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The map label for this gene is serA [H]

Identifier: 123969087

GI number: 123969087

Start: 1332660

End: 1334246

Strand: Reverse

Name: serA [H]

Synonym: A9601_15551

Alternate gene names: 123969087

Gene position: 1334246-1332660 (Counterclockwise)

Preceding gene: 123969093

Following gene: 123969086

Centisome position: 79.9

GC content: 37.56

Gene sequence:

>1587_bases
ATGACAAAAGTTCTCATTACAGATCCAATTGATCAAACAGGAATCGATATTCTTTCACAAGTTGCTCAGGTTGATCAGAA
GATAGGAATATCAGACTCTGAGTTAGCGTCTATTATTAAAGATTATGATGCTTTAATGATTCGTTCTGGGACCCAAGTGA
CTGAAGAGATTATTAACTCTTCAAGTAAACTTAGAATTATTGGAAGAGCCGGAGTTGGAGTCGATAATGTAGATGTTAAG
GCTGCTACACAAAAAGGAGTTCTTGTTGTTAATTCTCCAGGGGGTAACACAATAGCTGCTGCTGAACATACTATAGCTAT
GATGTTGGCCTTATCTAGACATATTCCAGTCGCTAATAGTAGTACTCTTTCAGGTAAATGGGAAAGAAAGAAATTTGTTG
GGAATGAGCTTTATAACAAAAAATTAGGTGTAGTAGGTTTAGGAAAAATTGGTGCTCATGTAGCGAAAGTTGCTAATGCA
TTAGGAATGGAAGTTTACGGATACGATCCCTTTGTCTCAACTGAAAGAGCTCAACAAATCCAAGTTAAACTATCTGAAAT
AAAGGATTTATTCCAACAATCTGATTACGTAACTTTGCATTTGCCTCGTACACCAGAGACAGAGAATTTAGTAAATATGA
AGGTGCTTAAAAGTATGAAAAGTAGCGCAAAATTAATTAATTGTGCCCGAGGAGGCTTAATTGACGAAGAAGCATTAGCA
GAAGCTTTAAATGAATCATTGATTGGAGGTGCTGCGATAGATGTCTTTTCTAAAGAGCCATTGGAATCTAATTCACCACT
TTTAAAGGTTGAAAAGAATCTTATTCTTACTCCTCACCTAGGAGCATCTACTCGAGAAGCGCAAGAAAATGTAGCTGTTG
ATGTTGCAGAACAAATCAGAGATGTCTTGCTTGGTTTGTCTGCTAGAACTGCCGTAAATATTCCAGGTTTGAGCCCTGAT
ATTATGGATAGCCTAAAACCTCATTTGCAGTTGGCTGAAACAATGGGTCTGCTTATAAGCCAGCTTTCAGGAGGACAGAT
TCAAAAACTAGAGGTGAAGCTTCAAGGCGAATTTGTTCAACATCCTTCCCAGCCATTAATAATAGCTAGTCTTAAAGGTC
TTCTAAGTAAAGCTTTGGGAGATAGGATCAATTACGTAAATGCTTCTCTAGAGGCAGATTCAAGAGGTATTTCAGTAGTC
GAGAGTAAAGATGAGGCAAGACCTGAATTTGCTAGTGGATCTTTGCAATTAACCACTTATGGAGATAATGGCGACCATAG
CGTAGCAGGAAGCATTTTTGCTGATGGGGAATTAAGAATTATTAGTATTGATCAATATCCTGTTAATGTATCGCCAAGTA
GATACATGTTGGTTACTAGGCACAGGGATATGCCTGGTATTATTGGCAAGCTTGGTTCTTTATTGGGTAGTAACAATGTA
AATATTGCTTCAATGCAAGTTGGGCGCAAAATTGTTAGAGGTGAAGCAGTTATGGTTCTAAGTATTGATGATCCAATTCC
TAATAAGTTGCTTGACACCATTATTGAAGTAGAGGGAATTACCAATGCTAATCCAGTTACTCTATAA

Upstream 100 bases:

>100_bases
AATTTCAATCCTCAAATGTTTGTGTGTTATTCAAATTAATAAAATAAGATACATACACTATAGATTAAGTTAAAGTAAAA
GATTAAAGAACCAATCTTAA

Downstream 100 bases:

>100_bases
AGAGGTCTGCTCTCTGTAATGACAATTAAAGATTGGTATAAACTAACTTTTTTGATTGAAAGTGATTCAGAAGAAATAAT
TATTTGGAAATTAAATGAGC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MTKVLITDPIDQTGIDILSQVAQVDQKIGISDSELASIIKDYDALMIRSGTQVTEEIINSSSKLRIIGRAGVGVDNVDVK
AATQKGVLVVNSPGGNTIAAAEHTIAMMLALSRHIPVANSSTLSGKWERKKFVGNELYNKKLGVVGLGKIGAHVAKVANA
LGMEVYGYDPFVSTERAQQIQVKLSEIKDLFQQSDYVTLHLPRTPETENLVNMKVLKSMKSSAKLINCARGGLIDEEALA
EALNESLIGGAAIDVFSKEPLESNSPLLKVEKNLILTPHLGASTREAQENVAVDVAEQIRDVLLGLSARTAVNIPGLSPD
IMDSLKPHLQLAETMGLLISQLSGGQIQKLEVKLQGEFVQHPSQPLIIASLKGLLSKALGDRINYVNASLEADSRGISVV
ESKDEARPEFASGSLQLTTYGDNGDHSVAGSIFADGELRIISIDQYPVNVSPSRYMLVTRHRDMPGIIGKLGSLLGSNNV
NIASMQVGRKIVRGEAVMVLSIDDPIPNKLLDTIIEVEGITNANPVTL

Sequences:

>Translated_528_residues
MTKVLITDPIDQTGIDILSQVAQVDQKIGISDSELASIIKDYDALMIRSGTQVTEEIINSSSKLRIIGRAGVGVDNVDVK
AATQKGVLVVNSPGGNTIAAAEHTIAMMLALSRHIPVANSSTLSGKWERKKFVGNELYNKKLGVVGLGKIGAHVAKVANA
LGMEVYGYDPFVSTERAQQIQVKLSEIKDLFQQSDYVTLHLPRTPETENLVNMKVLKSMKSSAKLINCARGGLIDEEALA
EALNESLIGGAAIDVFSKEPLESNSPLLKVEKNLILTPHLGASTREAQENVAVDVAEQIRDVLLGLSARTAVNIPGLSPD
IMDSLKPHLQLAETMGLLISQLSGGQIQKLEVKLQGEFVQHPSQPLIIASLKGLLSKALGDRINYVNASLEADSRGISVV
ESKDEARPEFASGSLQLTTYGDNGDHSVAGSIFADGELRIISIDQYPVNVSPSRYMLVTRHRDMPGIIGKLGSLLGSNNV
NIASMQVGRKIVRGEAVMVLSIDDPIPNKLLDTIIEVEGITNANPVTL
>Mature_527_residues
TKVLITDPIDQTGIDILSQVAQVDQKIGISDSELASIIKDYDALMIRSGTQVTEEIINSSSKLRIIGRAGVGVDNVDVKA
ATQKGVLVVNSPGGNTIAAAEHTIAMMLALSRHIPVANSSTLSGKWERKKFVGNELYNKKLGVVGLGKIGAHVAKVANAL
GMEVYGYDPFVSTERAQQIQVKLSEIKDLFQQSDYVTLHLPRTPETENLVNMKVLKSMKSSAKLINCARGGLIDEEALAE
ALNESLIGGAAIDVFSKEPLESNSPLLKVEKNLILTPHLGASTREAQENVAVDVAEQIRDVLLGLSARTAVNIPGLSPDI
MDSLKPHLQLAETMGLLISQLSGGQIQKLEVKLQGEFVQHPSQPLIIASLKGLLSKALGDRINYVNASLEADSRGISVVE
SKDEARPEFASGSLQLTTYGDNGDHSVAGSIFADGELRIISIDQYPVNVSPSRYMLVTRHRDMPGIIGKLGSLLGSNNVN
IASMQVGRKIVRGEAVMVLSIDDPIPNKLLDTIIEVEGITNANPVTL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=410, Percent_Identity=40, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI4557497, Length=271, Percent_Identity=36.90036900369, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI61743967, Length=271, Percent_Identity=36.90036900369, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI145580578, Length=282, Percent_Identity=35.8156028368794, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI4557499, Length=282, Percent_Identity=35.8156028368794, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI145580575, Length=282, Percent_Identity=35.8156028368794, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI6912396, Length=311, Percent_Identity=27.9742765273312, Blast_Score=130, Evalue=3e-30,
Organism=Escherichia coli, GI1789279, Length=323, Percent_Identity=36.5325077399381, Blast_Score=192, Evalue=5e-50,
Organism=Escherichia coli, GI87082289, Length=288, Percent_Identity=31.25, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1787645, Length=196, Percent_Identity=35.2040816326531, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1788660, Length=288, Percent_Identity=30.9027777777778, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI87081824, Length=242, Percent_Identity=26.0330578512397, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=323, Percent_Identity=42.4148606811146, Blast_Score=254, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI25147481, Length=276, Percent_Identity=30.4347826086957, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322116, Length=333, Percent_Identity=33.9339339339339, Blast_Score=180, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6320925, Length=326, Percent_Identity=34.0490797546012, Blast_Score=179, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6324964, Length=261, Percent_Identity=27.9693486590038, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324055, Length=243, Percent_Identity=26.7489711934156, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321253, Length=155, Percent_Identity=32.9032258064516, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=180, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6324980, Length=185, Percent_Identity=26.4864864864865, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19921140, Length=300, Percent_Identity=41, Blast_Score=244, Evalue=8e-65,
Organism=Drosophila melanogaster, GI24646446, Length=263, Percent_Identity=36.5019011406844, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646448, Length=263, Percent_Identity=36.5019011406844, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646452, Length=263, Percent_Identity=36.5019011406844, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646450, Length=263, Percent_Identity=36.5019011406844, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI62472511, Length=302, Percent_Identity=34.4370860927152, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI28571528, Length=312, Percent_Identity=29.1666666666667, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI28574286, Length=331, Percent_Identity=29.9093655589124, Blast_Score=126, Evalue=5e-29,
Organism=Drosophila melanogaster, GI28574284, Length=327, Percent_Identity=27.5229357798165, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24585514, Length=327, Percent_Identity=27.5229357798165, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI28574282, Length=327, Percent_Identity=27.5229357798165, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI45551003, Length=327, Percent_Identity=27.5229357798165, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI45552429, Length=327, Percent_Identity=27.5229357798165, Blast_Score=123, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24585516, Length=311, Percent_Identity=27.3311897106109, Blast_Score=120, Evalue=3e-27,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56565; Mature: 56434

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVLITDPIDQTGIDILSQVAQVDQKIGISDSELASIIKDYDALMIRSGTQVTEEIINS
CCEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEECCCHHHHHHHCC
SSKLRIIGRAGVGVDNVDVKAATQKGVLVVNSPGGNTIAAAEHTIAMMLALSRHIPVANS
CCEEEEEEECCCCCCCCEEEEECCCCEEEEECCCCCEEEHHHHHHHHHHHHHHCCCCCCC
STLSGKWERKKFVGNELYNKKLGVVGLGKIGAHVAKVANALGMEVYGYDPFVSTERAQQI
CCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCEEECCCCCCCCCHHHHH
QVKLSEIKDLFQQSDYVTLHLPRTPETENLVNMKVLKSMKSSAKLINCARGGLIDEEALA
HHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
EALNESLIGGAAIDVFSKEPLESNSPLLKVEKNLILTPHLGASTREAQENVAVDVAEQIR
HHHHHHHCCCCEEECCCCCCCCCCCCEEEEECCEEEECCCCCCCHHHHHHHHHHHHHHHH
DVLLGLSARTAVNIPGLSPDIMDSLKPHLQLAETMGLLISQLSGGQIQKLEVKLQGEFVQ
HHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECHHHC
HPSQPLIIASLKGLLSKALGDRINYVNASLEADSRGISVVESKDEARPEFASGSLQLTTY
CCCCCCHHHHHHHHHHHHHCCHHEEEECCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEC
GDNGDHSVAGSIFADGELRIISIDQYPVNVSPSRYMLVTRHRDMPGIIGKLGSLLGSNNV
CCCCCCCEECEEEECCCEEEEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCC
NIASMQVGRKIVRGEAVMVLSIDDPIPNKLLDTIIEVEGITNANPVTL
EEEHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TKVLITDPIDQTGIDILSQVAQVDQKIGISDSELASIIKDYDALMIRSGTQVTEEIINS
CEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEECCCHHHHHHHCC
SSKLRIIGRAGVGVDNVDVKAATQKGVLVVNSPGGNTIAAAEHTIAMMLALSRHIPVANS
CCEEEEEEECCCCCCCCEEEEECCCCEEEEECCCCCEEEHHHHHHHHHHHHHHCCCCCCC
STLSGKWERKKFVGNELYNKKLGVVGLGKIGAHVAKVANALGMEVYGYDPFVSTERAQQI
CCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCEEECCCCCCCCCHHHHH
QVKLSEIKDLFQQSDYVTLHLPRTPETENLVNMKVLKSMKSSAKLINCARGGLIDEEALA
HHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
EALNESLIGGAAIDVFSKEPLESNSPLLKVEKNLILTPHLGASTREAQENVAVDVAEQIR
HHHHHHHCCCCEEECCCCCCCCCCCCEEEEECCEEEECCCCCCCHHHHHHHHHHHHHHHH
DVLLGLSARTAVNIPGLSPDIMDSLKPHLQLAETMGLLISQLSGGQIQKLEVKLQGEFVQ
HHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECHHHC
HPSQPLIIASLKGLLSKALGDRINYVNASLEADSRGISVVESKDEARPEFASGSLQLTTY
CCCCCCHHHHHHHHHHHHHCCHHEEEECCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEC
GDNGDHSVAGSIFADGELRIISIDQYPVNVSPSRYMLVTRHRDMPGIIGKLGSLLGSNNV
CCCCCCCEECEEEECCCEEEEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCC
NIASMQVGRKIVRGEAVMVLSIDDPIPNKLLDTIIEVEGITNANPVTL
EEEHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]