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The map label for this gene is fumC [H]

Identifier: 123969200

GI number: 123969200

Start: 1409186

End: 1410571

Strand: Direct

Name: fumC [H]

Synonym: A9601_16681

Alternate gene names: 123969200

Gene position: 1409186-1410571 (Clockwise)

Preceding gene: 123969199

Following gene: 123969202

Centisome position: 84.39

GC content: 32.03

Gene sequence:

>1386_bases
ATGACCAAAAATTTTAGGATTGAAAAAGATAGTATGGGAACAATAGAGGTTCCCATGGAAGCTTTGTGGGGTGCCCAAAC
ACAAAGATCGATAATAAATTTTTCTATTGGAGAAGAATTAATTCCAATTGAGTTAATTTATTCACTGACCCTCATAAAAA
AAGCTGCTTCAATTGCGAATTTCAATTTAGGTTTAATAGATAAAAGGAAAAAAGATTTGATTGTAGAGGCATGTACGGAA
ATACTTGATGGGCTTCACGATTCACAGTTTCCCTTAAAGGTTTGGCAAACAGGTAGTGGTACGCAAACAAATATGAATGT
TAATGAAGTAATTTCAAATATTGCAGCTTTAAAAACTAATTCAGAGCTTGGTAGTCATCAACCAATTCATCCGAATGATG
ATGTAAATAAATCTCAGTCAACTAATGACACTTTTCCTGCTGCTATTCAAATATCTGTTGTTAATGAAATAATCAAAAAT
CTAGTTCCAACGATCAGAGAACTTACTAAGGTCTTTGATAAAAAAAGTGAAGAATGGAAAGACCTTATAAAGATAGGAAG
AACCCATTTTCAAGATGCAGTTCCCCTTACTTTTGGGCAAGAAATATCAGGATGGTCAGAGCAACTTAAAGATGCTGAGA
ATGCAATTATTATGAGTCTGAATGAATTGTATTTCTTACCTCTGGGAGGAACTGCGGTTGGTACAGGGATTAATTGTCCA
AAAGGATTTTGTGAAGAGTCTATAAAATCAATTTCCGATGATACTAATTTAATGTTCTATAAATCAAAAAATAATTTTTC
TATCATGGCCTCGCATGATCGTCTTGCTCAAGTAATGAGTCAGATAAAAATATTAGCAAGTGCATTATTTAAAATTTCAA
ATGACATAAAAATTCTATCTTCTGGTCCAAGATCAGGAATATATGAACTGATTATTCCTCAAAATGAACCTGGAAGTTCT
ATTATGCCAGGGAAAGTGAATCCAACTCAATGCGAAGCATTATCAATGGTTTGTACTCAGATAATGGGTCTTGAATATGC
AGTCTCAATGGCAAATTCTAGCGGCACTTTACAGATGAATGAATATAAGCCTCTTATTGGATTTAATATTCTCACAAGTT
TAAAATTACTTAAAAATGTAATAGAAAACTTCAGAAAAAAATTAGTTGATGGTATGCAACCTAATCAAAAGAAAATGAAG
TTAAATTTAGAAAATTCACTAATGTTGGTTACAGCCATAGTGCCAAAAGTTGGTTATGAAAAAGCAGCTGAAATTGCAAA
CCTTGCCTTCAAAGAATCATTAAATTTAAAAGAGGCAACAATTAAATTAGGTTATTTAAACGAAGATGAATTTGATGAAG
CAATGAATATCAATTCAATGATTTGA

Upstream 100 bases:

>100_bases
TTCAATTCATCTTAATAATTTAAGTGTAATATGGGAGAAGTTAGGTATCTAGGATTACTGAAAACCTTATCTAAGTTAAA
CCAGTGTTTTCAGAGGAATA

Downstream 100 bases:

>100_bases
TTAAAAAAATTTAAGAATTATTGTCAATTCGTTTTGTCGCAGGATTAACATCTTCAGAGACTTTTATAAGATCATTAGAT
TCAGAAACAGGAAAACGATT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MTKNFRIEKDSMGTIEVPMEALWGAQTQRSIINFSIGEELIPIELIYSLTLIKKAASIANFNLGLIDKRKKDLIVEACTE
ILDGLHDSQFPLKVWQTGSGTQTNMNVNEVISNIAALKTNSELGSHQPIHPNDDVNKSQSTNDTFPAAIQISVVNEIIKN
LVPTIRELTKVFDKKSEEWKDLIKIGRTHFQDAVPLTFGQEISGWSEQLKDAENAIIMSLNELYFLPLGGTAVGTGINCP
KGFCEESIKSISDDTNLMFYKSKNNFSIMASHDRLAQVMSQIKILASALFKISNDIKILSSGPRSGIYELIIPQNEPGSS
IMPGKVNPTQCEALSMVCTQIMGLEYAVSMANSSGTLQMNEYKPLIGFNILTSLKLLKNVIENFRKKLVDGMQPNQKKMK
LNLENSLMLVTAIVPKVGYEKAAEIANLAFKESLNLKEATIKLGYLNEDEFDEAMNINSMI

Sequences:

>Translated_461_residues
MTKNFRIEKDSMGTIEVPMEALWGAQTQRSIINFSIGEELIPIELIYSLTLIKKAASIANFNLGLIDKRKKDLIVEACTE
ILDGLHDSQFPLKVWQTGSGTQTNMNVNEVISNIAALKTNSELGSHQPIHPNDDVNKSQSTNDTFPAAIQISVVNEIIKN
LVPTIRELTKVFDKKSEEWKDLIKIGRTHFQDAVPLTFGQEISGWSEQLKDAENAIIMSLNELYFLPLGGTAVGTGINCP
KGFCEESIKSISDDTNLMFYKSKNNFSIMASHDRLAQVMSQIKILASALFKISNDIKILSSGPRSGIYELIIPQNEPGSS
IMPGKVNPTQCEALSMVCTQIMGLEYAVSMANSSGTLQMNEYKPLIGFNILTSLKLLKNVIENFRKKLVDGMQPNQKKMK
LNLENSLMLVTAIVPKVGYEKAAEIANLAFKESLNLKEATIKLGYLNEDEFDEAMNINSMI
>Mature_460_residues
TKNFRIEKDSMGTIEVPMEALWGAQTQRSIINFSIGEELIPIELIYSLTLIKKAASIANFNLGLIDKRKKDLIVEACTEI
LDGLHDSQFPLKVWQTGSGTQTNMNVNEVISNIAALKTNSELGSHQPIHPNDDVNKSQSTNDTFPAAIQISVVNEIIKNL
VPTIRELTKVFDKKSEEWKDLIKIGRTHFQDAVPLTFGQEISGWSEQLKDAENAIIMSLNELYFLPLGGTAVGTGINCPK
GFCEESIKSISDDTNLMFYKSKNNFSIMASHDRLAQVMSQIKILASALFKISNDIKILSSGPRSGIYELIIPQNEPGSSI
MPGKVNPTQCEALSMVCTQIMGLEYAVSMANSSGTLQMNEYKPLIGFNILTSLKLLKNVIENFRKKLVDGMQPNQKKMKL
NLENSLMLVTAIVPKVGYEKAAEIANLAFKESLNLKEATIKLGYLNEDEFDEAMNINSMI

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=47.8260869565217, Blast_Score=428, Evalue=1e-120,
Organism=Escherichia coli, GI1787896, Length=456, Percent_Identity=48.2456140350877, Blast_Score=443, Evalue=1e-125,
Organism=Escherichia coli, GI87082375, Length=466, Percent_Identity=37.1244635193133, Blast_Score=300, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI17553882, Length=458, Percent_Identity=48.471615720524, Blast_Score=444, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI32565146, Length=324, Percent_Identity=46.6049382716049, Blast_Score=306, Evalue=2e-83,
Organism=Saccharomyces cerevisiae, GI6324993, Length=455, Percent_Identity=45.9340659340659, Blast_Score=424, Evalue=1e-119,
Organism=Drosophila melanogaster, GI78710009, Length=461, Percent_Identity=48.590021691974, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24640177, Length=463, Percent_Identity=48.5961123110151, Blast_Score=443, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24640179, Length=463, Percent_Identity=48.5961123110151, Blast_Score=443, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24662684, Length=460, Percent_Identity=47.1739130434783, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24583245, Length=460, Percent_Identity=43.2608695652174, Blast_Score=399, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 51136; Mature: 51005

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKNFRIEKDSMGTIEVPMEALWGAQTQRSIINFSIGEELIPIELIYSLTLIKKAASIAN
CCCCCEECCCCCCCEECCHHHHCCCHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHC
FNLGLIDKRKKDLIVEACTEILDGLHDSQFPLKVWQTGSGTQTNMNVNEVISNIAALKTN
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCC
SELGSHQPIHPNDDVNKSQSTNDTFPAAIQISVVNEIIKNLVPTIRELTKVFDKKSEEWK
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
DLIKIGRTHFQDAVPLTFGQEISGWSEQLKDAENAIIMSLNELYFLPLGGTAVGTGINCP
HHHHHHHHHHCCCCCCCCCCHHCCHHHHHHHCCCCEEEEECCEEEEECCCCEECCCCCCC
KGFCEESIKSISDDTNLMFYKSKNNFSIMASHDRLAQVMSQIKILASALFKISNDIKILS
HHHHHHHHHHCCCCCCEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
SGPRSGIYELIIPQNEPGSSIMPGKVNPTQCEALSMVCTQIMGLEYAVSMANSSGTLQMN
CCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEC
EYKPLIGFNILTSLKLLKNVIENFRKKLVDGMQPNQKKMKLNLENSLMLVTAIVPKVGYE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEEECCCCEEEEHHHHCCCCHH
KAAEIANLAFKESLNLKEATIKLGYLNEDEFDEAMNINSMI
HHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHCCCCCCC
>Mature Secondary Structure 
TKNFRIEKDSMGTIEVPMEALWGAQTQRSIINFSIGEELIPIELIYSLTLIKKAASIAN
CCCCEECCCCCCCEECCHHHHCCCHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHC
FNLGLIDKRKKDLIVEACTEILDGLHDSQFPLKVWQTGSGTQTNMNVNEVISNIAALKTN
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCC
SELGSHQPIHPNDDVNKSQSTNDTFPAAIQISVVNEIIKNLVPTIRELTKVFDKKSEEWK
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
DLIKIGRTHFQDAVPLTFGQEISGWSEQLKDAENAIIMSLNELYFLPLGGTAVGTGINCP
HHHHHHHHHHCCCCCCCCCCHHCCHHHHHHHCCCCEEEEECCEEEEECCCCEECCCCCCC
KGFCEESIKSISDDTNLMFYKSKNNFSIMASHDRLAQVMSQIKILASALFKISNDIKILS
HHHHHHHHHHCCCCCCEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
SGPRSGIYELIIPQNEPGSSIMPGKVNPTQCEALSMVCTQIMGLEYAVSMANSSGTLQMN
CCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEC
EYKPLIGFNILTSLKLLKNVIENFRKKLVDGMQPNQKKMKLNLENSLMLVTAIVPKVGYE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEEECCCCEEEEHHHHCCCCHH
KAAEIANLAFKESLNLKEATIKLGYLNEDEFDEAMNINSMI
HHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]