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The map label for this gene is bioF [C]

Identifier: 123969202

GI number: 123969202

Start: 1413448

End: 1414587

Strand: Direct

Name: bioF [C]

Synonym: A9601_16701

Alternate gene names: 123969202

Gene position: 1413448-1414587 (Clockwise)

Preceding gene: 123969200

Following gene: 123969203

Centisome position: 84.64

GC content: 33.16

Gene sequence:

>1140_bases
ATGAGAAAAGTAAAAATTCCAAAAAATAGAATCCGTAAATTAAAAACATTTTCTTTAGGTAAAAAATCCTTCGAACTTCT
AAGTTTAAATTCACAAAATAAAAAACTTATAGACTTATGCAGTAATGATTATTTTGGATTAAGCAGGGACAAAGATTTAA
TAAAAGCTGCTTACGAAATAAGCTCGTTAGAAGGCATTGGTTCAGGAAGCTCTAGGTTTATTACAGGTTCAAGACCAATA
CATAAATTATTAGAAACAGAACTTGCCAAGTGGCTTGATCAAGAGAAAGTATTACTTTTCCCAAGCGGATTTCAAGCAAA
TATAGCCGCAATCCAGACTTTAGCAAACAGAAATAGTATCGTAATAGCAGATAAATTGATCCATAACTCTTTATTGGTTG
GAGTCAAAGCTGCTGAAGCAAAACTAGTTCGATTCTCACACAATAATTTAAAAGATTTAGAAGATAAGATTATTAAATCT
AACCCCACAAAAAATTCCATTTTAGTTGTTGTTGAATCTCTTTATAGCATGGAGGGATCAATTGCTCCGCTCAGAGAAAT
AACGGAAATTTGCAAAAAAAATAGTGTTCGATTATTAGTTGACGAAGCCCATGCAATTGGGATCTTGGGCCCTGAAGGCA
GGGGTTTAAGTTTTAATTGTCGTTCAGATATAGATATGATTACTGGAACTTTTGGCAAAGCATTTGGAAGCGGTGGAGCT
TTCATAGCTTCCAATTCAGAAATTGGAGAATATCTTATCCAAACAAGTGGTGCATTTAGGTATACAACTGCACTTGCGCC
ATCTTTGGCTGCTGGGGCACTAGAAGGTTTAAAAAAAATTTTAGAAAATAAAGAATGGGGTAATGATTTGTTATCTTGTG
CGAAAGTATGGAAAGATGAAATTATTAAAAATTTTAGTTTTCCAGTTCAGGGAGATTCTCACATTTTATCAATTATTGTT
GGCCAAGAAGAGAAAGCAATCTATCTACAAAAATATCTCGAAGAAAATGGGTTTTTAGCAATTGCGATAAGACCTCCAAC
TGTTCCAGTGGGGCAGTCAAGAATCAGAATAACAATACGAAGAAACTTAGATTTTAATCTGCTAAATAATTTCATTGCAG
TATTAAAAGAATTTAAATGA

Upstream 100 bases:

>100_bases
TATGATCTATATAGATATTAATAAACAAAAAATACCTTGCAAACTTTAATAGTAAATCTAAATCTTTTTAATTAAATCCA
CTATATTTTATTTTGCCAAA

Downstream 100 bases:

>100_bases
AACAAATTATTACTCAACATGGGTGGGGACTAAATAAATATTTCTGGGATGATTATAAAGTTGATTTTTTAAATAATAAT
TGGCATTGGCAAGATAATGA

Product: putative 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MRKVKIPKNRIRKLKTFSLGKKSFELLSLNSQNKKLIDLCSNDYFGLSRDKDLIKAAYEISSLEGIGSGSSRFITGSRPI
HKLLETELAKWLDQEKVLLFPSGFQANIAAIQTLANRNSIVIADKLIHNSLLVGVKAAEAKLVRFSHNNLKDLEDKIIKS
NPTKNSILVVVESLYSMEGSIAPLREITEICKKNSVRLLVDEAHAIGILGPEGRGLSFNCRSDIDMITGTFGKAFGSGGA
FIASNSEIGEYLIQTSGAFRYTTALAPSLAAGALEGLKKILENKEWGNDLLSCAKVWKDEIIKNFSFPVQGDSHILSIIV
GQEEKAIYLQKYLEENGFLAIAIRPPTVPVGQSRIRITIRRNLDFNLLNNFIAVLKEFK

Sequences:

>Translated_379_residues
MRKVKIPKNRIRKLKTFSLGKKSFELLSLNSQNKKLIDLCSNDYFGLSRDKDLIKAAYEISSLEGIGSGSSRFITGSRPI
HKLLETELAKWLDQEKVLLFPSGFQANIAAIQTLANRNSIVIADKLIHNSLLVGVKAAEAKLVRFSHNNLKDLEDKIIKS
NPTKNSILVVVESLYSMEGSIAPLREITEICKKNSVRLLVDEAHAIGILGPEGRGLSFNCRSDIDMITGTFGKAFGSGGA
FIASNSEIGEYLIQTSGAFRYTTALAPSLAAGALEGLKKILENKEWGNDLLSCAKVWKDEIIKNFSFPVQGDSHILSIIV
GQEEKAIYLQKYLEENGFLAIAIRPPTVPVGQSRIRITIRRNLDFNLLNNFIAVLKEFK
>Mature_379_residues
MRKVKIPKNRIRKLKTFSLGKKSFELLSLNSQNKKLIDLCSNDYFGLSRDKDLIKAAYEISSLEGIGSGSSRFITGSRPI
HKLLETELAKWLDQEKVLLFPSGFQANIAAIQTLANRNSIVIADKLIHNSLLVGVKAAEAKLVRFSHNNLKDLEDKIIKS
NPTKNSILVVVESLYSMEGSIAPLREITEICKKNSVRLLVDEAHAIGILGPEGRGLSFNCRSDIDMITGTFGKAFGSGGA
FIASNSEIGEYLIQTSGAFRYTTALAPSLAAGALEGLKKILENKEWGNDLLSCAKVWKDEIIKNFSFPVQGDSHILSIIV
GQEEKAIYLQKYLEENGFLAIAIRPPTVPVGQSRIRITIRRNLDFNLLNNFIAVLKEFK

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977444, Length=345, Percent_Identity=32.1739130434783, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI83977442, Length=345, Percent_Identity=32.1739130434783, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI83977440, Length=345, Percent_Identity=32.1739130434783, Blast_Score=165, Evalue=8e-41,
Organism=Homo sapiens, GI284448556, Length=339, Percent_Identity=28.6135693215339, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI7657118, Length=328, Percent_Identity=28.3536585365854, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI4502025, Length=346, Percent_Identity=30.3468208092486, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI40316939, Length=346, Percent_Identity=30.3468208092486, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI119220554, Length=364, Percent_Identity=27.7472527472527, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI4758668, Length=346, Percent_Identity=29.7687861271676, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI5454084, Length=249, Percent_Identity=28.9156626506024, Blast_Score=105, Evalue=9e-23,
Organism=Escherichia coli, GI1790046, Length=339, Percent_Identity=31.858407079646, Blast_Score=184, Evalue=6e-48,
Organism=Escherichia coli, GI1786993, Length=356, Percent_Identity=32.8651685393258, Blast_Score=182, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI71994529, Length=338, Percent_Identity=29.585798816568, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI32566772, Length=360, Percent_Identity=29.4444444444444, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17560912, Length=248, Percent_Identity=32.258064516129, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17560914, Length=248, Percent_Identity=32.258064516129, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71982617, Length=231, Percent_Identity=29.004329004329, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71982625, Length=231, Percent_Identity=29.004329004329, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320438, Length=368, Percent_Identity=30.7065217391304, Blast_Score=166, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6320267, Length=358, Percent_Identity=25.9776536312849, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6323954, Length=274, Percent_Identity=25.1824817518248, Blast_Score=99, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24662918, Length=337, Percent_Identity=29.3768545994065, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI17137420, Length=353, Percent_Identity=30.3116147308782, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI17136286, Length=363, Percent_Identity=27.8236914600551, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24653280, Length=288, Percent_Identity=25, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24653276, Length=288, Percent_Identity=25, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24653278, Length=288, Percent_Identity=25, Blast_Score=116, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 41939; Mature: 41939

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKVKIPKNRIRKLKTFSLGKKSFELLSLNSQNKKLIDLCSNDYFGLSRDKDLIKAAYEI
CCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHH
SSLEGIGSGSSRFITGSRPIHKLLETELAKWLDQEKVLLFPSGFQANIAAIQTLANRNSI
HHHCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCE
VIADKLIHNSLLVGVKAAEAKLVRFSHNNLKDLEDKIIKSNPTKNSILVVVESLYSMEGS
EEEHHHHHHHHHEEEEHHHEEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC
IAPLREITEICKKNSVRLLVDEAHAIGILGPEGRGLSFNCRSDIDMITGTFGKAFGSGGA
CCCHHHHHHHHHCCCEEEEEECCCEEEEECCCCCCCEEECCCCCHHHHHHHHHHHCCCCE
FIASNSEIGEYLIQTSGAFRYTTALAPSLAAGALEGLKKILENKEWGNDLLSCAKVWKDE
EEECCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
IIKNFSFPVQGDSHILSIIVGQEEKAIYLQKYLEENGFLAIAIRPPTVPVGQSRIRITIR
HHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEEEEE
RNLDFNLLNNFIAVLKEFK
ECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKVKIPKNRIRKLKTFSLGKKSFELLSLNSQNKKLIDLCSNDYFGLSRDKDLIKAAYEI
CCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHH
SSLEGIGSGSSRFITGSRPIHKLLETELAKWLDQEKVLLFPSGFQANIAAIQTLANRNSI
HHHCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCE
VIADKLIHNSLLVGVKAAEAKLVRFSHNNLKDLEDKIIKSNPTKNSILVVVESLYSMEGS
EEEHHHHHHHHHEEEEHHHEEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC
IAPLREITEICKKNSVRLLVDEAHAIGILGPEGRGLSFNCRSDIDMITGTFGKAFGSGGA
CCCHHHHHHHHHCCCEEEEEECCCEEEEECCCCCCCEEECCCCCHHHHHHHHHHHCCCCE
FIASNSEIGEYLIQTSGAFRYTTALAPSLAAGALEGLKKILENKEWGNDLLSCAKVWKDE
EEECCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
IIKNFSFPVQGDSHILSIIVGQEEKAIYLQKYLEENGFLAIAIRPPTVPVGQSRIRITIR
HHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEEEEE
RNLDFNLLNNFIAVLKEFK
ECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA