLLKGKLTNLQFIPEQHTDFIFS
ALGEELGFVGCIVVLFLFFFLIKKLINTATIARTNFESLIVIGIASTFLFQIIINLFMTIGLGPVTGIPLPFMSYGRTSL
VTNFISIGFVLSILKRSRSLRI

Sequences:

>Translated_422_residues
MFRRISLLNKRGFFPKKENFKRGFLFSPLLIIPLFLVIISGLLIKSIQGDFLVSNYLSHIFTGFLGYFLAFFISYIPLER
LRKYLVPFYLCTLISLLLIYFFGISVSGAQRWLNLGIFSFQPSEVAKLSTVLTLALVLDKKIICTIRDLILPLLVVVIPW
LLVFFQPDLGTSLVLIVLTGVMLYWSQMPIEWILLLVFCLVTSILYLTLPNLLVFWIPFIGYLAYRSSRKKIIFPAIAIS
FHLLVAKLTPFLWQYGLKEYQKDRLVLFLDPNRDPLGGGYHLIQSQIAIGSGGLFGTGLLKGKLTNLQFIPEQHTDFIFS
ALGEELGFVGCIVVLFLFFFLIKKLINTATIARTNFESLIVIGIASTFLFQIIINLFMTIGLGPVTGIPLPFMSYGRTSL
VTNFISIGFVLSILKRSRSLRI
>Mature_422_residues
MFRRISLLNKRGFFPKKENFKRGFLFSPLLIIPLFLVIISGLLIKSIQGDFLVSNYLSHIFTGFLGYFLAFFISYIPLER
LRKYLVPFYLCTLISLLLIYFFGISVSGAQRWLNLGIFSFQPSEVAKLSTVLTLALVLDKKIICTIRDLILPLLVVVIPW
LLVFFQPDLGTSLVLIVLTGVMLYWSQMPIEWILLLVFCLVTSILYLTLPNLLVFWIPFIGYLAYRSSRKKIIFPAIAIS
FHLLVAKLTPFLWQYGLKEYQKDRLVLFLDPNRDPLGGGYHLIQSQIAIGSGGLFGTGLLKGKLTNLQFIPEQHTDFIFS
ALGEELGFVGCIVVLFLFFFLIKKLINTATIARTNFESLIVIGIASTFLFQIIINLFMTIGLGPVTGIPLPFMSYGRTSL
VTNFISIGFVLSILKRSRSLRI

Specific function: This is one of the proteins responsible for the rod shape of the cell. It is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=412, Percent_Identity=33.7378640776699, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1786277, Length=360, Percent_Identity=28.8888888888889, Blast_Score=146, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 47878; Mature: 47878

Theoretical pI: Translated: 10.35; Mature: 10.35

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CC
>Mature Secondary Structure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CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]